The following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. This information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional.

Main criteria are listed hereafter:

Inclusion Criteria

• Patient hospitalised with ischemic symptoms (last episode within the last 48 hours before randomization) and at least one of the following characteristics of NSTEACS (non-ST-segment-elevation acute coronary syndromes):

  • ECG ST or T changes (ST depression or transient elevation of at least 1mm or T wave changes in at least 2 leads)
  • Positive troponin (according to local threshold)

Exclusion Criteria

• Women of child bearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 4 weeks after the study WOCBP using a prohibited contraceptive method (not applicable)
• Women who are pregnant or breast feeding
• Women with a positive pregnancy test on enrolment or prior to study drug administration
• Patient with dementia
• Persistent ST segment elevation at ECG
• Systolic blood pressure < 100 mmHg
• Bilateral stenosis of renal artery
• Creatinine clearance < or = 30ml/mn
• Congestive heart failure with symptoms consistent with New York Heart Association (NYHA) class III or IV.
• Aortic or mitral valve stenosis
• Hypertrophic cardiomyopathy
• Connective tissue disease with vascular involvement
• Angioplasty, surgery or trauma within the last 3 months
• Coronarography or angioplasty planned to be performed or performed before baseline sampling
• Febrile (≥ 38°C) disease, known concomitant viral or bacterial infection, chronic auto immune disease, chronic inflammatory disease, known cancer in evolution
• Hyperkalemia: serum potassium > 5.5mmol/l
• Sensitivity or intolerance to Angiotensin receptor blockers (ARBs) : olmesartan, candesartan, irbesartan, eprosartan, losartan, telmisartan, valsartan and/or any other ARB currently or previously in development.
• Sensitivity or intolerance to Angiotensin-converting Enzyme Inhibitors (ACE-I) : benazepril, captopril, enalapril, lisinopril, trandolapril, ramipril, quinapril, and/or any other ACE-I currently or previously in development.
• Chronic steroid or non-steroidal anti inflammatory drugs (NSAIDs) use. Aspirin is permitted.
• Treatment with allopurinol or procaïnamide
• Concomitant use of potassium sparing diuretics (eg. spironolactone, triamterene or amiloride), potassium preparations or salt substitutes containing potassium
• Treatment with Lithium
• Immunosupressive medication
• Administration of any other investigational drug in the last 30 days before enrolment and during the course of the study
• Treatment with ARB or ACE inhibitor within the last 3 days.