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| Sponsor: | Societe Internationale d'Oncologie Pediatrique |
|---|---|
| Collaborators: |
Children's Cancer and Leukaemia Group Societe Francaise Oncologie Pediatrique |
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00025441 |
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating children with metastatic rhabdomyosarcoma or other malignant mesenchymal tumors.
| Condition | Intervention | Phase |
|---|---|---|
|
Ovarian Cancer Sarcoma Small Intestine Cancer |
Biological: dactinomycin Biological: filgrastim Drug: carboplatin Drug: cyclophosphamide Drug: doxorubicin hydrochloride Drug: epirubicin hydrochloride Drug: etoposide Drug: ifosfamide Drug: vincristine sulfate Procedure: peripheral blood stem cell transplantation Radiation: radiation therapy |
Phase II |
| Study Type: | Interventional |
| Study Design: | Primary Purpose: Treatment |
| Official Title: | MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood |
Eligibility| Ages Eligible for Study: | 6 Years to 17 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically confirmed metastatic rhabdomyosarcoma or other malignant mesenchymal tumors
Standard risk defined as:
High risk defined as:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Contacts and Locations| France | |
| Centre Leon Berard | |
| Lyon, France, 69373 | |
| Ireland | |
| Our Lady's Hospital for Sick Children | |
| Crumlin, Ireland, 12 | |
| United Kingdom | |
| Birmingham Children's Hospital | |
| Birmingham, England, United Kingdom, B4 6NH | |
| Bristol Royal Hospital for Children | |
| Bristol, England, United Kingdom, BS2 8BJ | |
| Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust | |
| Cambridge, England, United Kingdom, CB2 2QQ | |
| Leicester Royal Infirmary | |
| Leicester, England, United Kingdom, LE1 5WW | |
| Royal Liverpool Children's Hospital, Alder Hey | |
| Liverpool, England, United Kingdom, L12 2AP | |
| Leeds Cancer Centre at St. James's University Hospital | |
| London, England, United Kingdom, W6 8RF | |
| Great Ormond Street Hospital for Children NHS Trust | |
| London, England, United Kingdom, WC1N 3JH | |
| Saint Bartholomew's Hospital | |
| London, England, United Kingdom, EC1A 7BE | |
| Meyerstein Institute of Oncology at University College of London Hospitals | |
| London, England, United Kingdom, WIT 3AA | |
| Central Manchester and Manchester Children's University Hospitals NHS Trust | |
| Manchester, England, United Kingdom, M27 4HA | |
| Newcastle Upon Tyne Hospitals NHS Trust | |
| Newcastle-Upon-Tyne, England, United Kingdom, NE7 7DN | |
| Queen's Medical Centre | |
| Nottingham, England, United Kingdom, NG7 2UH | |
| Oxford Radcliffe Hospital | |
| Oxford, England, United Kingdom, 0X3 9DU | |
| Children's Hospital - Sheffield | |
| Sheffield, England, United Kingdom, S10 2TH | |
| Southampton General Hospital | |
| Southampton, England, United Kingdom, SO16 6YD | |
| Royal Marsden NHS Foundation Trust - Surrey | |
| Sutton, England, United Kingdom, SM2 5PT | |
| Royal Belfast Hospital for Sick Children | |
| Belfast, Northern Ireland, United Kingdom, BT12 6BE | |
| Aberdeen Royal Infirmary | |
| Aberdeen, Scotland, United Kingdom, AB25 2ZN | |
| Royal Hospital for Sick Children | |
| Edinburgh, Scotland, United Kingdom | |
| Royal Hospital for Sick Children | |
| Glasgow, Scotland, United Kingdom, G3 8SJ | |
| Study Chair: | Heather P. McDowell, MD | Royal Liverpool Children's Hospital, Alder Hey |
| Study Chair: | Annabel B.M. Foot | Bristol Royal Hospital for Children |
| Study Chair: | Christophe Bergeron | Centre Leon Berard |
More Information
| ClinicalTrials.gov Identifier: | NCT00025441 History of Changes |
| Other Study ID Numbers: | CDR0000068961, SIOP-MMT-98, SFOP-SIOP-MMT-98, CCLG-SIOP-MMT-98, EU-20126, STS-1998 |
| Study First Received: | October 11, 2001 |
| Last Updated: | April 1, 2010 |
| Health Authority: | United States: Federal Government |
|
chondrosarcoma small intestine leiomyosarcoma fibrosarcomatous osteosarcoma embryonal childhood rhabdomyosarcoma alveolar childhood rhabdomyosarcoma pleomorphic childhood rhabdomyosarcoma mixed childhood rhabdomyosarcoma embryonal-botryoid childhood rhabdomyosarcoma metastatic childhood soft tissue sarcoma extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumor childhood fibrosarcoma childhood synovial sarcoma |
childhood malignant hemangiopericytoma childhood liposarcoma childhood alveolar soft-part sarcoma childhood leiomyosarcoma childhood angiosarcoma childhood epithelioid sarcoma childhood malignant mesenchymoma stage IV uterine sarcoma uterine leiomyosarcoma ovarian sarcoma previously untreated childhood rhabdomyosarcoma childhood desmoplastic small round cell tumor |
|
Ovarian Neoplasms Rhabdomyosarcoma Duodenal Neoplasms Ileal Neoplasms Jejunal Neoplasms Sarcoma Intestinal Neoplasms Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Ovarian Diseases Adnexal Diseases Genital Diseases, Female Genital Neoplasms, Female Urogenital Neoplasms |
Endocrine System Diseases Gonadal Disorders Myosarcoma Neoplasms, Muscle Tissue Neoplasms, Connective and Soft Tissue Neoplasms by Histologic Type Gastrointestinal Neoplasms Digestive System Neoplasms Digestive System Diseases Gastrointestinal Diseases Duodenal Diseases Intestinal Diseases Ileal Diseases Jejunal Diseases Dactinomycin |