The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

This study has been completed.

First Received on November 12, 2003. Last Updated on January 15, 2010 History of Changes

Sponsor:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:	NCT00072917

Purpose

This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

Condition
Obesity Thinness Weight Gain

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

Resource links provided by NLM:

MedlinePlus related topics: Obesity

U.S. FDA Resources

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Biospecimen Retention: Samples With DNA

Blood and urine

Estimated Enrollment:	100
Study Start Date:	October 2003
Estimated Study Completion Date:	June 2008

Eligibility

Ages Eligible for Study:	25 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Subjects have been recruited through advertisements in local news media and on the internet

Criteria

Half of the subjects will be women, half will be men,
age 25-35,
a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI>30.
Subjects should not engage in planned physical activity more than 3 hrs per week.
For the obesity prone group there should be at least 1 1st degree relative with a BMI>30.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00072917

Locations

United States, Colorado
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80262

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

More Information

No publications provided

Responsible Party:	Daniel H. Bessesen, MD, University of Colorado School of Medicine
ClinicalTrials.gov Identifier:	NCT00072917 History of Changes
Other Study ID Numbers:	OVOPOB DK62874 (complted), DK62874
Study First Received:	November 12, 2003
Last Updated:	January 15, 2010
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

obesity
thinness
weight gain
physical activity
diet

fat oxidation
hunger
feeding behavior
overfeeding

Additional relevant MeSH terms:

Obesity
Thinness
Weight Gain
Overnutrition
Nutrition Disorders

Overweight
Body Weight
Signs and Symptoms
Body Weight Changes

ClinicalTrials.gov processed this record on February 09, 2012