Antagonistic Interaction CB1-paracetamol - Full Text View

Sponsor:	University Hospital, Clermont-Ferrand
Information provided by:	University Hospital, Clermont-Ferrand
ClinicalTrials.gov Identifier:	NCT00750347

Purpose

Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of Paracetamol in healthy volunteers

Condition	Intervention	Phase
Pain	Drug: Rimonabant and Paracetamol and placebo	Phase I

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment
Official Title:	Evaluation of the Interaction of Rimonabant (Antagonist of CB1 Receptor) on the Analgesic Effect of Paracetamol in Intravenous Administration

Resource links provided by NLM:

MedlinePlus related topics: Drug Reactions

Drug Information available for: Acetaminophen SR 141716A CT 2584 Rimonabant

U.S. FDA Resources

Further study details as provided by University Hospital, Clermont-Ferrand:

Primary Outcome Measures:

Pain's threshold with electrical stimulation (Pain Matcher). Pain's threshold with mechanical stimulation (electronical Von Frey). [ Time Frame: during electrical stimulation ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

Plasmatic concentration of paracetamol or his metabolite with or without Rimonabant [ Time Frame: with or without rimonabant ] [ Designated as safety issue: Yes ]

Estimated Enrollment:	24
Study Start Date:	September 2008
Study Completion Date:	October 2008
Primary Completion Date:	October 2008 (Final data collection date for primary outcome measure)

Intervention Details:

evaluation of an possible inhibiting effect of rimonabant on the analgesic effect of paracetamol in healthy volunteers

Detailed Description:

Double Blind, cross-over, randomized and controlled versus placebo, study in healthy volunteers.

Eligibility

Criteria

Inclusion Criteria:

Exclusion Criteria:

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00750347

Locations

Sponsors and Collaborators

University Hospital, Clermont-Ferrand

Investigators

Principal Investigator:

Dubray Claude, Pr

University Hospital, Clermont-Ferrand

More Information

No publications provided

Responsible Party:	Pr Claude DUBRAY, CIC-CPC
ClinicalTrials.gov Identifier:	NCT00750347 History of Changes
Other Study ID Numbers:	CHU-0037
Study First Received:	September 9, 2008
Last Updated:	January 18, 2011
Health Authority:	France: Ministry of Health

Keywords provided by University Hospital, Clermont-Ferrand:

pain,
analgesia
Healthy volunteers

Additional relevant MeSH terms:

Acetaminophen
Analgesics
Antipyretics
Physiological Effects of Drugs
Pharmacologic Actions

Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on February 09, 2012