Inclusion Criteria

Patients must have:

• HIV infection.
• Antiretroviral naiveness (i.e., less than 4 weeks of prior treatment) to at least one of the licensed nucleoside drugs.
• No more than 2 weeks of prior treatment with a protease inhibitor.
• No active opportunistic infection or other serious AIDS-defining condition.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Malabsorption or inadequate oral intake.
• Lab or clinical abnormality worse than grade 3 (other than exercise-induced CPK elevations).
• Unexplained, chronic diarrhea, defined as more than three loose stools per day persisting for 2 weeks or more within the month prior to study entry.
• Active malignancy or anticipated need for chemotherapy during the study.
• Anticipated need for disallowed medications during the study.

Concurrent Medication:

Excluded:

• Other protease inhibitors.

Prior Medication:

Excluded:

• More than 4 weeks of the prior nucleoside antiretroviral selected for the patient's regimen.
• More than 2 weeks of any protease inhibitor.