Heredity of Retinal Vessel Tortuosity

This study has been completed.

First Received on January 25, 2007. No Changes Posted

Sponsor:	Glostrup University Hospital, Copenhagen
Collaborator:	Juvenile Diabetes Research Foundation
Information provided by:	Glostrup University Hospital, Copenhagen
ClinicalTrials.gov Identifier:	NCT00427063

Purpose

The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Condition
Retinopathy of Prematurity

Study Type:	Observational
Study Design:	Observational Model: Defined Population Observational Model: Natural History Time Perspective: Cross-Sectional Time Perspective: Prospective
Official Title:	Heredity of Retinal Vessel Tortuosity - A Twin Study

Resource links provided by NLM:

MedlinePlus related topics: Retinal Disorders

U.S. FDA Resources

Further study details as provided by Glostrup University Hospital, Copenhagen:

Estimated Enrollment:	218
Study Start Date:	January 1998
Estimated Study Completion Date:	December 1998

Detailed Description:

All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

Eligibility

Ages Eligible for Study:	20 Years to 46 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Samesex twin pairs of self-assessed good health

Exclusion Criteria:

Diabetes mellitus
Hypertension
Thyroid disease
Cataract or other opacities of the refractive media
Missing fundus photographs

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00427063

Locations

Denmark
Department of Ophthalmology Glostrup Hospital
Glostrup, Copenhagen County, Denmark, DK-2600

Sponsors and Collaborators

Glostrup University Hospital, Copenhagen

Juvenile Diabetes Research Foundation

Investigators

Principal Investigator:

Michael Larsen, Prof. MD

Department of Ophthalmology Glostrup Hospital University of Copenhagen

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00427063 History of Changes
Other Study ID Numbers:	Danish Twin Registry 1998
Study First Received:	January 25, 2007
Last Updated:	January 25, 2007
Health Authority:	Denmark: Ethics Committee

Keywords provided by Glostrup University Hospital, Copenhagen:

retinal vessels
tortuosity

Additional relevant MeSH terms:

Retinal Diseases
Retinopathy of Prematurity
Eye Diseases
Infant, Premature, Diseases
Infant, Newborn, Diseases

ClinicalTrials.gov processed this record on February 09, 2012