PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

• Sickle cell disease confirmed by electrophoresis or high pressure liquid chromatography
• At least one prior documented painful crisis episode but no greater than 10 crises per year for the last two years
• Sudden onset of acute pain lasting 4-12 hours and involving at least one site
• Severe crisis pain that requires parenteral analgesics and hospitalization, but not within the preceding 2 weeks

--Prior/Concurrent Therapy--

• Surgery: At least 2 weeks since prior major surgery No concurrent surgery
• Other: At least 2 weeks since prior puncture of noncompressible vessels No prior therapy using poloxamer 188 No concurrent investigational drug No concurrent use of nonsteroidal anti-inflammatory drugs

--Patient Characteristics--

• Hematopoietic: No significant bleeding or bleeding disorder
• Hepatic: ALT no greater than 2 times normal
• Renal: No active renal disease Creatinine no greater than 1.0 mg/dL OR Creatinine clearance greater than 50 mL/min Protein less than 300 mg/dL
• Cardiovascular: No evidence of acute myocardial ischemia or infarction
• Neurologic: At least 6 months since prior cerebrovascular accident or seizure
• Other: Not pregnant Fertile patients must use effective contraception during and for at least 30 days after treatment No history of chronic bacterial osteomyelitis No history of drug or alcohol abuse At least 6 months since prior use of illicit drug Have adequate IV access No crisis with life-threatening complications such as: Hepatic or splenic sequestration Acute chest syndrome Aplastic crisis No known infection or infection with encapsulated organism No evidence of septic shock Not concurrently hospitalized for other conditions Not concurrently on hypertransfusion program