Familial Amyotrophic Lateral Sclerosis (FALS) Study

This study is currently recruiting participants.

Verified February 2011 by University of Miami

First Received on August 25, 2005. Last Updated on October 17, 2011 History of Changes

Sponsor:	University of Miami
Information provided by:	University of Miami
ClinicalTrials.gov Identifier:	NCT00136500

Purpose

The goal of this study is to identify families with Amyotrophic Lateral Sclerosis (ALS). In addition, the investigators will identify families with ALS who may be eligible for the pre-fALS study or a clinical trial of arimoclomol in SOD1 positive familial ALS. For details of these studies, see independent entries on clincialtrials.gov.

Condition
Amyotrophic Lateral Sclerosis

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Familial Amyotrophic Lateral Sclerosis (FALS) Study

Resource links provided by NLM:

Genetics Home Reference related topics: amyotrophic lateral sclerosis Help Me Understand Genetics

MedlinePlus related topics: Amyotrophic Lateral Sclerosis

U.S. FDA Resources

Further study details as provided by University of Miami:

Biospecimen Retention: Samples With DNA

blood, DNA

Estimated Enrollment:	10000
Study Start Date:	February 2005

Detailed Description:

Participation in this study involves a telephone conversation in which the investigators will draw your family tree, identifying those relatives who have had or currently have ALS. The investigators would also like study participants to donate a blood sample for research purposes.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

People in families where at least two relatives have or have had ALS.

Criteria

Inclusion Criteria:

Having two or more family members who have or have had ALS

Exclusion Criteria:

No family history of more than one family member having ALS

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00136500

Contacts

Contact: Vanessa Vazquez, MPH

888-413-9315

fals@med.miami.edu

Locations

United States, Florida
University of Miami	Recruiting
Miami, Florida, United States, 33136
Contact: Vanessa Vazquez, MPH 888-413-9315 fals@med.miami.edu

Sponsors and Collaborators

University of Miami

Investigators

Principal Investigator:

Michael Benatar, MD, PhD.

University of Miami

More Information

Additional Information:

Muscular Dystrophy Association This link exits the ClinicalTrials.gov site

No publications provided

Responsible Party:	Michael Benatar, University of Miami
ClinicalTrials.gov Identifier:	NCT00136500 History of Changes
Other Study ID Numbers:	FALS feasibility
Study First Received:	August 25, 2005
Last Updated:	October 17, 2011
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Miami:

familial ALS
fALS
SOD1
genetics
family tree

Additional relevant MeSH terms:

Amyotrophic Lateral Sclerosis
Sclerosis
Motor Neuron Disease
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases

Neurodegenerative Diseases
TDP-43 Proteinopathies
Neuromuscular Diseases
Proteostasis Deficiencies
Metabolic Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on February 09, 2012