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Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01856192
First received: May 14, 2013
Last updated: November 20, 2014
Last verified: May 2014
  Purpose

This randomized phase II trial studies how well rituximab and combination chemotherapy with or without lenalidomide works in treating patients with newly diagnosed stage II-IV diffuse large B cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether rituximab and combination chemotherapy are more effective when given with or without lenalidomide in treating patients with diffuse large B cell lymphoma.


Condition Intervention Phase
Contiguous Stage II Adult Diffuse Large Cell Lymphoma
Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma
Stage III Adult Diffuse Large Cell Lymphoma
Stage IV Adult Diffuse Large Cell Lymphoma
Drug: lenalidomide
Biological: rituximab
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: vincristine sulfate
Drug: prednisone
Other: laboratory biomarker analysis
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients With Newly Diagnosed Diffuse Large B Cell Lymphoma

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • PFS [ Time Frame: Time from randomization to the earliest of documented disease progression, new primaries of the same type or death without progression, assessed up to 10 years ] [ Designated as safety issue: No ]
    The primary analysis of PFS will be performed including all randomized eligible patients using a one-sided log-rank test stratified on IPI (2-3 vs. 4-5), age (< 60 years vs >= 60 years) and molecular subtype (germinal center B-cell type [GCB] vs. activated B-cell type [ABC]). Cox proportional hazards models will be used to assess possible effects of baseline clinical and biological characteristics on outcome, including age, gender, disease stage, and IPI. Treatment and covariate interactions will also be examined.


Secondary Outcome Measures:
  • Overall RR based on PET-CT scan [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    The comparison of RR between two arms will be performed with Cochran-Mantel-Haenszel (CMH) test, stratified on IPI (2-3 vs 4-5), age (< 60 yrs vs >= 60 yrs) and molecular subtype (GCB vs. ABC). Exploratory logistic regression will be used to assess possible effects of baseline clinical and biological characteristics on outcome, including age, gender, disease stage, and IPI. Treatment and covariate interactions will also be examined.

  • CR rate based on PET-CT scan [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
    The comparison of CR between two arms will be performed with CMH test, stratified on IPI (2-3 vs 4-5), age (< 60 yrs vs >= 60 yrs) and molecular subtype (GCB vs. ABC). Exploratory logistic regression will be used to assess possible effects of baseline clinical and biological characteristics on outcome, including age, gender, disease stage, and IPI. Treatment and covariate interactions will also be examined.

  • OS [ Time Frame: Time from randomization until death due to any cause, assessed up to 10 years ] [ Designated as safety issue: No ]
    The method of Kaplan and Meier will be used to estimate OS, and stratified log-rank test will be used to compare OS between two arms.


Other Outcome Measures:
  • Impact of DLBCL molecular subtype on outcome [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]
  • Relation between interim PET scan and study outcome [ Time Frame: Up to 10 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 300
Study Start Date: August 2013
Estimated Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm A (rituximab, combination chemotherapy, lenalidomide)
Patients receive rituximab IV, cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone PO on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
Drug: lenalidomide
Given PO
Other Names:
  • CC-5013
  • IMiD-1
  • Revlimid
Biological: rituximab
Given IV
Other Names:
  • IDEC-C2B8
  • IDEC-C2B8 monoclonal antibody
  • Mabthera
  • MOAB IDEC-C2B8
  • Rituxan
Drug: cyclophosphamide
Given IV
Other Names:
  • CPM
  • CTX
  • Cytoxan
  • Endoxan
  • Endoxana
Drug: doxorubicin hydrochloride
Given IV
Other Names:
  • ADM
  • ADR
  • Adria
Drug: vincristine sulfate
Given IV
Other Names:
  • leurocristine sulfate
  • VCR
  • Vincasar PFS
Drug: prednisone
Given PO
Other Names:
  • DeCortin
  • Deltra
Other: laboratory biomarker analysis
Correlative studies
Active Comparator: Arm B (rituximab, combination chemotherapy)
Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
Biological: rituximab
Given IV
Other Names:
  • IDEC-C2B8
  • IDEC-C2B8 monoclonal antibody
  • Mabthera
  • MOAB IDEC-C2B8
  • Rituxan
Drug: cyclophosphamide
Given IV
Other Names:
  • CPM
  • CTX
  • Cytoxan
  • Endoxan
  • Endoxana
Drug: doxorubicin hydrochloride
Given IV
Other Names:
  • ADM
  • ADR
  • Adria
Drug: vincristine sulfate
Given IV
Other Names:
  • leurocristine sulfate
  • VCR
  • Vincasar PFS
Drug: prednisone
Given PO
Other Names:
  • DeCortin
  • Deltra
Other: laboratory biomarker analysis
Correlative studies

Detailed Description:

PRIMARY OBJECTIVES:

I. Progression-free survival (PFS).

SECONDARY OBJECTIVES:

I. Response rate (RR). II. Complete remission (CR) rate as defined by positron emission tomography (PET)-computed tomography (CT) criteria.

III. Overall survival (OS).

TERTIARY OBJECTIVES:

I. Impact of diffuse large B cell lymphoma (DLBCL) molecular subtype on outcome.

II. Interim PET scan results in relation to treatment outcome.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive rituximab intravenously (IV), cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone orally (PO) on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patient are followed up every 3 months for 2 years, every 6 months for 1 year, and then annually for up to 7 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Histologically confirmed DLBCL expressing cluster of differentiation (CD)20 antigen; patients with transform lymphoma are excluded; patients with known primary mediastinal large B-cell lymphoma (PMLBCL) are excluded; similarly, patients with known v-myc myelocytomatosis viral oncogene homolog (avian) (c-myc) translocation (by fluorescence in situ hybridization) positive DLBCL are encouraged to participate in trials specifically designed for these patients; however patients with known c-myc positive are NOT excluded from this study; c-myc testing prior to study enrollment is NOT required
  • Stages II bulky disease (defined as mass size of more than 10 cm), stage III, or IV (Ann Arbor staging); patients with stage I and stage II non-bulky disease are excluded from this study
  • A tumor tissue specimen from the initial diagnostic biopsy has been located and ready to ship to the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Pathology Coordinating Office within 30 days following registration; patients must have paraffin-embedded tumor specimen available for central pathology review and defined laboratory research studies; archived formalin fixed paraffin embedded (FFPE) tumor tissue block is required; if the block is unavailable for submission, please submit the below alternative requirements:

    • One (1) hematoxylin & eosin (H&E) slide, and
    • Twenty (20) 4 um unstained air-dried plus slides, and
    • One (1) or more core punches (minimum of 4 mm diameter)
  • International Prognostic Index (IPI) of 2 or greater
  • ECOG performance status 0-2
  • Patients must have measurable disease (at least 1 lesion of >= 1.5 cm in one diameter) as detected by CT or the CT images of the PET/CT
  • Previously untreated and not receiving any other agent that would be considered as a treatment for the lymphoma
  • No known central nervous system (CNS) lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells; these patients are usually treated with CNS directed therapy; screening for cerebrospinal fluid (CSF)/CNS involvement is NOT required but can be performed per treating medical doctor (MD) discretion
  • Absolute neutrophil count (ANC) >= 1500
  • Platelets (PLT) >= 100,000
  • Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN, the direct bilirubin must be normal
  • Alkaline (Alk.) phosphatase =< 3 x ULN unless evidence of the direct liver involvement by lymphoma--then =< 5 x ULN
  • Aspartate aminotransferase (AST) =< 3 x ULN unless evidence of the direct liver involvement by lymphoma-then =< 5 x ULN
  • Creatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/min
  • Ejection fraction of >= 45% by either multi gated acquisition scan (MUGA) or echocardiogram (ECHO)
  • Absence of co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Absence of history of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
  • Absence of history of deep venous thrombosis/embolism, threatening thromboembolism or known thrombophilia; patients with history of deep vein thrombosis/embolism/thrombophilia may participate if they are on full anticoagulation during the treatment (warfarin or low molecular weight heparin at therapeutic doses)
  • Patient must be able and willing to receive anticoagulation therapy with aspirin 325 mg daily prophylaxis, low molecular weight heparin, or warfarin; patients unable or unwilling to take any prophylaxis are NOT eligible
  • Absence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligible
  • No other active malignancy requiring therapy such as radiation, chemotherapy, or immunotherapy; exceptions to this are as follows: localized non-melanotic skin cancer and any cancer that in the judgment of the investigator has been treated with curative intent and will not interfere with the study treatment plan and response assessment
  • No history of radiation therapy to >= 25% of the bone marrow for other diseases or history of anthracycline therapy
  • Patients must not be receiving erythroid stimulating agents (erythropoietin [EPO]: Procrit, Aranesp)
  • Patient must be willing to provide informed written consent and to return to enrolling institution for follow-up
  • Women must not be pregnant or breast-feeding
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01856192

  Hide Study Locations
Locations
United States, Alaska
Katmai Oncology Group Active, not recruiting
Anchorage, Alaska, United States, 99508
Alaska Women's Cancer Care Active, not recruiting
Anchorage, Alaska, United States, 99508
Anchorage Oncology Centre Active, not recruiting
Anchorage, Alaska, United States, 99508
Providence Alaska Medical Center Active, not recruiting
Anchorage, Alaska, United States, 99508
Alaska Breast Care and Surgery LLC Active, not recruiting
Anchorage, Alaska, United States, 99508
United States, Arizona
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Contact: Grzegorz S. Nowakowski    507-538-7623      
Principal Investigator: Grzegorz S. Nowakowski         
United States, California
Kaiser Permanente Medical Group - Baldwin Park Active, not recruiting
Baldwin Park, California, United States, 91706
Southern California Permanente Medical Group Active, not recruiting
Irvine, California, United States, 92618
Memorial Medical Center Active, not recruiting
Modesto, California, United States, 95355
Kaiser Permanente - Panorama City Active, not recruiting
Panorama City, California, United States, 91402
Kaiser Permanente Active, not recruiting
San Diego, California, United States, 92120
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Penrose Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Active, not recruiting
Denver, Colorado, United States, 80210
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mercy Medical Center Recruiting
Durango, Colorado, United States, 81301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mountain Blue Cancer Care Center Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Breast Cancer Care Consultants Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Lakewood Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Littleton Recruiting
Littleton, Colorado, United States, 80120
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Parker Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Thornton Recruiting
Thornton, Colorado, United States, 80260
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
The Hospital of Central Connecticut Active, not recruiting
New Britain, Connecticut, United States, 06050
United States, Delaware
Bayhealth Medical Center at Kent General Active, not recruiting
Dover, Delaware, United States, 19901
Beebe Medical Center Active, not recruiting
Lewes, Delaware, United States, 19958
Regional Hematology and Oncology PA Active, not recruiting
Newark, Delaware, United States, 19713
Christiana Care Health System-Christiana Hospital Active, not recruiting
Newark, Delaware, United States, 19718
Delaware Clinical and Laboratory Physicians PA Active, not recruiting
Newark, Delaware, United States, 19713
Medical Oncology Hematology Consultants PA Active, not recruiting
Newark, Delaware, United States, 19713
Helen F Graham Cancer Center Active, not recruiting
Newark, Delaware, United States, 19713
United States, Georgia
Emory University/Winship Cancer Institute Active, not recruiting
Atlanta, Georgia, United States, 30322
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Active, not recruiting
Savannah, Georgia, United States, 31405
United States, Hawaii
Straub Clinic and Hospital Active, not recruiting
Honolulu, Hawaii, United States, 96813
Oncare Hawaii Inc-POB II Active, not recruiting
Honolulu, Hawaii, United States, 96813
Oncare Hawaii Inc-Kuakini Active, not recruiting
Honolulu, Hawaii, United States, 96817
The Cancer Center of Hawaii-Liliha Active, not recruiting
Honolulu, Hawaii, United States, 96817
University of Hawaii Cancer Center Active, not recruiting
Honolulu, Hawaii, United States, 96813
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Illinois CancerCare-Bloomington Active, not recruiting
Bloomington, Illinois, United States, 61701
Illinois CancerCare-Canton Active, not recruiting
Canton, Illinois, United States, 61520
Illinois CancerCare-Carthage Active, not recruiting
Carthage, Illinois, United States, 62321
Northwestern University Active, not recruiting
Chicago, Illinois, United States, 60611
Decatur Memorial Hospital Active, not recruiting
Decatur, Illinois, United States, 62526
Alexian Brothers Medical and Cancer Center Recruiting
Elk Grove Village, Illinois, United States, 60007
Contact: Bruce B. Bank    847-952-7164    fredianc@alexian.net   
Principal Investigator: Bruce B. Bank         
Illinois CancerCare-Eureka Active, not recruiting
Eureka, Illinois, United States, 61530
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Hinsdale Hematology Oncology Associates Incorporated Recruiting
Hinsdale, Illinois, United States, 60521
Contact: Elyse Schneiderman    630-654-1790    info@hhoaltd.com   
Principal Investigator: Elyse Schneiderman         
Illinois CancerCare-Kewanee Clinic Active, not recruiting
Kewanee, Illinois, United States, 61443
Illinois CancerCare-Macomb Active, not recruiting
Macomb, Illinois, United States, 61455
Trinity Medical Center Active, not recruiting
Moline, Illinois, United States, 61265
Illinois CancerCare-Monmouth Terminated
Monmouth, Illinois, United States, 61462
Illinois Cancer Specialists-Niles Active, not recruiting
Niles, Illinois, United States, 60714
Illinois CancerCare-Ottawa Clinic Active, not recruiting
Ottawa, Illinois, United States, 61350
Illinois CancerCare-Pekin Active, not recruiting
Pekin, Illinois, United States, 61554
Illinois CancerCare-Peoria Active, not recruiting
Peoria, Illinois, United States, 61615
Illinois Oncology Research Association CCOP Terminated
Peoria, Illinois, United States, 61615
Illinois CancerCare-Peru Active, not recruiting
Peru, Illinois, United States, 61354
Illinois CancerCare-Princeton Active, not recruiting
Princeton, Illinois, United States, 61356
Swedish American Hospital Withdrawn
Rockford, Illinois, United States, 61104
SwedishAmerican Regional Cancer Center/ACT Active, not recruiting
Rockford, Illinois, United States, 61107
Memorial Medical Center Active, not recruiting
Springfield, Illinois, United States, 62781-0001
Carle Cancer Center Active, not recruiting
Urbana, Illinois, United States, 61801
United States, Indiana
Elkhart Clinic Active, not recruiting
Elkhart, Indiana, United States, 46514-2098
Elkhart General Hospital Terminated
Elkhart, Indiana, United States, 46515
Michiana Hematology Oncology PC-Elkhart Active, not recruiting
Elkhart, Indiana, United States, 46514
Indiana University Medical Center Active, not recruiting
Indianapolis, Indiana, United States, 46202
IU Health Central Indiana Cancer Centers-East Active, not recruiting
Indianapolis, Indiana, United States, 46219
Community Howard Regional Health Terminated
Kokomo, Indiana, United States, 46904
IU Health La Porte Hospital Terminated
La Porte, Indiana, United States, 46350
IU Health Arnett Cancer Care Active, not recruiting
Lafayette, Indiana, United States, 47904
Premier Oncology Hematology Associates Active, not recruiting
Merrillville, Indiana, United States, 46410
Michiana Hematology Oncology PC-Mishawaka Active, not recruiting
Mishawaka, Indiana, United States, 46545-1470
Saint Joseph Regional Medical Center-Mishawaka Active, not recruiting
Mishawaka, Indiana, United States, 46545-1470
IU Health Ball Memorial Hospital Active, not recruiting
Muncie, Indiana, United States, 47303
Michiana Hematology Oncology PC-Plymouth Active, not recruiting
Plymouth, Indiana, United States, 46563
Michiana Hematology Oncology PC-South Bend Active, not recruiting
South Bend, Indiana, United States, 46601
Northern Indiana Cancer Research Consortium Active, not recruiting
South Bend, Indiana, United States, 46628
Michiana Hematology Oncology-PC Westville Active, not recruiting
Westville, Indiana, United States, 46391
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Active, not recruiting
Ames, Iowa, United States, 50010
Oncology Associates at Mercy Medical Center Active, not recruiting
Cedar Rapids, Iowa, United States, 52403
Medical Oncology and Hematology Associates-West Des Moines Active, not recruiting
Clive, Iowa, United States, 50325
Medical Oncology and Hematology Associates-Laurel Active, not recruiting
Des Moines, Iowa, United States, 50314
Medical Oncology and Hematology Associates-Des Moines Active, not recruiting
Des Moines, Iowa, United States, 50309
Iowa Oncology Research Association CCOP Active, not recruiting
Des Moines, Iowa, United States, 50309
Mercy Medical Center - North Iowa Recruiting
Mason City, Iowa, United States, 50401
Contact: Arvind Y. Vemula    800-433-3883      
Principal Investigator: Arvind Y. Vemula         
Ottumwa Regional Health Center Active, not recruiting
Ottumwa, Iowa, United States, 52501
Siouxland Hematology Oncology Associates Active, not recruiting
Sioux City, Iowa, United States, 51101
Covenant Medical Center Active, not recruiting
Waterloo, Iowa, United States, 50702
United States, Kansas
Lawrence Memorial Hospital Active, not recruiting
Lawrence, Kansas, United States, 66044
Wesley Medical Center Active, not recruiting
Wichita, Kansas, United States, 67214
United States, Louisiana
Ochsner Health Center-Summa Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
United States, Maine
Harold Alfond Center for Cancer Care Active, not recruiting
Augusta, Maine, United States, 04330
Eastern Maine Medical Center Active, not recruiting
Bangor, Maine, United States, 04401
United States, Maryland
Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Active, not recruiting
Baltimore, Maryland, United States, 21287
Greater Baltimore Medical Center Active, not recruiting
Baltimore, Maryland, United States, 21204
Union Hospital of Cecil County Active, not recruiting
Elkton MD, Maryland, United States, 21921
United States, Massachusetts
Tufts Medical Center Active, not recruiting
Boston, Massachusetts, United States, 02111
University of Massachusetts Medical School Active, not recruiting
Worcester, Massachusetts, United States, 01655
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48124
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Wayne State University/Karmanos Cancer Institute Active, not recruiting
Detroit, Michigan, United States, 48201
Green Bay Oncology - Escanaba Active, not recruiting
Escanaba, Michigan, United States, 49431
Green Bay Oncology - Iron Mountain Active, not recruiting
Iron Mountain, Michigan, United States, 49801
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
West Michigan Cancer Center Active, not recruiting
Kalamazoo, Michigan, United States, 49007
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint Joseph Mercy Port Huron Recruiting
Port Huron, Michigan, United States, 48060
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    734-712-4673      
Principal Investigator: Christopher M. Reynolds         
United States, Minnesota
Sanford Clinic North-Bemidgi Active, not recruiting
Bemidji, Minnesota, United States, 56601
Fairview Ridges Hospital Active, not recruiting
Burnsville, Minnesota, United States, 55337
Mercy Hospital Active, not recruiting
Coon Rapids, Minnesota, United States, 55433
Saint Luke's Hospital of Duluth Active, not recruiting
Duluth, Minnesota, United States, 55805
Essentia Health Cancer Center Active, not recruiting
Duluth, Minnesota, United States, 55805
Fairview-Southdale Hospital Active, not recruiting
Edina, Minnesota, United States, 55435
Lake Region Healthcare Corporation-Cancer Care Active, not recruiting
Fergus Falls, Minnesota, United States, 56537
Unity Hospital Active, not recruiting
Fridley, Minnesota, United States, 55432
Hutchinson Area Health Care Active, not recruiting
Hutchinson, Minnesota, United States, 55350
Saint John's Hospital - Healtheast Active, not recruiting
Maplewood, Minnesota, United States, 55109
Minnesota Oncology Hematology PA-Maplewood Active, not recruiting
Maplewood, Minnesota, United States, 55109
Abbott-Northwestern Hospital Active, not recruiting
Minneapolis, Minnesota, United States, 55407
Hennepin County Medical Center Active, not recruiting
Minneapolis, Minnesota, United States, 55415
North Memorial Medical Health Center Active, not recruiting
Robbinsdale, Minnesota, United States, 55422
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Grzegorz S. Nowakowski    507-538-7623      
Principal Investigator: Grzegorz S. Nowakowski         
Coborn Cancer Center at Saint Cloud Hospital Active, not recruiting
Saint Cloud, Minnesota, United States, 56303
Metro-Minnesota CCOP Terminated
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Clinic - Saint Louis Park Active, not recruiting
Saint Louis Park, Minnesota, United States, 55416
Regions Hospital Active, not recruiting
Saint Paul, Minnesota, United States, 55101
United Hospital Active, not recruiting
Saint Paul, Minnesota, United States, 55102
Saint Francis Regional Medical Center Active, not recruiting
Shakopee, Minnesota, United States, 55379
Lakeview Hospital Active, not recruiting
Stillwater, Minnesota, United States, 55082
Ridgeview Medical Center Active, not recruiting
Waconia, Minnesota, United States, 55387
Rice Memorial Hospital Active, not recruiting
Willmar, Minnesota, United States, 56201
Minnesota Oncology and Hematology PA-Woodbury Active, not recruiting
Woodbury, Minnesota, United States, 55125
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center Recruiting
Bolivar, Missouri, United States, 65613
Contact: Jay W. Carlson    800-821-7532      
Principal Investigator: Jay W. Carlson         
Saint Francis Medical Center Active, not recruiting
Cape Girardeau, Missouri, United States, 63703
Saint Luke's Hospital Active, not recruiting
Chesterfield, Missouri, United States, 63017
Missouri Baptist Medical Center Active, not recruiting
Saint Louis, Missouri, United States, 63131
Saint John's Mercy Medical Center Active, not recruiting
Saint Louis, Missouri, United States, 63141
Saint Louis Cancer and Breast Institute-South City Active, not recruiting
Saint Louis, Missouri, United States, 63109
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59107
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Nebraska Cancer Research Center Active, not recruiting
Lincoln, Nebraska, United States, 68510
United States, Nevada
Nevada Cancer Research Foundation CCOP Active, not recruiting
Las Vegas, Nevada, United States, 89106
University Medical Center of Southern Nevada Active, not recruiting
Las Vegas, Nevada, United States, 89102
United States, New Hampshire
New Hampshire Oncology-Hematology PA Active, not recruiting
Concord, New Hampshire, United States, 03301
New Hampshire Oncology Hematology Associates Active, not recruiting
Hooksett, New Hampshire, United States, 03106
LRGHealthcare-Lakes Region General Hospital Active, not recruiting
Laconia, New Hampshire, United States, 03246
United States, New Jersey
Cooper Hospital University Medical Center Active, not recruiting
Camden, New Jersey, United States, 08103
Saint Barnabas Medical Center Recruiting
Livingston, New Jersey, United States, 07039
Contact: Miguel A. Conde    973-322-2470      
Principal Investigator: Miguel A. Conde         
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Active, not recruiting
Mount Holly, New Jersey, United States, 08060
Inspira Medical Center Vineland Recruiting
Vineland, New Jersey, United States, 08360
Contact: Ramakrishna R. Sudhindra    856-641-7933      
Principal Investigator: Ramakrishna R. Sudhindra         
United States, New Mexico
University of New Mexico Active, not recruiting
Albuquerque, New Mexico, United States, 87106
Presbyterian Kaseman Hospital Active, not recruiting
Albuquerque, New Mexico, United States, 87110
Memorial Medical Center - Las Cruces Active, not recruiting
Las Cruces, New Mexico, United States, 88011
United States, New York
Albert Einstein College of Medicine Active, not recruiting
Bronx, New York, United States, 10461
Montefiore Medical Center - Moses Campus Active, not recruiting
Bronx, New York, United States, 10467-2490
Montefiore Medical Center-Einstein Campus Active, not recruiting
Bronx, New York, United States, 10461
Kings County Hospital Active, not recruiting
Brooklyn, New York, United States, 11203
State University of New York Downstate Medical Center Active, not recruiting
Brooklyn, New York, United States, 11203
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263
Contact: Francisco J. Hernandez-ILizaliturri    877-275-7724      
Principal Investigator: Francisco J. Hernandez-ILizaliturri         
Hematology Oncology Associates of Central New York-East Syracuse Active, not recruiting
East Syracuse, New York, United States, 13057
New York University Langone Medical Center Active, not recruiting
New York, New York, United States, 10016
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830      
Principal Investigator: Jonathan W. Friedberg         
State University of New York Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Teresa C. Gentile    315-464-5476      
Principal Investigator: Teresa C. Gentile         
United States, North Carolina
Randolph Hospital Active, not recruiting
Asheboro, North Carolina, United States, 27203
University of North Carolina Active, not recruiting
Chapel Hill, North Carolina, United States, 27599
Wayne Memorial Hospital Active, not recruiting
Goldsboro, North Carolina, United States, 27534
Cone Health Cancer Center Active, not recruiting
Greensboro, North Carolina, United States, 27403
Margaret R Pardee Memorial Hospital Active, not recruiting
Hendersonville, North Carolina, United States, 28791
Kinston Medical Specialists PA Active, not recruiting
Kinston, North Carolina, United States, 28501
Annie Penn Memorial Hospital Active, not recruiting
Reidsville, North Carolina, United States, 27320
Iredell Memorial Hospital Active, not recruiting
Statesville, North Carolina, United States, 28677
Marion L Shepard Cancer Center Active, not recruiting
Washington, North Carolina, United States, 27889
Wake Forest University Health Sciences Active, not recruiting
Winston-Salem, North Carolina, United States, 27157
United States, North Dakota
Sanford Bismarck Medical Center Active, not recruiting
Bismarck, North Dakota, United States, 58501
Roger Maris Cancer Center Active, not recruiting
Fargo, North Dakota, United States, 58122
Sanford Clinic North-Fargo Active, not recruiting
Fargo, North Dakota, United States, 58122
Sanford Medical Center-Fargo Active, not recruiting
Fargo, North Dakota, United States, 58122
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Active, not recruiting
Akron, Ohio, United States, 44304
Summa Barberton Hospital Active, not recruiting
Barberton, Ohio, United States, 44203
Mercy Medical Center Active, not recruiting
Canton, Ohio, United States, 44708
University of Cincinnati Active, not recruiting
Cincinnati, Ohio, United States, 45267
Case Western Reserve University Active, not recruiting
Cleveland, Ohio, United States, 44106
Columbus Oncology and Hematology Associates Inc Active, not recruiting
Columbus, Ohio, United States, 43214
Mount Carmel Health Center West Active, not recruiting
Columbus, Ohio, United States, 43222
Ohio State University Medical Center Active, not recruiting
Columbus, Ohio, United States, 43210
Riverside Methodist Hospital Active, not recruiting
Columbus, Ohio, United States, 43214
The Mark H Zangmeister Center Active, not recruiting
Columbus, Ohio, United States, 43219
Columbus CCOP Terminated
Columbus, Ohio, United States, 43215
Samaritan North Health Center Active, not recruiting
Dayton, Ohio, United States, 45415
Good Samaritan Hospital - Dayton Active, not recruiting
Dayton, Ohio, United States, 45406
Miami Valley Hospital Active, not recruiting
Dayton, Ohio, United States, 45409
Saint Rita's Medical Center Active, not recruiting
Lima, Ohio, United States, 45801
Marietta Memorial Hospital Active, not recruiting
Marietta, Ohio, United States, 45750
Licking Memorial Hospital Active, not recruiting
Newark, Ohio, United States, 43055
Springfield Regional Medical Center Active, not recruiting
Springfield, Ohio, United States, 45505
Flower Hospital Active, not recruiting
Sylvania, Ohio, United States, 43560
Toledo Clinic Cancer Centers-Toledo Active, not recruiting
Toledo, Ohio, United States, 43623
University of Toledo Active, not recruiting
Toledo, Ohio, United States, 43614
Saint Ann's Hospital Active, not recruiting
Westerville, Ohio, United States, 43081
United States, Oregon
Providence Newberg Medical Center Active, not recruiting
Newberg, Oregon, United States, 97132
Providence Willamette Falls Medical Center Active, not recruiting
Oregon City, Oregon, United States, 97045
Providence Portland Medical Center Active, not recruiting
Portland, Oregon, United States, 97213
Providence Saint Vincent Medical Center Active, not recruiting
Portland, Oregon, United States, 97225
United States, Pennsylvania
Lehigh Valley Hospital Active, not recruiting
Allentown, Pennsylvania, United States, 18105
Saint Luke's University Hospital-Bethlehem Campus Active, not recruiting
Bethlehem, Pennsylvania, United States, 18015
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Albert S. DeNittis    866-225-5654      
Principal Investigator: Albert S. DeNittis         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Doylestown Hospital Active, not recruiting
Doylestown, Pennsylvania, United States, 18901
Delaware County Memorial Hospital Active, not recruiting
Drexel Hill, Pennsylvania, United States, 19026
Ephrata Cancer Center Recruiting
Ephrata, Pennsylvania, United States, 17522
Contact: Amir Tabatabai    877-441-7957      
Principal Investigator: Amir Tabatabai         
Ephrata Community Hospital Recruiting
Ephrata, Pennsylvania, United States, 17522
Contact: Amir Tabatabai    877-441-7957      
Principal Investigator: Amir Tabatabai         
Adams Cancer Center Recruiting
Gettysburg, Pennsylvania, United States, 17325
Contact: Amir Tabatabai    877-441-7957      
Principal Investigator: Amir Tabatabai         
Cherry Tree Cancer Center Recruiting
Hanover, Pennsylvania, United States, 17331
Contact: Amir Tabatabai    877-441-7957      
Principal Investigator: Amir Tabatabai         
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Penn State Milton S Hershey Medical Center Active, not recruiting
Hershey, Pennsylvania, United States, 17033-0850
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Albert S. DeNittis    866-225-5654      
Principal Investigator: Albert S. DeNittis         
Fox Chase Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19111
Contact: Nadia Khan    215-728-4790      
Principal Investigator: Nadia Khan         
Temple University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Nadia Khan    215-728-4790      
Principal Investigator: Nadia Khan         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Barbara Pro    215-955-6084      
Principal Investigator: Barbara Pro         
Pottstown Memorial Medical Center Recruiting
Pottstown, Pennsylvania, United States, 19464
Contact: Wei (. Song    610-327-7544      
Principal Investigator: Wei (. Song         
Hematology and Oncology Associates of North East Pennsylvania Recruiting
Scranton, Pennsylvania, United States, 18508
Contact: Barbara Pro    215-955-6084      
Principal Investigator: Barbara Pro         
Grand View Hospital Withdrawn
Sellersville, Pennsylvania, United States, 18960
Mount Nittany Medical Center Active, not recruiting
State College, Pennsylvania, United States, 16803
Chester County Hospital Active, not recruiting
West Chester, Pennsylvania, United States, 19380
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Terrence P. Cescon    610-988-9323      
Principal Investigator: Terrence P. Cescon         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Lankenau Medical Center Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Albert S. DeNittis    866-225-5654      
Principal Investigator: Albert S. DeNittis         
WellSpan Health-York Hospital Recruiting
York, Pennsylvania, United States, 17405
Contact: Amir Tabatabai    877-441-7957      
Principal Investigator: Amir Tabatabai         
United States, South Carolina
Greenville Health System Cancer Institute-Easley Active, not recruiting
Easley, South Carolina, United States, 29640
Greenville Health System Cancer Institute-Faris Active, not recruiting
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Butternut Active, not recruiting
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Eastside Active, not recruiting
Greenville, South Carolina, United States, 29615
Greenville Health System Cancer Institute-Andrews Active, not recruiting
Greenville, South Carolina, United States, 29605
Greenville Memorial Hospital Active, not recruiting
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Greer Active, not recruiting
Greer, South Carolina, United States, 29650
Greenville Health System Cancer Institute-Seneca Active, not recruiting
Seneca, South Carolina, United States, 29672
Greenville Health System Cancer Institute-Spartanburg Active, not recruiting
Spartanburg, South Carolina, United States, 29307
United States, South Dakota
Rapid City Regional Hospital Active, not recruiting
Rapid City, South Dakota, United States, 57701
Sanford Cancer Center-Oncology Clinic Active, not recruiting
Sioux Falls, South Dakota, United States, 57104
Sanford USD Medical Center - Sioux Falls Active, not recruiting
Sioux Falls, South Dakota, United States, 57117-5134
United States, Tennessee
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Nishitha Reddy    800-811-8480      
Principal Investigator: Nishitha Reddy         
United States, Texas
University Medical Center Brackenridge Active, not recruiting
Austin, Texas, United States, 78701
University of Texas Southwestern Medical Center Active, not recruiting
Dallas, Texas, United States, 75390
United States, Virginia
University of Virginia Active, not recruiting
Charlottesville, Virginia, United States, 22908
Memorial Hospital Of Martinsville Active, not recruiting
Martinsville, Virginia, United States, 24115
United States, Washington
PeaceHealth Southwest Medical Center Active, not recruiting
Vancouver, Washington, United States, 98664
United States, West Virginia
West Virginia University Charleston Active, not recruiting
Charleston, West Virginia, United States, 25304
United States, Wisconsin
Langlade Hospital and Cancer Center Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Hamied R. Rezazadeh    877-405-6866      
Principal Investigator: Hamied R. Rezazadeh         
Aurora Cancer Care-Burlington Active, not recruiting
Burlington, Wisconsin, United States, 53105
Marshfield Clinic Cancer Center at Sacred Heart Active, not recruiting
Eau Claire, Wisconsin, United States, 54701
Sacred Heart Hospital Active, not recruiting
Eau Claire, Wisconsin, United States, 54701
Aurora Cancer Care-Southern Lakes Active, not recruiting
Elkhorn, Wisconsin, United States, 53121
Aurora Cancer Care-Grafton Active, not recruiting
Grafton, Wisconsin, United States, 53024
Saint Vincent Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301
Bellin Memorial Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301
Green Bay Oncology at Saint Vincent Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54301-3526
Green Bay Oncology Limited at Saint Mary's Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54303
Aurora BayCare Medical Center Active, not recruiting
Green Bay, Wisconsin, United States, 54311-6519
Saint Mary's Hospital Active, not recruiting
Green Bay, Wisconsin, United States, 54303
UW Cancer Center Johnson Creek Active, not recruiting
Johnson Creek, Wisconsin, United States, 53038
Aurora Cancer Care-Kenosha South Active, not recruiting
Kenosha, Wisconsin, United States, 53142
Gundersen Lutheran Medical Center Active, not recruiting
La Crosse, Wisconsin, United States, 54601
Dean Hematology and Oncology Clinic Active, not recruiting
Madison, Wisconsin, United States, 53717
University of Wisconsin Hospital and Clinics Active, not recruiting
Madison, Wisconsin, United States, 53792
Bay Area Medical Center Active, not recruiting
Marinette, Wisconsin, United States, 54143
Vince Lombardi Cancer Clinic-Marinette Active, not recruiting
Marinette, Wisconsin, United States, 54143
Marshfield Clinic Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Saint Joseph's Hospital Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Aurora Advanced Healthcare Inc-Menomonee Falls Active, not recruiting
Menomonee Falls, Wisconsin, United States, 53051
Aurora Cancer Care-Milwaukee Active, not recruiting
Milwaukee, Wisconsin, United States, 53209
Aurora Cancer Care-Milwaukee South Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Rubina Qamar    888-709-2080      
Principal Investigator: Rubina Qamar         
Aurora Saint Luke's Medical Center Active, not recruiting
Milwaukee, Wisconsin, United States, 53215
Aurora Sinai Medical Center Active, not recruiting
Milwaukee, Wisconsin, United States, 53233
Froedtert and the Medical College of Wisconsin Active, not recruiting
Milwaukee, Wisconsin, United States, 53226
Marshfield Clinic-Minocqua Center Active, not recruiting
Minocqua, Wisconsin, United States, 54548
Oconomowoc Memorial Hospital-ProHealth Care Inc Active, not recruiting
Oconomowoc, Wisconsin, United States, 53066-3896
Green Bay Oncology - Oconto Falls Active, not recruiting
Oconto Falls, Wisconsin, United States, 54154
Vince Lombardi Cancer Clinic - Oshkosh Active, not recruiting
Oshkosh, Wisconsin, United States, 54904
Aurora Cancer Care-Racine Active, not recruiting
Racine, Wisconsin, United States, 53406-5661
Marshfield Clinic at James Beck Cancer Center Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Saint Mary's Hospital Active, not recruiting
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic-Rice Lake Center Active, not recruiting
Rice Lake, Wisconsin, United States, 54868
Vince Lombardi Cancer Clinic-Sheboygan Active, not recruiting
Sheboygan, Wisconsin, United States, 53081
Marshfield Clinic Cancer Care at Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Saint Michael's Hospital Active, not recruiting
Stevens Point, Wisconsin, United States, 54481
Green Bay Oncology - Sturgeon Bay Active, not recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Aurora Medical Center in Summit Active, not recruiting
Summit, Wisconsin, United States, 53066
Vince Lombardi Cancer Clinic Active, not recruiting
Two Rivers, Wisconsin, United States, 54241
Aurora Cancer Care-Waukesha Active, not recruiting
Waukesha, Wisconsin, United States, 53188
Waukesha Memorial Hospital - ProHealth Care Active, not recruiting
Waukesha, Wisconsin, United States, 53188
Aspirus Regional Cancer Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Hamied R. Rezazadeh    877-405-6866      
Principal Investigator: Hamied R. Rezazadeh         
Marshfield Clinic-Wausau Center Active, not recruiting
Wausau, Wisconsin, United States, 54401
Aurora Cancer Care-Milwaukee West Active, not recruiting
Wauwatosa, Wisconsin, United States, 53226
Aurora West Allis Medical Center Active, not recruiting
West Allis, Wisconsin, United States, 53227
Marshfield Clinic - Weston Center Active, not recruiting
Weston, Wisconsin, United States, 54476
Marshfield Clinic - Wisconsin Rapids Center Active, not recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Riverview Hospital Active, not recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Sponsors and Collaborators
Investigators
Principal Investigator: Grzegorz Nowakowski ECOG-ACRIN Cancer Research Group
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01856192     History of Changes
Other Study ID Numbers: NCI-2013-00959, NCI-2013-00959, ECOG-E1412, E1412, E1412, U10CA180820, U10CA021115
Study First Received: May 14, 2013
Last Updated: November 20, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Lymphoma
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Non-Hodgkin
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases
Lymphoproliferative Disorders
Neoplasms
Neoplasms by Histologic Type
Cyclophosphamide
Doxorubicin
Lenalidomide
Liposomal doxorubicin
Prednisone
Rituximab
Thalidomide
Vincristine
Alkylating Agents
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Anti-Bacterial Agents
Anti-Infective Agents
Anti-Inflammatory Agents
Antibiotics, Antineoplastic
Antimitotic Agents
Antineoplastic Agents
Antineoplastic Agents, Alkylating
Antineoplastic Agents, Hormonal
Antineoplastic Agents, Phytogenic

ClinicalTrials.gov processed this record on November 20, 2014