Inclusion Criteria:

• Age 18-75
• History of acromegaly with biochemical cure documented with a normal OGTT and/or a non-elevated IGF-I without concurrent use of somatostatin analogs, dopamine agonists or GH receptor antagonists. Subjects will have been treated with medication, surgery, radiation, or a combination of these
• At the time of enrollment a minimum of 6 months must have elapsed since surgery.
• No malignancy on colonoscopy performed since the diagnosis of acromegaly
• GHD due to surgical or radiation treatment
• GHD will be defined as a peak plasma GH of less than 5 ng/ml in response to an insulin tolerance test or a GHRH plus arginine stimulation test
• GHD will also be diagnosed if IGF-I levels are below 2 standard deviations for the age-sex normal range in a patient with at least two other documented anterior pituitary hormone deficiencies

Exclusion Criteria:

• Untreated thyroid or adrenal insufficiency. Subjects on replacement therapy must be stable for at least 3 months prior to entry into the study
• History of malignancy except for non-melanoma skin cancer
• Hemoglobin <11.0 gm/dl
• Uncontrolled hypertension
• Hepatic or renal disease (AST/ALT > 3x ULN or creatinine level >2.5 mg/dl)
• Congestive heart failure (New York Heart Association's classification system Class II-IV CHF will be excluded)
• Unstable cardiovascular disease (coronary artery or cerebrovascular disease) or symptoms within one year prior to entry into the study
• Initiation or discontinuation of gonadal steroid therapy within 3 months of entry
• Diabetes mellitus, impaired fasting glucose, impaired glucose tolerance
• Pregnancy or nursing
• Active carpal tunnel syndrome
• Subjects who have received GH therapy within one year prior to entry into the study
• For female subjects age >40 a screening mammogram must have been obtained within one year prior to their baseline visit.
• Sensitivity to m-cresol