Inclusion Criteria

Concurrent Medication:

Allowed:

• Prophylactic antibiotics.
• Tylenol (650 mg orally every 6 hours as needed for temperature > 38.5 degrees C).
• Meperidine (25 - 50 mg intravenously, once, for severe rigors if systolic blood pressure is > 90 mmHg).

Patients must meet criteria for AIDS classification (CDC) category IV C-1.

• Patients must have had one or more prior opportunistic infections identified in surveillance definition of AIDS. Patients whose AIDS-defining illness is Kaposi's sarcoma are also eligible if they have previously had one of the secondary infectious diseases identified in category C-1.

Prior Medication:

Required:

• Patients must have been receiving zidovudine (AZT) on a stable dosage regimen for at least 8 weeks immediately preceding entry into study.

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Clinically significant cardiac (= or > class II, New York Heart Association) or peripheral vascular disease that requires treatment.
• Presence of an active opportunistic infection that requires treatment.
• Hemorrhagic diathesis or active bleeding disorder.
• Clinically apparent vascular disease.

Concurrent Medication:

Excluded:

• Medications required for treatment of active cardiac disease.
• Ongoing therapy with anticoagulants or thrombolytic agents.

Patients with the following are excluded:

• Clinically significant cardiac (= or > class II, New York Heart Association) or peripheral vascular disease that requires treatment.
• Presence of an active opportunistic infection that requires treatment.
• Hemorrhagic diathesis or active bleeding disorder.
• Clinically apparent vascular disease.

Prior Medication:

Excluded within 4 weeks of study entry:

• Antiviral chemotherapy other than zidovudine.
• Excluded within 12 weeks of study entry:
• Immunosuppressive or cytotoxic therapy.