Background

This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations. This protocol was developed to allow subject enrollment for teaching purposes and to allow for second opinions regarding relatively complicated patients. The latter function promotes a critical link between the NCI, CCR Dermatology Branch and the local and national extramural medical communities.

Objective

Primary:

- To provide clinical material to fulfill the educational mission of the

Dermatology Branch.

- To learn about the natural history of selected dermatologic diseases.

Secondary:

• To screen patients for inclusion in other protocols.
• To assist in the diagnosis and/or management of patients with rare skin diseases and congenital or genetically linked skin conditions.

Eligibility

All subjects regardless of age, gender, or racial/ethnic group with dermatologic disease or systemic disease with cutaneous manifestations.

Design

Patients enrolled in this protocol will be evaluated and treated according to generally available, standard procedures and therapeutic modalities. Samples of blood and skin will be studied by routine and specialized investigative methods to establish these patients' diagnosis, response to treatment, and/or disease progression.