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| Sponsor: | University of California, San Diego |
|---|---|
| Collaborator: |
Forest Laboratories |
| Information provided by: | University of California, San Diego |
| ClinicalTrials.gov Identifier: | NCT00652457 |
Purpose
To determine if memantine in doses of 10 mg BID affects memory, cognition, and behavior in patients with Huntington's disease (HD).
| Condition | Intervention | Phase |
|---|---|---|
|
Huntington's Disease |
Drug: Memantine |
Phase IV |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | A Pilot Study of Memantine for Cognitive and Behavioral Dysfunction in Huntington's Disease" |
| Estimated Enrollment: | 60 |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Memantine 10 mg BID for three months
|
Drug: Memantine
10 mg BID x 3 months
Other Name: Namenda
|
Results of several published clinical trials suggest that memantine has a beneficial effect in dementing conditions, such as Alzheimer's disease; however, the effects of memantine on cognitive and behavioral function in HD are unknown. Our hypotheses are that HD patients who are administered memantine will show improved performance on psychometric tests of memory and executive functions in addition to behavior and that patients treated with memantine will show more improvement after six months than after three months of treatment.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Jody Corey-Bloom, MD, PhD | 858-642-3470 | jcoreybl@vapop.ucsd.edu |
| Contact: Jody Goldstein, BA | 858-622-5854 | jlgoldstein@ucsd.edu |
| United States, California | |
| University of California, San Diego | Recruiting |
| La Jolla, California, United States, 92037 | |
| Contact: Jody Corey-Bloom, MD, PhD 858-642-3470 jcoreybl@vapop.ucsd.edu | |
| Contact: Jody Goldstein, BA 858-622-5854 jlgoldstein@ucsd.edu | |
| Principal Investigator: Jody Corey-Bloom, MD, PhD | |
| United States, Kansas | |
| University of Kansas Medical Center | Recruiting |
| Kansas City, Kansas, United States, 66160 | |
| Contact: Richard Dubinsky, MD, MPH rdubinsky@safetyresearch.com | |
| Contact: Janice Broyles-Gorman jbroyles-gorman@kumc.edu | |
| Principal Investigator: Richard Dubinsky, MD, MPH | |
| United States, Maryland | |
| Johns Hopkins Hospital | Recruiting |
| Baltimore, Maryland, United States, 21287 | |
| Contact: Adam Roseblatt, MD 410-955-2398 arosenb3@jhmi.edu | |
| Contact: Nadine Yoritomo nyorito1@jhmi.edu | |
| Principal Investigator: Adam Rosenblatt, MD | |
More Information
| Responsible Party: | Jody Corey-Bloom, MD, PhD, Department of Neurosciences, University of California San Diego |
| ClinicalTrials.gov Identifier: | NCT00652457 History of Changes |
| Other Study ID Numbers: | MEM-HD |
| Study First Received: | March 31, 2008 |
| Last Updated: | March 31, 2008 |
| Health Authority: | United States: Food and Drug Administration (IND exemption) |
|
Huntington Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Dementia Chorea Dyskinesias Movement Disorders Heredodegenerative Disorders, Nervous System Neurodegenerative Diseases Genetic Diseases, Inborn Cognition Disorders Delirium, Dementia, Amnestic, Cognitive Disorders |
Mental Disorders Memantine Dopamine Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Physiological Effects of Drugs Excitatory Amino Acid Antagonists Excitatory Amino Acid Agents Antiparkinson Agents Anti-Dyskinesia Agents Central Nervous System Agents Therapeutic Uses |