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Found 441 studies with search of: Neurotoxicity
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Rank Status Study
1 Completed Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery
Conditions: Colorectal Cancer;   Neurotoxicity
Interventions: Drug: calcium gluconate;   Drug: magnesium sulfate;   Other: placebo
2 Recruiting Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
Conditions: Chemotherapeutic Agent Toxicity;   Colorectal Cancer;   Neuropathy;   Neurotoxicity
Interventions: Drug: calcium gluconate;   Drug: magnesium sulfate;   Other: placebo
3 Unknown † Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin
Conditions: Chemotherapeutic Agent Toxicity;   Colorectal Cancer;   Neurotoxicity
Interventions: Drug: FOLFOX regimen;   Drug: fluorouracil;   Drug: leucovorin calcium;   Drug: oxaliplatin;   Genetic: gene expression analysis;   Genetic: protein expression analysis;   Genetic: proteomic profiling;   Other: laboratory biomarker analysis;   Other: pharmacogenomic studies
4 Terminated A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity
Condition: Neurotoxicity Syndromes
Intervention: Drug: Dextromethorphan
5 Unknown † Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer
Condition: Cancer
Interventions: Drug: oxaliplatin;   Procedure: management of therapy complications
6 Unknown † Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly Paclitaxel
Conditions: Breast Neoplasms;   Breast Diseases;   Metastases, Neoplasm
Interventions: Drug: BNP7787;   Drug: Placebo
7 Completed Use of FACT-GOG/NTX Questionnaire in Peripheral Neurotoxicity & Validation of a French Version of This Questionnaire
Conditions: Ovarian Cancer;   Fallopian Tube Cancer;   Peritoneal Neoplasms
Interventions: Drug: Paclitaxel;   Drug: EPO
8 Completed Protective Effect of Mangafodipir Against Oxaliplatin Neurotoxicity
Conditions: Neurotoxic Disorders;   Cancer
Intervention: Drug: Mangafodipir
9 Recruiting Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through Vitamin D Pathway
Condition: Neurotoxicity
Intervention: Drug: Vitamin D3
10 Completed XENOX – Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Chemotherapy
Conditions: Metastases;   Colorectal Neoplasms;   Colorectal Carcinoma
Intervention: Drug: SR57746A
11 Completed Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Chemotherapy.
Conditions: Metastases;   Colorectal Neoplasms;   Colorectal Carcinoma
Interventions: Drug: xaliproden (SR57746A);   Drug: Placebo;   Drug: oxaliplatin
12 Recruiting Oral Glutamine in the Prevention of Oxaliplatin-induced Neurotoxicity
Condition: Colorectal Neoplasms
Interventions: Drug: Glutamine;   Drug: Calcium and Magnesium
13 Recruiting Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients Receiving Vincristine for Wilms' Tumor, Rhabdomyosarcoma, Acute Lymphoblastic Leukemia, or Non-Hodgkin's Lymphoma
Conditions: Kidney Cancer;   Leukemia;   Lymphoma;   Neurotoxicity;   Peripheral Neuropathy;   Sarcoma
Interventions: Dietary Supplement: glutamic acid;   Other: placebo
14 Active, not recruiting Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, Stage II, or Stage IIIA Breast Cancer Undergoing Chemotherapy
Conditions: Breast Cancer;   Chemotherapeutic Agent Toxicity;   Fatigue;   Neuropathy;   Neurotoxicity
Interventions: Dietary Supplement: acetyl-L-carnitine hydrochloride;   Other: placebo
15 Completed Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer
Conditions: Cervical Cancer;   Endometrial Cancer;   Fallopian Tube Cancer;   Neurotoxicity;   Ovarian Cancer;   Primary Peritoneal Cavity Cancer;   Sarcoma
Interventions: Drug: amifostine trihydrate;   Drug: cisplatin;   Drug: paclitaxel
16 Recruiting Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors
Condition: Primary Central Nervous System Lymphoma (PCNSL)
Intervention:
17 Recruiting Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
Conditions: Cognitive/Functional Effects;   Leukemia;   Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment
Interventions: Genetic: microarray analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Other: pharmacological study;   Procedure: cognitive assessment;   Procedure: diffusion tensor imaging;   Procedure: management of therapy complications;   Procedure: psychosocial assessment and care
18 Recruiting Side Effects of Radiation Therapy in Young Patients With CNS Tumors
Conditions: Brain and Central Nervous System Tumors;   Cognitive/Functional Effects;   Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment;   Radiation Toxicity
Interventions: Genetic: polymorphism analysis;   Genetic: proteomic profiling;   Other: bioluminescence;   Other: diagnostic laboratory biomarker analysis;   Other: immunoenzyme technique;   Other: mass spectrometry;   Other: physiologic testing;   Procedure: cognitive assessment;   Procedure: dynamic contrast-enhanced magnetic resonance imaging;   Procedure: magnetic resonance spectroscopic imaging;   Procedure: management of therapy complications;   Procedure: psychosocial assessment and care;   Procedure: quality-of-life assessment
19 Unknown † Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma
Conditions: Lymphoma;   Neurotoxicity
Interventions: Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: prednisolone;   Drug: procarbazine hydrochloride;   Drug: vincristine sulfate;   Radiation: radiation therapy
20 Unknown † Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer
Conditions: Neurotoxicity;   Unspecified Adult Solid Tumor, Protocol Specific;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: alpha-lipoic acid;   Other: placebo

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† Indicates status has not been verified in more than two years
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