Antiemetic Effect of the Addition of Ondansetron to the Morphine Solution in Patient-Controlled Analgesia (PCA)

This study has been completed.

First Received on September 14, 2005. Last Updated on October 31, 2007 History of Changes

Sponsor:	Khon Kaen University
Information provided by:	Khon Kaen University
ClinicalTrials.gov Identifier:	NCT00199329

Purpose

PCA morphine always introduces nausea and vomiting during the postoperative period. Ondansetron can reduce PONV (postoperative nausea vomiting). We, the researchers at Khon Kaen University, are trying to add ondansetron in PCA morphine. Patients receive a small dose of ondansetron when they request morphine.

Condition	Intervention
Postoperative Nausea and Vomiting	Drug: ondansetron adding in PCA

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment

Resource links provided by NLM:

MedlinePlus related topics: Nausea and Vomiting

Drug Information available for: Ondansetron hydrochloride Ondansetron

U.S. FDA Resources

Further study details as provided by Khon Kaen University:

Primary Outcome Measures:

PONV [ Time Frame: 24 hr ]

Enrollment:	160
Study Start Date:	January 2005

Eligibility

Ages Eligible for Study:	15 Years to 60 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Age between 15-60 years old

Exclusion Criteria:

History of motion sickness, smoking

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00199329

Locations

Thailand
Khon Kaen university, Srinagarind Hospital
Muang, Khon Kaen, Thailand, 40002

Sponsors and Collaborators

Khon Kaen University

Investigators

Study Director:

Polpun Boonmak, MD

lecturer in Khon Kaen University

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00199329 History of Changes
Other Study ID Numbers:	I48027
Study First Received:	September 14, 2005
Last Updated:	October 31, 2007
Health Authority:	Thailand: Food and Drug Administration

Keywords provided by Khon Kaen University:

ondansetron
PCA

Additional relevant MeSH terms:

Vomiting
Postoperative Nausea and Vomiting
Signs and Symptoms, Digestive
Signs and Symptoms
Postoperative Complications
Pathologic Processes
Nausea
Ondansetron
Antiemetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents

Therapeutic Uses
Gastrointestinal Agents
Antipruritics
Dermatologic Agents
Serotonin Antagonists
Serotonin Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
Anti-Anxiety Agents

ClinicalTrials.gov processed this record on February 09, 2012