Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients - 1

This study has been completed.

First Received on September 20, 1999. Last Updated on June 23, 2005 History of Changes

Sponsor:	National Institute on Drug Abuse (NIDA)
Collaborator:	University of Pennsylvania
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00000352

Purpose

The purpose of this study is to determine if addition of dextromethorphan to a stable dose of methadone in opioid dependent subjects will significantly affect physical and psychological aspects of opioid tolerance.

Condition	Intervention	Phase
Opioid-Related Disorders Substance-Related Disorders	Drug: Dextromethorphan	Phase II

Study Type:	Interventional
Study Design:	Primary Purpose: Treatment
Official Title:	Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients

Resource links provided by NLM:

MedlinePlus related topics: Drug Abuse

Drug Information available for: Dextromethorphan hydrochloride Methadone Levomethorphan Dextromethorphan Racemethorphan Methadone hydrochloride Dextromethorphan hydrobromide

U.S. FDA Resources

Further study details as provided by National Institute on Drug Abuse (NIDA):

Estimated Enrollment:	0
Study Start Date:	December 1996

Eligibility

Ages Eligible for Study:	21 Years to 55 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Please contact site for information.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000352

Locations

United States, Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104 6178

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

University of Pennsylvania

Investigators

Principal Investigator:

Charles O'Brien, M.D., Ph.D.

PDVAMC Treatment Research Center

More Information

No publications provided

ClinicalTrials.gov Identifier:	NCT00000352 History of Changes
Other Study ID Numbers:	NIDA-3-0012-1, Y01-3-0012-1
Study First Received:	September 20, 1999
Last Updated:	June 23, 2005
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Opioid-Related Disorders
Substance-Related Disorders
Mental Disorders
Dextromethorphan
Methadone
Analgesics, Opioid
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions

Physiological Effects of Drugs
Antitussive Agents
Central Nervous System Agents
Therapeutic Uses
Respiratory System Agents
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Depressants
Narcotics

ClinicalTrials.gov processed this record on February 09, 2012