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| Sponsor: | Samsung Medical Center |
|---|---|
| Information provided by: | Samsung Medical Center |
| ClinicalTrials.gov Identifier: | NCT00624039 |
Purpose
The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility.
| Condition | Intervention |
|---|---|
|
Presbyopia Cataract |
Other: UBM with pilocarpine in presbyopia |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Double Blind (Investigator, Outcomes Assessor) Primary Purpose: Basic Science |
| Official Title: | The Effect of Cataract Extraction on the Contractility of Ciliary Muscle |
| Enrollment: | 15 |
| Study Start Date: | May 2006 |
| Estimated Study Completion Date: | March 2008 |
| Estimated Primary Completion Date: | March 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
1
ultrasound biomicrocopic examinations and pilocarpine instillation
|
Other: UBM with pilocarpine in presbyopia
ultrasound biomicroscopic examination in both eyes 30 minutes after one drop of 2% pilocarpine hydrochloride (Ocucarpine®, Samil Pharm., Seoul, Korea) instillation before and two months after cataract surgery
Other Name: UBM with pilocarpine
|
The functional changes in the ciliary body in presbyopia are not only important in a study of the mechanism for presbyopia but are also a key to various procedures or devices used to restore accommodation. Therefore, it is becoming increasingly important to quantify the in vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before and 2 months after cataract extraction. Images of the ciliary body will be compared visually using Adobe Photoshop 7.0.
Eligibility| Ages Eligible for Study: | 55 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Korea, Republic of | |
| Samsung Medical Center | |
| Seoul, Korea, Republic of, 135-710 | |
| Study Director: | Changwon Kee, M.D. | Department of Ophthalmology, Samsung Medical Center, Ilwon-dong, Kangnam-gu, Seoul, 135-710, Republic of Korea. E-mail: ckee@skku.edu |
More Information
| Responsible Party: | Changwon Kee, Department of Ophthalmology, Samsung Medical Center, Seoul, Korea |
| ClinicalTrials.gov Identifier: | NCT00624039 History of Changes |
| Other Study ID Numbers: | CB2006 |
| Study First Received: | February 18, 2008 |
| Last Updated: | February 18, 2008 |
| Health Authority: | South Korea: Institutional Review Board |
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presbyopia |
|
Presbyopia Cataract Refractive Errors Eye Diseases Lens Diseases Pilocarpine Miotics Autonomic Agents |
Peripheral Nervous System Agents Physiological Effects of Drugs Pharmacologic Actions Muscarinic Agonists Cholinergic Agonists Cholinergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action |
