Trial record 1 of 1 for:    A091102
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Alisertib in Treating Patients With Advanced or Metastatic Sarcoma

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01653028
First received: July 26, 2012
Last updated: June 16, 2014
Last verified: March 2014
  Purpose

This phase II trial studies how well alisertib works in treating patients with advanced or metastatic sarcoma. Alisertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.


Condition Intervention Phase
Adult Alveolar Soft-part Sarcoma
Adult Angiosarcoma
Adult Epithelioid Sarcoma
Adult Extraskeletal Chondrosarcoma
Adult Fibrosarcoma
Adult Leiomyosarcoma
Adult Liposarcoma
Adult Neurofibrosarcoma
Chondrosarcoma
Endometrial Stromal Sarcoma
Mast Cell Sarcoma
Metastatic Adult Malignant Fibrous Histiocytoma of Bone
Ovarian Carcinosarcoma
Ovarian Sarcoma
Recurrent Adult Malignant Fibrous Histiocytoma of Bone
Recurrent Adult Soft Tissue Sarcoma
Small Intestine Leiomyosarcoma
Stage III Adult Soft Tissue Sarcoma
Stage IV Adult Soft Tissue Sarcoma
Drug: alisertib
Other: laboratory biomarker analysis
Phase 2

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase II Study of MLN8237 in Advanced / Metastatic Sarcoma

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • The confirmed response rate (CR/PR) [ Time Frame: Up to 18 months ] [ Designated as safety issue: No ]
    The overall response rate (CR + PR) will be estimated and a 90% confidence interval provided.


Secondary Outcome Measures:
  • PFS [ Time Frame: The time between registration to disease progression or death, assessed up to 18 months ] [ Designated as safety issue: No ]
    The distribution will be estimated by the methods of Kaplan and Meier. The estimates of PFS at specific time points will be calculated (eg, median, 1 year PFS).

  • OS [ Time Frame: The time between registration and death, assessed up to 18 months ] [ Designated as safety issue: No ]
    The distribution will be estimated by the methods of Kaplan and Meier. The estimates of survival at specific time points will be calculated (eg, median, 6 month survival).

  • Incidence of adverse events, assessed using National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [ Time Frame: Up to 4 weeks ] [ Designated as safety issue: Yes ]
    Adverse events will be summarized using summary statistics and frequency tables for each separate cohort. Analyses will be descriptive in nature.


Other Outcome Measures:
  • Biopsy protein levels [ Time Frame: Baseline ] [ Designated as safety issue: No ]
    For tumor biopsies, pre- and post-treatment protein levels will be compared by Wilcoxon signed-rank test (for paired samples). The association of response or clinical benefit with the presence or absence of markers of pathway inhibition in patient tumors will be tested using Fisher's exact test.

  • Biopsy protein levels [ Time Frame: Up to 18 months ] [ Designated as safety issue: No ]
    For tumor biopsies, pre- and post-treatment protein levels will be compared by Wilcoxon signed-rank test (for paired samples). The association of response or clinical benefit with the presence or absence of markers of pathway inhibition in patient tumors will be tested using Fisher's exact test.

  • Changes in FLT-PET uptake [ Time Frame: Baseline to 1 week ] [ Designated as safety issue: No ]
    Changes in FLT-PET uptake at baseline versus after one week of treatment will be compared by Wilcoxon Rank Sum test between responders and non-responders defined by RECIST criteria. Fisher's exact test will be used to assess the association between dichotomous change in FLT-PET uptake change and RECIST response status.


Estimated Enrollment: 135
Study Start Date: August 2012
Estimated Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Treatment (alisertib)
Patients receive alisertib PO BID on days 1-7. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: alisertib
Given PO
Other Names:
  • Aurora A kinase inhibitor MLN8237
  • MLN8237
Other: laboratory biomarker analysis
Correlative studies

Detailed Description:

PRIMARY OBJECTIVES:

I. To determine the response rate (complete response [CR] + partial response [PR]) assessed for patients within each cohort: liposarcoma (cohort 1); leiomyosarcoma (non-uterine) (cohort 2); undifferentiated sarcoma (including pleomorphic undifferentiated sarcoma, formerly known as malignant fibrous histiocytoma, and myxofibrosarcoma) (cohort 3); malignant peripheral nerve sheath tumor (cohort 4); and other sarcomas (cohort 5).

SECONDARY OBJECTIVES:

I. To estimate the progression-free survival (PFS) and overall survival (OS) for patients treated with alisertib (MLN8237) in each cohort.

II. To assess the adverse events associated with patients treated with MLN8237 in each cohort.

TERTIARY OBJECTIVES:

I. To correlate potential clinical benefit with markers of aurora kinase inhibition in pre- and post-treatment tumor biopsies.

II. To correlate clinical outcome with change in fluorine F 18 fluorothymidine (FLT)-positron emission tomography (PET) uptake at baseline versus after one week of treatment (i.e., week 2 of cycle 1).

OUTLINE:

Patients receive alisertib orally (PO) twice daily (BID) on days 1-7. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 6 months for 18 months.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must have histologically or cytologically confirmed sarcoma that is metastatic and/or locally advanced or locally recurrent and unresectable; confirmation of pathologic diagnosis will be performed at the registering site; patients will been rolled on one of five cohorts of the study:

    • Cohort 1: liposarcoma
    • Cohort 2: leiomyosarcoma (non-uterine)
    • Cohort 3: undifferentiated sarcoma (including malignant fibrous histiocytoma and myxofibrosarcoma)
    • Cohort 4: malignant peripheral nerve sheath tumor
    • Cohort 5: other sarcomas
  • Patients must have measurable disease per Response Evaluation Criteria in Solid Tumors(RECIST) 1.1; note: defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as >= 2 cm with conventional techniques or as >= 1 cm with spiral computed tomography (CT) scan, magnetic resonance imaging (MRI), or calipers by clinical exam
  • Any number of prior therapies is permitted; note: the last dose of systemic therapy (including tyrosine kinase inhibitors) must have been given >= 4 weeks prior to initiation of study therapy; patients receiving BCNU or mitomycin C must have received their last dose of such therapy at least 6 weeks prior to initiation of therapy
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS) =< 2
  • Leukocytes >= 3,000/mcL
  • Absolute neutrophil count >= 1,500/mcL
  • Platelet count >= 100,000/mcL
  • Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)
  • Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) and serum glutamate pyruvate transaminase (alanine aminotransferase [AST]) < 3 times ULN if no liver metastases or < 5 times ULN if liver metastases present
  • Creatinine =< 1.5 times ULN OR creatinine clearance >= 60 mL/min/1.73m^2 for patients with creatinine levels above institutional normal
  • Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of MLN8237 administration
  • Ability to understand and the willingness to sign a written informed consent document
  • According to current guidelines, patients must be able to take oral medication and to maintain a fast as required for approximately one hour before and two hours after MLN8237 administration

Exclusion Criteria:

  • Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier; patients who have had radiation therapy to more than 25% of the bone marrow; whole pelvic radiation is considered to be over 25%
  • Patients who are receiving any other investigational agents
  • Patients with known brain metastases
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to MLN8237 including, but not limited to, established allergic reaction to benzodiazepines
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, New York Heart Association (NYHA) class II-IV heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Pregnant women; women of child-bearing potential must have a negative serum or urine pregnancy test within 7 days prior to registration; breastfeeding should be discontinued if the mother is treated with MLN8237
  • Leiomyosarcoma of the uterus
  • Patients known to be human immunodeficiency virus (HIV)-positive on antiretroviral therapy
  • Prior allogeneic bone marrow or organ transplantation
  • Known history of uncontrolled sleep apnea syndrome and other conditions that could result in excessive daytime sleepiness such as severe chronic obstructive pulmonary disease, requirement for supplemental oxygen, or any conditions that could result in excessive toxicity associated with the benzodiazepine-like effects of MLN8237
  • Requirement for constant administration of proton pump inhibitor, histamine-2 (H2) antagonist, or pancreatic enzymes; note: intermittent uses of antacids or H2 antagonists are allowed
  • Inability to swallow oral medication or to maintain a required fast for approximately one hour before and two hours after MLN8237 administration or any condition that would modify small bowel absorption of oral medications, including malabsorption or resection of pancreas or upper bowel
  • Treatment with clinically significant enzyme inducers, such as the enzyme-inducing antiepileptic drugs phenytoin, carbamazepine, oxcarbazepine, primidone or phenobarbital, or rifampin, rifabutin, rifapentine, or St. John's wort within 14 days prior to the first dose of MLN8237 and during the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01653028

  Hide Study Locations
Locations
United States, Arizona
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Contact: Scott H. Okuno    507-538-7623      
Principal Investigator: Scott H. Okuno         
United States, Colorado
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Penrose Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mercy Medical Center Recruiting
Durango, Colorado, United States, 81301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Front Range Cancer Specialists Terminated
Fort Collins, Colorado, United States, 80528
Poudre Valley Hospital Terminated
Fort Collins, Colorado, United States, 80524
Mountain Blue Cancer Care Center Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Breast Cancer Care Consultants Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Lakewood Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Longmont Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Parker Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers - Pueblo Recruiting
Pueblo, Colorado, United States, 81008
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, District of Columbia
Washington Hospital Center Recruiting
Washington, District of Columbia, United States, 20010
Contact: Dennis A. Priebat    202-877-8839      
Principal Investigator: Dennis A. Priebat         
United States, Florida
Memorial Healthcare System - Joe DiMaggio Children's Hospital Recruiting
Hollywood, Florida, United States, 33021
Contact: Atif M. Hussein    954-265-2234      
Principal Investigator: Atif M. Hussein         
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224-9980
Contact: Scott H. Okuno    507-538-7623      
Principal Investigator: Scott H. Okuno         
United States, Georgia
John B Amos Cancer Center Recruiting
Columbus, Georgia, United States, 31904
Contact: Andrew W. Pippas    706-660-6404      
Principal Investigator: Andrew W. Pippas         
United States, Hawaii
Oncare Hawaii Inc-Pali Momi Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Pali Momi Medical Center Recruiting
Aiea, Hawaii, United States, 96701
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Kapiolani Medical Center for Women and Children Recruiting
Honolulu, Hawaii, United States, 96826
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
OnCare Hawaii-Liliha Recruiting
Honolulu, Hawaii, United States, 96817-3169
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-POB II Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-Kuakini Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Straub Clinic and Hospital Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
University of Hawaii Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Castle Medical Center Recruiting
Kailua, Hawaii, United States, 96734
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Wilcox Memorial Hospital and Kauai Medical Clinic Recruiting
Lihue, Hawaii, United States, 96766
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
United States, Idaho
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Mark Agulnik    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Mark Agulnik         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Aileen Go    708-226-4357      
Principal Investigator: Aileen Go         
Garneau, Stewart C MD (UIA Investigator) Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Porubcin, Michael MD (UIA Investigator) Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Spector, David MD (UIA Investigator) Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Trinity Medical Center Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Maria T. Grosse-Perdekamp    800-446-5532    kcheek@dmhhs.org   
Principal Investigator: Maria T. Grosse-Perdekamp         
United States, Indiana
Franciscan Saint Francis Health-Indianapolis Recruiting
Indianapolis, Indiana, United States, 46237
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Reid Hospital and Health Care Services Recruiting
Richmond, Indiana, United States, 47374
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
United States, Iowa
Mary Greeley Medical Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Constantinou, Costas L MD (UIA Investigator) Recruiting
Bettendorf, Iowa, United States, 52722
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
McFarland Clinic PC-Boone Recruiting
Boone, Iowa, United States, 50036
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Medical Oncology and Hematology Associates-West Des Moines Recruiting
Clive, Iowa, United States, 50325
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Medical Oncology and Hematology Associates-Laurel Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Iowa Oncology Research Association CCOP Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Medical Oncology and Hematology Associates-Des Moines Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Iowa Lutheran Hospital Recruiting
Des Moines, Iowa, United States, 50316
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Mohammed M. Milhem    800-237-1225      
Principal Investigator: Mohammed M. Milhem         
McFarland Clinic PC-Jefferson Recruiting
Jefferson, Iowa, United States, 50129
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Marshalltown Recruiting
Marshalltown, Iowa, United States, 50158
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Mercy Medical Center-Sioux City Recruiting
Sioux City, Iowa, United States, 51104
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Saint Luke's Regional Medical Center Recruiting
Sioux City, Iowa, United States, 51104
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Mercy Medical Center-West Lakes Recruiting
West Des Moines, Iowa, United States, 50266
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Methodist West Hospital Recruiting
West Des Moines, Iowa, United States, 50266-7700
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
United States, Kansas
Cancer Center of Kansas - Chanute Recruiting
Chanute, Kansas, United States, 66720
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Dodge City Recruiting
Dodge City, Kansas, United States, 67801
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - El Dorado Recruiting
El Dorado, Kansas, United States, 67042
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Fort Scott Recruiting
Fort Scott, Kansas, United States, 66701
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Independence Recruiting
Independence, Kansas, United States, 67301
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Kingman Recruiting
Kingman, Kansas, United States, 67068
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Liberal Recruiting
Liberal, Kansas, United States, 67901
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Manhattan Recruiting
Manhattan, Kansas, United States, 66502
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - McPherson Recruiting
McPherson, Kansas, United States, 67460
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Newton Recruiting
Newton, Kansas, United States, 67114
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Saint Luke's South Hospital Recruiting
Overland Park, Kansas, United States, 66213
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Menorah Medical Center Recruiting
Overland Park, Kansas, United States, 66209
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Cancer Center of Kansas - Parsons Recruiting
Parsons, Kansas, United States, 67357
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Kansas City CCOP Recruiting
Prairie Village, Kansas, United States, 66208
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Cancer Center of Kansas - Pratt Recruiting
Pratt, Kansas, United States, 67124
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Salina Recruiting
Salina, Kansas, United States, 67401
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Wellington Recruiting
Wellington, Kansas, United States, 67152
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Associates In Womens Health Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Wichita Medical Arts Tower Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Via Christi Regional Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Main Office Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Wichita CCOP Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Winfield Recruiting
Winfield, Kansas, United States, 67156
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
Oncology Hematology Care Incorporated Recruiting
Crestview Hills, Kentucky, United States, 41017
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
United States, Massachusetts
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Adam Lerner    617-638-8265      
Principal Investigator: Adam Lerner         
United States, Michigan
Bixby Medical Center Recruiting
Adrian, Michigan, United States, 49221
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Hickman Cancer Center Recruiting
Adrian, Michigan, United States, 49221
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Green Bay Oncology - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Green Bay Oncology - Iron Mountain Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Community Cancer Center of Monroe Recruiting
Monroe, Michigan, United States, 48162
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Mercy Memorial Hospital Recruiting
Monroe, Michigan, United States, 48162
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
United States, Minnesota
Sanford Clinic North-Bemidgi Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Scott H. Okuno    507-538-7623      
Principal Investigator: Scott H. Okuno         
Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
Coborn Cancer Center at Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Metro-Minnesota CCOP Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Daniel M. Anderson    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Daniel M. Anderson         
United States, Missouri
Southeast Cancer Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Centerpoint Medical Center LLC Recruiting
Independence, Missouri, United States, 64057
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Capital Region Medical Center-Goldschmidt Cancer Center Recruiting
Jefferson City, Missouri, United States, 65109
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Heartland Hematology and Oncology Associates Incorporated Recruiting
Kansas City, Missouri, United States, 64118
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
North Kansas City Hospital Terminated
Kansas City, Missouri, United States, 64116
Research Medical Center Recruiting
Kansas City, Missouri, United States, 64132
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's East - Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64086
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Liberty Hospital Recruiting
Liberty, Missouri, United States, 64068
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Heartland Regional Medical Center Recruiting
Saint Joseph, Missouri, United States, 64506
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Joseph Oncology Inc Active, not recruiting
Saint Joseph, Missouri, United States, 64507
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Brian A. Van Tine    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Brian A. Van Tine         
United States, Montana
Hematology-Oncology Centers of the Northern Rockies PC Terminated
Billings, Montana, United States, 59102
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Montana Cancer Consortium CCOP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Montana Cancer Specialists Active, not recruiting
Missoula, Montana, United States, 59802
Saint Patrick Hospital - Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Saint Francis Medical Center Recruiting
Grand Island, Nebraska, United States, 68803
Contact: Nicole A. Shonka    800-999-5465      
Principal Investigator: Nicole A. Shonka         
Nebraska Methodist Hospital Withdrawn
Omaha, Nebraska, United States, 68114
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Nicole A. Shonka    800-999-5465      
Principal Investigator: Nicole A. Shonka         
United States, New Jersey
Memorial Sloan Kettering Cancer Center at Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Mark A. Dickson    212-639-7202      
Principal Investigator: Mark A. Dickson         
UMDNJ - New Jersey Medical School Withdrawn
Newark, New Jersey, United States, 07103
United States, New York
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263
Contact: Nikhil I. Khushalani    877-275-7724      
Principal Investigator: Nikhil I. Khushalani         
Memorial Sloan Kettering Cancer Center Commack Recruiting
Commack, New York, United States, 11725
Contact: Mark A. Dickson    212-639-8895      
Principal Investigator: Mark A. Dickson         
Glens Falls Hospital Withdrawn
Glens Falls, New York, United States, 12801
Memorial Sloan-Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Mark A. Dickson    212-639-7202      
Principal Investigator: Mark A. Dickson         
Memorial Sloan-Kettering Cancer Center Rockville Centre Recruiting
Rockville Centre, New York, United States, 11570
Contact: Mark A. Dickson    212-639-7202      
Principal Investigator: Mark A. Dickson         
Memorial Sloan-Kettering Cancer Center at Sleepy Hallow Recruiting
Sleepy Hollow, New York, United States, 10591
Contact: Mark A. Dickson    212-639-7202      
Principal Investigator: Mark A. Dickson         
United States, North Carolina
Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27710
Contact: Jeffrey Crawford    888-275-3853      
Principal Investigator: Jeffrey Crawford         
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Iredell Memorial Hospital Recruiting
Statesville, North Carolina, United States, 28677
Contact: Ruby A. Grimm    704-873-5661      
Principal Investigator: Ruby A. Grimm         
United States, North Dakota
Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Clinic North-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Medical Center-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
United States, Ohio
Toledo Clinic Cancer Centers-Bowling Green Recruiting
Bowling Green, Ohio, United States, 43402
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Oncology Hematology Care Inc - Kenwood Recruiting
Cincinnati, Ohio, United States, 45236
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Oncology and Hematology Care Incorporated Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Oncology and Hematology Care Inc - Blue Ash Recruiting
Cincinnati, Ohio, United States, 45242
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc - Western Hills Recruiting
Cincinnati, Ohio, United States, 45248
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Oncology Hematology Care Inc - Anderson Recruiting
Cincinnati, Ohio, United States, 45230
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Good Samaritan Hospital - Dayton Recruiting
Dayton, Ohio, United States, 45406
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Grandview Hospital Terminated
Dayton, Ohio, United States, 45405
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Samaritan North Health Center Recruiting
Dayton, Ohio, United States, 45415
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Dayton CCOP Recruiting
Dayton, Ohio, United States, 45420
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Mercy Cancer Center-Elyria Terminated
Elyria, Ohio, United States, 44035
Hematology Oncology Center Incorporated Terminated
Elyria, Ohio, United States, 44035
Oncology Hematology Care Inc Recruiting
Fairfield, Ohio, United States, 45014
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Blanchard Valley Hospital Recruiting
Findlay, Ohio, United States, 45840
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Atrium Medical Center-Middletown Regional Hospital Recruiting
Franklin, Ohio, United States, 45005-1066
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Wayne Hospital Recruiting
Greenville, Ohio, United States, 45331
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Kettering Medical Center Recruiting
Kettering, Ohio, United States, 45429
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Lima Memorial Hospital Recruiting
Lima, Ohio, United States, 45804
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Toledo Clinic Cancer Centers-Maumee Recruiting
Maumee, Ohio, United States, 43537
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Recruiting
Maumee, Ohio, United States, 43537
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Saint Charles Hospital Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Toledo Clinic Cancer Centers-Oregon Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Flower Hospital Recruiting
Sylvania, Ohio, United States, 43560
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Mercy Hospital of Tiffin Recruiting
Tiffin, Ohio, United States, 44883
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
The Toledo Hospital/Toledo Children's Hospital Terminated
Toledo, Ohio, United States, 43606
Toledo Clinic Cancer Centers-Toledo Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Toledo Community Hospital Oncology Program CCOP Recruiting
Toledo, Ohio, United States, 43617
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Saint Vincent Mercy Medical Center Recruiting
Toledo, Ohio, United States, 43608
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
University of Toledo Recruiting
Toledo, Ohio, United States, 43614
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Mercy Saint Anne Hospital Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Upper Valley Medical Center Recruiting
Troy, Ohio, United States, 45373
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Fulton County Health Center Recruiting
Wauseon, Ohio, United States, 43567
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Wright-Patterson Medical Center Active, not recruiting
Wright-Patterson Afb, Ohio, United States, 45433-5529
Greene Memorial Hospital Terminated
Xenia, Ohio, United States, 45385
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Carla Kurkjian    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Carla Kurkjian         
Oklahoma Oncology Inc Recruiting
Tulsa, Oklahoma, United States, 74104
Contact: Jihad Khattab    918-494-2200      
Principal Investigator: Jihad Khattab         
Natalie Warren Bryant Cancer Center at Saint Francis Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Jihad Khattab    918-494-2200      
Principal Investigator: Jihad Khattab         
Warren Cancer Research Foundation Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Jihad Khattab    918-494-2200      
Principal Investigator: Jihad Khattab         
United States, Pennsylvania
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822-2001
Contact: Christian S. Adonizio    570-271-5251      
Principal Investigator: Christian S. Adonizio         
Geisinger Medical Center-Cancer Center Hazleton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Christian S. Adonizio    570-271-5251      
Principal Investigator: Christian S. Adonizio         
Geisinger Medical Oncology at Evangelical Community Hospital Recruiting
Lewisburg, Pennsylvania, United States, 17837
Contact: Christian S. Adonizio    570-271-5251      
Principal Investigator: Christian S. Adonizio         
Geisinger Medical Oncology-Pottsville Recruiting
Pottsville, Pennsylvania, United States, 17901
Contact: Christian S. Adonizio    570-271-5251      
Principal Investigator: Christian S. Adonizio         
Geisinger Medical Group Recruiting
State College, Pennsylvania, United States, 16801
Contact: Christian S. Adonizio    570-271-5251      
Principal Investigator: Christian S. Adonizio         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Christian S. Adonizio    570-271-5251      
Principal Investigator: Christian S. Adonizio         
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Andrew S. Kraft    843-792-9321      
Principal Investigator: Andrew S. Kraft         
McLeod Regional Medical Center Active, not recruiting
Florence, South Carolina, United States, 29506
United States, South Dakota
Sanford Cancer Center-Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
United States, Utah
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Launce G. Gouw    801-408-1347    clinical.trials@hci.utah.edu   
Principal Investigator: Launce G. Gouw         
United States, Vermont
Central Vermont Medical Center/National Life Cancer Treatment Active, not recruiting
Berlin, Vermont, United States, 05602
University of Vermont Active, not recruiting
Burlington, Vermont, United States, 05401
United States, Virginia
Fredericksburg Oncology Inc Recruiting
Fredericksburg, Virginia, United States, 22401
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
United States, Wisconsin
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Holy Family Memorial Hospital Recruiting
Manitowoc, Wisconsin, United States, 54221
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: John A. Charlson    414-805-4380      
Principal Investigator: John A. Charlson         
Cancer Center of Western Wisconsin Recruiting
New Richmond, Wisconsin, United States, 54017
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Green Bay Oncology - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Saint Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Anthony J. Jaslowski    800-432-6049      
Principal Investigator: Anthony J. Jaslowski         
United States, Wyoming
Rocky Mountain Oncology Recruiting
Casper, Wyoming, United States, 82609
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Sponsors and Collaborators
Investigators
Principal Investigator: Mark Dickson Cancer and Leukemia Group B
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01653028     History of Changes
Other Study ID Numbers: NCI-2012-01991, NCI-2012-01991, CDR0000737403, CALGB-A091102, A091102, A091102, U10CA180821, U10CA031946
Study First Received: July 26, 2012
Last Updated: June 16, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Histiocytoma
Histiocytoma, Benign Fibrous
Carcinosarcoma
Mixed Tumor, Mullerian
Chondrosarcoma
Fibrosarcoma
Fibrosis
Hemangiosarcoma
Leiomyosarcoma
Liposarcoma
Mast-Cell Sarcoma
Sarcoma
Sarcoma, Endometrial Stromal
Sarcoma, Alveolar Soft Part
Neurofibrosarcoma
Neurilemmoma
Histiocytoma, Malignant Fibrous
Ovarian Neoplasms
Neoplasms, Fibrous Tissue
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Complex and Mixed
Pathologic Processes
Neoplasms, Vascular Tissue
Neoplasms, Muscle Tissue
Neoplasms, Adipose Tissue
Mastocytosis
Endometrial Stromal Tumors

ClinicalTrials.gov processed this record on July 22, 2014