Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

The recruitment status of this study is unknown because the information has not been verified recently.

Verified March 2007 by Melbourne Health. Recruitment status was Recruiting

First Received on March 8, 2007. No Changes Posted

Sponsor:	Melbourne Health
Information provided by:	Melbourne Health
ClinicalTrials.gov Identifier:	NCT00446212

Purpose

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Condition	Intervention	Phase
Anaesthesia Dreaming	Drug: Propofol Drug: desflurane	Phase IV

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Diagnostic
Official Title:	Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Resource links provided by NLM:

Drug Information available for: I 653 Propofol

U.S. FDA Resources

Further study details as provided by Melbourne Health:

Primary Outcome Measures:

Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire

Estimated Enrollment:	300
Study Start Date:	August 2006
Estimated Study Completion Date:	August 2007

Detailed Description:

Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Eligibility

Ages Eligible for Study:	18 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Male and female patients
Age between 18 and 50 years
Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

Inadequate English language comprehension
Major drug abuse problem

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00446212

Contacts

Contact: Kate Leslie, MD

61-3-93427000

kate.leslie@mh.org.au

Locations

Australia, Victoria
Royal Melbourne Hospital	Recruiting
Parkville, Victoria, Australia, 3050
Contact: Kate Leslie, MD 61-3-93427000 kate.leslie@mh.org.au
Principal Investigator: Kate Leslie, MD
Australia, Western Australia
Royal Perth Hospital	Recruiting
Perth, Western Australia, Australia, 6000
Contact: Michael Paech, MD 61-8-9340 2222 michael. paech@health.wa.gov.au
Principal Investigator: Michael Paech, MD
King Edward Memorial Hospital for Women	Recruiting
Subiaco, Western Australia, Australia, 6008
Contact: Michael Paech, MD 61-8-9340 2222 michael.paech@health.wa.gov.au
Principal Investigator: Michael Paech, MD
New Zealand
Waikato Hospital	Recruiting
Hamilton, New Zealand
Contact: Jamie Sleigh, MD 64-7-8398899 sleighj@waikatodhb.govt.nz
Principal Investigator: Michael Paech, MD

Sponsors and Collaborators

Melbourne Health

Investigators

Principal Investigator:

Kate Leslie, MD

Melbourne Health

More Information

No publications provided by Melbourne Health

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Leslie K, Sleigh J, Paech MJ, Voss L, Lim CW, Sleigh C. Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane. Anesthesiology. 2009 Sep;111(3):547-55.

ClinicalTrials.gov Identifier:	NCT00446212 History of Changes
Other Study ID Numbers:	2006.125
Study First Received:	March 8, 2007
Last Updated:	March 8, 2007
Health Authority:	Australia: Department of Health and Ageing Therapeutic Goods Administration

Keywords provided by Melbourne Health:

anaesthesia
propofol
desflurane
dreaming
electroencephalography

Additional relevant MeSH terms:

Anesthetics
Propofol
Desflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions

Central Nervous System Agents
Therapeutic Uses
Anesthetics, Intravenous
Anesthetics, General
Hypnotics and Sedatives
Anesthetics, Inhalation

ClinicalTrials.gov processed this record on February 09, 2012