Tissue Penetration of Antibiotics in Obesity

This study has been completed.

First Received on September 12, 2008. Last Updated on June 27, 2011 History of Changes

Sponsor:	Washington University School of Medicine
Information provided by:	Washington University School of Medicine
ClinicalTrials.gov Identifier:	NCT00752908

Purpose

The purpose of this study is to evaluate cefoxitin pharmacokinetics in obese surgical patients.

Condition
Obesity

Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Prospective
Official Title:	Tissue Penetration of Antibiotics in Obesity

Resource links provided by NLM:

MedlinePlus related topics: Antibiotics Obesity

U.S. FDA Resources

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:

plasma and tissue cefoxitin concentrations at the time of incision [ Time Frame: 8 hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

cefoxitin pharmacokinetic parameters [ Time Frame: 8 hours ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples Without DNA

plasma, interstitial fluid

Estimated Enrollment:	30
Study Start Date:	February 2008
Study Completion Date:	June 2011
Primary Completion Date:	June 2011 (Final data collection date for primary outcome measure)

Groups/Cohorts
1
2

Eligibility

Study Population

Surgical Patients at BJH

Criteria

Inclusion Criteria:

Exclusion Criteria:

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00752908

Locations

United States, Missouri
Barnes Jewish Hospital
St. Louis, Missouri, United States, 63110

Sponsors and Collaborators

Washington University School of Medicine

Investigators

Principal Investigator:

Evan D Kharasch, MD, PhD

Washington University School of Medicine

More Information

No publications provided

Responsible Party:	Evan Kharasch, MD, PhD, Washington University School of Medicine
ClinicalTrials.gov Identifier:	NCT00752908 History of Changes
Other Study ID Numbers:	070678
Study First Received:	September 12, 2008
Last Updated:	June 27, 2011
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:

Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight

Signs and Symptoms
Anti-Bacterial Agents
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on February 09, 2012