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Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry

This study is currently recruiting participants.
Verified November 2012 by ResMed
Sponsor:
Information provided by (Responsible Party):
ResMed
ClinicalTrials.gov Identifier:
NCT01500759
First received: December 23, 2011
Last updated: November 30, 2012
Last verified: November 2012
History of Changes
  Purpose

Objective target of the registry is to investigate the prevalence of SDB as well as the clinical characteristics of patients with and without SDB as well as the predominant type of sdb.

For this purpose data from patients suffering from chronic, symptomatic heart failure with impaired left ventricular ejection fraction will be collected prospectively.


Condition
Congestive Heart Failure
Left Ventricular Systolic Dysfunction

Study Type: Observational [Patient Registry]
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 4 Weeks
Official Title: Prevalence, Clinical Characteristics and Type of Sleep-disordered Breathing in Patients With Chronic, Symptomatic, Systolic Heart Failure

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by ResMed:

Estimated Enrollment: 12000
Study Start Date: November 2007
Estimated Study Completion Date: March 2015
Estimated Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Detailed Description:

Despite recent advances in pharmacological treatment, congestive heart failure (CHF) continues to cause debilitating symptoms, frequent hospital admissions and a high mortality. Despite of therapy with beta-blockers and ACE-inhibitors many patients have persistent symptoms and most will eventually die of cardiovascular causes, often from progressive heart failure.

Sleep Disordered Breathing (SDB) is known to cause consequences, which have negative effects on heart failure.

Objective target of the registry is to investigate the prevalence of SDB, clinical characteristics, symptoms and the degree and type of SDB in patients with chronic HF.

For this purpose data from patients with chronic heart failure will be collected prospectively.In the registry several cardiologists in private practice or hospital and cooperating sleep laboratories shall participate.

Cardiologists screen patients with Chronic Heart Failure (chronic HF) prospectively. In case of suffering from chronic HF for at least 12 weeks since diagnosis, with NYHA III-IV or NYHA class II with at least one hospitalisation for HF in the last 12 months. Written informed consent for data privacy aspects must be obtained before screening for SDB. Patients who satisfy to all inclusion- and exclusion criteria will be included consecutively into the registry.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Adult patients with Chronic Heart Failure with LVEF ≤ 45% and NYHA III-IV or NYHA class II with at least one hospitalisation for HF in the last 24 months.

Criteria

Inclusion Criteria:

  • Patients must be over 18
  • Chronic heart failure (at least 12 weeks since diagnosis) according to the current applicable guidelines
  • Left ventricular systolic dysfunction (LVEF ≤ 45% by imaging method such as echocardiography, radionuclide angiography, left ventriculography, or cardiac magnetic resonance imaging) documented less than 12 weeks
  • NYHA class III or IV at the time of inclusion or NYHA class II with at least one hospitalisation for HF in the last 24 months
  • Patient is able to fully understand study information and signed informed consent

Exclusion Criteria:

  • Life expectancy < 1 year for diseases unrelated to chronic HF
  • Cardiac surgery, Percutaneous coronary intervention (PCI), Myocardial Infarction (MI) or unstable angina within 6 months
  • CRT-implantation (either CRT-D or CRT-P) scheduled or within 6 months
  • Transient ischemic attack (TIA) or Stroke within 3 months
  • Hemodynamically significant uncorrected primary valvular heart disease, obstructive or regurgitant, or any valvular disease expected to lead to surgery
  • Acute myocarditis/pericarditis within 6 months
  • Current CPAP or bilevel therapy
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01500759

Contacts
Contact: Holger Woehrle, MD +491605386000 holger.woehrle@resmed.com
Contact: Andrea Ballentin, MD +49899901649 ext 980 serve-hf@cri-muc.eu

  Hide Study Locations
Locations
Australia, New South Wales
Westmead Hospital Recruiting
Westmead, New South Wales, Australia, 2145
Contact: David Michail, MBBS     +61 2 9845 9900     David_Michail@wsahs.nsw.gov.au    
Australia, Queensland
Rivercity Private Hospital Recruiting
Auchenflower, Queensland, Australia, 4066
Contact: Irene Szollosi, PhD     +61 7 3870 4192     Irene.Szollosi@sleepspecialists.com.au    
Australia, South Australia
Royal Adelaide Hospital Recruiting
Adelaide, South Australia, Australia, 5000
Contact: Aeneas Yeo, M.D.     +61 8 8222 5435     Aeneas.Yeo@health.sa.gov.au    
Australia, Victoria
St Vincents and Mercy Private Hospital Recruiting
Melbourne, Victoria, Australia, 3065
Contact: John Swieca, MBBS     +61 3 9663 1993     swieca@msdc.com.au    
Baker IDI Heart and Diabetes Institute Recruiting
Melbourne, Victoria, Australia, 3004
Contact: Paul Zimmet, MBBS MD PhD     + 61 3 9258 5049     pzimmet@idi.org.au    
Contact: Jonathan Shaw, MD FRACP     + 61 3 9258 5047     jshaw@idi.org.au    
Principal Investigator: Jonathan Shaw, MD FRACP            
Australia, Western Australia
Hollywood Private Hospital (CVS) Recruiting
Nedlands, Western Australia, Australia, 6009
Contact: Philip Currie, M.D.     +61 8 6389 3510     philip.currie@cvs.net.au    
Germany
Praxis Dr. Frieske Recruiting
Aachen, Germany, 52062
Contact: Ralf Frieske, M.D.     +49 (0) 241 21141     dr.frieske@online.de    
Principal Investigator: Ralf Frieske, M.D.            
Universitätsklinikum Aachen Recruiting
Aachen, Germany, 52074
Contact: Stefan Krüger, M.D.     +49 (0) 241-808 4444     stkrueger@ukaachen.de    
Contact: Gabriele Soiron     +49 (0) 241-803 6465     gsoiron@ukaachen.de    
DRK Krankenhaus Recruiting
Alzey, Germany, 55232
Contact: Otto Laakmann, M.D.     +49-(0) 6731-407-104     otto.laakmann@drk-kh-alzey.de    
Gemeinschaftspraxis Weiß/ Dr. Heesing Recruiting
Arnsberg, Germany, 59821
Contact: Beate Heesing, M.D.     +49 (0) 2931 - 21477        
Principal Investigator: Beate Heesing, M.D.            
Gemeinschaftspraxis Weiß / Dr. Heesing Recruiting
Arnsberg, Germany, 59821
Contact: Beate Heesing, M.D.     +49 (0) 293121477        
Principal Investigator: Beate Heesing, M.D.            
Klinik Lazariterhof Recruiting
Bad Krozingen, Germany, 79189
Contact: Valentina Giebelhaus, M.D.     +49 (0) 7633937871     v.giebelhaus@median-bk.de    
Principal Investigator: Gerd Bönner, Prof., M.D.            
Herzzentrum Bad Krozingen Recruiting
Bad Krozingen, Germany, 79189
Contact: Wolfgang Zeh, M.D.     +49 (0) 7633/4026230     wolfgang.zeh@herzzentrum.de    
Contact: Sandra Eble     +49 (0) 7633/4024820     sandra.eble@herzzentrum.de    
HDZ NRW Recruiting
Bad Oeynhausen, Germany, 32545
Contact: Olaf Oldenburg, M.D.     +49 (0) 5731-970     ooldenburg@hdz-nrw.de    
Contact: Natalie Prib     +49 (0) 5731-97 3399     nprib@cru-hdz.de    
Kardiopraxis Rheinberg Recruiting
Bergisch Gladbach, Germany, 51465
Contact: Georg Weyers, M.D.     +49 (0) 2202-38 555     weyers@kardiopraxis-rheinberg.de    
Principal Investigator: Georg Weyers, M.D.            
Praxis Westend Recruiting
Berlin, Germany, 14050
Contact: Ursula Kühne, M.D.     +49 (0) 30 - 30 11 82 30     kuehne@praxis-westend.de    
Principal Investigator: Ursula Kühne, M.D.            
Charité Campus Virchow-Klinikum Recruiting
Berlin, Germany, 13353
Contact: Hans-Dirk Düngen, M.D.     +49 (0) 30-450676818     hans-dirk.duengen@charite.de    
Principal Investigator: Hans-Dirk Düngen, M.D.            
Gemeinschaftspraxis Groß-Ziethener Chaussee Recruiting
Berlin, Germany, 12355
Contact: Klaus Laskos, M.D.     +49 (0) 30 - 66909403     klauslaskos@t-online.de    
Principal Investigator: Klaus Laskos, M.D.            
POLIKUM Friedenau Recruiting
Berlin, Germany, 12157
Contact: Marc Oliver Grad, M.D.     +49 (0) 30 7201100     marc-oliver.grad@polikum.de    
Contact: Kerstin Tyler, M.D.     +49 (0) 30 720110222     kerstin.tyler@polikum.de    
Unfallkrankenhaus Berlin Recruiting
Berlin, Germany, 12683
Contact: Leonhard Bruch, M.D.         leonhard.bruch@ukb.de    
Contact: Carla Krüger         carla.krueger@ukb.de    
Principal Investigator: Leonhard Bruch, M.D.            
Charité Campus Mitte Recruiting
Berlin, Germany, 10117
Contact: Mark Beling, M.D.     +49 (0) 30-450513     mark.beling@charite.de    
Jüdisches Krankenhaus Berlin Recruiting
Berlin, Germany, 13347
Contact: Kristof Graf, Prof.         kristof.graf@jkb-online.de    
Contact: Lidia Fischer     +49 (0) 30 - 4994 5341     lidia.fischer@jkb-online.de    
Principal Investigator: Kristof Graf, Prof.            
Praxis Gemeinschaft Frille Recruiting
Berlin, Germany, 10178
Contact     +49 (0) 30 2407060 15     j.frille@mac.com    
Gemeinschaftspraxis Groß-Ziethener Chaussee Recruiting
Berlin, Germany, 12355
Contact: Martin Messerschmidt, M.D.     +49 (0) 30 - 66 90 90 93     martin.messerschmidt@t-online.de    
Principal Investigator: Klaus Laskos, M.D.            
Charité Campus Mitte CCM Recruiting
Berlin, Germany, 10117
Contact: Christoph Schöbel, M.D.     +49 (0) 30 450 513 228     christoph.schoebel@charite.de    
Charité Campus Virchow Klinikum Recruiting
Berlin, Germany, 13353
Contact: Dennis Lischewski     +49 (0) 30 / 450 513 228        
Principal Investigator: Hans-Dirk Düngen, Dr.            
Unfallkrankenhaus Berlin Recruiting
Berlin, Germany, 12683
Contact: Stefanie Geistert         stefanie.geistert@ukb.de    
Principal Investigator: Leonhard Bruch, M.D.            
Herzzentrum Brandenburg Recruiting
Bernau, Germany, 16321
Contact: Christian Butter, M.D.         c.butter@immanuel.de    
Contact: Martina Ninnemann     +49 (0) 3338-69 46 04     m.ninnemann@immanuel.de    
Principal Investigator: Christian Butter, M.D.            
Praxis für Lunge,Herz und Schlaf Recruiting
Bielefeld, Germany, 33617
Contact: Hermann Storm, M.D.     +49 (0) 521 5575550     storm@lunge-herz-schlaf.de    
Principal Investigator: Hermann Storm, M.D.            
Augusta Krankenanstalten Bochum Recruiting
Bochum, Germany, 44791
Contact: Walther Lucanus, M.D.     +49 (0) 234 - 517 23 51     w.lucanus@augusta-bochum.de    
Contact: Annika Machleit     +49 (0) 2323-49892249     a.machleit@evk-herne.de    
Kardiologie Kemnade Recruiting
Bochum, Germany, 44797
Contact: Clemens Seifert, M.D.     +49 (0) 171-3887882     seifert@ghqn.de    
Principal Investigator: Clemens Seifert, M.D.            
Kardiologie Gemeinschaftspraxis Dr. Tenholt Recruiting
Bochum, Germany, 44787
Contact: Michael Tenholt, M.D.     +49 (0) 234 60 8 60-0        
Principal Investigator: Michael Tenholt, M.D.            
Universitätsklinikum Bergmannsheil Recruiting
Bochum, Germany, 44789
Contact: Hans-Werner Duchna, M.D.         hans-werner.duchna@rub.de    
Principal Investigator: Hans-Werner Duchna, M.D.            
Kardiologische Praxis Dr. Staubach Recruiting
Bochum, Germany, 44866
Contact: Peter Staubach, M.D.     +49 (0) 2327-82222     praxis@dr-med-staubach.de    
Principal Investigator: Peter Staubach, M.D.            
Kardiologische Praxis Marschner Recruiting
Bonn, Germany, 53225
Contact: Jürgen Marschner, M.D.     +49 (0) 228-223677     juergen.marschner@dgn.de    
Principal Investigator: Jürgen Marschner, M.D.            
Universitätsklinikum Bonn Recruiting
Bonn, Germany, 53127
Contact: Joerg Schwab, Prof.         joerg.schwab@ukb.uni-bonn.de    
Principal Investigator: Gert Nickening, Prof.            
Praxis für Kardiologie Bonn Recruiting
Bonn, Germany, 53127
Contact: Hannelore Bachmeier     +49 (0) 228 - 62 33 24     hannelore.bachmeier@klassetechnik.de    
Principal Investigator: Thomas Klingenheben, Prof.            
Gemeinschaftspraxis Kardiologie Recruiting
Bottrop, Germany, 46236
Contact: Kerstin Mucha     +49 (0) 2041/ 18 25 03     herz71@gmx.net    
Principal Investigator: Gert Kerkhoff, M.D.            
Gemeinschaftspraxis Dres. Tinnefeld Recruiting
Bottrop, Germany, 46240
Contact: Ulrich Tinnefeld, M.D.     +49 (0) 2041 - 760071        
Kardiologie Bühl Recruiting
Brühl, Germany, 50321
Contact: Jörg Pütz, M.D.     +49 (0) 2232945470     j.puetz@kardiologie-bruehl.de    
Principal Investigator: Jörg Pütz, M.D.            
Kardiologische Praxis Dr. Isbruch Recruiting
Castrop-Rauxel, Germany, 44577
Contact: Frank Isbruch, M.D.     +49 (0) 2305-963636333     fisbruch@web.de    
Fachkrankenhaus Coswig Recruiting
Coswig, Germany, 01640
Contact: Olaf Stiller, M.D.         stiller@fachfrankenhaus-coswig.de    
Principal Investigator: Gert Höffken, Prof.            
Kardiologische Praxis Dr. Wetzel Recruiting
Dortmund, Germany, 44141
Contact: Thomas Wetzel, M.D.         willgeroth-wetzel@dokom.net    
Kardiologische Praxis Dr. Golling Recruiting
Dortmund, Germany, 44137
Contact: Felix R. Golling, M.D.     +49 (0) 231 16825     info@kardiologe-dortmund.de    
Principal Investigator: Felix R. Gollling, M.D.            
Kardiologische Praxis Dr. Lodde Recruiting
Dortmund, Germany, 44147
Contact: Bernhard-Paul Lodde, M.D.     +49 (0) 231 5678430     b.lodde.k@rdiologe.de    
Principal Investigator: Bernhard-Paul Lodde, M.D.            
Kardiologie-Gemeinschaftspraxis Dortmund Recruiting
Dortmund, Germany, 44137
Contact: Ute Heine     +49 (0) 231 9580800     heine@ctss-dortmund.de    
Principal Investigator: Matthias Stratmann, M.D.            
Praxis Dr. Hecker Recruiting
Dortmund, Germany, 44135
Contact: Thomas Hecker, M.D.     +49 (0) 231 527513     thomas.hecker@telemed.de    
Principal Investigator: Thomas Hecker, M.D.            
Kardiologie - Gemeinschaftspraxis Dortmund Recruiting
Dortmund, Germany, 44137
Contact: Matthias Stratmann, M.D.     +49 (0) 231/9580800        
Herzzentrum Universität Dresden Recruiting
Dresden, Germany, 01307
Contact: Karin Haacke     +49 (0) 351 / 450 1330     studien.kardiologie@mailbox.tu-dresden.de    
Praxis Dr. Hohensee Recruiting
Dresden, Germany, 01277
Contact     +49 (0) 351 4707245        
Facharztzentrum Dresden-Neustadt GbR Recruiting
Dresden, Germany, 01099
Contact: Kerstin Bonin     +49 (0) 351/8064 440     kerstin.bonin@zfkp-dresden.de    
Principal Investigator: Stefan Spitzer, M.D.            
Gemeinschaftpraxis Dres. Schmidt/Gronke Recruiting
Dresden, Germany, 01219
Contact: Karin Gronke, M.D.     +49 (0) 351-4769572     Karin.Gronke@web.de    
Principal Investigator: Schmidt, M.D.            
Gemeinschaftspraxis Dres. Schmidt/Gronke Recruiting
Dresden, Germany, 01219
Contact: Karin Gronke, M.D.     +49 (0) 351-4769572     karin.gronke@web.de    
Principal Investigator: Frank Schmidt, M.D.            
Khs Florence-Nightingale Recruiting
Duesseldorf, Germany, 40489
Contact: Hartmut Grueger, M.D.     +49 (0) 211-4092181     grueger@kaiserswerther-diakonie.de    
Principal Investigator: Ulrich Heidland, M.D.            
Kardiologische Praxis Dr. Raff Recruiting
Düsseldorf, Germany, 40237
Contact: Tatjana Hartmann     +49 (0) 211 - 50 666 50     empfang@uhlandpraxen.de    
Principal Investigator: Franziska Raff, M.D.            
Kardiologische Praxis Dr. Horowitz Recruiting
Düsseldorf, Germany, 40215
Contact: Antje Linge     +49 (0) 211 - 16 888 999     kardiologe@horowitz.de    
Principal Investigator: Avner Horowitz, M.D.            
Florence-Nightingale Krankenhaus Recruiting
Düsseldorf, Germany, 40489
Contact: Roman Pernice, M.D.         pernice@kaiserswerther-diakonie.de    
Contact: Hartmut Grueger, M.D.         grueger@kaiserswerther-diakonie.de    
Principal Investigator: Joachim Erkenbrecht, Prof.            
Sub-Investigator: Rainer Kappes, M.D.            
Kardiologie Oberkassel Recruiting
Düsseldorf, Germany, 40545
Contact: Rüdiger Strelow     +49 (0) 211 - 577 290     dr.hauer@kardiologie-oberkassel.de    
Principal Investigator: Franz Hauer, M.D.            
Gemeinschaftspraxis PD Dr. Lankisch Recruiting
Düsseldorf, Germany, 40597
Contact: Mark Lankisch, M.D.     +49 (0) 211 9847806     lankisch@kardio-gemeinschaftspraxis.de    
Helios Klinikum Erfurt-Schlafmedizin Recruiting
Erfurt, Germany, 99089
Contact: Bernd Mross         bernd.mross@helios-kliniken.de    
Contact: Juliane Oellers     +49 (0) 361-7815141     juliane.oellers@helios-kliniken.de    
Principal Investigator: Karl-Matthias Deppermann, M.D.            
Helios Klinikum Erfurt-Kardiologie Recruiting
Erfurt, Germany, 99089
Contact: Laszlo Halmagy, M.D.     +49 (0) 361 781 63 97        
Principal Investigator: Harald Lapp, M.D.            
Kardiologische Praxis Dr. Cord Müller Recruiting
Essen, Germany, 45131
Contact: Cord Müller, M.D.     +49 (0) 201 - 287091     cord.mueller@rub.de    
Principal Investigator: Cord Müller, M.D.            
Kardiologische Praxis Prof. Winter Recruiting
Essen, Germany, 45134
Contact: Ulrich Winter, Prof. M.D.     +49 (0) 201678821        
Principal Investigator: Ulrich Winter, Prof. M.D.            
Praxis Dr. Tekiyeh Recruiting
Essen, Germany, 45136
Contact: Mohsen Tekiyeh, M.D.     +40 (0) 201-17 54 5-0        
Kath. Kliniken Essen / Philippusstift Recruiting
Essen, Germany, 45359
Contact: Birgit Hailer, Prof.     +49 (0) 201/6400 3301        
Contact: Christiane Willger, M.D.     +49 (0) 201/64001370     C.Willger@kkenw.de    
Kardiologie Praxis Dr. Bonnekamp Recruiting
Essen, Germany, 45136
Contact: Gerhard Bonnekamp, M.D.     +49 (0) 201 894030        
Schwerpunktpraxis Kardiologie Drs. Ophoff/Fritzsch Recruiting
Essen, Germany, 45131
Contact: Norbert Ophoff, M.D.     +49 (0) 201-233025     Norbert.Ophoff@t-online.de    
Principal Investigator: Norbert Ophoff, M.D.            
Westdeutsches Herzzentrum, Universitätsklinikum Essen Recruiting
Essen, Germany, 45122
Contact: Till Neumann, P.D. M.D.     +49 (0) 201/ 723-4878     till.neumann@uk-essen.de    
Principal Investigator: Till Neumann, M.D.            
Praxis Dr. Rau Recruiting
Essen, Germany, 45276
Contact: Thorsten Rau, M.D.     +49 (0) 201/847160     praxis-rau@arcor.de    
Principal Investigator: Thorsten Rau, M.D.            
Ruhrlandklinik Essen Recruiting
Essen, Germany, 45239
Contact: Gerhard Weinreich     +49 (0) 201 433 4046     gerhard.weinreich@uni-duisburg-essen.de    
Principal Investigator: Björn Kleibrink            
Gemeinschaftspraxis Dres. Guckenbiehl Recruiting
Flonheim, Germany, 55237
Contact: Markus Guckenbiehl, M.D.     +49 (0) 6734-1041     markus.guckenbiehl@t-online.de    
Kardiologische Praxis Dr. Kruse Recruiting
Forst, Germany, 03149
Contact: Hubertus Kruse, M.D.     +49 (0) 3562-2030     hubertus.kruse@t-online.de    
Principal Investigator: Hubertus Kruse, M.D.            
CardioVasculäres Centrum Frankfurt Recruiting
Frankfurt, Germany, 60389
Contact: Ilona Hofmann     +49 (0) 694603 1340     i.hofmann@cvcfrankfurt.de    
Principal Investigator: Ilona Hofmann            
Praxis Dr. Diedrichs Recruiting
Frechen, Germany, 50226
Universitaetsklinikum Freiburg Recruiting
Freiburg im Breisgau, Germany, 79106
Contact: Emelie Ekkernkamp, M.D.     +49 (0) 761-27037070     emelie.ekkernkamp@uniklinik-freiburg.de    
Principal Investigator: Joachim Mueller-Quernheim, Prof.            
Universitätsklinikum Freiburg Recruiting
Freiburg im Breisgau, Germany, 79106
Contact: Stephan Sorichter, Prof., Prof.         stephan.sorichter@uniklinik-freiburg.de    
Principal Investigator: Joachim Mueller-Quernheim, Prof.            
Gemeinschaftspraxis Dres. Böhmeke/Schmidt Recruiting
Gladbeck, Germany, 45964
Contact: Thomas Böhmeke, M.D.     +49 (0) 2043378837        
Principal Investigator: Thomas Böhmeke, M.D.            
Kardiologische Praxis Dr. Hug Recruiting
Günzburg, Germany, 89312
Contact: Jürgen Hug, M.D.     +49 (0) 822196969035     j.hug@ckm-gz.de    
Principal Investigator: Jürgen Hug, M.D.            
Kardiologische Praxis Gütersloh Recruiting
Gütersloh, Germany, 33330
Kardiologische Praxis Dr. Arens Recruiting
Hagen, Germany, 58095
Contact: Petra Blum     +49 (0) 2331386750        
Principal Investigator: Reinhard Arens, M.D.            
Gemeinschaftspraxis Dres Leischik/Littwitz Recruiting
Hagen, Germany, 58095
Contact: Roman Leischik, M.D.     +49 (0) 2331-18 25 00        
Gemeinschaftspraxis Dres. Subin/Lutter Recruiting
Hamburg, Germany, 20095
Contact: Behrus Subin, M.D.     +49 (0) 40 325 297 40     kontakt@internisten-alster.de    
Principal Investigator: Behrus Subin, M.D.            
Asklepios Klinik Barmbek Recruiting
Hamburg, Germany, 22291
Contact: Heinrich Becker, Prof.     +49 (0)40 181 882 4801     he.becker@asklepios.com    
Principal Investigator: Becker, Prof., M.D.            
Universitätsklinikum Hamburg-Eppendorf Recruiting
Hamburg, Germany, 20246
Contact: Claudia Schmidt     +49 (0) 40 74105 5550     cl.schmidt@uke.uni-hamburg.de    
Principal Investigator: Angelika Costard-Jäckle, Prof.            
Kardiologische Praxis Dr. Schröder Recruiting
Hamburg, Germany, 22765
Contact: Thomas Schröder, M.D.     +49 (0) 403892476     dr.schroeder@herzpraxis-altona.de    
Principal Investigator: Thomas Schröder, M.D.            
Praxis Dr. Hötte Recruiting
Hannover, Germany, 30449
Contact: Rainer Hötte, M.D.     +49 (0) 511453021     RainerHoette@aol.com    
Principal Investigator: Rainer Hötte, M.D.            
Kardiologische Praxis Dr. Hartung Recruiting
Hannover, Germany, 30559
Contact: Wolfgang Hartung, M.D.     +49 (0) 511-511033     hartung.wolfgang.m@yahoo.de    
Principal Investigator: Wolfgang Hartung, P.D. M.D.            
Kardiologische Praxis Dr. Cierpka Recruiting
Hannover, Germany, 30159
Contact: Rainer Cierpka, M.D.     +49 (0) 511 30 66 03     Aleksandra.Beckmann@t-online.de    
Principal Investigator: Rainer Cierpka, M.D.            
Universitätsklinikum Heidelberg Recruiting
Heidelberg, Germany, 69120
Contact: Karen Slottje     +49 (0) 6221-56-39786     karen_slottje@med.uni-heidelberg.de    
Thoraxklinik Heidelberg gGmbH Recruiting
Heidelberg, Germany, 69126
Contact: Heinrich Wenz, M.D.     +49 (0) 6221/396 8175     Heinrich.Wenz@thoraxklinik-heidelberg.de    
Praxis Dr. Durak Recruiting
Heidelberg, Germany, 69115
Contact: Ebru Esen     06221/404 49 06     praxis@kardio-durak.de    
Principal Investigator: Mustafa Durak, M.D.            
Heidelberger Praxisklinik für Kardiologie Recruiting
Heidelberg, Germany, 69115
Contact     +49 (0) 6221 43 41 40     praxis@hpk-kardiologie.de    
Kardiologische Praxis Dr. Furche Recruiting
Herne, Germany, 44623
Contact: Karl-Georg Furche, M.D.     +49 (0) 2323 - 14 78 40     Karl-Georg-F@t-online.de    
Principal Investigator: Karl-Georg Furche, M.D.            
Gemeinschaftspraxis Dr. Bruch Recruiting
Herne, Germany, 44629
Contact: Michael Bruch, M.D.     +49 (0) 2323 - 23375     michael.bruch@hernerhausaerzte.de    
Kardiologische Praxis Dr. Schlichting Recruiting
Herne, Germany, 44649
Contact: Jürgen Schlichting, M.D.     +49 (0) 2325-53537     info@praxis-schlichting.de    
St. Elisabeth-Hospital Herten gGmbH Recruiting
Herten, Germany, 45699
Contact: Gerhard Wambach, Prof.         gerhard.Wambach@eherten.de    
Praxis für Innere Medizin/Kardiologie Recruiting
Hoyerswerda, Germany, 02977
Contact: Jörn Schäfer, M.D.     +49 (0) 3571 - 607330     joern-schaefer@online.de    
Principal Investigator: Jörn Schäfer, M.D.            
Cardiopraxis Ingelheim Recruiting
Ingelheim, Germany, 55218
Contact: Angelika Guth, M.D.     +49 (0) 6132-75 666     angelikaguth@web.de    
Gemeinschaftspraxis Dres. Dobler/Turin Recruiting
Karlstadt, Germany, 97753
Contact: Michael Dobler, M.D.         Kardiologie@gp-karlstadt.de    
Ambulantes Herzzentrum Kassel Recruiting
Kassel, Germany, 34121
Contact: Andreas Utech, M.D.     +49 (0) 561- 937 690     a.u.g.utech@t-online.de    
Principal Investigator: Andreas Utech, M.D.            
Kardiologische Praxis Dr. Siegfried Frickel Recruiting
Kempen, Germany, 47906
Contact: Siegfried Frickel, M.D.     +49 (0) 2152-516 100        
Principal Investigator: Siegfried Frickel, M.D.            
Klinik Kitzinger Land Recruiting
Kitzingen, Germany, 97318
Helios Klinikum Krefeld Recruiting
Krefeld, Germany, 47805
Contact: Manuel Streuter, M.D.     +49 (0) 2151-322696     streuter_med@klinikum-krefeld.de    
Principal Investigator: M. Streuter, M.D.            
Praxis Dr. Krater Recruiting
Krefeld, Germany, 47799
Contact: Leon Krater, M.D.     +49 (0) 2151-67081     leonkrater@freenet.de    
Principal Investigator: Leon Krater, M.D.            
Universitätsklinikum Köln-Herzzentrum Recruiting
Köln, Germany, 50937
Contact: Tatjana Schewior     +49 (0) 221 - 478 88273     tatjana.schewior@uk-koeln.de    
Principal Investigator: Jochen Müller-Ehmsen, M.D.            
Gemeinschaftspraxis Dres. Gysan/Heinzler/May Recruiting
Köln, Germany, 51105
Contact: Elvira Link, M.D.     +49 (0)221-99 87 990        
Praxis Dr. Anselm Bäumer Recruiting
Köln, Germany, 51065
Contact: Anselm Bäumer, M.D.     +49 (0) 221 - 671940     anselm@baeumer-koeln.de    
St.-Vinzenz Hospital Recruiting
Köln, Germany, 50733
Contact: Wolfgang Fehske, P.D. M.D.     +49 (0) 221-7712-0     inneremedkardio@vinzenz-hospital.de    
Principal Investigator: Wolfgang Fehske, P.D. M.D.            
Klinikum der Universität zu Köln- Herzzentrum Recruiting
Köln, Germany, 50937
Contact: Jochen Müller-Ehmsen, M.D.         muller.ehmsen@uni-koeln.de    
Malteser Krankenhaus St. Hildegardis Recruiting
Köln, Germany, 50931
Contact: Stefan Krämer, M.D.     +49 (0) 221-4003-8012     stefan.kraemer@malteser.de    
Klinikum Dahme-Spreewald GmbH Recruiting
Königs Wusterhausen, Germany, 15711
Contact: Katrin Zeiske     +49 (0) 3375 - 288 291     k.zeiske@klinikum-ds.de    
Principal Investigator: Peer E Waurick, M.D.            
Universität Leipzig -Herzzentrum Recruiting
Leipzig, Germany, 04289
Contact: Stephan Gielen, M.D.     +49 (0) 341-8651468     stephan.gielen@medizin.uni-leipzig.de    
Universitätsklinikum Leipzig-Herzzentrum Recruiting
Leipzig, Germany, 04289
Contact: Stephan Gielen, M.D.     +49 (0) 341-8651468     stephan.gielen@herzzentrum-leipzig.de    
Principal Investigator: Schuler, Prof., M.D.            
Helios Krankenhaus Leisnig Recruiting
Leisnig, Germany, 04703
Contact: Wolfgang Krahwinkel, M.D.     +49 (0) 34321 8231     wolfgang.krahwinkel@helios-kliniken.de    
Principal Investigator: Wolfgang Krahwinkel, M.D.            
Gemeinschaftspraxis Dr. Hilgedieck/Sava Recruiting
Lengerich, Germany, 49525
Contact: Manfred Hilgedieck, M.D.     +49 (0) 5481 - 93640     hilgedieck-manfred@Osnanet.de    
Principal Investigator: Manfred Hilgedieck, M.D.            
Ärztezentrum Holthausen-Biene Recruiting
Lingen, Germany, 49808
Contact: Ludger Stauff, M.D.p     +49 (0) 591-96 39 30     stauff@praxis-hps-lingen.de    
Principal Investigator: Ludger Stauff, M.D.            
Kardiologische Praxis Ludwigsburg Recruiting
Ludwigsburg, Germany, 71634
Contact: Ralph Bosch, M.D.     +49 (0) 7141 - 942011     ralph.bosch@kardio-praxis-lb.de    
Universitätsklinikum Schleswig-Holstein Campus Lübeck-Kardiologie Recruiting
Lübeck, Germany, 23538
Contact: Frank Bode, M.D.         frank.bode@uk-sh.de    
Universitätsklinik Mannheim-Kardiologie Recruiting
Mannheim, Germany, 68167
Contact: Thorsten Kälsch, M.D.     +49 (0) 621-3831417     Thorsten.kaelsch@umm.de    
Gemeinschaftspraxis Dres. Brandt / Jakobs Recruiting
Mannheim, Germany, 68305
Contact: Christian Jakobs, M.D.     +49 (0) 621/75 20 34     Chrisjac@gmx.de    
Principal Investigator: Christian Jakobs, M.D.            
Gemeinschaftspraxis für Herz & Gefäße Recruiting
Mannheim, Germany, 68161
Contact: Rainer Kohl, M.D.     +49 (0) 621/10 11 19     Kohl@kardangma.de    
Principal Investigator: Rainer Kohl, M.D.            
Gemeinschaftspraxis Dres. Heifer/Loster/Schernus Recruiting
Mannheim, Germany, 68161
Contact: Udo Loster, M.D.     +49 (0) 621-12 05 50     praxis@kardiologie-mannheim.de    
Principal Investigator: Udo Loster, M.D.            
Universitätsklinikum Gießen/Marburg Standort Marburg-Kardiologie Recruiting
Marburg, Germany, 35043
Contact: Peter Alter, Prof.     +49 (0) 6421-58 649 46        
Praxis Dr. Schnabel Recruiting
Meissen, Germany, 01662
Contact: Andreas Schnabel, M.D.     +49 (0) 35217195897     schnabel@kardiologie-meissen.de    
Principal Investigator: Andreas Schnabel, M.D.            
Gemeinschaftspraxis Dr. Jocham Recruiting
Memmingen, Germany, 87700
Contact: Kurt Joacham, M.D.     +49 (0) 8331 834 330     kurt.jocham@t-online.de    
Principal Investigator: Kurt Jocham, M.D.            
Praxis für Kardiologie Dr. med. Menz Recruiting
Menden, Germany, 58706
Contact: Volker Menz, M.D.     +49 (0) 2373-39 38 80     dr.menz@telemed.de    
Herz und Gefäßpraxis Recruiting
Metzingen, Germany, 72555
Contact: Tobias Autenrieth, M.D.     +49 (0) 7123 609 62        
Herz-& Gefäßpraxis Recruiting
Metzingen, Germany, 72555
Contact: Tobias Autenrieth, M.D.     +49 (0) 7123 - 609 62     info@kardio-autenrieth.de    
Principal Investigator: Tobias Authenried, M.D.            
Kardiologische Praxis Dr. Schön Recruiting
Mühldorf, Germany, 84453
Contact: Norbert Schön, M.D.     +49 (0) 8631/18 4114 11     info@herz-gefaesse.de    
Evangelisches Krankenhaus Mülheim Recruiting
Mülheim an der Ruhr, Germany, 45468
Contact: Peter Högner, MD     +49 208 309 2671     peter.hoegner@evkmh.de    
Contact: Cornelia Lenze     +49 208 309 2671     cornelia.lenze@evkmh.de    
Principal Investigator: Peter Högner, Dr.            
Kardiologie am Rotkreuzplatz Recruiting
München, Germany, 80634
Contact: Karim Sven Liem, M.D.     +49 (0) 89-161941     info@dr-liem.de    
Principal Investigator: Karim Sven Liem, M.D.            
Klinikum Augustinum München Recruiting
München, Germany, 81375
Contact: Michael Block, Prof.         Block@med.augustinum.de    
Praxis Dres. Böhme/Linke Recruiting
München, Germany, 81667
Contact: Eike Böhme, M.D.     +49 (0) 89-45 85 56 13     office@herzdoc-linke.de    
Principal Investigator: Eike Böhme, M.D.            
Praxis für Kardiologie Dr. med. Hewing Recruiting
Münster, Germany, 48151
Contact: Ralf Hewing, M.D.     +49 (0) 251531445     ralf_hewing@t-online.de    
Principal Investigator: Ralf Hewing, M.D.            
Universitätsklinikum Münster Recruiting
Münster, Germany, 48149
Contact: Jörg Stypmann, M.D.         stypmann@mednet.unimuenster.de    
Contact: Peter Young, Prof.     +49 (0) 2518348331        
Principal Investigator: Guenther Breithardt, Prof.            
Städtisches Khs Lukas Recruiting
Neuss, Germany, 41472
Contact: Breise, M.D.         mbreise@lukasneuss.de    
Principal Investigator: Michael Haude, Prof.            
Kardiologische Praxis Nienburg Recruiting
Nienburg, Germany, 31582
Contact: Nicolaos Proskynitopoulos, M.D.     +49 (0) 5021 977444     kontakt@kardiologie-nienburg.de    
Kardiologische Praxis Dr. Gumbrecht Recruiting
Ochtrup, Germany, 48607
Contact: Hilmar Gumbrecht, M.D.     +49 (0) 2553 - 9354 12     h.gumbrecht@heilsam-team.de    
Principal Investigator: Hilmar Gumbrecht, M.D.            
Kardiologische Praxis Dr. Wiethölter Recruiting
Radebeul, Germany, 01445
Contact: Kerstin Wiethölter, M.D.     +49 (0) 3518305427     k.wiethoelter@aol.com    
Principal Investigator: Kerstin Wiethölter, M.D.            
Praxis Dr. Fröhlich Recruiting
Ratingen, Germany, 40885
Contact: Tobias Fröhlich, M.D.     +49 (0) 2102-35 208     info@dres-froehlich.de    
Praxis für Kardiologie Ratingen Recruiting
Ratingen, Germany, 40878
Contact: Karl-Friedrich Schmitz, M.D.     +49 (0) 210228059     kf.schmitz@kardiologie-ratingen.de    
Principal Investigator: Karl-Friedrich Schmitz, M.D.            
DRK Krankenhaus Mölln-Ratzeburg Recruiting
Ratzeburg, Germany, 23909
Contact: Daniela Wischnewski     +49 (0) 4541-884 281     daniela.wischnewski@gmx.de    
Principal Investigator: Olaf Schult-Kronefeld, M.D.            
Ambulantes Cardiovaskuläres Centrum Recruiting
Ravensburg, Germany, 88212
Contact: Klaus Schlotterbeck, M.D.     +49 (0) 751 22 75 9     k.schlotterbeck@t-online.de    
Principal Investigator: Schlotterbeck, M.D.            
Universitätsklinikum Regensburg Recruiting
Regensburg, Germany, 93053
Contact: Michael Arzt, Prof.     +49 (0) 941 - 944 7281     michael.arzt@klinik.uni-regensburg.de    
Khs St. Adolf Stift Recruiting
Reinbek, Germany, 21465
Contact: Cläre Wagner, M.D.     +49 (0) 4072805051     christine.eisi@web.de    
Principal Investigator: Herbert Naegele, M.D.            
Praxis Dr. Hein Recruiting
Reinbek, Germany, 21465
Contact: Isabel Diebold, M.D.     +49 (0) 40-7280-5155        
Kardiologische Praxis Dr. Kleinz Recruiting
Remscheid, Germany, 42853
Contact: Bernhard Kleinz, M.D.     +49 (0) 2191 - 77 800     bernhardkleinz@web.de    
Principal Investigator: Bernhard Kleinz, M.D.            
Praxis Dr. Kestermann Recruiting
Rheine, Germany, 48431
Contact: Olaf Kestermann, M.D.     +49 (0) 5971/8031504     olaf@kestermann.info    
Principal Investigator: Olaf Kestermann, M.D.            
Praxis Dr. Nebel Recruiting
Rheine, Germany, 48429
Contact: Wilfried Nebel, M.D.     +49 (0) 5971-15733     wnebel@web.de    
Principal Investigator: Wilfried Nebel, M.D.            
Kardiologische Praxis Dr. Figura Recruiting
Rinteln, Germany, 31737
Contact: Torsten Figura, M.D.     +49 (0) 57513235     Dr.Figura@web.de    
Principal Investigator: Torsten Figura, M.D.            
Praxis Dr. Ebeling Recruiting
Schönefeld, Germany, 12529
Contact: Olaf Ebeling, M.D.     +49 (0) 30-633 12 000     s.ebeling@t-online.de    
Principal Investigator: Olaf Ebeling, M.D.            
Facharztzentrum Sonneberg Recruiting
Sonneberg, Germany, 96515
Contact: Christian Franke, M.D.     +49 (0) 3675-894440     dr.christianfranke@arcor.de    
Principal Investigator: Christian Franke, M.D.            
Zentrum für Innere Medizin Uni Ulm Recruiting
Ulm, Germany, 89081
Contact     ++49-731-500-45001 (Sekr) ode        
Herzklinik Ulm Dr. Haerer und Partner Recruiting
Ulm, Germany, 89077
Contact: Winfried Haerer, M.D.     +49 (0) 731-935 30 70     winfried.haerer@herzklinik-ulm.de    
Principal Investigator: Winfried Haerer            
Katharinen Hospital Unna Recruiting
Unna, Germany, 59423
Contact: Jan Börgel, M.D.     +49 (0) 2303 1002672     j.boergel@katharinen-hospital.de    
Principal Investigator: Jan Börgel, M.D.            
Kardiologische Praxis Dr. Burkhard-Meier Recruiting
Viersen, Germany, 41747
Contact: Caspar Burkhard-Meier, M.D.     +49 (0) 216-2265970        
Principal Investigator: Caspar Burkhard-Meier, M.D.            
Praxis Dr. Gerritsen Recruiting
Waldkraiburg, Germany, 84478
Contact: Robert Gerritsen, M.D.     +49 (0) 8638 - 3061     info@r-gerritsen.de    
Fachkliniken Wangen Recruiting
Wangen, Germany, 88239
Contact: Barbara Schüle     +49 (0) 7522-797-1228     barbara.schuele@wz-kliniken.de    
Contact: Heribert Knape, M.D.     +49 (0) 7522-7970     heribert.knape@wz-kliniken.de    
Principal Investigator: Heribert Knape, M.D.            
Stiftungsklinik Weißenhorn Recruiting
Weißenhorn, Germany, 89264
Contact: Christa Rämisch-Mayer     +49 (0) 7309 8709415     kh.schlaflabor@stiftungsklinik-weissenhorn.de    
Principal Investigator: Alfred Resch, M.D.            
Kardiologisch angiologische Gemeinschaftspraxis Recruiting
Wiesbaden, Germany, 65183
Contact: Michael Stellwaag, M.D.     +49 (0) 611 34 17 00 0        
Kardiologische Gemeinschaftspraxis Dr. K. Vorbeck Recruiting
Wiesbaden, Germany, 65183
Contact: Klaus Vorbeck, M.D.     +49 (0) 611 335 990        
Kardiologische Praxis Dr. Vrettos Recruiting
Witten, Germany, 58452
Contact: Zois Vrettos, M.D.     +49 (0) 2302-55868        
Principal Investigator: Zois Vrettos, M.D.            
Kardiologische Praxis Dr. Rudolf/ Dr. Bernhardt Recruiting
Worms, Germany, 67547
Contact: Hans-Jürgen Rudolf, M.D.     +49 (0) 6241/27772     info@kardiologischepraxis.de    
Contact: Peter Bernhardt, M.D.         Dr.Peter.Bernhardt@t-online.de    
Principal Investigator: Hans-Jürgen Rudolf, M.D.            
Comprehensive Heart Failure Center, Universitätsklinikum Würzburg Recruiting
Würzburg, Germany, 97080
Contact: Susanne Brenner, M.D.     +49 (0) 931-2010     Brenner_S@klinik.uni-wuerzburg.de    
Universitätsklinikum Würzburg Recruiting
Würzburg, Germany, 97080
Contact: Delia Popp-Marschall         pop_d@medizin.uni-wuerzburg.de    
Contact: Susanne Brenner, M.D.     +49 (0) 931- 201 70880     Brenner_S@klinik.uni-wuerzburg.de    
Principal Investigator: Christiane Angermann, Prof.            
Sponsors and Collaborators
ResMed
Investigators
Principal Investigator: Erland Erdmann, Prof Klinikum der Universität zu Köln
Principal Investigator: Helmut Teschler, Prof Ruhrlandklinik Essen
Study Director: Holger Woehrle, MD ResMed
  More Information

No publications provided

Responsible Party: ResMed
ClinicalTrials.gov Identifier: NCT01500759     History of Changes
Other Study ID Numbers: 001
Study First Received: December 23, 2011
Last Updated: November 30, 2012
Health Authority: Germany: Ethics Commission
Australia: Human Research Ethics Committee

Keywords provided by ResMed:
chronic heart failure
heart failure
hf
sleep-disordered breathing
sdb
 nyha
lvef
cheyne stokes
central sleep apnoea
sleep apnoea

Additional relevant MeSH terms:
Respiratory Aspiration
Heart Failure
Sleep Apnea Syndromes
Heart Failure, Systolic
Ventricular Dysfunction, Left
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
 Heart Diseases
Cardiovascular Diseases
Apnea
Sleep Disorders, Intrinsic
Dyssomnias
Sleep Disorders
Nervous System Diseases
Ventricular Dysfunction

ClinicalTrials.gov processed this record on May 23, 2013