Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

This study has been completed.

First Received on October 30, 2008. Last Updated on July 25, 2011 History of Changes

Sponsor:	Seoul National University Hospital
Information provided by:	Seoul National University Hospital
ClinicalTrials.gov Identifier:	NCT00783731

Purpose

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Condition	Intervention
Intubation	Drug: Low dose midazolam

Study Type:	Interventional
Study Design:	Primary Purpose: Treatment

Resource links provided by NLM:

Drug Information available for: Midazolam Midazolam maleate Midazolam hydrochloride

U.S. FDA Resources

Further study details as provided by Seoul National University Hospital:

Study Start Date:	October 2008
Study Completion Date:	January 2011
Primary Completion Date:	October 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: Low dose midazolam	Drug: Low dose midazolam

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

patients who need rapid sequence intubation in emergency room

Exclusion Criteria:

in hypotension(systolic blood pressure less than 90 mmHg
severe trauma patients
pregnant
allergic to midazolam, etomidate

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00783731

Locations

Korea, Republic of
Seoul National University Bundang Hospital, Emergency room
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707
Boramae Medical Center
Seoul, Korea, Republic of, 156-707

Sponsors and Collaborators

Seoul National University Hospital

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00783731 History of Changes
Other Study ID Numbers:	RSI study
Study First Received:	October 30, 2008
Last Updated:	July 25, 2011
Health Authority:	Korea: Food and Drug Administration

Keywords provided by Seoul National University Hospital:

intubation

Additional relevant MeSH terms:

Midazolam
Adjuvants, Anesthesia
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions
Anti-Anxiety Agents
Tranquilizing Agents
Central Nervous System Depressants
Physiological Effects of Drugs

Psychotropic Drugs
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
GABA Modulators
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on February 09, 2012