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| Sponsor: | Montreal Heart Institute |
|---|---|
| Collaborator: |
AstraZeneca |
| Information provided by: | Montreal Heart Institute |
| ClinicalTrials.gov Identifier: | NCT00400582 |
Purpose
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
| Condition | Intervention | Phase |
|---|---|---|
|
Heart Failure |
Drug: Candesartan up to 32 mg daily |
Phase IV |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Pharmacodynamics Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | Effect of ACE Inhibitor Plus High Dose Candesartan on BNP and Inflammation in Patients With LV Dysfunction: Impact of Renin-angiotensin-aldosterone System Genetic Polymorphisms |
| Estimated Enrollment: | 300 |
| Study Start Date: | November 2006 |
| Study Completion Date: | April 2010 |
| Primary Completion Date: | April 2010 (Final data collection date for primary outcome measure) |
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Principal Inclusion Criteria:
Principal Exclusion Criteria:
Contacts and Locations| Canada, Quebec | |
| Montreal Heart Institute | |
| Montreal, Quebec, Canada, H1T 1C8 | |
| Principal Investigator: | Michel White, MD | Montreal Heart Institute |
| Principal Investigator: | Simon de Denus, B. Pharm, MSc,PhD | Montreal Heart Institute/ Faculty of Pharmacy, University of Montreal |
More Information
| Responsible Party: | Michel White, Montreal Heart Institute |
| ClinicalTrials.gov Identifier: | NCT00400582 History of Changes |
| Other Study ID Numbers: | MHI 06-890, D2454L00003 |
| Study First Received: | November 15, 2006 |
| Last Updated: | July 20, 2011 |
| Health Authority: | Canada: Health Canada |
|
Heart failure Gene polymorphism Candesartan |
ACE inhibitors BNP Pharmacogenomics |
|
Heart Failure Heart Diseases Cardiovascular Diseases Angiotensin-Converting Enzyme Inhibitors Candesartan Candesartan cilexetil Protease Inhibitors Enzyme Inhibitors |
Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Antihypertensive Agents Cardiovascular Agents Therapeutic Uses Angiotensin II Type 1 Receptor Blockers Angiotensin Receptor Antagonists |