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Found 58 studies with search of: Open Studies | "Scleroderma, Systemic"
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Rank Status Study
1 Recruiting Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis
Conditions: Scleroderma, Systemic;   Scleroderma, Diffuse;   Scleroderma, Limited;   Raynaud Phenomenon
Interventions: Drug: Sildenafil citrate;   Drug: Placebo
2 Recruiting Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients
Conditions: Systemic Sclerosis;   Scleroderma;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension
Intervention:
3 Unknown † Scleroderma Registry
Conditions: Systemic Sclerosis;   Scleroderma
Intervention:
4 Recruiting Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis
Conditions: Systemic Sclerosis;   Scleroderma
Intervention: Drug: Ambrisentan with an anti-fibrotic agent to assess benefit on skin.
5 Recruiting A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
Conditions: Pulmonary Arterial Hypertension;   Systemic Sclerosis;   Scleroderma Spectrum of Diseases;   Connective Tissue Disease;   Pulmonary Hypertension
Interventions: Drug: Tadalafil monotherapy;   Drug: Ambrisentan monotherapy;   Drug: tadalafil and ambrisentan
6 Recruiting Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)
Conditions: Scleroderma;   Interstitial Lung Disease
Interventions: Drug: Mycophenolate mofetil;   Drug: Cyclophosphamide;   Drug: Placebo
7 Unknown † Effectiveness of UVA1-irradiation in the Treatment of Early Skin Fibrosis in Patients Suffering From Systemic Sclerosis
Conditions: Systemic Scleroderma;   Systemic Sclerosis
Interventions: Radiation: UVA1;   Other: UVA1
8 Not yet recruiting Scleroderma: Cyclophosphamide or Transplantation (SCOT) Substudy 02
Conditions: Scleroderma, Systemic;   Sclerosis
Intervention: Procedure: Skin biopsy and blood sampling
9 Unknown † Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Controls
Condition: Scleroderma
Intervention:
10 Recruiting SCOT Scleroderma Treatment Alternative Registry (STAR Registry)
Conditions: Scleroderma, Systemic;   Sclerosis
Intervention: Behavioral: Telephone Call
11 Recruiting Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosis
Condition: Systemic Sclerosis
Intervention: Other: Magnetic resonance Imaging
12 Recruiting Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial
Condition: Scleroderma
Interventions: Procedure: Rituximab sandwich regiment followed by SCT;   Procedure: cyclophosphamide regiment followed by SCT
13 Not yet recruiting Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients
Conditions: Scleroderma, Systemic;   Hypertension, Pulmonary
Intervention:
14 Unknown † Platelet Gel in Systemic Sclerosis
Condition: Scleroderma, Systemic
Intervention: Drug: Platelet Gel
15 Recruiting Fludarabine Phosphate and Total-Body Irradiation Followed By Donor Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Severe Systemic Sclerosis
Condition: Systemic Sclerosis
Interventions: Drug: fludarabine phosphate;   Drug: mycophenolate mofetil;   Drug: tacrolimus;   Radiation: total-body irradiation;   Procedure: peripheral blood stem cell transplantation;   Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation;   Procedure: quality-of-life assessment;   Other: laboratory biomarker analysis;   Other: flow cytometry;   Procedure: biopsy;   Procedure: allogeneic bone marrow transplantation
16 Unknown † High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis
Condition: Scleroderma, Diffuse
Intervention: Drug: N-acetylcysteine (NAC)
17 Unknown † Influenza Vaccination in Patients With Scleroderma
Condition: Influenza Vaccine in Scleroderma
Intervention: Biological: Influenza vaccine
18 Recruiting Nilotinib in the Treatment of Systemic Sclerosis
Condition: Systemic Sclerosis
Intervention: Drug: Nilotinib (Tasigna)
19 Unknown † Genetic Study of the FBN1 Gene and Fibrillin-1 Abnormalities in Choctaw Native Americans and Other Patients With Systemic Sclerosis
Condition: Systemic Sclerosis
Intervention:
20 Recruiting Sonographic and Laboratory Evaluation of the Thyroid Gland in Patients With Systemic Sclerosis
Conditions: Systemic Sclerosis;   Hashimoto Thyroiditis;   Thyroid Nodules
Intervention:

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† Indicates status has not been verified in more than two years
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