Trial record 1 of 1 for:    NCT01522976
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Azacitidine With or Without Lenalidomide or Vorinostat in Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

This study is currently recruiting participants.
Verified March 2014 by National Cancer Institute (NCI)
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01522976
First received: January 27, 2012
Last updated: March 19, 2014
Last verified: March 2014
  Purpose

This randomized phase II trial studies how well giving azacitidine works with or without lenalidomide or vorinostat in treating patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells or stopping them from dividing. Lenalidomide may stop the growth of cancer cells by stopping blood flow to the cancer. Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. It is not yet known whether azacitidine is more effective with or without lenalidomide or vorinostat in treating myelodysplastic syndromes or chronic myelomonocytic leukemia.


Condition Intervention Phase
Chronic Myelomonocytic Leukemia
de Novo Myelodysplastic Syndromes
Previously Treated Myelodysplastic Syndromes
Refractory Anemia With Excess Blasts
Secondary Myelodysplastic Syndromes
Drug: azacitidine
Drug: lenalidomide
Drug: vorinostat
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Randomized Phase II Study of Azacitidine in Combination With Lenalidomide (NSC-703813) vs. Azacitidine Alone vs. Azacititdine in Combination With Vorinostat (NSC-701852) for Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Response rate (RR) (any of complete hematological remission [CR], partial response [PR], or hematologic improvement [HI]) [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
    The final analysis will consist of two one-sided tests of whether the RR is improved in either of the combination arms compared to the single-agent azacitidine arm. Each test will be performed at the 0.05 level.


Secondary Outcome Measures:
  • Overall survival [ Time Frame: From the date of initial registration to date of death due to any cause, assessed up to 5 years ] [ Designated as safety issue: No ]
    Will be estimated by the Kaplan-Meier method.

  • Relapse-free survival [ Time Frame: From the date of response to the date of first documentation of relapse from response, or death due to any cause, assessed up to 5 years ] [ Designated as safety issue: No ]
    Will be estimated by the Kaplan-Meier method.

  • Toxicity rates on each arm assessed using National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: Up to 5 years ] [ Designated as safety issue: Yes ]
  • Frequency of pre-study cytogenetic abnormalities [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
    Will be examined in descriptive analyses.

  • Cytogenetic response rates [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
    Will be estimated in descriptive analyses.


Estimated Enrollment: 267
Study Start Date: March 2012
Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I (azacitidine and lenalidomide)
Patients receive azacitidine SC or IV on days 1-7 or days 1-5 and 8-9, and lenalidomide PO QD on days 1-21. Courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.
Drug: azacitidine
Given SC or IV
Other Names:
  • 5-AC
  • 5-azacytidine
  • azacytidine
  • Vidaza
Drug: lenalidomide
Given PO
Other Names:
  • CC-5013
  • IMiD-1
  • Revlimid
Experimental: Arm II (azacitidine)
Patients receive azacitidine as in arm I. Courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.
Drug: azacitidine
Given SC or IV
Other Names:
  • 5-AC
  • 5-azacytidine
  • azacytidine
  • Vidaza
Experimental: Arm III (azacitidine and vorinostat)
Patients receive azacitidine as in arm I and vorinostat PO BID on days 3-9. Courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.
Drug: azacitidine
Given SC or IV
Other Names:
  • 5-AC
  • 5-azacytidine
  • azacytidine
  • Vidaza
Drug: vorinostat
Given PO
Other Names:
  • L-001079038
  • SAHA
  • suberoylanilide hydroxamic acid
  • Zolinza

Detailed Description:

PRIMARY OBJECTIVES:

I. To test whether the response rate (complete remission, partial remission, or hematologic improvement) of patients with higher-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) who receive either the combination of lenalidomide and azacitidine or the combination of vorinostat and azacitidine is improved compared to patients who receive single-agent azacitidine.

SECONDARY OBJECTIVES:

I. To estimate relapse-free survival, overall survival and cytogenetic response rate of patients treated on each regimen.

II. To estimate the frequency and severity of toxicities of the three regimens in this patient population.

III. To investigate in a preliminary manner the frequency of subgroups from pre-study cytogenetic studies and correlate these subgroups with clinical outcomes in this patient population.

IV. To collect specimens for banking for use in future research studies.

OUTLINE: Patients are randomized to 1 of 3 treatment arms.

ARM I: Patients receive azacitidine subcutaneously (SC) or intravenously (IV) on days 1-7 or days 1-5 and 8-9, and lenalidomide orally (PO) once daily (QD) on days 1-21.

ARM II: Patients receive azacitidine as in arm I.

ARM III: Patients receive azacitidine as in arm I and vorinostat PO twice daily (BID) on days 3-9.

In all arms, courses repeat every 28 days for up to 5 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for up to 5 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must have morphologically confirmed diagnosis of myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) based on one of the following:

    • French-American-British (FAB) classifications:

      • Refractory anemia with excess blasts (RAEB - defined as having 5-20% myeloblasts in the bone marrow)
      • CMML with 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood
    • World Health Organization (WHO) Classifications:

      • RAEB-1 (defined as having 5-9% myeloblasts in the bone marrow)
      • RAEB-2 (defined as having 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood)
      • CMML-1 (defined as having < 5% myeloblasts in the bone marrow and/or < 10% blasts in the blood)
      • CMML-2 (defined as having 10-19% myeloblasts in the bone marrow and/or 5-19% blasts in the blood)
    • International prognostic score (IPSS) of Intermediate 2 (1.5-2.0 points) or High (>= 2.5 points); a score of Intermediate 1 (0.5-1.0 points) is only allowable in the setting of >= 5% myeloblasts
    • Patients with acute myeloid leukemia (AML) are not eligible
    • Procedures to obtain specimens for establishing baseline disease must be done within 30 days prior to registration
  • Patients must not have received lenalidomide, azacitidine, vorinostat, or decitabine as treatment previously; any hematopoietic growth factors must be stopped for at least 14 days prior to registration

    • Patients may have received low-dose cytarabine for MDS treatment previously, but they must have discontinued its use for at least 28 days prior to registration
  • Patients must not have received radiation therapy, chemotherapy, or cytotoxic therapy to treat conditions other than MDS within 12 months prior to registration
  • Patients must not have undergone prior allogeneic stem cell or bone marrow transplantation at any time; patients that have undergone an autologous stem cell transplant are eligible
  • Patients must not have used or be using histone deacetylase (HDAC) inhibitor agents for anticancer treatment
  • Patients may not have received agents such as valproic acid for epilepsy within 30 days prior to registration
  • Patients must have Zubrod performance status of 0-2
  • Patients must not have any pre-existing neurotoxicity/neuropathy of >= grade 2 according to the National Cancer Institute (NCI) Common Toxicity Criteria (CTC) Version 4.0, or prior >= grade 3 allergic reaction/hypersensitivity or rash to thalidomide that has not resolved to < grade 2
  • Patients must not have any serious medical condition, laboratory abnormality, or psychiatric illness that, in the view of the treating physician, would place the participant at an unacceptable risk if he or she were to participate in the study or would prevent that person from giving informed consent
  • Patients must not have history of thromboembolic event or other condition requiring current use of anticoagulation with Coumadin (warfarin) or low molecular-weight heparin
  • Patients must not have known or suspected hypersensitivity to mannitol
  • Patients must receive a 12-lead electrocardiogram (EKG), chest x-ray, serum creatinine, complete metabolic panel including serum glutamic oxaloacetic transaminase (SGOT) or serum glutamic pyruvic transaminase (SGPT), electrolytes, and bilirubin testing within 28 days prior to registration in order to establish baseline measurements; questions regarding patient safety in regards to results of these tests should be directed to the Study Coordinator
  • Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10 - 14 days prior to registration; FCBP must agree to have a second pregnancy test within 24 hours prior to starting course 1 if randomized to receive lenalidomide

    • A FCBP is a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
  • Patients must commit to the following if they are randomized to receive lenalidomide; FCBP must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control: one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before starting lenalidomide; FCBP must also agree to ongoing pregnancy testing; men must agree to use a latex condom during sexual contact with a FCBP, even if they have had a successful vasectomy

    • All patients must be counseled by a trained counselor every 28 days about pregnancy precautions and risks of fetal exposure
  • Patients not randomized to receive lenalidomide will not be required to undergo serial pregnancy testing or lenalidomide counseling after registration
  • No prior malignancy is allowed except for adequately treated basal cell (or squamous cell) skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for three years
  • Cytogenetics requirements:

    • Southwestern Oncology Group (SWOG) (and other sites not affiliated with Cancer and Leukemia Group B [CALGB] or Eastern Cooperative Oncology Group [ECOG]): Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 14 days prior to registration to SWOG-S1117
    • CALGB: CALGB patients must enroll on CALGB 8461, the cytogenetics protocol
    • ECOG: Pretreatment cytogenetics must be performed on all patients; collection of pretreatment specimens must be completed within 30 days prior to registration to S1117
  • Banking requirements:

    • SWOG and ECOG (and other sites not affiliated with CALGB): Patients must be offered participation in specimen banking
    • CALGB: CALGB patients must be offered participation in CALGB 9665, the CALGB Leukemia Tissue bank protocol
    • National Cancer Institute of Canada (NCIC) Clinical Trials Group (CTG): NCIC CTG patients must be offered participation in specimen submission and banking
  • All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
  • As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01522976

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Harry P. Erba    205-934-0309      
Principal Investigator: Harry P. Erba         
University of South Alabama Mitchell Cancer Institute Recruiting
Mobile, Alabama, United States, 36688
Contact: David R. Clarkson    251-665-8000      
Principal Investigator: David R. Clarkson         
United States, Arizona
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Contact: Mrinal M. Patnaik    507-538-7623      
Principal Investigator: Mrinal M. Patnaik         
University of Arizona Health Sciences Center Recruiting
Tucson, Arizona, United States, 85724
Contact: Ravitharan Krishnadasan    520-626-9008      
Principal Investigator: Ravitharan Krishnadasan         
Arizona Cancer Center at University Medical Center North Recruiting
Tucson, Arizona, United States, 85719
Contact: Ravitharan Krishnadasan    520-626-9008      
Principal Investigator: Ravitharan Krishnadasan         
United States, Arkansas
Veteran's Administration Medical Center Active, not recruiting
Little Rock, Arkansas, United States, 72205
United States, California
Kaiser Permanente-Deer Valley Medical Center Recruiting
Antioch, California, United States, 94531
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
City of Hope Medical Center Active, not recruiting
Duarte, California, United States, 91010
University of Southern California Recruiting
Los Angeles, California, United States, 90033
Contact: Casey L. O'Connell    323-865-0451      
Principal Investigator: Casey L. O'Connell         
Kaiser Permanente-Oakland Recruiting
Oakland, California, United States, 94611
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Richmond Recruiting
Richmond, California, United States, 94801
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente - Sacramento Recruiting
Sacramento, California, United States, 95825
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-South Sacramento Recruiting
Sacramento, California, United States, 95823
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-Santa Teresa-San Jose Recruiting
San Jose, California, United States, 95119
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-San Rafael Recruiting
San Rafael, California, United States, 94903
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Sutter Pacific Medical Foundation Terminated
Santa Rosa, California, United States, 95403
Kaiser Permanente-Santa Rosa Recruiting
Santa Rosa, California, United States, 95403
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Kaiser Permanente-South San Francisco Recruiting
South San Francisco, California, United States, 94080
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Stanford University Hospitals and Clinics Recruiting
Stanford, California, United States, 94305
Contact: Bruno C. de Medeiros    650-498-7061    ccto-office@stanford.edu   
Principal Investigator: Bruno C. de Medeiros         
Kaiser Permanente-Walnut Creek Recruiting
Walnut Creek, California, United States, 94596
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
United States, Colorado
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
University of Colorado Cancer Center - Anschutz Cancer Pavilion Recruiting
Aurora, Colorado, United States, 80045
Contact: Daniel A. Pollyea    720-848-0650      
Principal Investigator: Daniel A. Pollyea         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Regina J. Brown    970-297-6150      
Principal Investigator: Regina J. Brown         
Front Range Cancer Specialists Terminated
Fort Collins, Colorado, United States, 80528
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
University of Connecticut Recruiting
Farmington, Connecticut, United States, 06030
Contact: Jeffrey S. Wasser    800-579-7822      
Principal Investigator: Jeffrey S. Wasser         
Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Christopher M. Reynolds    734-712-3456      
Principal Investigator: Christopher M. Reynolds         
The Hospital of Central Connecticut Recruiting
New Britain, Connecticut, United States, 06050
Contact: Brian J. Byrne    860-224-5660      
Principal Investigator: Brian J. Byrne         
United States, Delaware
Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
United States, District of Columbia
Sibley Memorial Hospital Recruiting
Washington, District of Columbia, United States, 20016
Contact: Bruce R. Kressel    202-243-2373      
Principal Investigator: Bruce R. Kressel         
Veterans Affairs Medical Center -Washington DC Terminated
Washington, District of Columbia, United States, 20422
United States, Florida
University of Florida Recruiting
Gainesville, Florida, United States, 32610
Contact: Jack W. Hsu    352-273-8675    trials@cancer.ufl.edu   
Principal Investigator: Jack W. Hsu         
Jupiter Medical Center Recruiting
Jupiter, Florida, United States, 33458
Contact: Michael A. Schwartz    305-674-2625    info@msccop.com   
Principal Investigator: Michael A. Schwartz         
Mount Sinai Medical Center CCOP Recruiting
Miami Beach, Florida, United States, 33140
Contact: Michael A. Schwartz    305-674-2625    info@msccop.com   
Principal Investigator: Michael A. Schwartz         
Florida Hospital Recruiting
Orlando, Florida, United States, 32803
Contact: Lee M. Zehngebot    407-303-5623      
Principal Investigator: Lee M. Zehngebot         
United States, Georgia
Georgia Regents University Active, not recruiting
Augusta, Georgia, United States, 30912
United States, Hawaii
Kaiser Permanente Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Tatjana Kolevska    626-564-3455      
Principal Investigator: Tatjana Kolevska         
Oncare Hawaii Inc-Kuakini Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Oncare Hawaii Inc-POB II Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Straub Clinic and Hospital Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
University of Hawaii Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
United States, Illinois
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Hematology and Oncology Associates Terminated
Chicago, Illinois, United States, 60611
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Olatoyosi M. Odenike    773-834-7424      
Principal Investigator: Olatoyosi M. Odenike         
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: John G. Quigley    312-355-3046      
Principal Investigator: John G. Quigley         
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Olga Frankfurt    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Olga Frankfurt         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Evanston CCOP-NorthShore University HealthSystem Recruiting
Evanston, Illinois, United States, 60201
Contact: Lynne S. Kaminer    847-570-1381      
Principal Investigator: Lynne S. Kaminer         
Illinois CancerCare Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Havana Terminated
Havana, Illinois, United States, 62644
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Danielle A. Shafer    708-226-4357      
Principal Investigator: Danielle A. Shafer         
Trinity Medical Center Recruiting
Moline, Illinois, United States, 61265
Contact: David M. Spector    309-779-4200      
Principal Investigator: David M. Spector         
Illinois CancerCare-Monmouth Recruiting
Monmouth, Illinois, United States, 61462
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Community Cancer Center Terminated
Normal, Illinois, United States, 61761
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Oncology Research Association CCOP Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Swedish American Hospital Withdrawn
Rockford, Illinois, United States, 61104
SwedishAmerican Regional Cancer Center/ACT Recruiting
Rockford, Illinois, United States, 61107
Contact: Harvey E. Einhorn    779-696-9400    cancercare@swedishamerican.org   
Principal Investigator: Harvey E. Einhorn         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Vamsi K. Vasireddy    800-446-5532      
Principal Investigator: Vamsi K. Vasireddy         
United States, Indiana
Premier Oncology Hematology Associates Recruiting
Merrillville, Indiana, United States, 46410
Contact: Bharat H. Barai    219-736-2800      
Principal Investigator: Bharat H. Barai         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Thomas H. Carter    800-237-1225      
Principal Investigator: Thomas H. Carter         
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Covenant Medical Center Recruiting
Waterloo, Iowa, United States, 50702
Contact: Mohammed T. Masri    319-272-2070      
Principal Investigator: Mohammed T. Masri         
United States, Kansas
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Peter J. Van Veldhuizen    800-525-1483      
Principal Investigator: Peter J. Van Veldhuizen         
Kansas City CCOP Recruiting
Prairie Village, Kansas, United States, 66208
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Stormont-Vail Regional Health Center Recruiting
Topeka, Kansas, United States, 66604
Contact: David E. Einspahr    785-270-4963      
Principal Investigator: David E. Einspahr         
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536
Contact: Dianna S. Howard    859-257-3379      
Principal Investigator: Dianna S. Howard         
United States, Louisiana
Ochsner Health Center-Summa Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Ochsner Medical Center Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Robert V. Emmons    888-562-4763      
Principal Investigator: Robert V. Emmons         
Louisiana State University Health Sciences Center Shreveport Recruiting
Shreveport, Louisiana, United States, 71130
Contact: Nebu V. Koshy    318-813-1412      
Principal Investigator: Nebu V. Koshy         
United States, Maine
Eastern Maine Medical Center Recruiting
Bangor, Maine, United States, 04401
Contact: Thomas H. Openshaw    207-973-4274      
Principal Investigator: Thomas H. Openshaw         
United States, Maryland
Johns Hopkins University-Sidney Kimmel Cancer Center Recruiting
Baltimore, Maryland, United States, 21287
Contact: Steven D. Gore    410-955-8804    jhcccro@jhmi.edu   
Principal Investigator: Steven D. Gore         
Union Hospital of Cecil County Terminated
Elkton MD, Maryland, United States, 21921
United States, Massachusetts
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02115
Contact: David P. Steensma    866-790-4500      
Principal Investigator: David P. Steensma         
Massachusetts General Hospital Cancer Center Recruiting
Boston, Massachusetts, United States, 02114
Contact: David P. Steensma    866-790-4500      
Principal Investigator: David P. Steensma         
Caritas Saint Elizabeth's Medical Center Recruiting
Brighton, Massachusetts, United States, 02135-2997
Contact: Uma Narayanasami    617-789-2903      
Principal Investigator: Uma Narayanasami         
Baystate Medical Center Recruiting
Springfield, Massachusetts, United States, 01199
Contact: Syed S. Ali    413-794-3565    tamara.wrenn@baystatehealth.org   
Principal Investigator: Syed S. Ali         
University of Massachusetts Medical School Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Muthalagu Ramanathan    508-856-3216    cancer.research@umassmed.edu   
Principal Investigator: Muthalagu Ramanathan         
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Christopher M. Reynolds    734-712-3456      
Principal Investigator: Christopher M. Reynolds         
Bronson Battle Creek Recruiting
Battle Creek, Michigan, United States, 49017
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Wayne State University-Karmanos Cancer Institute Recruiting
Detroit, Michigan, United States, 48201
Contact: Jay Yang    313-576-9363      
Principal Investigator: Jay Yang         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Christopher M. Reynolds    734-712-3456      
Principal Investigator: Christopher M. Reynolds         
Green Bay Oncology - Escanaba Recruiting
Escanaba, Michigan, United States, 49431
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Mercy Health Saint Mary's Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Grand Rapids Clinical Oncology Program Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Green Bay Oncology - Iron Mountain Recruiting
Iron Mountain, Michigan, United States, 49801
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Mercy Health Mercy Campus Recruiting
Muskegon, Michigan, United States, 49444
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint Joseph Mercy Port Huron Recruiting
Port Huron, Michigan, United States, 48060
Contact: Christopher M. Reynolds    734-712-3456      
Principal Investigator: Christopher M. Reynolds         
Spectrum Health Reed City Hospital Recruiting
Reed City, Michigan, United States, 49677
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Christopher M. Reynolds    734-712-3456      
Principal Investigator: Christopher M. Reynolds         
United States, Minnesota
Sanford Clinic North-Bemidgi Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Essentia Health Duluth Clinic CCOP Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel A. Nikcevich    888-203-7267      
Principal Investigator: Daniel A. Nikcevich         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Minneapolis Veterans Medical Center Recruiting
Minneapolis, Minnesota, United States, 55417
Contact: Sharon D. Luikart    612-467-2800      
Principal Investigator: Sharon D. Luikart         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Mrinal M. Patnaik    507-538-7623      
Principal Investigator: Mrinal M. Patnaik         
Coborn Cancer Center at Saint Cloud Hospital Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Donald J. Jurgens    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Donald J. Jurgens         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Metro-Minnesota CCOP Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Patrick J. Flynn    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Patrick J. Flynn         
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Stephanie L. Elkins    601-815-6700      
Principal Investigator: Stephanie L. Elkins         
United States, Missouri
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
University of Missouri - Ellis Fischel Recruiting
Columbia, Missouri, United States, 65212
Contact: Carl E. Freter    573-882-7440      
Principal Investigator: Carl E. Freter         
Veterans Administration Recruiting
Columbia, Missouri, United States, 65201
Contact: Shadi M. Haddadin    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Shadi M. Haddadin         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Jay W. Carlson    888-244-6061    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
United States, Montana
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, New Jersey
Cooper Hospital University Medical Center Recruiting
Camden, New Jersey, United States, 08103
Contact: Stephen S. Grubbs    302-733-6227      
Principal Investigator: Stephen S. Grubbs         
United States, New Mexico
Presbyterian Kaseman Hospital Recruiting
Albuquerque, New Mexico, United States, 87110
Contact: Elizabeth A. McGuire    505-272-6972      
Principal Investigator: Elizabeth A. McGuire         
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Elizabeth A. McGuire    505-272-6972      
Principal Investigator: Elizabeth A. McGuire         
United States, New York
Albert Einstein College of Medicine Recruiting
Bronx, New York, United States, 10461
Contact: Amit K. Verma    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Amit K. Verma         
Montefiore Medical Center Recruiting
Bronx, New York, United States, 10467-2490
Contact: Amit K. Verma    718-904-2730    aecc@aecom.yu.edu   
Principal Investigator: Amit K. Verma         
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263
Contact: Eunice S. Wang    877-275-7724      
Principal Investigator: Eunice S. Wang         
Monter Cancer Center Recruiting
Lake Success, New York, United States, 11042
Contact: Cristina M. Ghiuzeli    516-562-3467      
Principal Investigator: Cristina M. Ghiuzeli         
North Shore University Hospital Recruiting
Manhasset, New York, United States, 11030
Contact: Cristina M. Ghiuzeli    516-562-3467      
Principal Investigator: Cristina M. Ghiuzeli         
Winthrop University Hospital Recruiting
Mineola, New York, United States, 11501
Contact: Harry Staszewski    866-946-8476      
Principal Investigator: Harry Staszewski         
Weill Medical College of Cornell University Active, not recruiting
New York, New York, United States, 10065
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830      
Principal Investigator: Jonathan W. Friedberg         
United States, North Carolina
Randolph Hospital Recruiting
Asheboro, North Carolina, United States, 27203
Contact: Peter Rubin    336-832-0821      
Principal Investigator: Peter Rubin         
Wayne Memorial Hospital Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins    919-580-0000      
Principal Investigator: James N. Atkins         
Cone Health Cancer Center Recruiting
Greensboro, North Carolina, United States, 27403
Contact: Peter Rubin    336-832-0821      
Principal Investigator: Peter Rubin         
Margaret R Pardee Memorial Hospital Recruiting
Hendersonville, North Carolina, United States, 28791
Contact: James E. Radford    828-696-4716      
Principal Investigator: James E. Radford         
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
FirstHealth of the Carolinas-Moore Regional Hosiptal Recruiting
Pinehurst, North Carolina, United States, 28374
Contact: Charles S. Kuzma    910-715-2200      
Principal Investigator: Charles S. Kuzma         
Annie Penn Memorial Hospital Recruiting
Reidsville, North Carolina, United States, 27320
Contact: Peter Rubin    336-832-0821      
Principal Investigator: Peter Rubin         
Iredell Memorial Hospital Recruiting
Statesville, North Carolina, United States, 28677
Contact: Ruby A. Grimm    704-873-5661      
Principal Investigator: Ruby A. Grimm         
United States, North Dakota
Sanford Bismarck Medical Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Mid Dakota Clinic Terminated
Bismarck, North Dakota, United States, 58501
Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Clinic North-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
Sanford Medical Center-Fargo Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
United States, Ohio
Cleveland Clinic Cancer Center Beachwood Terminated
Beachwood, Ohio, United States, 44122
University of Cincinnati Active, not recruiting
Cincinnati, Ohio, United States, 45267
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Brenda W. Cooper    800-641-2422      
Principal Investigator: Brenda W. Cooper         
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Columbus CCOP Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Miami Valley Hospital Recruiting
Dayton, Ohio, United States, 45409
Contact: Howard M. Gross    765-983-3000      
Principal Investigator: Howard M. Gross         
Cleveland Clinic Cancer Center Independence Recruiting
Independence, Ohio, United States, 44131
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Parma Community General Hospital Terminated
Parma, Ohio, United States, 44129
North Coast Cancer Care Recruiting
Sandusky, Ohio, United States, 44870
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Cleveland Clinic Cancer Center-Strongsville Recruiting
Strongsville, Ohio, United States, 44136
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
University of Toledo Recruiting
Toledo, Ohio, United States, 43614
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John P. Kuebler    800-446-5532      
Principal Investigator: John P. Kuebler         
Cleveland Clinic Wooster Specialty Center Recruiting
Wooster, Ohio, United States, 44691
Contact: Anjali S. Advani    866-223-8100      
Principal Investigator: Anjali S. Advani         
United States, Oklahoma
Cancer Care Associates-Norman Recruiting
Norman, Oklahoma, United States, 73071
Contact: Vikki A. Canfield    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Vikki A. Canfield         
Cancer Care Associates-Mercy Recruiting
Oklahoma City, Oklahoma, United States, 73120
Contact: Vikki A. Canfield    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Vikki A. Canfield         
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: George B. Selby    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: George B. Selby         
United States, Oregon
Providence Milwaukie Hospital Recruiting
Milwaukie, Oregon, United States, 97222
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Legacy Good Samaritan Hospital and Medical Center Recruiting
Portland, Oregon, United States, 97210
Contact: Jacqueline Vuky    503-299-6500      
Principal Investigator: Jacqueline Vuky         
United States, Pennsylvania
Lehigh Valley Hospital Recruiting
Allentown, Pennsylvania, United States, 18105
Contact: Eliot L. Friedman    610-402-2273      
Principal Investigator: Eliot L. Friedman         
Carlisle Regional Cancer Center Recruiting
Carlisle, Pennsylvania, United States, 17015
Contact: David F. Claxton    717-531-3779    CTO@hmc.psu.edu   
Principal Investigator: David F. Claxton         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822-2001
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Doylestown Hospital Recruiting
Doylestown, Pennsylvania, United States, 18901
Contact: Mitchell B. Alden    215-345-2378    lheacock@dh.org   
Principal Investigator: Mitchell B. Alden         
Geisinger Medical Center-Cancer Center Hazelton Recruiting
Hazleton, Pennsylvania, United States, 18201
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
Penn State Milton S Hershey Medical Center Recruiting
Hershey, Pennsylvania, United States, 17033-0850
Contact: David F. Claxton    717-531-3779    CTO@hmc.psu.edu   
Principal Investigator: David F. Claxton         
University of Pittsburgh Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Annie P. Im    412-647-8073      
Principal Investigator: Annie P. Im         
Guthrie Medical Group PC-Robert Packer Hospital Recruiting
Sayre, Pennsylvania, United States, 18840
Contact: Edward T. O'Brien    800-836-0388      
Principal Investigator: Edward T. O'Brien         
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Terrence P. Cescon    610-988-9323      
Principal Investigator: Terrence P. Cescon         
Geisinger Wyoming Valley Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Edward J. Gorak    570-271-5251      
Principal Investigator: Edward J. Gorak         
United States, South Carolina
Roper Hospital Recruiting
Charleston, South Carolina, United States, 29401
Contact: James M. Orcutt    843-720-8386    elizabeth.strojny@roperstfrancis.com   
Principal Investigator: James M. Orcutt         
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Instutite/Greenville CCOP Recruiting
Greenville, South Carolina, United States, 29615
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Memorial Hospital Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Saint Francis Hospital Recruiting
Greenville, South Carolina, United States, 29601
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Cancer Centers of the Carolinas-Greer Medical Oncology Terminated
Greer, South Carolina, United States, 29650
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Upstate Carolina CCOP Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Mark T. Schroeder    605-716-3982    research@rcrh.org   
Principal Investigator: Mark T. Schroeder         
Sanford Cancer Center-Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
United States, Tennessee
Thompson Cancer Survival Center Recruiting
Knoxville, Tennessee, United States, 37916
Contact: Samuel S. McCachren    865-541-1812      
Principal Investigator: Samuel S. McCachren         
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Sanjay R. Mohan    800-811-8480      
Principal Investigator: Sanjay R. Mohan         
United States, Texas
The Don and Sybil Harrington Cancer Center Recruiting
Amarillo, Texas, United States, 79106
Contact: Stewart A. Sharp    806-359-4673    ryokubaitis@harringtoncc.org   
Principal Investigator: Stewart A. Sharp         
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Prapti Patel    214-648-7097      
Principal Investigator: Prapti Patel         
United States, Utah
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Paul J. Shami    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Paul J. Shami         
United States, Virginia
Memorial Hospital Of Martinsville Recruiting
Martinsville, Virginia, United States, 24115
Contact: Sreedhar Katragadda    276-666-7827      
Principal Investigator: Sreedhar Katragadda         
United States, Washington
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Soumit K. Basu    304-293-2745    sfilburn@hsc.wvu.edu   
Principal Investigator: Soumit K. Basu         
United States, Wisconsin
Marshfield Clinic-Chippewa Center Recruiting
Chippewa Falls, Wisconsin, United States, 54729
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Sacred Heart Hospital Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Marshfield Clinic Cancer Center at Sacred Heart Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311-6519
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Green Bay Oncology Limited at Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Mercy Health System Recruiting
Janesville, Wisconsin, United States, 53547
Contact: Emily G. Robinson    800-928-1103      
Principal Investigator: Emily G. Robinson         
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Kurt Oettel    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Kurt Oettel         
Dean Hematology and Oncology Clinic Recruiting
Madison, Wisconsin, United States, 53717
Contact: Amit Sanyal    608-410-2700      
Principal Investigator: Amit Sanyal         
Vince Lombardi Cancer Clinic-Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Marshfield Clinic Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Saint Joseph's Hospital Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Ehab L. Atallah    414-805-4380      
Principal Investigator: Ehab L. Atallah         
Marshfield Clinic-Minocqua Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Oconomowoc Memorial Hospital-ProHealth Care Inc Recruiting
Oconomowoc, Wisconsin, United States, 53066-3896
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Green Bay Oncology - Oconto Falls Recruiting
Oconto Falls, Wisconsin, United States, 54154
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Marshfield Clinic at James Beck Cancer Center Recruiting
Rhinelander, Wisconsin, United States, 54501
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Marshfield Clinic-Rice Lake Center Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Marshfield Clinic Cancer Care at Saint Michael's Hospital Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Saint Michael's Hospital Recruiting
Stevens Point, Wisconsin, United States, 54481
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Green Bay Oncology - Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235
Contact: Matthew L. Ryan    800-432-6049      
Principal Investigator: Matthew L. Ryan         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Dhimant R. Patel    800-252-2990      
Principal Investigator: Dhimant R. Patel         
Waukesha Memorial Hospital - ProHealth Care Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Timothy R. Wassenaar    262-928-7878      
Principal Investigator: Timothy R. Wassenaar         
Aurora Cancer Care-Milwaukee West Recruiting
Wauwatosa, Wisconsin, United States, 53226
Contact: Rubina Qamar    888-709-2080      
Principal Investigator: Rubina Qamar         
Marshfield Clinic - Weston Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Marshfield Clinic - Wisconsin Rapids Center Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Ali W. Bseiso    715-389-4457      
Principal Investigator: Ali W. Bseiso         
Canada, Alberta
Tom Baker Cancer Centre Recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Mary L. Savoie    403-521-3433      
Principal Investigator: Mary L. Savoie         
Canada, British Columbia
Clinical Research Unit at Vancouver Coastal Health Authority Recruiting
Vancouver, British Columbia, Canada, V5Z 3P1
Contact: Sujaatha Narayanan       research@vch.ca   
Principal Investigator: Sujaatha Narayanan         
Canada, Manitoba
CancerCare Manitoba Recruiting
Winnipeg, Manitoba, Canada, R3E 0V9
Contact: Rajat Kumar    866-561-1026    CIO_Web@cancercare.mb.ca   
Principal Investigator: Rajat Kumar         
Canada, New Brunswick
The Moncton Hospital Recruiting
Moncton, New Brunswick, Canada, E1C 6Z8
Contact: Sheldon H. Rubin    506-857-5267      
Principal Investigator: Sheldon H. Rubin         
Atlantic Health Sciences Corporation-Saint John Regional Hospital Recruiting
Saint John, New Brunswick, Canada, E2L 4L2
Contact: Terrance Comeau    506-648-6890      
Principal Investigator: Terrance Comeau         
Canada, Nova Scotia
QEII Health Sciences Centre/Capital District Health Authority Recruiting
Halifax, Nova Scotia, Canada, B3H 1V8
Contact: Andrea K. Kew    902-473-6000      
Principal Investigator: Andrea K. Kew         
Canada, Ontario
Juravinski Cancer Centre at Hamilton Health Sciences Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Brian F. Leber    905-387-9495      
Principal Investigator: Brian F. Leber         
Odette Cancer Centre- Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N 3M5
Contact: Rena J. Buckstein    416-480-5000      
Principal Investigator: Rena J. Buckstein         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Karen W. Yee    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: Karen W. Yee         
Canada, Quebec
CSSS Champlain-Charles Le Moyne Recruiting
Greenfield Park, Quebec, Canada, J4V 2H1
Contact: Celine Devaux    450-466-5065      
Principal Investigator: Celine Devaux         
McGill University Department of Oncology Recruiting
Montreal, Quebec, Canada, H2W 1S6
Contact: John M. Storring    514-398-1444    penny.chipman@mcgill.ca   
Principal Investigator: John M. Storring         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Vamsee K. Torri    306-766-2213      
Principal Investigator: Vamsee K. Torri         
Saskatoon Cancer Centre Recruiting
Saskatoon, Saskatchewan, Canada, S7N 4H4
Contact: Waleed S. Ismail    306-655-2914      
Principal Investigator: Waleed S. Ismail         
Sponsors and Collaborators
Investigators
Principal Investigator: Mikkael Sekeres Southwest Oncology Group
  More Information

No publications provided

Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT01522976     History of Changes
Other Study ID Numbers: NCI-2012-00242, NCI-2012-00242, SWOG-S1117, CDR0000723909, S1117, S1117, U10CA032102
Study First Received: January 27, 2012
Last Updated: March 19, 2014
Health Authority: United States: Food and Drug Administration

Additional relevant MeSH terms:
Anemia
Anemia, Refractory
Anemia, Refractory, with Excess of Blasts
Leukemia
Leukemia, Myelomonocytic, Chronic
Myelodysplastic Syndromes
Preleukemia
Leukemia, Myelomonocytic, Acute
Hematologic Diseases
Bone Marrow Diseases
Neoplasms by Histologic Type
Neoplasms
Leukemia, Myeloid
Myelodysplastic-Myeloproliferative Diseases
Precancerous Conditions
Azacitidine
Vorinostat
Lenalidomide
Thalidomide
Antimetabolites, Antineoplastic
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antineoplastic Agents
Therapeutic Uses
Enzyme Inhibitors
Histone Deacetylase Inhibitors
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on April 15, 2014