Trial record 2 of 4 for:    Rindopepimut

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV)

This study is currently recruiting participants.
Verified April 2014 by Celldex Therapeutics
Sponsor:
Information provided by (Responsible Party):
Celldex Therapeutics
ClinicalTrials.gov Identifier:
NCT01480479
First received: November 21, 2011
Last updated: April 16, 2014
Last verified: April 2014
  Purpose

This 2-arm, randomized, phase III study will investigate the efficacy and safety of the addition of rindopepimut (an experimental cancer vaccine that may act to promote anti-cancer effects in patients who have tumors that express the EGFRvIII protein) to the current standard of care (temozolomide) in patients with recently diagnosed glioblastoma, a type of brain cancer.

All patients will be administered temozolomide, the standard treatment for glioblastoma. Half the patients will be randomly assigned to receive rindopepimut and half the patients will be randomly assigned to receive a control called keyhole limpet hemocyanin.

Patients will be treated in a blinded fashion (neither the patient or the doctor will know which arm of the study the patient is on). Patients will be treated until disease progression or intolerance to therapy and all patients will be followed for survival.


Condition Intervention Phase
Glioblastoma
Small Cell Glioblastoma
Giant Cell Glioblastoma
Gliosarcoma
Glioblastoma With Oligodendroglial Component
Drug: Rindopepimut (CDX-110) with GM-CSF
Drug: Temozolomide
Drug: KLH
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
Official Title: An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma

Resource links provided by NLM:


Further study details as provided by Celldex Therapeutics:

Primary Outcome Measures:
  • Overall Survival [ Time Frame: During treatment and every three months from end of treatment through end of study or approximately up to 5 years. ] [ Designated as safety issue: No ]
    The primary efficacy endpoint of Overall Survival is defined as the number of months from randomization to the date of death (whatever the cause), and will be censored for patients who remain alive at completion of the study for patients with a gross total resection (~n=374). The overall survival of patients will be monitored and compared between the two study arms until the end of the study.


Secondary Outcome Measures:
  • Progression-free survival [ Time Frame: Every 12 weeks from Day 1 through progression or initiation of other anti-cancer therapy ] [ Designated as safety issue: No ]
    Compare progression-free survival between the two treatment arms

  • Safety and Tolerability [ Time Frame: Until day 28 of follow up ] [ Designated as safety issue: Yes ]
    Safety and tolerability will be measured by comparing the two arms in regards to vital sign measurement, physical and neurological examination, adverse events reporting, ECOG performance status, and EORTC core Quality of Life Questionnaire


Estimated Enrollment: 700
Study Start Date: November 2011
Estimated Primary Completion Date: November 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Rindopepimut/GM-CSF plus Temozolomide Drug: Rindopepimut (CDX-110) with GM-CSF

Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance.

Each dose will be 0.8 mL containing approximately 500 mcg CDX-110 and 150 mcg GM CSF.

Other Name: CDX-110 with sargramostim (GM-CSF) (Leukine®)
Drug: Temozolomide
150 to 200 mg/m2 for 5 days during each 28-day cycle for a minimum of six cycles or a maximum of 12 cycles, or until intolerance or progression.
Other Names:
  • Temodar
  • Temodal
Active Comparator: KLH plus Temozolomide Drug: Temozolomide
150 to 200 mg/m2 for 5 days during each 28-day cycle for a minimum of six cycles or a maximum of 12 cycles, or until intolerance or progression.
Other Names:
  • Temodar
  • Temodal
Drug: KLH
Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance. Each dose will be 0.8mL containing approximately 100mcg of KLH.

Detailed Description:

The purpose of this research study is to find out whether adding an experimental vaccine called rindopepimut (also known as CDX-110) to the commonly used chemotherapy drug temozolomide can help improve the life expectancy of patients with newly diagnosed, resected EGFRvIII positive glioblastoma.

The duration of participation in this study may be up to 5 years. After you are screened and enrolled in the study, you will be administered temozolomide and either rindopepimut/GM-CSF or KLH until either disease progression or intolerance to the medications. If your tumor progresses while on this study, your doctor may treat you with other therapies that are not part of the study.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria-

Among other criteria, patients must meet the following conditions to be eligible for the study:

  1. Adult patients, ≥ 18 years old
  2. Newly diagnosed glioblastoma
  3. Attempted surgical resection followed by conventional chemoradiation
  4. Documented EGFRvIII positive tumor status by a Sponsor designated laboratory
  5. No evidence of progressive disease from the post-operative period to the post-chemoradiation period
  6. Candidate for, and agrees to receive, adjuvant (maintenance) temozolomide therapy
  7. Systemic corticosteroid therapy at ≤2 mg of dexamethasone or equivalent per day for at least 3 days prior to randomization
  8. WHO-ECOG Performance Status ≤ 2
  9. Patients of childbearing/reproductive potential will be instructed to use birth control as defined by your doctor.

Exclusion Criteria-

Among other criteria, patients who meet the following conditions are NOT eligible for the study:

  1. Stereotactic biopsy only (without further surgical resection)
  2. Presence of diffuse leptomeningeal disease, gliomatosis cerebri, or infratentorial disease.
  3. History, presence, or suspicion of metastatic disease
  4. Patients who have received any additional treatment for glioblastoma, aside from surgical resection and chemoradiation with temozolomide
  5. Active systemic infection requiring treatment
  6. History of any malignancy (other than glioblastoma) during the last three years except non-melanoma skin cancer, in situ cervical cancer, treated superficial bladder cancer, cured, early-stage prostate cancer in a patient with PSA level less than ULN,or other carcinoma in situ that has been adequately treated and cured.
  7. Planned major surgery
  8. Evidence of current drug or alcohol abuse
  9. Known allergy or hypersensitivity to keyhole limpet hemocyanin (KLH), GM-CSF (sargramostim; LEUKINE®), polysorbate 80 or yeast derived products, or a history of anaphylactic reactions to shellfish proteins
  10. Severe acute or chronic medical or psychiatric condition or laboratory abnormality that could increase the risk associated with participating in a clinical trial
  11. Women who are pregnant or lactating
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01480479

Contacts
Contact: Celldex Therapeutics Info@celldextherapeutics.com

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Louis B Nabors, MD    205-934-1813    bnabors@uab.edu   
Principal Investigator: Louis B Nabors, MD         
University of South Alabama Mitchell Cancer Institute Recruiting
Mobile, Alabama, United States, 36604
Contact: Melanie Alford, RN    251-445-9649    malford@usouthal.edu   
Contact: Pamela Francisco, CCRP    251-445-9870    pfrancisco@usouthal.edu   
Principal Investigator: Suzanne Russo, MD         
United States, Arizona
Barrow Neurological Institute at St. Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: Lynn Ashby, MD    602-406-6262    LASHBY@CHW.EDU   
Principal Investigator: Lynn Ashby, MD         
University of Arizona Health Network Recruiting
Tucson, Arizona, United States, 85724
Contact: Jamie Holt    520-626-6800    jholt1@email.arizona.edu   
Contact: Baldassarre Stea, MD, PhD    (520) 626-6723    bstea@email.arizona.edu   
Principal Investigator: Baldassarre Stea, MD, PhD, FASTRO         
United States, Arkansas
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Wilma Brooks, RN    501-686-8530      
Contact: Amanda Eubanks, APN    501-686-7435    ALEubanks@uams.edu   
Principal Investigator: Shirley Ong, MD         
United States, California
Alta Bates Summit Comprehensive Cancer Center Withdrawn
Berkeley, California, United States, 94704
City of Hope Cancer Center Recruiting
Duarte, California, United States, 91010
Contact: Alexandra Ching    866-235-3031    aching@coh.org   
Contact: Annette Carson    626-256-4673 ext 62961    acarson@coh.org   
Principal Investigator: Jana Portnow, MD         
San Diego Pacific Oncology & Hematology Associates, Inc Withdrawn
Encinitas, California, United States, 92024
UC San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Contact: Nadia Faiq    858-822-1847    nfaiq@ucsd.edu   
Principal Investigator: Santosh Kesari, MD, PhD         
USC Norris Comprehensive Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Aida Lozada, MA    323-865-3980    lozada@usc.edu   
Principal Investigator: Rose K Lai, MD         
Chao Family Comprehensive Cancer Center Recruiting
Orange, California, United States, 92868
Contact: Christina Siwak    714-456-8549    csiwak@uci.edu   
Contact: Daniela Bota, M.D., Ph.D    1-714-456-7214    dbota@uci.edu   
Principal Investigator: Daniela Bota         
Kaiser Permanente, Redwood City Medical Center Recruiting
Redwood City, California, United States, 94063
Contact: Nancy Mendelssohn    650-299-4165    nancy.d.mendelssohn@kp.org   
Principal Investigator: Scott J Peak, MD         
University of California, Davis Recruiting
Sacramento, California, United States, 95817
Contact: Frances Lara    916-734-8134    Frances.lara@ucdmc.ucdavis.edu   
Contact: Eunice Laws    916-734-0561    Eunice.laws@ucdmc.ucdavis.edu   
Principal Investigator: Robert O'Donnell, MD, PhD.         
University of California, San Francisco Recruiting
San Francisco, California, United States, 94143
Contact: Thelma Munoz    415-353-2523    munozt@neurosurg.ucsf.edu   
Contact: Margaretta Page, MSN    415-353-2652    PageM@neurosurg.ucsf.edu   
Principal Investigator: Nicholas Butowski         
Stanford Cancer Institute, Stanford University Recruiting
Stanford, California, United States, 94305
Contact: Sophie Bertrand    650-723-4467    sophieb@stanford.edu   
Contact: Cathy Recht, RN    650-723-6095    ckrecht@stanford.edu   
Principal Investigator: Lawrence Recht, MD         
United States, Connecticut
Hartford Hospital Recruiting
Hartford, Connecticut, United States, 06102
Contact: Danytza Ward, RN    860-545-5371    dward02@harthosp.org   
Contact: Susanne Morrill    860-545-1588      
Principal Investigator: Alexandra Flowers, MD         
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Kimberly Hall    203-737-5228    Kimberly.hall@yale.edu   
Contact: Kevin M Becker, MD    203-785-7284    kevin.becker@yale.edu   
Principal Investigator: Kevin Becker, MD         
United States, Delaware
Christiana Care Health Services Recruiting
Newark, Delaware, United States, 19713
Contact: Kathleen Combs, RN, OCN, CCRP    302-623-4450    kcombs@christianacare.org   
Contact: Carla Bruegel, RN, MSN, CCRP    302-623-4450    cbruegel@christianacare.org   
Principal Investigator: Michael Guarino, MD         
United States, Florida
University of Florida Completed
Gainesville, Florida, United States, 32611
Mount Sinai Medical Center, Comprehensive Cancer Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Jose Lutzky,, MD    305-535-3300    JLutzky@aptiumoncology.com   
Contact: Yvonne Enriquez-Nunez, BSHA    305-535-3350    Yenrique@msmc.com   
Principal Investigator: Jose Lutzky, MD         
MD Anderson Cancer Center Orlando Recruiting
Orlando, Florida, United States, 32806
Contact: Mollie Geismer, RN, PhD    312-841-5206    mollie.geismer@orlandohealth.com   
Contact: Clinical Research Coordinators    321-841-1620      
Principal Investigator: Nicholas G Avgeropoulous, MD         
Tampa General Hospital Recruiting
Tampa, Florida, United States, 33606
Contact: Denise Fife,, RN, CCRP    813-844-7829    dafife@tgh.org   
Contact: Sandra Sanchez,, RN    813-844-8442    slsanchez@tgh.org   
Principal Investigator: Lawrence B Berk, MD, PhD         
United States, Georgia
Winship Cancer Institute, Emory University School of Medicine Recruiting
Atlanta, Georgia, United States, 30322
Contact: Costas Hadjipanayis, MD    404-778-1900    chadjip@emory.edu   
Contact: Katarzyna Kopcewicz    404-778-2981    kkopcew@emory.edu   
Principal Investigator: Costas Hadjipanayis, MD         
Atlanta Cancer Care Recruiting
Atlanta, Georgia, United States, 30005
Contact: Julie F Carney, RN, BSN    770-777-1315    jcarney@atlantacancercare.com   
Principal Investigator: Ronald G Steis, MD         
Georgia Health Sciences University Recruiting
Augusta, Georgia, United States, 30912
Contact: GHSU Referral Office    888-658-0422    pbourbo@georgiahealth.edu   
Contact: GHSU Referral Backup    1-888-658-0422    rdobbins@georgiahealth.edu   
Principal Investigator: Oliver Rixe, MD         
United States, Hawaii
Kaiser Permanente Hawaii Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Shelley A Clark,, RN    808-432-4689    Shelley.A.Clark@kp.org   
Contact: Heila Gamiao, RN    808-432-8214    heila.LR.gamiao@kp.org   
Principal Investigator: Jennifer F Carney, MD         
United States, Illinois
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Crista Brawley, PhD    773-702-0316    cbrawley@surgery.bsd.uchicago.edu   
Principal Investigator: Maciej Lesniak, MD         
Northwestern University Robert H. Lurie Comprehensive Cancer Center Recruiting
Chicago, Illinois, United States, 60611
Contact: Jeffrey Raizer, MD    312-695-1301    cancertrials@northwestern.edu   
Contact: Katie McCarthy    312-695-1301    katie-mccarthy@northwestern.edu   
Principal Investigator: Jeffrey Raizer, MD         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Amanda Begley, RN, BS    312-563-2713    Amanda_Begley@rush.edu   
Contact: Nicole Reinholdt,, BS, CCRP    312-942-3310    nicole_reinholdt@rush.edu   
Principal Investigator: Nina Paleologos, MD         
North Shore University Health System Recruiting
Evanston, Illinois, United States, 60201
Contact: Patricia Lada, RN    847-570-2025    plada@northshore.org   
Contact: Nancy Miedzianowski, RN    847-570-2025    nmiedzianowski@northshore.org   
Principal Investigator: Ryan Merrell, MD         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Sandra Zakrweski, BSN    708-327-2831    SZakrze@lumc.edu   
Contact: Rosalinda Tuazon    708-327-3224    RTuazon@lumc.edu   
Principal Investigator: Kevin Barton, MD         
United States, Iowa
Covenant Clinic / Iowa Spine and Brain Institute Recruiting
Waterloo, Iowa, United States, 50702
Contact: Kimberly Maxfield, RN    319-272-2388    kimberly.maxfield@wfhc.org   
Principal Investigator: Timothy Ryken, MD         
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536-0093
Contact: John L Villano, MD, PhD    859-323-8043    jlvillano@uky.edu   
Contact: Tonya Gardner, CCRP    (859) 323-0532    tonya.gardner@uky.edu   
Principal Investigator: John L Villano, MD, PhD         
Norton Cancer Institute Recruiting
Louisville, Kentucky, United States, 40202
Contact: Leanne Coleman, RN    502-629-4594    leanne.coleman@nortonhealthcare.org   
Contact: Kelly Rogers, BA    502-629-2229    kelly.rogers@nortonhealthcare.org   
Principal Investigator: Renato LaRocca, MD         
United States, Louisiana
Mary Bird Perkins Cancer Center Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Karla Tullier, RN, BSN    225-215-1129    ktullier@marybird.com   
Contact: Daveta Jenkins, BS    225-215-1315    djenkins@marybird.com   
Principal Investigator: Jon Olson, MD         
LSU Health Sciences Center, Feist-Weiller Cancer Center Recruiting
Shreveport, Louisiana, United States, 71103
Contact: Stacy Moss    318-813-1422    smoss@lsuhsc.edu   
Contact: Janice Yager    (318) 813-1403    jyager@lsuhsc.edu   
Principal Investigator: Gary V Burton, MD         
United States, Maryland
Anne Arundel Medical Center Recruiting
Annapolis, Maryland, United States, 21401
Contact: Emily Ross, CCRC    443-481-4392    eross@aahs.org   
Contact: Carol Bell, RN    443-481-4393      
Principal Investigator: Peter Graze, MD         
Johns Hopkins University School of Medicine Recruiting
Baltimore, Maryland, United States, 21231
Contact: Susan Zhen, RN    410-502-4081    szhen1@jhmi.edu   
Contact: Michael Lim, MD    410-614-1627    mlim3@jhmi.edu   
Principal Investigator: Michael Lim, MD         
Center for Cancer and Blood Disorders, PC Recruiting
Bethesda, Maryland, United States, 20817
Contact: Natalie Bongiorno, RN,BSN,MSHS    301-571-2016    nbongiorno@ccbdmd.com   
Contact: Ralph Boccia, MD    301-571-2016    rboccia@ccbdmd.com   
Principal Investigator: Ralph Boccia, MD         
United States, Massachusetts
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02215
Contact: Debra LaFrankie, RN    617-632-6327    debra_lafrankie@dfci.harvard.edu   
Contact: Sanda Ruland, RN    617-632-6372    Sandra_Ruland@dfci.harvard.edu   
Principal Investigator: Lakshmi Nayak, MD         
University of Massachusetts Memorial Medical Center Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Kathryn Clarke    508-856-5461    kathryn.clarke@umassmemorial.org   
Contact: Meera Sreedhara    508-856-2023    meera.sreedhara@umassmemorial.org   
Principal Investigator: Shakeeb Yunus, MD         
United States, Michigan
University of Michigan Health System Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Larry Junck, MD    734-936-7910    ljunck@umich.edu   
Contact: University of Michigan Cancer Answer Line    1-800-865-1125    canceranswerline@umich.edu   
Principal Investigator: Larry Junck, MD         
Edward W. Sparrow Hospital Association - Sparrow Regional Cancer Center Recruiting
Lansing, Michigan, United States, 48912
Contact: Harsha Trivedi, PhD    517-364-3712    harsha.trivedi@sparrow.org   
Contact: Vicki Gilreath, RN, OCN    517-364-2811    vicki.gilreath@sparrow.org   
Principal Investigator: Gordan Srkalovic, MD, PhD.         
St. Mary's of Michigan Medical Center/Field Neurosciences Institute Recruiting
Saginaw, Michigan, United States, 48604
Contact: Richard Herm, MSN, RN    989-497-3046    rherm@stmarysofmichigan.org   
Contact: Heather Clark, MSCS, RN, BS    989-497-3023    hclark@stmarysofmichigan.org   
Principal Investigator: Malcolm Field, MD         
United States, Minnesota
Allina Health, Abbott Northwestern Hospital, John Nasseff Neuroscience Institute Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Grace Wilson, RN, BSN    612-863-9166    grace.wilson@allina.com   
Contact: Amy Schrecengost, CCRC    612-863-6562    amy.schrecengost@allina.com   
Principal Investigator: John E Trusheim, MD         
United States, Missouri
Ellis Fischel Cancer Center Recruiting
Columbia, Missouri, United States, 65203
Contact: Chris Ehlenbeck, RN    573-882-7440    ehlenbeckc@health.missouri.edu   
Contact: Angie Vick    573-882-7440    vicka@health.missouri.edu   
Principal Investigator: Carl Freter, MD         
Washington University in St. Louis Recruiting
St. Louis, Missouri, United States, 63110
Contact: Madelyn Kissel    314-747-5384    mkissel@dom.wustl.edu   
Contact: David Tran, MD    314-362-5677    dtran@dom.wustl.edu   
Principal Investigator: David Tran, MD         
United States, Nebraska
Southeast Nebraska Cancer Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Lindsay Clements, RN,BSN,OCN    402-327-7363    lindsayc@leadingcancercare.com   
Contact: Candice Toombs, RN,BSN,OCN    402-327-7363      
Principal Investigator: Stacey Knox, MD         
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Crystalle J Newton    603-650-4428    Crystalle.J.Newton@hitchcock.org   
Contact: Camilo Fadul, MD    603-650-6312    Camilo.E.Fadul@hitchcock.org   
Principal Investigator: Camilo Fadul, MD, F.A.A.N         
United States, New Jersey
New Jersey Neuroscience Institute, JFK Medical Center Recruiting
Edison, New Jersey, United States, 08818
Contact: Charles Porbeni, MD, BS, MSC    732-321-7000 ext 68897    CPorbeni@JFKHealth.org   
Contact: Nnamdi Uhegwu, MBBS    732-321-7000 ext 62683    NUhegwu@JFKHealth.org   
Principal Investigator: Joseph Landolfi, DO         
John Theurer Cancer Center at Hackensack University Medical Center Recruiting
Hackensack, New Jersey, United States, 07601
Contact: Lori Cappello, RN    201-996-5098    LCappello@humed.com   
Principal Investigator: Samuel A Goldlust, MD         
Monmouth Medical Center Recruiting
Long Branch, New Jersey, United States, 07740
Contact: Heather Paxton, R.N.    732-923-6557    hpaxton@barnabashealth.org   
Contact: Kimberly Chow, B.A.    732-923-6564    kchow@barnabashealth.org   
Principal Investigator: Sumul N Raval, MD         
United States, New York
Dent Neurosciences Research Institute Recruiting
Amherst, New York, United States, 14226
Contact: Olga I Ananina, BS, CRC    716-558-5670    oananina@dentinstitute.com   
Contact: Laszlo L Mechtler, MD    716-558-5661    lmechtler@dentinstitute.com   
Principal Investigator: Laszlo L Mechtler, MD         
Montefiore Medical Center Recruiting
Bronx, New York, United States, 10467
Contact: Hilda Haynes-Lewis, NP    718-920-8819    hhayes@montefiore.org   
Contact: Emily Mapplebeck    718-920-5636    emapple@montefiore.org   
Principal Investigator: Jerome Graber, MD         
New York Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Adel Guirquis, MD, MS    718-780-3677    adg9003@nyp.org   
Contact: Bahaa Mokhtar, MD    718-780-3677      
Principal Investigator: Hani Ashamalla, MD, FCCP         
The Long Island Brain Tumor Center at Neurology Surgery, P.C. Recruiting
Great Neck, New York, United States, 11021
Contact: Kimberly Prabhu, MA, CCRP    516-478-0010    kprabhu@nspc.com   
Contact: Kerry McConie, RN, OCN    516-478-0010    kmcconie@nspc.com   
Principal Investigator: J. Paul Duic, M.D.         
North Shore University Hospital Recruiting
Manhasset, New York, United States, 11030-3186
Contact: Michael Schulder, MD    516-562-3065    mschulder@nshs.edu   
Contact: Louise A Purcell, MS ANP-C    516-562-3058    lpurcell@nshs.edu   
Principal Investigator: Michael Schulder, MD         
Columbia University Medical Center - The Neurologic Institute of New York Recruiting
New York, New York, United States, 10032
Contact: Fabio Iwamoto, M.D.    212-342-0571    fi2146@columbia.edu   
Contact: Francine Armentano, N.P    212-342-3967    fa2301@columbia.edu   
Principal Investigator: Fabio Iwamato, MD         
Weill Cornell Medical College Recruiting
New York, New York, United States, 10065
Contact: Melissa D. Ricketts    212-746-7373    mdr2001@med.cornell.edu   
Contact: Tamika Wong, MPH    212-746-1788    taw2015@med.cornell.edu   
Principal Investigator: Susan Pannullo, MD         
University of Rochester Medical Center Recruiting
Rochester, New York, United States, 14642
Contact: Jennifer Serventi, RPA-C    585-276-3971    jennifer_servent@urmc.rochester.edu   
Contact: Nimish A Mohile, MD    585-276-3971    Nimish_mohile@urmc.rochester.edu   
Principal Investigator: Nimish A Mohile, MD         
SUNY Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Wendy Barry    315-464-8271    barryw@upstate.edu   
Contact: Diane Gould, AAS    315-464-8235    gouldd@upstate.edu   
Principal Investigator: Thomas E Coyle, MD         
Brain and Spine Surgeons of New York Recruiting
White Plains, New York, United States, 10604
Contact: Jan Strack, RN    914-517-7982    jstrack@bssny.com   
Contact: John Abrahams, MD    914-948-6688      
Principal Investigator: John Abrahams, MD         
United States, North Carolina
The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27710
Contact: Alise Brickhouse, CRC    919-684-3107    alise.brickhouse@duke.edu   
Contact: Susan Boulton, CRC    919-668-0896    susan.boulton@duke.edu   
Principal Investigator: Annick Desjardins, MD         
Wake Forest Baptist Health Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Jennifer Maclean, BS, RN    336-713-3539    jemaclea@wakehealth.edu   
Contact: Glenn Lesser, MD    336-713-5440    glesser@wakehealth.edu   
Principal Investigator: Glenn Lesser, MD         
United States, Ohio
University of Cincinnati Cancer Institute Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Suzanne Sifri, BSN    513-584-0618    Suzanne.sifri@uc.edu   
Contact: Ruth Steele, BS, CCRC    513-584-2951    Ruth.steele@uc.edu   
Principal Investigator: Rekha Chaudhary, MD         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Gene Barnett, MD    216-444-5381      
Contact: Kathy Smolenski, RN    216-445-1067    smolenk2@ccf.org   
Principal Investigator: Gene Barnett, MD         
University Hospitals, Case Medical Center (Cleveland) Recruiting
Cleveland, Ohio, United States, 44106
Contact: Henry Krzemien    216-983-3021    Henry.krzemien@uhhospitals.org   
Principal Investigator: Andrew Sloan, MD         
Ohio State University Recruiting
Columbus, Ohio, United States, 43210
Contact: Jill Brown, MS    614-293-5554    jill.brown@osumc.edu   
Contact: Herbert Newton, MD    614-293-4448    newton.12@osu.edu   
Principal Investigator: Herbert Newton, MD         
United States, Oregon
Providence Portland Medical Center, Oncology & Hematology Care Recruiting
Portland, Oregon, United States, 97213
Contact: Chris Fountain, RN    503-215-2691    Christopher.fountain@providence.org   
Principal Investigator: Marka Crittenden, MD         
Pacific Neurosurgical Recruiting
Portland, Oregon, United States, 97227
Contact: Susan Staat, RN    503-413-8330    sstaat@lhs.org   
Principal Investigator: Jeff Chen, MD         
United States, Pennsylvania
Lehigh Valley Physician Group-Hematology-Oncology Associates Recruiting
Allentown, Pennsylvania, United States, 18103
Contact: Yasmin O Candelo, RN    610-402-9543    Yasmin_O.Candelo@lvhn.org   
Contact: Samiyyah Q Whitney, RN    610-402-0546    Samiyyah_Q.Whitney@lvhn.org   
Principal Investigator: Suresh Nair, MD         
Temple University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Douglas W Laske, MD    215-707-2618    dlaske@temple.edu   
Contact: Michael W Weaver, MD    215-707-2621    Michael.Weaver@temple.edu   
Principal Investigator: Douglas Laske, MD         
University of Pennsylvania Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Francis Quattrone, BS, CRC    215-615-4590    Francis.Quattrone@uphs.upenn.edu   
Contact: Eileen Maloney, MSN, ACNP-BC    215-662-6462    Eileen.Maloney@uphs.upenn.edu   
Principal Investigator: James Schuster, MD, PhD         
West Penn. Allegheny Health System Recruiting
Pittsburg, Pennsylvania, United States, 15212
Contact: Gloria Flannery, RN    412-359-8379    gflanner@wpahs.org   
Contact: Helen Andreko    412-359-4896    handreko@wpahs.org   
Principal Investigator: Jane Raymond, MD         
University of Pittsburgh Cancer Institute Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Rita Johnson    412-647-8571    johnsonr1@upmc.edu   
Contact: Mara Yerk    412-623-8362    yerkma@upmc.edu   
Principal Investigator: Jan Drappatz, MD         
United States, South Carolina
Medical University of South Carolina - Department of Neuroscience Recruiting
Charleston, South Carolina, United States, 29425
Contact: Michele DeCandio, RN, OCN, CCRP    843-792-9016    decandio@musc.edu   
Contact: Bruce Frankel, MD    843-792-1470    frankel@musc.edu   
Principal Investigator: Bruce Frankel, MD         
United States, Tennessee
University of Tennessee Medical Center - Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Shanna Overbey, RN    865-305-9773 ext 4    soverbey@utmck.edu   
Contact: Barbara Munsey, BS    865-305-9773 ext 3    bmunsey@utmck.edu   
Principal Investigator: Wahid Hanna, MD         
Sarah Cannon Research Institute Recruiting
Nashville, Tennessee, United States, 37203
Contact: Kent Shih, MD    615-329-7274    kshih@tnonc.com   
Principal Investigator: Kent Shih, MD         
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: VICC-Clinical Trials Information Program    800-811-8480    viccweb@vanderbilt.edu   
Contact: Tanya Davis    615-875-1188    tanya.e.davis@vanderbilt.edu   
Principal Investigator: Reid Thompson, MD         
United States, Texas
Texas Oncology Midtwon Recruiting
Austin, Texas, United States, 78705
Contact: Marlena Griffin,, BSc    512-421-4100    marlena.griffin@usoncology.com   
Contact: Deborah Borner, BS    972-490-2961    deborah.borner@usoncology.com   
Principal Investigator: Morris D Groves, MD         
Baylor Research Institute Recruiting
Dallas, Texas, United States, 75246
Contact: Clinical Oncology Research Coordination    214-818-8472    cancer.trials@baylorhealth.edu   
Principal Investigator: Karen Fink, MD, PhD         
The Methodist Neurological Institute Recruiting
Houston, Texas, United States, 77030
Contact: Kimbra S Harris, CCRP    713-441-3800    ksharris@tmhs.org   
Principal Investigator: Pamela Z New, MD         
United States, Utah
University of Utah Department of Neurosurgery Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Katy Philips    801-587-4420      
Contact: Aimee Maxwell    801-587-5562      
Principal Investigator: Randy Jensen, MD         
United States, Vermont
Fletcher Allen Health Care Recruiting
Burlington, Vermont, United States, 05405
Contact: Kate Murray, BS    802-656-9401    Kathryn.Murray@uvm.edu   
Contact: Sam Cory, BS    802-656-9446    Samuel.Cory@uvm.edu   
Principal Investigator: Steven Emmons, MD         
United States, Virginia
University of Virginia Healthcare System Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Kim Chapman    434-243-9360    kc9zy@virginia.edu   
Contact: Monika Thielen    434-243-9900    mjt3c@virginia.edu   
Principal Investigator: Benjamin Purow, MD         
United States, Washington
Swedish Neuroscience Institute Recruiting
Seattle, Washington, United States, 98122
Contact: Nathan Hansen, BA    206-320-3542    nathan.hansen@swedish.org   
Contact: Jeannie Steed, BS    206-386-3878    Jeannie.steed@swedish.org   
Principal Investigator: John W Henson, MD FAAN         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: Fereshteh Assadian, RN    206-288-6693    fassadia@uw.edu   
Contact: Sandra K Johnston, PhD    206-616-7117    stonesk@uw.edu   
Principal Investigator: Maciej Mrugala, MD         
United States, Wisconsin
University of Wisconsin Paul P Carbone Comprehensive Cancer Center Recruiting
Madison, Wisconsin, United States, 53792
Contact: Ian Robins, MD PhD    608-263-1416    hirobins@wisc.edu   
Contact: Diana Trask, BS    608-263-9528    trask@humonc.wisc.edu   
Principal Investigator: Ian H Robins, MD         
Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Jennifer Connelly, MD    414-805-5204    jconnelly@mcw.edu   
Contact: Barbara Blaney, CCRC    414-805-8328    bblaney@mcw.edu   
Principal Investigator: Jennifer Connelly, MD         
Australia, New South Wales
Prince of Wales Hospital Recruiting
Randwick, New South Wales, Australia, 2031
Contact: Elizabeth Hovey, MSc, MBBS, FRACP    61 2 9382 2956      
Contact: Daisy Buchanan    61 2 9382 2956    Daisy.Buchanan@sesiahs.health.nsw.gov.au   
Principal Investigator: Elizabeth Hovey, MSc, MBBS, FRACP         
Royal North Shore Hospital Recruiting
St Leonards, New South Wales, Australia, 2605
Contact: Helen R Wheeler, MBBS FRACP    61 2 94371900    hrwheeler@optusnet.com.au   
Principal Investigator: Helen R Wheeler, MBBS FRACP         
The Crown Princess Mary Cancer Centre, Westmead Hospital Recruiting
Westmead, New South Wales, Australia, 2145
Contact: Ka Yeung Mark Wong, MBBS FRACP PhD    61 2 9845 5200    mark.wong@sydney.edu.au   
Contact: Vicky Wegener, M. Hlth Sc    02 9845 8935    vicky.wegener@sydney.edu.au   
Principal Investigator: Ka Yeung Mark Wong, MBBS FRACP PhD         
Australia, Queensland
Royal Brisbane and Women's Hospital Recruiting
Herston, Queensland, Australia, 4029
Contact: Po-Ling Inglis, BSc, MBBS, FRACP    61 7 3636 7712      
Contact: Annette Cubitt    61 7 3636 7712    Annette_Cubitt@health.qld.gov.au   
Principal Investigator: Po-Ling Inglis, BSc, MBBS, FRACP         
Mater Adult Hospital, Mater Misericordiae Health Services Brisbane Limited Completed
South Brisbane, Queensland, Australia, 4101
Australia, South Australia
Royal Adelaide Hospital Recruiting
Adelaide, South Australia, Australia, 5000
Contact: Nimit Singhal, MBBS FRACP    61-8-822-4398    nimit.singhal@health.sa.gov.au   
Contact: RAH Clinical Trials       rahcancerclinicaltrials@health.sa.gov.au   
Principal Investigator: Nimit Singhal, MBBS FRACP         
Calvary North Adelaide Hospital Recruiting
North Adelaide, South Australia, Australia, 5006
Contact: William K Patterson, MBBS FRACP    61 8 8463 2500    William.Patterson@health.sa.gov.au   
Contact: Evy Hillenbrand, BHSc (Hons)    61 8 8239 9199    ehillenbrand@calvarysa.com.au   
Principal Investigator: William K Patterson, MBBS FRACP         
Australia, Tasmania
Royal Hobart Hospital Recruiting
Hobart, Tasmania, Australia, 7000
Contact: Rosemary A Harrup, MBBS    61-3-6222-8157    rosemary.harrup@dhhs.tas.gov.au   
Contact: David J Boadle, MBBS    61-3-6222-6750    David.Boadle@dhhs.tas.gov.au   
Principal Investigator: Rosemary A Harrup, MBBS         
Launceston General Hospital Recruiting
Launceston, Tasmania, Australia, 7250
Contact: Stainslaw Gauden, MBBS, FRACP    61 3 6348 7140      
Contact: Angela Neville, BSc, MSci    61 3 6348 7160    angela.neville@dhhs.tas.gov.au   
Principal Investigator: Stainslaw Gauden, MBBS, FRACP         
Australia, Victoria
Monash Medical Centre Recruiting
Clayton, Victoria, Australia, 3199
Contact: Jason Derrick Lickliter, MBBS FRACP    61 3 9594 7100    jason.lickliter@monash.edu   
Contact: Ronnie John Freilich, MBBS FRACP    61 3 9594 2240    rfreilich@me.com   
Principal Investigator: Jason Derrick Lickliter, MBBS FRACP         
Austin Health Recruiting
Heidelberg, Victoria, Australia, 3084
Contact: Lawrence M Cher, MBBS    61 3 9625-2323    lmcher@mac.com   
Contact: Madeleine A Chow    03 9496 3352    Madeleine.Chow@austin.org.au   
Principal Investigator: Lawrence M Cher, MBBS         
Epworth Healthcare Recruiting
Richmond, Victoria, Australia, 3121
Contact: Ross R Jennens, MBBS    61-3-9421-6085    jennens@bigpond.net.au   
Contact: Felicity C Osmond, RN    61-3-9936-8055    felicity.osmond@epworth.org.au   
Principal Investigator: Ross R Jennens, MBBS         
Australia, Western Australia
Sir Charles Gairdner Hospital Recruiting
Nedlands, Western Australia, Australia, 06008
Contact: Anna Nowak, MBBS FRACP PhD    61 8 9346 3841    anowak@meddent.uwa.edu.au   
Contact: Arman Hasani, FRACP MBBS    61 8 9346 3841    Arman.Hasani@health.wa.gov.au   
Principal Investigator: Anna Nowak, MBBS FRACP PhD         
Australia
Liverpool Hospital Recruiting
Liverpool, Australia, 2107
Contact: Paul Linus de Souza, MBBS FRACP    61 2 9616 4407    p.desousa@uws.edu.au   
Contact: Jennifer Aung    61 2 9828 5234    Jennifer.Aung@sswahs.nsw.gov.au   
Principal Investigator: Paul Linus de Souza, MBBS FRACP         
Austria
Medical University Innsbruck, Dept of Neurology, Anichstrabe 35 Recruiting
Innsbruck, Austria, 6020
Contact: Günther Stockhammer, Ao.Univ.-Prof.Dr.    43 512 504 26310    guenther.stockhammer@i-med.ac.at   
Contact: Sarah Iglseder, MD    43 512 504 82958    sarah.iglseder@i-med.ac.at   
Principal Investigator: Günther Stockhammer, Ao.Univ.-Prof.Dr.         
Medizinische Universität Wien, Innere Medizin I, Onkologie Recruiting
Vienna, Austria, 1090
Contact: Christine Marosi, a.o. Univ. Prof. Dr.    431404004421    christine.marosi@meduniwien.ac.at   
Contact: Judith Stellnberger, MSc    431404004421    judith.stellnberger@meduniwien.ac.at   
Principal Investigator: Christine Marosi, a.o.Univ.Prof.Dr         
Belgium
Universitair Ziekenhuis Antwerpen Recruiting
Edegem, Antwerp, Belgium, 2650
Contact: Iris Verhaegen    32 (0) 3 821 5681    iris.verhaegen@uza.be   
Contact: Ann Decoene    32 (0) 3 821 4719    ann.decoene@uza.de   
Principal Investigator: Pol Specenier, MD, PhD         
ZNA Middelheim Recruiting
Antwerpen, Belgium, B-2020
Contact: Frank Van Fraeyenhove, Dr    +32 3 280 40 40    ffraeyenhove@yahoo.com   
Contact: Anita Boumans    +32 3 280 23 39    anita.boumans@zna.be   
Principal Investigator: Frank Van Fraeyenhove, Dr         
Ghent University Hospital Recruiting
Ghent, Belgium, 9000
Contact: Tom Boterberg, MD    +3293323015    tom.boterberg@ugent.be   
Principal Investigator: Tom Boterberg, MD         
Brazil
NEO-Núcleo de Estudos Oncológico Withdrawn
Curitiba, Paraná, Brazil, 80440-210
Hospital Mae de Deus-Centro de Pesquisa em Oncologia Clinica Recruiting
Porto Alegre, Rio Grande do Sul, Brazil, 90840-440
Contact: Fabiana Spillari Viola, MD    55 51 32523930    fsviola@terra.com.br   
Contact: Carmela Nicolini    55 51 32523931    carmela.pesquisa@gmail.com   
Principal Investigator: Fabiana Spillari Viola, MD         
Centro de Pesquisas Clinicas da Fundação Dr Amaral Carvalho Not yet recruiting
Jaú, São Paulo, Brazil, 17210-120
Contact: Gustavo Fernando Veraldi Ismael, MD    55 14 3602-1399    gismael@uol.com.br   
Contact: Daniela Zanotti    55 14 36021399    danielazanotti@amaralcarvalho.org.br   
Principal Investigator: Gustavo Fernando Veraldi Ismael, MD         
Fundação Faculdade Regional de Medicina de de São José do Rio Preto - Hospital de Base Recruiting
São José do Rio Preto, São Paulo, Brazil, 15090-000
Contact: Gustavo Colagiovanni Girotto, MD    55-17-81194244    oncofamerp@yahoo.com.br   
Contact: Kamylla Caldeira, MD    55-17-32015154    oncofamerp@yahoo.com.br   
Principal Investigator: Gustavo Colagiovanni Girotto, MD         
Instituto Nacional do Cancer (INCA) Recruiting
Rio de Janeiro, Brazil, 20231-050
Contact: Clarissa Serôdio da Rocha Baldotto, MD    55 21 3207 6585    cbaldotto@gmail.com   
Contact: Débora Cristina Victorino de Azevedo    55 21 3207 6569    dcazevendo@inca.gov.br   
Principal Investigator: Clarissa Serôdio da Rocha Baldotto, MD         
Hospital Albert Einstein Recruiting
Sao Paulo, Brazil, 05652-900
Contact: Suzana Maria F Malheiros, MD    55 11 2151-1127    smfmalheiros@gmail.com   
Contact: Fernanda Cardoso    55 11 2151 1127    fernanda.ccardoso@einstein.br   
Principal Investigator: Suzana Maria F Malheiros, MD         
Hospital A C Camargo Recruiting
São Paulo, Brazil, 01509-900
Contact: Ana Carolina Sigolo Levy, MD    55 11 21895178    ana.levy@accamargo.org.br   
Contact: Tatiana Lafuso    55 11 21895178    caep@accamargo.org.br   
Principal Investigator: Ana Carolina Sigolo Levy, MD         
Instituto do Câncer do Estado de São Paulo - ICESP Recruiting
São Paulo, Brazil, 01246-000
Contact: Olavo Feher, MD    55-11-38932619    ofeher@terra.com.br   
Contact: Suleima Hussein Abou Jokh    55 11 38932617    suleima.jokh@icesp.org.br   
Principal Investigator: Olavo Feher, MD         
Real e Benemerita Associação Portuguesa de Beneficiência/ Hospital São José Recruiting
São Paulo, Brazil, 01321-001
Contact: Marcos André de Sá Barreto Costa, MD    55 11 3505 6693    mandre_med@yahoo.com.br   
Contact: Leticia Lucchesi    55 11 3505 6693    leticia.lucchesi@hospitalsjose.org.br   
Principal Investigator: Marcos André de Sá Barreto Costa, MD         
Canada, Alberta
Foothills Hospital Medical Centre Recruiting
Calgary, Alberta, Canada, T3J 5N6
Contact: Ish Bains    403-944-4334    ish.bains@albertahealthservices.ca   
Contact: Mark Hamilton, MD    403-944-1626    mark.hamilton@albertahealthservices.ca   
Principal Investigator: Mark Hamilton, MD         
Canada, British Columbia
British Columbia Cancer Agency, Vancouver Clinic Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Shane Brown    604-877-6000 ext 2370    sbrown9@bccancer.bc.ca   
Contact: Brian Thiessen, MD    604-877-6000 ext 2032    bthiesse@bccancer.bc.ca   
Principal Investigator: Brian Thiessen, MD         
BC Cancer Agency - Vancouver Island Centre Recruiting
Victoria, British Columbia, Canada, V8X 4V6
Contact: John P McGhie, MD    250-519-5580    jmcghie@bccancer.bc.ca   
Contact: Katalin Todor    250-519-5500    Katalin.todor@bccancer.bc.ca   
Principal Investigator: John P McGhie, MD         
Canada, Manitoba
University of Manitoba-Cancer Care Manitoba Recruiting
Winnipeg, Manitoba, Canada, R3E0V9
Contact: Marshall Pitz, MD, FRCPC    204-787-2108    pitz@cc.umanitoba.ca   
Principal Investigator: Marshall Pitz, MD, FRCPC         
Canada, Nova Scotia
QEII Health Sciences Centre Recruiting
Halifax, Nova Scotia, Canada, B3H 1V7
Contact: Sharon Hebb    902-473-2161    sharon.hebb@cdha.nshealth.ca   
Principal Investigator: Mary MacNeil, MD         
Canada, Ontario
Juravinski Cancer Centre Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Lisa Rudd-Scott, RN, BScN MN    905-387-9711 ext 64407    lisa.rudd-scott@jcc.hhsc.ca   
Contact: Theresa Stokes, RN    905-387-9711 ext 64420    theresa.stokes@jcc.hhsc.ca   
Principal Investigator: Hal Hirte, MD         
London Regional Cancer Program, London Health Sciences Centre Recruiting
London, Ontario, Canada, N6A 4L6
Contact: David R Macdonald, MD       David.Macdonald@lhsc.on.ca   
Principal Investigator: David Macdonald, MD         
Ottawa Hospital, Regional Cancer Centre Recruiting
Ottawa, Ontario, Canada, K1H 8L6
Contact: Roxanne Ward    613-737-7700 ext 73328    rward@ohri.ca   
Contact: Sharon Kelly    613-737-7700 ext 75212    Shakelly@toh.on.ca   
Principal Investigator: Garth Nicholas, MD         
Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N3M5
Contact: Hyla Okorofsky, RN    416-480-5000 ext 7474    hyla.okorofsky@sunnybrook.ca   
Principal Investigator: James Perry, MD         
Canada, Quebec
Montreal Neurological Institute and Hospital Recruiting
Montreal, Quebec, Canada, H3A 2B4
Contact: Marc Lemieux    514-398-2667    marc.lemieux@mcgill.ca   
Contact: Jad Al-Shami    514-398-5750    jad.al-shami@mcgill.ca   
Principal Investigator: Petr Kavan, MD         
Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Karl Belanger, MD    514-890-8000 ext 25381    karl.belanger.chum@ssss.gouv.qc.ca   
Contact: Francine Richard    514-890-8000 ext 24853    francine.richard.chum@ssss.gouv.qc.ca   
Principal Investigator: Karl Belanger, MD         
CHUQ - L'Hôtel-Dieu De Québec Recruiting
Québec, Quebec, Canada, G1R2J6
Contact: Josée Allard, RN    418-691-5264      
Principal Investigator: Isabelle Valliéres, MD         
CHUS Hôpital Fleurimont Recruiting
Shenbrooke, Quebec, Canada, J1H5N4
Contact: David Mathieu, MD    819-346-1110 ext 14887      
Contact: Anick Champoux, RN    819-346-1110 ext 12811      
Principal Investigator: David Mathieu, MD         
Canada
CHUQ L'Hotel Dieu Recruiting
Quebec, Canada, G1R 2J6
Contact: Josee Allard    418-525-4444 ext 16730    josee.allard@chug.qc.ca   
Contact: Isabelle Desrosiers    418-525-4444 ext 21679    isabelle.derosiers@mail.chug.qc.ca   
Principal Investigator: Nathalie Lessard, MD         
Colombia
Fundacion Santa Fe Recruiting
Bogota, Bogota D.C, Colombia, 000
Contact: Martha L Celis Herrans    +57-3123722226    martha.celis@fsfb.org.co   
Contact: Andres F Cardona, MD    +57-301 634-8173    a_cardonaz@yahoo.com   
Principal Investigator: Andres Felipe Cardona, MD         
Clinica del Country Withdrawn
Bogota D.C., Colombia
Czech Republic
Hospital Ceske Budejovice Recruiting
Ceske Budejovice, Czech Republic, 370 01
Contact: Petr Vitek, MD    00420 387 875 001    vitek@nemcb.cz   
Contact: Jiri Fiedler, MD    00420 387 876 001    fiedler@nemcb.cz   
Principal Investigator: Petr Vitek, MD         
Hospital Na Homolce Recruiting
Prague, Czech Republic, 150 30
Contact: Jan Sroubek, MD    00420 257 273 091    jan.sroubek@homolka.cz   
Contact: Josef Kasik, MD    00420 257 273 091    josef.kasik@homolka.cz   
Principal Investigator: Jan Sroubek, MD         
Fakultni nemocnice Motol Recruiting
Praha, Czech Republic, 150 06
Contact: Bela Malinova, MD    00420 224 434 764    Bela.Malinova@fnmotol.cz   
Contact: Gabriela Kasacova, MD    00420 224 434 764    Gabriela.Kasacova@fnmotol.cz   
Principal Investigator: Bela Malinova, MD         
Multiscan s.r.o. Recruiting
Praha 5, Czech Republic, 155-00
Contact: Karel Odrazka, MD, PhD    00420 466 016 413    odrazka@seznam.cz   
Contact: Barbora Simkova    00420 466 616 261    simb@seznam.cz   
Principal Investigator: Karel Odrazka, MD, PhD         
Masaryk´s Hospital Usti nad Labem Recruiting
Usti nad Labem, Czech Republic, 401-13
Contact: Martin Sames, MD, PhD    00420 477 112 871    Martin.Sames@KZCR.EU   
Contact: Robert Bartos    00420 775 611 215    robert.bartos@mnul.cz   
Principal Investigator: Martin Sames, MD, PhD         
France
Institut de Cancerologie de I'Quest-Paul Papin Recruiting
Angers, France, 49933
Contact: Patrick Soulie, MD    +33 2 41 35 27 00    Patrick.Soulie@ico.unicancer.fr   
Contact: Marie Celine Namour    +33 2 41 35 27 00 ext 4028    Celine.Namour@ico.unicancer.fr   
Principal Investigator: Patrick Soulie, MD         
Institute Bergonie Not yet recruiting
Bordeaux, France, 33076
Contact: Guy Kantor, MD    33 556333333    g.kantor@bordeaux.unicancer.fr   
Contact: Leslie Ardilouze    33 556337883    L.Ardilouze@bordeaux.unicancer.fr   
Principal Investigator: Guy Kantor, MD         
Institut de Cancerologie de L'Quest-Center Rane Gauducheau Recruiting
Nantes, France, 44805
Contact: Mario Campone, MD    +33 2 40 679 977    mario.campone@ico.unicancer.fr   
Contact: Carole Gourmelon, MD    +33 2 40 679 960    carole.gourmelon@ico.unicancer.fr   
Principal Investigator: Mario Campone, MD         
Service de Neurologie-GH Recruiting
Paris, France, 75013
Contact: Ahmed Idbaih, MD    00 33 1 42 16 04 31    ahmed.idgaih@gmail.com   
Contact: Nabila Rousseaux    00 33 1 42 16 04 31    nabila.rousseaux@psl.aphp.fr   
Principal Investigator: Ahmed Idbaih, MD         
Centre Eugene Marquis Recruiting
Rennes, France, 35042
Contact: Elodie Vauleon, MD    00 33 2 99 25 32 26    e.vauleon@rennes.unicancer.fr   
Contact: Christophe Perrin, MD    00 33 2 99 25 32 93    c.perrin@rennes.unicancer.fr   
Principal Investigator: Elodie Vauleon, MD         
Institut Gustave Roussy Recruiting
Villejuif, France, 94805
Contact: Julien Domont, MD    00 33 1 42 11 43 16    julien.domont@igr.fr   
Contact: Dhermain Frederic, MD    00 33 1 42 11 62 20    dhermain@igr.fr   
Principal Investigator: Julien Domont, MD         
Germany
Klinik und Poliklinik fur Neurologie der Universitat Regensburg Not yet recruiting
Regensburg, Bavaria, Germany, 93053
Contact: Peter Hau, Prof. Dr.    ++49(0)9419418464    Peter.Hau@medbo.de   
Contact: Martin Uhl, Dr    ++49(0)9419410    Neuroonkologie@medbo.de   
Principal Investigator: Peter Hau, Prof. Dr.         
Strahlenklinik Universitatsklinikum Erlangen Not yet recruiting
Erlangen, Germany, D-91054
Contact: Dorota Lubgan, PhD.    +49-(0)9131-85-44254    Dorota.Lubgan@uk-erlangen.de   
Contact: Sabine Semrau, Dr. med.    +49-(0)9131-85-44254    sabine.semrau@uk-erlangen.de   
Principal Investigator: Rainer Fietkau, Prof. Dr. med.         
Universitaetsklinikum Heidelberg, Neurologische Klinik, IM Neuenheimer Feld 672 Not yet recruiting
Heidelberg, Germany, 69120
Contact: Wolfgang Wick, Prof. MD    +0049 6221 56 7075    wolfgang.wick@med.uni-heidelberg.de   
Contact: Antje Wick, Dr.    +0049 6221 56 7484    antje.wick@med.uni-heidelberg.de   
Principal Investigator: Wolfgang Wick, Prof. Dr.         
University Medical Centre Recruiting
Kiel, Germany, 24105
Contact: Brigitte Hirschhausen    +49 431 597 8807 ext 4907    brigitte.hirschhausen@UKSH.de   
Contact: Nils Warneke, MD    +49 431 597 8807 ext 8550    nils.warneke@UKSH.de   
Principal Investigator: Maximilian Mehdorn, MD         
Universitaetsklinikum Muenster Recruiting
Muenster, Germany, 48149
Contact: Oliver Grauer, MD PhD    0049 251 83 46814    oliver.grauer@ukmuenster.de   
Contact: Johannes Wolfer, MD    0049 251 83 43236    johannes.woelfer@ukmuenster.de   
Principal Investigator: Oliver Grauer, MD PhD         
LMU Munich Not yet recruiting
Munich, Germany, D-81377
Contact: Oliver Schnell, Dr    +49 (0)89 7095-0    oschnell@med.lmu.de   
Contact: Christoph Barth    +49(0)89 7095-3548/6548    cbarth@med.Imu.de   
Principal Investigator: Oliver Schnell, Dr         
Greece
NNA Recruiting
Athens, Attiki, Greece, 11521
Contact: Panagiotis Papadopoulos, MD, PhD    +302107261374    pgpapad@gmail.com   
Contact: Theofanis Floros    +30 6986 729952    Fanis_fl@yahoo.gr   
Principal Investigator: Panagiotis Papadopoulos, MD, PhD         
"HYGEIA" Hospital Recruiting
Marousi, District of Attica, Greece, 151 23
Contact: Evangelia Razi, MD, PhD    30 210 6867165    e.razis@hygeia.gr   
Contact: Ioanna Theodorakopoulou    30 210 6867071    itheodorakopoulou@oncologists.gr   
Principal Investigator: Evangelia Razi, MD, PhD         
Hungary
Országos Onkológiai Intézet Sugárterápiás Osztály Recruiting
Budapest, Hungary, 1122
Contact: József Lövey, MD, Prof    +36 20 455 3579    lovey@oncol.hu   
Contact: Ágnes SC Sarai    +36 70 255 9869    saraiagi@oncol.hu   
Principal Investigator: József Lövey, MD. Prof         
Debreceni Egyetem Orvos- és Egészségtudományi Centrum Onkológiai Intézet Recruiting
Debrecen, Hungary, 4032
Contact: Zsolt Horvath, Prof. Dr    3606304913443    horvathzsolt@med.unideb.hu   
Contact: Angéla Tóth    36 30 240 8966    toth.angela@dote.hu   
Principal Investigator: Zsolt Horvath, Dr         
Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Sugárterápiás Osztály Recruiting
Miskolc, Hungary, 3526
Contact: Katalin Molnár, Dr    36 30 203 2489    moka.onkorad@bazmkorhaz.hu   
Contact: András CSókay    36 30 222 7075    csokay@bazmkorhaz.hu   
Principal Investigator: Katalin Molnár, MD         
Pécsi Tudományegyetem Általános Orvostudományi Kar Recruiting
Pécs, Hungary, 7624
Contact: László Mangel, MD    +36 30 245 7110    laszlo.mangel@aok.pte.hu   
Contact: Szilvia Csák    +36 30 987 2059    szilvia.csak@aok.pte.hu   
Principal Investigator: László Mangel, MD         
Szegedi Tudományegyetem Onkoterápiás Klinika Recruiting
Szeged, Hungary, 6720
Contact: Katalin Hideghéty    36 30 292 1638    katalin.hideghety@gmail.com   
Contact: Petra Mózes    36 70 363 9191    mozespetra@gmail.com   
Principal Investigator: Katalin Hideghéty, MD, PhD         
Vas Megyei Markusovszky Lajos Általános Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktatókórház Nonprofit Zrt Recruiting
Szombathely, Hungary, 9700
Contact: Miklós Wenczl, MD    +36 30 600 3359    wenczl.miklos@markusovszky.hu   
Contact: Gergő Padányi, MD    +36 20 392 8442    pagergo@gmail.com   
Principal Investigator: Miklós Wenczl, MD         
India
City Cancer Centre, Vijayawada Active, not recruiting
Vijayawada, Andhra Pradesh, India, 520002
HCG - Bangalore Institute of Oncology, Bangalore Active, not recruiting
Bengaluru, Karnataka, India, 560027
Amrita Institute of Medical Sciences and Research Centre, Kochi Active, not recruiting
Kochi, Kerala, India, 682 026
Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram Active, not recruiting
Thiruvananthapuram, Kerala, India, 695 011
Marathwada Regional Cancer Centre and Research Institute - Government Not yet recruiting
Aurangabad, Maharashtra, India, 431001
Contact: Shewalkar Balaji, M.D., DNB    91 9850632639    bkrish_e@rediffmail.com   
Contact: Imran Khan, M.Sc    91 9673222022    imranonsas@gmail.com   
Principal Investigator: Shewalkar Balaji, M.D., DNB         
Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute Not yet recruiting
Andheri-West, Mumbai, India, 400 053
Contact: Anandh Balasubramaniam, MCh.    91-9324599906      
Contact: Sarang Bedhe    91-9960875913    medicalresearch.kh@relianceada.com   
Principal Investigator: Anandh Balasubramaniam, MCh         
Tata Memorial Hospital , Mumbai Active, not recruiting
Parel, Mumbai, India, 400012
Indraprastha Apollo Hospital, New Delhi Active, not recruiting
Jasola Viha, New Delhi, India, 110076
Sahyadri Hospitals Limited Active, not recruiting
Erandauame, Pune, India, 411004
Dr. Rai Memorial Medical Centre, Chennai Active, not recruiting
Chennai, Tamil Nadu, India, 600018
HCG Shanti Mukand Hospital - Curie Cancer Centre, Delhi Not yet recruiting
Delhi, India, 110092
Contact: Munish Gairola, MD    91 9958 431 596    gairolam@hotmail.com   
Contact: Manish Chaurasia, MSc    91 9717720353    manish16chaurasia@gmail.com   
Principal Investigator: Munish Gairola, MD         
Israel
Soroka University M.C. Recruiting
Beer-Sheva, Israel, 84101
Contact: Konstantin Lavrenkov, Dr    +972 (0) 86244127    KonstantinL@clalit.org.il   
Contact: Nataly Israeli    +972 (0) 547377077    natalyis@clalit.org.il   
Principal Investigator: Konstantin Lavrenkov, Dr         
Rambam Health Care Campus Recruiting
Haifa, Israel, 3109601
Contact: Tzahala Tzuk Shina, Dr    +972-4-8543811    t_shina@rambam.health.gov.il   
Contact: Alejandro Lokiec, Dr    +972-4-8543811    a.lokiec@rambam.health.gov.il   
Principal Investigator: Tzahala Tzuk Shina, Dr         
Hadassah Medical Center Recruiting
Jerusalem, Israel, 91120
Contact: Alexander Lossos, MD    +972-50-8946874    ALOS@hadassah.org.il   
Contact: Edward Linetsky, MD    +972-50-7874581    E_linetsky@hotmail.com   
Principal Investigator: Alexander Lossos, MD         
SHEBA Medical Center Recruiting
Tel Hashomer, Israel, 52126
Contact: Leor Zach, MD    912-3-530 2290    Leor.zach@sheba.health.gov.il   
Contact: Ayelet Huri    +912-3-530-1033      
Principal Investigator: Leor Zach, MD         
Tel-Aviv Sourasky Medical Center Recruiting
Tel-Aviv, Israel, 64239
Contact: Deborah T Blumenthal, MD    +972 3 6973494    deborahblumenthal@gmail.com   
Contact: Felix Bokstein, MD    +972 3 6973494    felixb@tlvmc.gov.il   
Principal Investigator: Deborah T Blumenthal, MD         
Italy
UO Oncologie Medica Dipartimento Oncologico Recruiting
Bologna, Italy, 40139
Contact: Alba Brandes, MD    +390516225697    a.brandes@ausi.bo.it   
Contact: Enrico Franceschi, MD    +390516225796    e.franceschi@ausi.bo.it   
Principal Investigator: Alba Brandes, MD         
Fondazione IRCCS Instituto Neurologico Carlo Besta Recruiting
Milano, Italy, 20133
Contact: Gaetano Finocchiaro, MD    +39 02 23942454    gaetano.finocchiaro@istituto-besta.it   
Contact: Marica Eoli, MD    +39 02 23942285    marica.eoli@istituto-besta.it   
Principal Investigator: Gaetano Finocchiaro, MD         
Sacred Heart Catholic University Recruiting
Rome, Italy, 00168
Contact: Silvia Chiesa, MD    +39 33 84 35 7241    silvia.chiesa@gmail.com   
Contact: Mario Balducci, MD    +39 33 84 35 4743    mbalducci@rm.unicatt.it   
Principal Investigator: Mario Balducci, MD         
Universita e AO Citta delia Scienza, Universita Di Torino Recruiting
Torino, Italy, 10126
Contact: Riccardo Soffietti, MD    +39 011 633 4904    riccardo.soffietti@unito.it   
Contact: Roberta Ruda, MD    +39 011 633 4904    rudarob@hotmail.com   
Principal Investigator: Riccardo Soffietti, MD         
Mexico
Grupo Médico Camino S.C. Recruiting
Mexico, D.F, Mexico, 03310
Contact: Freddy Guillermo Castro Farfán, MD    52 (55) 4168 9873    guillermocastrof@gmail.com   
Principal Investigator: Freddy Guillermo Castro Farfán, MD         
Hospital Civil de Guadalajara "Fray Antonio Alcalde" Recruiting
Guadalajara, Jalisco, Mexico, 34000
Contact: Francisco Javier Ramírez Godínez,, MD    52 33 36 140482    drpacoramirez@yahoo.com.mx   
Principal Investigator: Francisco Javier Ramírez Godínez,, MD         
Ensayos Clínicos y Medicina de Alta Especialidad, S.C. Recruiting
Culiacán, Sinaloa, Mexico, 80020
Contact: José Ángel Félix Torrontegui, MD    52 667 758 7952    angel_f_t@hotmail.com   
Contact: Elmer Lopez Meza    52 1 667 189 0432    elmerlopez@hotmail.com   
Principal Investigator: José Ángel Félix Torrontegui, MD         
Servicios Medicos de Investigacion Clinica Sc Recruiting
Durango, Mexico, 34000
Contact: Jesús López Hernández,, MD    52 618 1858977    jlh_durango@yahoo.com.mx   
Contact: Monica Montaño Alva    52 618 1858970    mony_ma@yahoo.com   
Principal Investigator: Jesús López Hernández, MD         
Hospital Central "Ignacio Morones Prieto" Recruiting
San Luis Potosí, Mexico, 78240
Contact: Ildefonso Rodríguez Leyva, MD    52 444 817 6692    ilrole@yahoo.com.mx   
Contact: Rocio Rodríguez Leyva, MD    52 1 4442043616    roroleymx@yahoo.com.mx   
Principal Investigator: Ildefonso Rodríguez Leyva, MD         
Netherlands
Medisch Centrum Haaglanden Recruiting
The Hague, Zuid Holland, Netherlands, 2512 VA
Contact: M J Vox, MD    +31 7033 02 508    m.vos@mchaaglanden.nl   
Contact: Ellen Gortmaker    +31 7033 02 183    e.gortmaker@mchaaglanden.nl   
Principal Investigator: Maaike Vos, MD         
VUMC Recruiting
Amsterdam, Netherlands, 1081HV
Contact: Myra van Linde, MD    +31 (0) 20 4444 321    m.vanlinde@VUMC.nl   
Principal Investigator: Myra van Linde, MD         
Radboud University Nijmegen Medical Center Recruiting
Nijmegen, Netherlands, 6525 GA
Contact: Sasja Mulder, MD    +31 24 3655388    s.mulder@onco.umcn.nl   
Contact: Johanna Gijtenbeek, MD, PhD.    +31 24 3616600    j.gijtenbeek@neuro.umcn.nl   
Principal Investigator: Sasja Mulder, MD         
New Zealand
Christchurch Hospital Recruiting
Christchurch Central, Christchurch, New Zealand, 8011
Contact: Bridget A Robinson, BMed Sci MBChB FRACP    64-3-394-0020    bridget.robinson@cdhb.govt.nz   
Contact: Anne Smith, BA, RN    64-3-364-0368    anne.smith@cdhb.govt.nz   
Principal Investigator: Bridget A Robinson, BMed Sci MBChB FRACP         
Palmerston North Hospital Recruiting
Roslyn, Palmerston North, New Zealand, 4414
Contact: Claire Hardie, BSc (Hons) MBChB MRCP FRCR    64 6350 8430    claire.hardie@midcentraldhb.govt.nz   
Contact: Susan Newlands or Audrey Shepherd    64 6 3508098 or 64 6 3508099    susan.newlands@midcentraldhb.govt.nz   
Principal Investigator: Claire Hardie, BSc (Hons) MBChB MRCP FRCR         
Waikato Hospital, Regional Cancer Centre Recruiting
Hamilton, Waikato District, New Zealand, 3240
Contact: Michael R Tills, MBChB DRACR    64-7-839-8976    Michael.Tills@waikatodhb.health.nz   
Contact: Jenny Boyd, RN    64-7-839-8976      
Principal Investigator: Michael Tills, MBChB DRACR         
Peru
Hospital Almanzor Aguinaga Asenjo Recruiting
Chiclayo, Peru
Contact: Rodrigo Auqui, MD    (+51) 979-928-159    roaflo@yahoo.es   
Principal Investigator: Rodrigo Auqui, MD         
Instituto Oncologico Miraflores Recruiting
Lima, Peru, Lima 18
Contact: PEDRO RIOS    (51) 990899299    omarivers@hotmail.com   
Principal Investigator: Fernando Salas, MD         
Clinica Anglo Americana Recruiting
Lima, Peru, Lima 27
Contact: Claudia Lozada, MD    (+51) 997-921-444    clalozada@yahoo.com   
Principal Investigator: Claudia Lozada, MD         
Clinica Ricardo Palma Recruiting
Lima, Peru, Lima 27
Contact: Wuilbert Rodriguez, MD    (+51) 993-513-544    oncologiawrp@yahoo.es   
Principal Investigator: Wuilbert Rodriguez, MD         
Oncosalud Recruiting
Lima, Peru, Lima 41
Contact: Carlos O Munive, MD    (+51) 964-646451    carlosmunive@hotmail.com   
Principal Investigator: Carlos O Munive, MD         
Spain
Institut Catala d Oncologia Recruiting
LaHospitalet de Lubregat, Catalonia, Spain, 08908
Contact: Miguel Gil-Gil, MD    +34 93 260 7744    mgilgil@icomcologia.net   
Contact: Carlos Mesia-Barroso    +34 93 260 7744    mgilgil@icomcologia.net   
Principal Investigator: Manuel Gil-Gil, MD         
Dra. Sonia Del Barco Berron, ICO Girona Avda, Recruiting
Franca, Girona, Spain, 17007
Contact: Sonia Del Barco Berron, MD    972225834    sdel@iconcologia.net   
Contact: Begona M Castillo    972225828    bmartin@iconcologia.net   
Principal Investigator: Sonia Del Barco Berron, MD         
Hospital Clinic Recruiting
Barcelona, Spain, 8036
Contact: Estela Pineda, MD    +93 2275402    epineda@clinic.ub.es   
Contact: Teresa Vilille    +93 2275400 ext 2811      
Principal Investigator: Estela Pineda, MD         
ICO Badalona-Hospital Germans Trias i Pujol Recruiting
Barcelonia, Spain, 08916
Contact: Carmen Balana, MD    +34 93 497 89 24/5    cbalana@iconcologia.net   
Principal Investigator: Carmen Balana, MD         
Hospital 12 de Octubre Recruiting
Madrid, Spain, 28041
Contact: Juan Manuel Sepulveda Sanchez, Dr    +34913908003    jmsepulveda76@gmail.com   
Contact: Jessica Gonzalez    +34913908339      
Principal Investigator: Juan Manuel Sepulveda Sanchez, Dr         
Switzerland
Kantonsspital Aarau Medizinische Onkologie Tellstrasse Recruiting
Aarau, AG, Switzerland, 5001
Contact: Christoph Mamot, MD    ++41 62 838 60 53    christoph.mamot@ksa.ch   
Contact: Moosmann Peter, MD    ++41 62 838 60 53    peter.moosmann@ksa.ch   
Principal Investigator: Christoph Mamot, MD         
CHUV, Centre Hospitalier Universitaire Vaudois Recruiting
Lausanne, VD, Switzerland, 1011
Contact: Andreas F Hottinger, MD, PhD    +41 21 314 0168    andreas.hottinger@chuv.ch   
Contact: Krisztian Homicsko, MD, PhD    +41 21 3140155    marie.galmiche@chuv.ch   
Principal Investigator: Andreas F Hottinger, MD, PhD         
Oncology Institute of Southern Switzerland (IOSI) Recruiting
Bellinzona, Switzerland, 6500
Contact: Jolanda de Jong, SRn    +41 91 811 8945    jolanda.dejong@eoc.ch   
Contact: Gianfranco Pesce, MD    +41 91 811 8673    gianfrancoAngelo.Pesce@eoc.ch   
Principal Investigator: Gianfranco Pesce, MD         
Inselspital, Universitatsspital Bern, Universitatsklinik fur Medizinische Onkologie, Freiburgstrasse Recruiting
Bern, Switzerland, 3010
Contact: Andrea Schmid, MD    +41 31 632 41 15    andrea.schmid@insel.ch   
Contact: Martin Dave Berger, MD    +41 31 632 41 15    martin.berger@insel.ch   
Principal Investigator: Andrea Schmid, MD         
Hopitaux Universitaires de Geneve-HUG-Centre d'Oncologie Recruiting
Geneva, Switzerland, 1211
Contact: Pierre-Yves Dietrich, MD, PhD.    +41 22 372 32 70    Ouerre-Yves.Detrich@hcuge.ch   
Contact: Denis Migliorini, MD    +41 79 553 44 17    Denis.Migliorini@hcuge.ch   
Principal Investigator: Pierre-Yves Dietrich, MD, PhD.         
Brain Tumor Center, University Hospital Zurich Recruiting
Zurich, Switzerland, 8091
Contact: Michael Weller, MD    +41 44 2555500    michael.weller@usz.ch   
Contact: Verena Reichl, SN    +41 44 25551111    neuroonkologie@usz.ch   
Principal Investigator: Michael Weller, MD         
Taiwan
National Cheng Kung University Hospital Recruiting
Tainan City, Bei District, Taiwan, 704
Contact: E-Jian Lee, M.D. PhD    886- 6-2353535 ext 5204    ejian@mail.ncku.edu.tw   
Principal Investigator: E-Jian Lee, M.D. PhD         
Kaohsiung Chang Gung Memorial Hospital Recruiting
Kaohsiung, Taiwan, 83301
Contact: Jih-Tsun Ho, MD    886- 7-731-7123 ext 8011    jihtsunho@yahoo.com.tw   
Principal Investigator: Jih-Tsun Ho, MD         
Chang Gung Memorial Hospital Linkou Branch Recruiting
Taichung, Taiwan, 40705
Contact: Cheng-Neng Chang, MD    886- 3-328-1200    justin@mail.cgu.edu.tw   
Contact: Pei-Ru Chung    886-910-385-772    Rinachung.tw@yahoo.com.tw   
Principal Investigator: Cheng-Neng Chang, MD         
Taichung Veterans General Hospital Recruiting
Taichung, Taiwan, 40705
Contact: Wen-Yu Cheng, MD    886- 4-2359-2525 ext 5081    wycheng@vghtc.gov.tw   
Principal Investigator: Wen-Yu Cheng         
Chi Mei Medical Center Recruiting
Tainan City - Yongkang District, Taiwan, 710
Contact: Chin-Hong Chang, MD    886 6-2812811 ext 57112    cmh7520@gmail.com   
Principal Investigator: Chang Chin-Hong         
Tri-Service General Hospital Recruiting
Taipei city - Neihu District, Taiwan, 00114
Contact: Hsin-I Ma, MD, PhD    886- 2-87927177    uf004693@mail2000.com.tw   
Principal Investigator: Hsin-I Ma         
National Taiwan University Hospital Recruiting
Taipei City - Zhongzheng Dist, Taiwan, 00100
Contact: Ms Chieh-Ying Lan    886 915 283 373    lan8882@gmail.com   
Contact: Ms Han Ting Chang    886 988385438    antigone_3535@yahoo.com.tw   
Principal Investigator: Ham-Min Tseng, MD         
Thailand
Siriraj Hospital Recruiting
Bangkok, Bangkok Noi, Thailand, 10700
Contact: Sith Sathornsumetee, MD    66 81 812 7830    drsith@gmail.com   
Contact: Monica Engchuan    66 81 7210116    engchuan_99@hotmail.com   
Principal Investigator: Sith Sathornsumetee, MD         
Maharaj Nakorn Chiang Mai Hospital Recruiting
Mueang Chiangmai, Chiang Mai, Thailand, 50200
Contact: Kanokwan Kanokwan, MD    66 816 811 910    watcharasaksilp@gmail.com   
Contact: Karaket Sukchanchai    66 86 198 9939    ks_kade@yahoo.com   
Principal Investigator: Kanokwan Watcharasaksilp, MD         
King Chulalongkorn Memorial Hospital Recruiting
Bangkok, Pathumwan, Thailand, 10330
Contact: Iyavut Thaipisuttikul, MD    66 81 938 7087    iyavut@gmail.com   
Contact: Jeeratheep Laporn    66 86 887 5599    laporna9@gmail.com   
Principal Investigator: Iyavut Thaipisuttikul, MD         
Prince of Songkhla University Hospital Recruiting
Hat Yai, Songkhla, Thailand, 90110
Contact: Arundee Dechaphunkul, MD    MD 66 74 451469    dearunee@medicine.psu.ac.th   
Contact: Katekanok Kamonmarttayakul, RN    66-85-444-8441    kkatekanok@gmail.com   
Principal Investigator: Arundee Dechaphunkul, MD         
United Kingdom
Royal Marsden NHS Foundation Trust Recruiting
Sutton, Surrey, United Kingdom, SM2 5PT
Contact: Kathy Greenwood    0208-661-3300    Kathy.greenwood@rmh.nhs.uk   
Contact: Angela Morgan    0208-661-3877    angela.morgan@rmh.nhs.uk   
Principal Investigator: Frank Saran, MD, FRCR         
The Bristol Haematology and Oncology Centre Recruiting
Bristol, United Kingdom, BS2 8ED
Contact: Kirsten Hopkins, MD    44 0117 342 3008    Kirsten.Hopkins@UHBristol.nhs.uk   
Principal Investigator: Kirsten Hopkins, MD         
Edinburgh Cancer Centre Western General Hospital Recruiting
Edinburgh, United Kingdom, EH4 2XU
Contact: Sara Erridge, Dr.    +44 (0) 131 537 1052    serridge@staffmail.ed.ac.uk   
Principal Investigator: Sara Erridge, Dr         
Beatson West of Scotland Cancer Centrel Recruiting
Glasgow, United Kingdom, G12 0NY
Contact: Anthony Chalmers, Professor    +44 (0) 141 301 7097    Anthony.Chalmers@glasgow.ac.uk   
Contact: Debbie Rai    +44 (0) 141 301 7214    debbie.rai@glasgow.ac.uk   
Principal Investigator: Anthony Chalmers, Professor         
Guy's and St Thomas' NHS, Westminister Bridge Road Recruiting
London, United Kingdom, SE17EH
Contact: Kelly Radford, RN    020 7188 2020    kelly.radford@gstt.nhs.uk   
Contact: Ashmi Patel, MSc    0207188 1474    ashmi.patel@gstt.nhs.uk   
Principal Investigator: Ronald Beaney, MD         
Nottingham City Hospital Recruiting
Nottingham, United Kingdom, NG5 1PB
Contact: Karen Foweraker, Dr    +44 0115969 1169    Karen.Foweraker@nuh.nhs.uk   
Contact: Leanne Alder    +44 0115 969 1169    Leanne.Alder@nuh.nhs.uk   
Sponsors and Collaborators
Celldex Therapeutics
  More Information

Additional Information:
No publications provided

Responsible Party: Celldex Therapeutics
ClinicalTrials.gov Identifier: NCT01480479     History of Changes
Other Study ID Numbers: CDX110-04
Study First Received: November 21, 2011
Last Updated: April 16, 2014
Health Authority: United States: Food and Drug Administration
United States: Institutional Review Board

Keywords provided by Celldex Therapeutics:
EGFRvIII
Glioblastoma
Small cell
Giant cell
Gliosarcoma
oligodendroglial
Brain Cancer
Brain Tumor
radiotherapy
chemoradiation
Tumor
temozolomide
EGFR variant III

Additional relevant MeSH terms:
Glioblastoma
Gliosarcoma
Astrocytoma
Glioma
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Temozolomide
Dacarbazine
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antineoplastic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on April 16, 2014