Inclusion Criteria

Concurrent Medication:

Allowed:

• Zidovudine (AZT).
• Necessary topical agents such as nystatin, clotrimazole, and acyclovir.
• Aerosolized pentamidine for Pneumocystis carinii pneumonia (PCP) prophylaxis.
• Oral antibiotics for PCP prophylaxis if hematologically stable for = or > 30 days prior to study entry.
• Necessary systemic agents for the treatment of other chronic disorders, such as diabetes or asthma.

Patients must have:

• HIV-1 seropositivity.
• Asymptomatic.
• No opportunistic infection for 8 weeks prior to study entry.
• Been on azidothymidine (AZT) (= or > 500 mg/day) for at least 8 weeks prior to beginning interleukin-2 (IL-2), with stable CD4 cell counts.

Prior Medication:

Allowed:

• Zidovudine (AZT).

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

• Active, life-threatening opportunistic infection (OI) with bacterial, viral, fungal, or protozoan pathogens.
• Fever = or > 101 F. within 10 days prior to study entry.
• Significant central nervous system (CNS) disease including AIDS dementia, psychiatric disability, or seizure disorder.
• Significant cardiac disease (New York Heart Association Stage III or IV).
• Significant pulmonary disease (Forced Expiratory Volume < 75 percent.
• Weight loss = or > 10 percent within last 3 months.

Concurrent Medication:

Excluded:

• Systemic therapy for opportunistic infection (OI).

Patients with the following are excluded:

• Presence of antibody to interleukin-2 (IL-2).
• Diseases or symptoms listed in Exclusion Co-Existing Conditions.

Prior Medication:

Excluded within 12 weeks prior to study entry:

• Other immunomodulators.
• Corticosteroids.
• Other experimental therapy.
• Anti-neoplastic chemotherapy.

Active drug or alcohol abuse.