Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV)

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2014 by Celldex Therapeutics
Information provided by (Responsible Party):
Celldex Therapeutics Identifier:
First received: November 21, 2011
Last updated: August 6, 2014
Last verified: August 2014

This 2-arm, randomized, phase III study will investigate the efficacy and safety of the addition of rindopepimut (an experimental cancer vaccine that may act to promote anti-cancer effects in patients who have tumors that express the EGFRvIII protein) to the current standard of care (temozolomide) in patients with recently diagnosed glioblastoma, a type of brain cancer.

All patients will be administered temozolomide, the standard treatment for glioblastoma. Half the patients will be randomly assigned to receive rindopepimut and half the patients will be randomly assigned to receive a control called keyhole limpet hemocyanin.

Patients will be treated in a blinded fashion (neither the patient or the doctor will know which arm of the study the patient is on). Patients will be treated until disease progression or intolerance to therapy and all patients will be followed for survival.

Condition Intervention Phase
Small Cell Glioblastoma
Giant Cell Glioblastoma
Glioblastoma With Oligodendroglial Component
Drug: Rindopepimut (CDX-110) with GM-CSF
Drug: Temozolomide
Drug: KLH
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
Official Title: An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma

Resource links provided by NLM:

Further study details as provided by Celldex Therapeutics:

Primary Outcome Measures:
  • Overall Survival [ Time Frame: During treatment and every three months from end of treatment through end of study or approximately up to 5 years. ] [ Designated as safety issue: No ]
    The primary efficacy endpoint of Overall Survival is defined as the number of months from randomization to the date of death (whatever the cause), and will be censored for patients who remain alive at completion of the study for patients with a gross total resection (~n=374). The overall survival of patients will be monitored and compared between the two study arms until the end of the study.

Secondary Outcome Measures:
  • Progression-free survival [ Time Frame: Every 12 weeks from Day 1 through progression or initiation of other anti-cancer therapy ] [ Designated as safety issue: No ]
    Compare progression-free survival between the two treatment arms

  • Safety and Tolerability [ Time Frame: Until day 28 of follow up ] [ Designated as safety issue: Yes ]
    Safety and tolerability will be measured by comparing the two arms in regards to vital sign measurement, physical and neurological examination, adverse events reporting, ECOG performance status, and EORTC core Quality of Life Questionnaire

Estimated Enrollment: 700
Study Start Date: November 2011
Estimated Primary Completion Date: November 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Rindopepimut/GM-CSF plus Temozolomide Drug: Rindopepimut (CDX-110) with GM-CSF

Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance.

Each dose will be 0.8 mL containing approximately 500 mcg CDX-110 and 150 mcg GM CSF.

Other Name: CDX-110 with sargramostim (GM-CSF) (Leukine®)
Drug: Temozolomide
150 to 200 mg/m2 for 5 days during each 28-day cycle for a minimum of six cycles or a maximum of 12 cycles, or until intolerance or progression.
Other Names:
  • Temodar
  • Temodal
Active Comparator: KLH plus Temozolomide Drug: Temozolomide
150 to 200 mg/m2 for 5 days during each 28-day cycle for a minimum of six cycles or a maximum of 12 cycles, or until intolerance or progression.
Other Names:
  • Temodar
  • Temodal
Drug: KLH
Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance. Each dose will be 0.8mL containing approximately 100mcg of KLH.

Detailed Description:

The purpose of this research study is to find out whether adding an experimental vaccine called rindopepimut (also known as CDX-110) to the commonly used chemotherapy drug temozolomide can help improve the life expectancy of patients with newly diagnosed, resected EGFRvIII positive glioblastoma.

The duration of participation in this study may be up to 5 years. After you are screened and enrolled in the study, you will be administered temozolomide and either rindopepimut/GM-CSF or KLH until either disease progression or intolerance to the medications. If your tumor progresses while on this study, your doctor may treat you with other therapies that are not part of the study.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria-

Among other criteria, patients must meet the following conditions to be eligible for the study:

  1. Adult patients, ≥ 18 years old
  2. Newly diagnosed glioblastoma
  3. Attempted surgical resection followed by conventional chemoradiation
  4. Documented EGFRvIII positive tumor status by a Sponsor designated laboratory
  5. No evidence of progressive disease from the post-operative period to the post-chemoradiation period
  6. Candidate for, and agrees to receive, adjuvant (maintenance) temozolomide therapy
  7. Systemic corticosteroid therapy at ≤2 mg of dexamethasone or equivalent per day for at least 3 days prior to randomization
  8. WHO-ECOG Performance Status ≤ 2
  9. Patients of childbearing/reproductive potential will be instructed to use birth control as defined by your doctor.

Exclusion Criteria-

Among other criteria, patients who meet the following conditions are NOT eligible for the study:

  1. Stereotactic biopsy only (without further surgical resection)
  2. Presence of diffuse leptomeningeal disease, gliomatosis cerebri, or infratentorial disease.
  3. History, presence, or suspicion of metastatic disease
  4. Patients who have received any additional treatment for glioblastoma, aside from surgical resection and chemoradiation with temozolomide
  5. Active systemic infection requiring treatment
  6. History of any malignancy (other than glioblastoma) during the last three years except non-melanoma skin cancer, in situ cervical cancer, treated superficial bladder cancer, cured, early-stage prostate cancer in a patient with PSA level less than ULN,or other carcinoma in situ that has been adequately treated and cured.
  7. Planned major surgery
  8. Evidence of current drug or alcohol abuse
  9. Known allergy or hypersensitivity to keyhole limpet hemocyanin (KLH), GM-CSF (sargramostim; LEUKINE®), polysorbate 80 or yeast derived products, or a history of anaphylactic reactions to shellfish proteins
  10. Severe acute or chronic medical or psychiatric condition or laboratory abnormality that could increase the risk associated with participating in a clinical trial
  11. Women who are pregnant or lactating
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01480479

Contact: Celldex Therapeutics

  Hide Study Locations
United States, Alabama
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Louis B Nabors, MD    205-934-1813   
Principal Investigator: Louis B Nabors, MD         
University of South Alabama Mitchell Cancer Institute Recruiting
Mobile, Alabama, United States, 36604
Contact: Melanie Alford, RN    251-445-9649   
Contact: Pamela Francisco, CCRP    251-445-9870   
Principal Investigator: Suzanne Russo, MD         
United States, Arizona
Barrow Neurological Institute at St. Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: Lynn Ashby, MD    602-406-6262    LASHBY@CHW.EDU   
Principal Investigator: Lynn Ashby, MD         
University of Arizona Health Network Recruiting
Tucson, Arizona, United States, 85724
Contact: Jamie Holt    520-626-6800   
Contact: Baldassarre Stea, MD, PhD    (520) 626-6723   
Principal Investigator: Baldassarre Stea, MD, PhD, FASTRO         
United States, Arkansas
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Wilma Brooks, RN    501-686-8530      
Contact: Amanda Eubanks, APN    501-686-7435   
Principal Investigator: Shirley Ong, MD         
United States, California
Alta Bates Summit Comprehensive Cancer Center Withdrawn
Berkeley, California, United States, 94704
City of Hope Cancer Center Recruiting
Duarte, California, United States, 91010
Contact: Alexandra Ching    866-235-3031   
Contact: Annette Carson    626-256-4673 ext 62961   
Principal Investigator: Jana Portnow, MD         
San Diego Pacific Oncology & Hematology Associates, Inc Withdrawn
Encinitas, California, United States, 92024
UC San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Contact: Nadia Faiq    858-822-1847   
Principal Investigator: Santosh Kesari, MD, PhD         
USC Norris Comprehensive Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Aida Lozada, MA    323-865-3980   
Principal Investigator: Naveed Wagle, MD         
Chao Family Comprehensive Cancer Center Recruiting
Orange, California, United States, 92868
Contact: Jinah Chung    714-456-8442   
Contact: Blake Johnson    714-456-3476   
Principal Investigator: Daniela Bota         
Kaiser Permanente, Redwood City Medical Center Recruiting
Redwood City, California, United States, 94063
Contact: Nancy Mendelssohn    650-299-4165   
Principal Investigator: Scott J Peak, MD         
University of California, Davis Recruiting
Sacramento, California, United States, 95817
Contact: Frances Lara    916-734-8134   
Contact: Eunice Laws    916-734-0561   
Principal Investigator: Robert O'Donnell, MD, PhD.         
University of California, San Francisco Recruiting
San Francisco, California, United States, 94143
Contact: Thelma Munoz    415-353-2523   
Contact: Margaretta Page, MSN    415-353-2652   
Principal Investigator: Nicholas Butowski         
Stanford Cancer Institute, Stanford University Recruiting
Stanford, California, United States, 94305
Contact: Sophie Bertrand    650-723-4467   
Contact: Cathy Recht, RN    650-723-6095   
Principal Investigator: Lawrence Recht, MD         
United States, Connecticut
Hartford Hospital Recruiting
Hartford, Connecticut, United States, 06102
Contact: Tamara Montgomery    860-972-9828   
Principal Investigator: Alexandra Flowers, MD         
Yale University Medical Center Recruiting
New Haven, Connecticut, United States, 06520
Contact: Danielle Wanik    203-737-1889   
Principal Investigator: Kevin Becker, MD         
United States, Delaware
Christiana Care Health Services Recruiting
Newark, Delaware, United States, 19713
Contact: Kathleen Combs, RN, OCN, CCRP    302-623-4450   
Contact: Carla Bruegel, RN, MSN, CCRP    302-623-4450   
Principal Investigator: Michael Guarino, MD         
United States, Florida
University of Florida Completed
Gainesville, Florida, United States, 32611
Mount Sinai Medical Center, Comprehensive Cancer Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Jose Lutzky,, MD    305-535-3300   
Contact: Yvonne Enriquez-Nunez, BSHA    305-535-3350   
Principal Investigator: Jose Lutzky, MD         
MD Anderson Cancer Center Orlando Recruiting
Orlando, Florida, United States, 32806
Contact: Mollie Geismer, RN, PhD    312-841-5206   
Contact: Clinical Research Coordinators    321-841-1620      
Principal Investigator: Nicholas G Avgeropoulous, MD         
Tampa General Hospital Recruiting
Tampa, Florida, United States, 33606
Contact: Denise Fife,, RN, CCRP    813-844-7829   
Contact: Sandra Sanchez,, RN    813-844-8442   
Principal Investigator: Lawrence B Berk, MD, PhD         
United States, Georgia
Winship Cancer Institute, Emory University School of Medicine Recruiting
Atlanta, Georgia, United States, 30322
Contact: Costas Hadjipanayis, MD    404-778-1900   
Contact: Katarzyna Kopcewicz    404-778-2981   
Principal Investigator: Costas Hadjipanayis, MD         
Atlanta Cancer Care Recruiting
Atlanta, Georgia, United States, 30005
Contact: Julie F Carney, RN, BSN    770-777-1315   
Principal Investigator: Ronald G Steis, MD         
Georgia Regents University Recruiting
Augusta, Georgia, United States, 30912
Contact: GHSU Referral Office    888-658-0422   
Contact: GHSU Referral Backup    1-888-658-0422   
Principal Investigator: Frank Mott, MD         
United States, Hawaii
Kaiser Permanente Hawaii Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Shelley A Clark,, RN    808-432-4689   
Contact: Heila Gamiao, RN    808-432-8214   
Principal Investigator: Jennifer F Carney, MD         
United States, Illinois
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Crista Brawley, PhD    773-702-0316   
Principal Investigator: Maciej Lesniak, MD         
Northwestern University Robert H. Lurie Comprehensive Cancer Center Recruiting
Chicago, Illinois, United States, 60611
Contact: Jeffrey Raizer, MD    312-695-1301   
Contact: Katie McCarthy    312-695-1301   
Principal Investigator: Jeffrey Raizer, MD         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Amanda Begley, RN, BS    312-563-2713   
Contact: Nicole Reinholdt,, BS, CCRP    312-942-3310   
Principal Investigator: Nina Paleologos, MD         
North Shore University Health System Recruiting
Evanston, Illinois, United States, 60201
Contact: Patricia Lada, RN    847-570-2025   
Contact: Nancy Miedzianowski, RN    847-570-2025   
Principal Investigator: Ryan Merrell, MD         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Sandra Zakrweski, BSN    708-327-2831   
Contact: Rosalinda Tuazon    708-327-3224   
Principal Investigator: Kevin Barton, MD         
United States, Iowa
Covenant Clinic / Iowa Spine and Brain Institute Recruiting
Waterloo, Iowa, United States, 50702
Contact: Kimberly Maxfield, RN    319-272-2388   
Principal Investigator: Timothy Ryken, MD         
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536-0093
Contact: John L Villano, MD, PhD    859-323-8043   
Contact: Tonya Gardner, CCRP    (859) 323-0532   
Principal Investigator: John L Villano, MD, PhD         
Norton Cancer Institute Recruiting
Louisville, Kentucky, United States, 40202
Contact: Leanne Coleman, RN    502-629-4594   
Contact: Kelly Rogers, BA    502-629-2229   
Principal Investigator: Renato LaRocca, MD         
United States, Louisiana
Mary Bird Perkins Cancer Center Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Karla Tullier, RN, BSN    225-215-1129   
Contact: Daveta Jenkins, BS    225-215-1315   
Principal Investigator: Jon Olson, MD         
LSU Health Sciences Center, Feist-Weiller Cancer Center Recruiting
Shreveport, Louisiana, United States, 71103
Contact: Stacy Moss    318-813-1422   
Contact: Janice Yager    (318) 813-1403   
Principal Investigator: Gary V Burton, MD         
United States, Maryland
Anne Arundel Medical Center Recruiting
Annapolis, Maryland, United States, 21401
Contact: Emily Ross, CCRC    443-481-4392   
Contact: Carol Bell, RN    443-481-4393      
Principal Investigator: Peter Graze, MD         
Johns Hopkins University School of Medicine Recruiting
Baltimore, Maryland, United States, 21231
Contact: Susan Zhen, RN    410-502-4081   
Contact: Michael Lim, MD    410-614-1627   
Principal Investigator: Michael Lim, MD         
Center for Cancer and Blood Disorders, PC Recruiting
Bethesda, Maryland, United States, 20817
Contact: Natalie Bongiorno, RN,BSN,MSHS    301-571-2016   
Contact: Ralph Boccia, MD    301-571-2016   
Principal Investigator: Ralph Boccia, MD         
United States, Massachusetts
Dana-Farber Cancer Institute and Mass General Hospital Recruiting
Boston, Massachusetts, United States, 02115
Contact: Jorge Deitrich, MD    617-643-1935   
Contact: Karley Griffen, RN, OCN    617-632-6749   
Principal Investigator: Jorge Dietrich, MD         
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02215
Contact: Debra LaFrankie, RN    617-632-6327   
Contact: Sanda Ruland, RN    617-632-6372   
Principal Investigator: Lakshmi Nayak, MD         
University of Massachusetts Memorial Medical Center Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Kathryn Clarke    508-856-5461   
Contact: Meera Sreedhara    508-856-2023   
Principal Investigator: Shakeeb Yunus, MD         
United States, Michigan
University of Michigan Health System Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Larry Junck, MD    734-936-7910   
Contact: University of Michigan Cancer Answer Line    1-800-865-1125   
Principal Investigator: Larry Junck, MD         
Edward W. Sparrow Hospital Association - Sparrow Regional Cancer Center Recruiting
Lansing, Michigan, United States, 48912
Contact: Harsha Trivedi, PhD    517-364-3712   
Contact: Vicki Gilreath, RN, OCN    517-364-2811   
Principal Investigator: Gordan Srkalovic, MD, PhD.         
St. Mary's of Michigan Medical Center/Field Neurosciences Institute Recruiting
Saginaw, Michigan, United States, 48604
Contact: Richard Herm, MSN, RN    989-497-3046   
Contact: Heather Clark, MSCS, RN, BS    989-497-3023   
Principal Investigator: Malcolm Field, MD         
United States, Minnesota
Allina Health, Abbott Northwestern Hospital, John Nasseff Neuroscience Institute Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Grace Wilson, RN, BSN    612-863-9166   
Contact: Amy Schrecengost, CCRC    612-863-6562   
Principal Investigator: John E Trusheim, MD         
United States, Missouri
Ellis Fischel Cancer Center Recruiting
Columbia, Missouri, United States, 65203
Contact: Angela Waller, RN    573-882-7440   
Contact: Angie Vick    573-884-6479   
Principal Investigator: Donald Doll, MD         
Washington University in St. Louis Recruiting
St. Louis, Missouri, United States, 63110
Contact: Madelyn Kissel    314-747-5384   
Contact: David Tran, MD    314-362-5677   
Principal Investigator: David Tran, MD         
United States, Nebraska
Southeast Nebraska Cancer Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Lindsay Clements, RN,BSN,OCN    402-327-7363   
Contact: Candice Toombs, RN,BSN,OCN    402-327-7363      
Principal Investigator: Stacey Knox, MD         
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Crystalle J Newton    603-650-4428   
Contact: Camilo Fadul, MD    603-650-6312   
Principal Investigator: Camilo Fadul, MD, F.A.A.N         
United States, New Jersey
New Jersey Neuroscience Institute, JFK Medical Center Recruiting
Edison, New Jersey, United States, 08818
Contact: Charles Porbeni, MD, BS, MSC    732-321-7000 ext 68897   
Contact: Nnamdi Uhegwu, MBBS    732-321-7000 ext 62683   
Principal Investigator: Joseph Landolfi, DO         
John Theurer Cancer Center at Hackensack University Medical Center Recruiting
Hackensack, New Jersey, United States, 07601
Contact: Lori Cappello, RN    201-996-5098   
Principal Investigator: Samuel A Goldlust, MD         
Monmouth Medical Center Recruiting
Long Branch, New Jersey, United States, 07740
Contact: Heather Paxton, R.N.    732-923-6557   
Contact: Kimberly Chow, B.A.    732-923-6564   
Principal Investigator: Sumul N Raval, MD         
United States, New York
Dent Neurosciences Research Institute Recruiting
Amherst, New York, United States, 14226
Contact: Olga I Ananina, BS, CRC    716-558-5670   
Contact: Laszlo L Mechtler, MD    716-558-5661   
Principal Investigator: Laszlo L Mechtler, MD         
Montefiore Medical Center Recruiting
Bronx, New York, United States, 10467
Contact: Emily Mapplebeck    718-920-5636   
Principal Investigator: Jerome Graber, MD         
New York Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Adel Guirquis, MD, MS    718-780-3677   
Contact: Bahaa Mokhtar, MD    718-780-3677      
Principal Investigator: Hani Ashamalla, MD, FCCP         
The Long Island Brain Tumor Center at Neurology Surgery, P.C. Recruiting
Great Neck, New York, United States, 11021
Contact: Kimberly Prabhu, MA, CCRP    516-478-0010   
Contact: Mariegold Namoca, BS, MBA    516-478-0010   
Principal Investigator: J. Paul Duic, M.D.         
North Shore University Hospital Recruiting
Manhasset, New York, United States, 11030-3186
Contact: Michael Schulder, MD    516-562-3065   
Contact: Louise A Purcell, MS ANP-C    516-562-3058   
Principal Investigator: Michael Schulder, MD         
Columbia University Medical Center - The Neurologic Institute of New York Recruiting
New York, New York, United States, 10032
Contact: Maritsa Polykarpou    212-342-4435   
Contact: Francine Armentano, N.P    212-342-3967   
Principal Investigator: Fabio Iwamato, MD         
Weill Cornell Medical College Recruiting
New York, New York, United States, 10065
Contact: Melissa D. Ricketts    212-746-7373   
Principal Investigator: Susan Pannullo, MD         
University of Rochester Medical Center Recruiting
Rochester, New York, United States, 14642
Contact: Jennifer Serventi, RPA-C    585-276-3971   
Contact: Nimish A Mohile, MD    585-276-3971   
Principal Investigator: Nimish A Mohile, MD         
SUNY Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Wendy Barry    315-464-8271   
Contact: Diane Gould, AAS    315-464-8235   
Principal Investigator: Thomas E Coyle, MD         
Brain and Spine Surgeons of New York Recruiting
White Plains, New York, United States, 10604
Contact: Jan Strack, RN    914-517-7982   
Contact: John Abrahams, MD    914-948-6688      
Principal Investigator: John Abrahams, MD         
United States, North Carolina
The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27710
Contact: Woody Massey, CRC    919-668-1814   
Contact: Susan Boulton, CRC    919-668-0896   
Principal Investigator: Annick Desjardins, MD         
Wake Forest Baptist Health Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Jennifer Maclean, BS, RN    336-713-3539   
Contact: Glenn Lesser, MD    336-713-5440   
Principal Investigator: Glenn Lesser, MD         
United States, Ohio
University of Cincinnati Cancer Institute Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Suzanne Sifri, BSN    513-584-0618   
Contact: Richard Curry, MD    513-584-7698   
Principal Investigator: Richard Curry, MD         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Gene Barnett, MD    216-444-5381      
Contact: Kathy Smolenski, RN    216-445-1067   
Principal Investigator: Gene Barnett, MD         
University Hospitals, Case Medical Center (Cleveland) Recruiting
Cleveland, Ohio, United States, 44106
Contact: Henry Krzemien    216-983-3021   
Principal Investigator: Andrew Sloan, MD         
Ohio State University Recruiting
Columbus, Ohio, United States, 43210
Contact: Jill Brown, MS    614-293-5554   
Contact: Herbert Newton, MD    614-293-4448   
Principal Investigator: Herbert Newton, MD         
United States, Oregon
Providence Portland Medical Center, Oncology & Hematology Care Recruiting
Portland, Oregon, United States, 97213
Contact: Chris Fountain, RN    503-215-2691   
Principal Investigator: Marka Crittenden, MD         
Pacific Neurosurgical Active, not recruiting
Portland, Oregon, United States, 97227
United States, Pennsylvania
Lehigh Valley Physician Group-Hematology-Oncology Associates Recruiting
Allentown, Pennsylvania, United States, 18103
Contact: Yasmin O Candelo, RN    610-402-9543   
Contact: Samiyyah Q Whitney, RN    610-402-0546   
Principal Investigator: Suresh Nair, MD         
Temple University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Carol Von Hofen, RN    215-707-4071   
Principal Investigator: Michael W Weaver, MD         
University of Pennsylvania Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Francis Quattrone, BS, CRC    215-615-4590   
Contact: Eileen Maloney, MSN, ACNP-BC    215-662-6462   
Principal Investigator: James Schuster, MD, PhD         
West Penn. Allegheny Health System Recruiting
Pittsburg, Pennsylvania, United States, 15212
Contact: Gloria Flannery, RN    412-359-8379   
Contact: Helen Andreko    412-359-4896   
Principal Investigator: Jane Raymond, MD         
University of Pittsburgh Cancer Institute Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Melinda Vargas-Jaffe, RN    412-235-1320   
Contact: Kelli Davis, RN    412-235-1316   
Principal Investigator: Jan Drappatz, MD         
United States, South Carolina
Medical University of South Carolina - Department of Neuroscience Recruiting
Charleston, South Carolina, United States, 29425
Contact: Michele DeCandio, RN, OCN, CCRP    843-792-9016   
Contact: Bruce Frankel, MD    843-792-1470   
Principal Investigator: Bruce Frankel, MD         
United States, Tennessee
University of Tennessee Medical Center - Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Shanna Overbey, RN    865-305-9773 ext 4   
Contact: Barbara Munsey, BS    865-305-9773 ext 3   
Principal Investigator: Wahid Hanna, MD         
Sarah Cannon Research Institute Recruiting
Nashville, Tennessee, United States, 37203
Contact: Kent Shih, MD    615-329-7274   
Principal Investigator: Kent Shih, MD         
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: VICC-Clinical Trials Information Program    800-811-8480   
Contact: Tanya Davis    615-875-1188   
Principal Investigator: Reid Thompson, MD         
United States, Texas
Texas Oncology Midtwon Recruiting
Austin, Texas, United States, 78705
Contact: Marlena Griffin,, BSc    512-421-4100   
Contact: Deborah Borner, BS    972-490-2961   
Principal Investigator: Morris D Groves, MD         
Baylor Research Institute Recruiting
Dallas, Texas, United States, 75246
Contact: Clinical Oncology Research Coordination    214-818-8472   
Principal Investigator: Karen Fink, MD, PhD         
The Methodist Neurological Institute Recruiting
Houston, Texas, United States, 77030
Contact: Kimbra S Harris, CCRP    713-441-3800   
Principal Investigator: Pamela Z New, MD         
United States, Utah
University of Utah Department of Neurosurgery Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Katy Philips    801-587-4420      
Contact: Aimee Maxwell    801-587-5562      
Principal Investigator: Randy Jensen, MD         
United States, Vermont
Fletcher Allen Health Care Recruiting
Burlington, Vermont, United States, 05405
Contact: Kate Murray, BS    802-656-9401   
Contact: Sam Cory, BS    802-656-9446   
Principal Investigator: Steven Emmons, MD         
United States, Virginia
University of Virginia Healthcare System Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Monika Thielen    434-243-9900   
Contact: Johanna Loomba    434-924-5859   
Principal Investigator: Benjamin Purow, MD         
United States, Washington
Swedish Neuroscience Institute Recruiting
Seattle, Washington, United States, 98122
Contact: Nathan Hansen, BA    206-320-3542   
Contact: Jeannie Steed, BS    206-386-3878   
Principal Investigator: John W Henson, MD FAAN         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: Fereshteh Assadian, RN    206-288-6693   
Contact: Sandra K Johnston, PhD    206-616-7117   
Principal Investigator: Maciej Mrugala, MD         
United States, Wisconsin
University of Wisconsin Paul P Carbone Comprehensive Cancer Center Recruiting
Madison, Wisconsin, United States, 53792
Contact: Ian Robins, MD PhD    608-263-1416   
Contact: Diana Trask, BS    608-263-9528   
Principal Investigator: Ian H Robins, MD         
Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Jennifer Connelly, MD    414-805-5204   
Contact: Barbara Blaney, CCRC    414-805-8328   
Principal Investigator: Jennifer Connelly, MD         
Australia, New South Wales
Prince of Wales Hospital Recruiting
Randwick, New South Wales, Australia, 2031
Contact: Elizabeth Hovey, MSc, MBBS, FRACP    61 2 9382 2956      
Contact: Daisy Buchanan    61 2 9382 2956   
Principal Investigator: Elizabeth Hovey, MSc, MBBS, FRACP         
Royal North Shore Hospital Recruiting
St Leonards, New South Wales, Australia, 2605
Contact: Helen R Wheeler, MBBS FRACP    61 2 94371900   
Principal Investigator: Helen R Wheeler, MBBS FRACP         
The Crown Princess Mary Cancer Centre, Westmead Hospital Recruiting
Westmead, New South Wales, Australia, 2145
Contact: Ka Yeung Mark Wong, MBBS FRACP PhD    61 2 9845 5200   
Contact: Vicky Wegener, M. Hlth Sc    02 9845 8935   
Principal Investigator: Ka Yeung Mark Wong, MBBS FRACP PhD         
Australia, Queensland
Royal Brisbane and Women's Hospital Recruiting
Herston, Queensland, Australia, 4029
Contact: Po-Ling Inglis, BSc, MBBS, FRACP    61 7 3636 7712      
Contact: Annette Cubitt    61 7 3636 7712   
Principal Investigator: Po-Ling Inglis, BSc, MBBS, FRACP         
Mater Adult Hospital, Mater Misericordiae Health Services Brisbane Limited Completed
South Brisbane, Queensland, Australia, 4101
Australia, South Australia
Royal Adelaide Hospital Recruiting
Adelaide, South Australia, Australia, 5000
Contact: Nimit Singhal, MBBS FRACP    61-8-822-4398   
Contact: RAH Clinical Trials   
Principal Investigator: Nimit Singhal, MBBS FRACP         
Calvary North Adelaide Hospital Recruiting
North Adelaide, South Australia, Australia, 5006
Contact: Nancy Olszewski    61 8 8239 9175   
Principal Investigator: William K Patterson, MBBS FRACP         
Australia, Tasmania
Royal Hobart Hospital Recruiting
Hobart, Tasmania, Australia, 7000
Contact: Elizabeth Taylor-Campbell    61-3-6222-7890   
Contact: J         
Principal Investigator: Rosemary A Harrup, MBBS         
Launceston General Hospital Recruiting
Launceston, Tasmania, Australia, 7250
Contact: Stainslaw Gauden, MBBS, FRACP    61 3 6348 7140      
Contact: Angela Neville, BSc, MSci    61 3 6348 7160   
Principal Investigator: Stainslaw Gauden, MBBS, FRACP         
Australia, Victoria
Monash Medical Centre Recruiting
Clayton, Victoria, Australia, 3199
Contact: Jason Derrick Lickliter, MBBS FRACP    61 3 9594 7100   
Contact: Ronnie John Freilich, MBBS FRACP    61 3 9594 2240   
Principal Investigator: Jason Derrick Lickliter, MBBS FRACP         
Austin Health Recruiting
Heidelberg, Victoria, Australia, 3084
Contact: Lawrence M Cher, MBBS    61 3 9625-2323   
Contact: Madeleine A Chow    03 9496 3352   
Principal Investigator: Lawrence M Cher, MBBS         
Epworth Healthcare Recruiting
Richmond, Victoria, Australia, 3121
Contact: Ross R Jennens, MBBS    61-3-9421-6085   
Contact: Felicity C Osmond, RN    61-3-9936-8055   
Principal Investigator: Ross R Jennens, MBBS         
Australia, Western Australia
Sir Charles Gairdner Hospital Recruiting
Nedlands, Western Australia, Australia, 06008
Contact: Gemma Dines, BSc    61 8 9346 3841   
Principal Investigator: Anna Nowak, MBBS FRACP PhD         
Liverpool Hospital Recruiting
Liverpool, Australia, 2107
Contact: Paul Linus de Souza, MBBS FRACP    61 2 9616 4407   
Contact: Jennifer Aung    61 2 9828 5234   
Principal Investigator: Paul Linus de Souza, MBBS FRACP         
Medical University Innsbruck, Dept of Neurology, Anichstrabe 35 Recruiting
Innsbruck, Austria, 6020
Contact: Günther Stockhammer, Ao.Univ.-Prof.Dr.    43 512 504 26310   
Contact: Sarah Iglseder, MD    43 512 504 82958   
Principal Investigator: Günther Stockhammer, Ao.Univ.-Prof.Dr.         
Medizinische Universität Wien, Innere Medizin I, Onkologie Recruiting
Vienna, Austria, 1090
Contact: Christine Marosi, a.o. Univ. Prof. Dr.    4314040044210   
Contact: Judith Stellnberger, MSc    4314040044210   
Principal Investigator: Christine Marosi, a.o.Univ.Prof.Dr         
Universitair Ziekenhuis Antwerpen Recruiting
Edegem, Antwerp, Belgium, 2650
Contact: Iris Verhaegen    32 (0) 3 821 5681   
Contact: Ann Decoene    32 (0) 3 821 4719   
Principal Investigator: Pol Specenier, MD, PhD         
ZNA Middelheim Recruiting
Antwerpen, Belgium, B-2020
Contact: Frank Van Fraeyenhove, Dr    +32 3 280 40 40   
Contact: Anita Boumans    +32 3 280 23 39   
Principal Investigator: Frank Van Fraeyenhove, Dr         
Ghent University Hospital Recruiting
Ghent, Belgium, 9000
Contact: Tom Boterberg, MD    +3293323015   
Principal Investigator: Tom Boterberg, MD         
NEO-Núcleo de Estudos Oncológico Withdrawn
Curitiba, Paraná, Brazil, 80440-210
Hospital Mae de Deus-Centro de Pesquisa em Oncologia Clinica Recruiting
Porto Alegre, Rio Grande do Sul, Brazil, 90840-440
Contact: Fabiana Spillari Viola, MD    55 51 32523930   
Contact: Carmela Nicolini    55 51 32523931   
Principal Investigator: Fabiana Spillari Viola, MD         
Centro de Pesquisas Clinicas da Fundação Dr Amaral Carvalho Terminated
Jaú, São Paulo, Brazil, 17210-120
Fundação Faculdade Regional de Medicina de de São José do Rio Preto - Hospital de Base Recruiting
São José do Rio Preto, São Paulo, Brazil, 15090-000
Contact: Gustavo Colagiovanni Girotto, MD    55-17-81194244   
Contact: Kamylla Caldeira, MD    55-17-32015154   
Principal Investigator: Gustavo Colagiovanni Girotto, MD         
Instituto Nacional do Cancer (INCA) Recruiting
Rio de Janeiro, Brazil, 20231-050
Contact: Clarissa Serôdio da Rocha Baldotto, MD    55 21 3207 6585   
Contact: Débora Cristina Victorino de Azevedo    55 21 3207 6569   
Principal Investigator: Clarissa Serôdio da Rocha Baldotto, MD         
Hospital Albert Einstein Recruiting
Sao Paulo, Brazil, 05652-900
Contact: Suzana Maria F Malheiros, MD    55 11 2151-1127   
Contact: Fernanda Cardoso    55 11 2151 1127   
Principal Investigator: Suzana Maria F Malheiros, MD         
Hospital A C Camargo Recruiting
São Paulo, Brazil, 01509-900
Contact: Ana Carolina Sigolo Levy, MD    55 11 21895178   
Contact: Tatiana Lafuso    55 11 21895178   
Principal Investigator: Ana Carolina Sigolo Levy, MD         
Instituto do Câncer do Estado de São Paulo - ICESP Recruiting
São Paulo, Brazil, 01246-000
Contact: Olavo Feher, MD    55-11-38932619   
Contact: Suleima Hussein Abou Jokh    55 11 38932617   
Principal Investigator: Olavo Feher, MD         
Real e Benemerita Associação Portuguesa de Beneficiência/ Hospital São José Recruiting
São Paulo, Brazil, 01321-001
Contact: Marcos André de Sá Barreto Costa, MD    55 11 3505 6693   
Contact: Leticia Lucchesi    55 11 3505 6693   
Principal Investigator: Marcos André de Sá Barreto Costa, MD         
Canada, Alberta
Foothills Hospital Medical Centre Recruiting
Calgary, Alberta, Canada, T3J 5N6
Contact: Ish Bains    403-944-4334   
Contact: Mark Hamilton, MD    403-944-1626   
Principal Investigator: Mark Hamilton, MD         
Canada, British Columbia
British Columbia Cancer Agency, Vancouver Clinic Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Shane Brown    604-877-6000 ext 2370   
Contact: Brian Thiessen, MD    604-877-6000 ext 2032   
Principal Investigator: Brian Thiessen, MD         
BC Cancer Agency - Vancouver Island Centre Recruiting
Victoria, British Columbia, Canada, V8X 4V6
Contact: John P McGhie, MD    250-519-5580   
Contact: Katalin Todor    250-519-5500   
Principal Investigator: John P McGhie, MD         
Canada, Manitoba
University of Manitoba-Cancer Care Manitoba Recruiting
Winnipeg, Manitoba, Canada, R3E0V9
Contact: Marshall Pitz, MD, FRCPC    204-787-2108   
Principal Investigator: Marshall Pitz, MD, FRCPC         
Canada, Nova Scotia
QEII Health Sciences Centre Recruiting
Halifax, Nova Scotia, Canada, B3H 1V7
Contact: Sharon Hebb    902-473-2161   
Principal Investigator: Mary MacNeil, MD         
Canada, Ontario
Juravinski Cancer Centre Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Lisa Rudd-Scott, RN, BScN MN    905-387-9711 ext 64407   
Contact: Theresa Stokes, RN    905-387-9711 ext 64420   
Principal Investigator: Hal Hirte, MD         
London Regional Cancer Program, London Health Sciences Centre Recruiting
London, Ontario, Canada, N6A 4L6
Contact: David R Macdonald, MD   
Principal Investigator: David Macdonald, MD         
Ottawa Hospital, Regional Cancer Centre Recruiting
Ottawa, Ontario, Canada, K1H 8L6
Contact: Roxanne Ward    613-737-7700 ext 73328   
Contact: Sharon Kelly    613-737-7700 ext 75212   
Principal Investigator: Garth Nicholas, MD         
Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N3M5
Contact: Hyla Okorofsky, RN    416-480-5000 ext 7474   
Principal Investigator: James Perry, MD         
Canada, Quebec
Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Karl Belanger, MD    514-890-8000 ext 25381   
Contact: Francine Richard    514-890-8000 ext 24853   
Principal Investigator: Karl Belanger, MD         
Montreal Neurological Institute and Hospital Recruiting
Montreal, Quebec, Canada, H3A 2B4
Contact: Marc Lemieux    514-398-2667   
Contact: Lisa Nezvitski    514-398-2801   
Principal Investigator: Petr Kavan, MD         
CHUS Hôpital Fleurimont Recruiting
Shenbrooke, Quebec, Canada, J1H5N4
Contact: David Mathieu, MD    819-346-1110 ext 14887      
Contact: Anick Champoux, RN    819-346-1110 ext 12811      
Principal Investigator: David Mathieu, MD         
CHUQ L'Hotel Dieu de Qujebec Recruiting
Quebec, Canada, G1R 2J6
Contact: Josee Allard    418-691-5264   
Contact: Isabelle Desrosiers    418-525-4444 ext 21679   
Principal Investigator: Nathalie Lessard, MD         
Fundacion Santa Fe Recruiting
Bogota, Bogota D.C, Colombia, 000
Contact: Martha L Celis Herrans    +57-3123722226   
Contact: Andres F Cardona, MD    +57-301 634-8173   
Principal Investigator: Andres Felipe Cardona, MD         
Clinica del Country Withdrawn
Bogota D.C., Colombia
Czech Republic
Hospital Ceske Budejovice Recruiting
Ceske Budejovice, Czech Republic, 370 01
Contact: Petr Vitek, MD    00420 387 875 001   
Contact: Jiri Fiedler, MD    00420 387 876 001   
Principal Investigator: Petr Vitek, MD         
Hospital Na Homolce Recruiting
Prague, Czech Republic, 150 30
Contact: Jan Sroubek, MD    00420 257 273 091   
Contact: Josef Kasik, MD    00420 257 273 091   
Principal Investigator: Jan Sroubek, MD         
Umiversity Hospital (Fakultni Nemocnice) Recruiting
Prague, Czech Republic, 150 06
Contact: Bela Malinova, MD    00420 224 434 764   
Contact: Gabriela Kasacova, MD    00420 224 434 764   
Principal Investigator: Bela Malinova, MD         
Multiscan s.r.o. Recruiting
Praha 5, Czech Republic, 155-00
Contact: Karel Odrazka, MD, PhD    00420 466 016 413   
Contact: Barbora Simkova    00420 466 616 261   
Principal Investigator: Karel Odrazka, MD, PhD         
Masaryk´s Hospital Usti nad Labem Recruiting
Usti nad Labem, Czech Republic, 401-13
Contact: Martin Sames, MD, PhD    00420 477 112 871    Martin.Sames@KZCR.EU   
Contact: Robert Bartos    00420 775 611 215   
Principal Investigator: Martin Sames, MD, PhD         
Institut de Cancerologie de I'Quest-Paul Papin Recruiting
Angers, France, 49933
Contact: Patrick Soulie, MD    +33 2 41 35 27 00   
Contact: Marie Celine Namour    +33 2 41 35 27 00 ext 4028   
Principal Investigator: Patrick Soulie, MD         
Institute Bergonie Recruiting
Bordeaux, France, 33076
Contact: Guy Kantor, MD    33 556333333   
Contact: Leslie Ardilouze    33 556337883   
Principal Investigator: Guy Kantor, MD         
Centre Leon Berard de Lyon Recruiting
Lyon, France, 69373
Contact: Didier Frappaz, MD    00 33478782881   
Contact: Yves Deveaux    00 33478782871   
Principal Investigator: Didier Frappaz, MD         
ICM Val d'Aurel Montpellier Recruiting
Montpellier, France, 342298
Contact: Michel Fabbro, MD    +33 467613042   
Contact: Christine Gestin-Boyer    +33 467612515   
Principal Investigator: Michel Fabbro, MD         
Institut de Cancerologie de L'Quest-Center Rane Gauducheau Recruiting
Nantes, France, 44805
Contact: Mario Campone, MD    +33 2 40 679 977   
Contact: Carole Gourmelon, MD    +33 2 40 679 960   
Principal Investigator: Mario Campone, MD         
Service de Neurologie-GH Recruiting
Paris, France, 75013
Contact: Ahmed Idbaih, MD    00 33 1 42 16 04 31   
Contact: Nabila Rousseaux    00 33 1 42 16 04 31   
Principal Investigator: Ahmed Idbaih, MD         
Centre Eugene Marquis Recruiting
Rennes, France, 35042
Contact: Elodie Vauleon, MD    00 33 2 99 25 32 26   
Contact: Christophe Perrin, MD    00 33 2 99 25 32 93   
Principal Investigator: Elodie Vauleon, MD         
Institut de Cancerologie de l'ouest-Center Rene Gauducheau Recruiting
St Herblain, France, 44805
Contact: Jean S Frenel, MD    00 33 2 40 67 99 00   
Contact: Marlo Campone, PhD    00 33 2 40 67 99 77   
Principal Investigator: Jean S Frenel, MD         
Institut Gustave Roussy Recruiting
Villejuif, France, 94805
Contact: Julien Domont, MD    00 33 1 42 11 43 16   
Contact: Dhermain Frederic, MD    00 33 1 42 11 62 20   
Principal Investigator: Julien Domont, MD         
Klinik und Poliklinik fur Neurologie der Universitat Regensburg Recruiting
Regensburg, Bavaria, Germany, 93053
Contact: Peter Hau, Prof. Dr.    ++49(0)9419418464   
Contact: Martin Uhl, Dr    ++49(0)9419410   
Principal Investigator: Peter Hau, Prof. Dr.         
Strahlenklinik Universitatsklinikum Erlangen Recruiting
Erlangen, Germany, D-91054
Contact: Dorota Lubgan, PhD.    +49-(0)9131-85-44254   
Contact: Sabine Semrau, Dr. med.    +49-(0)9131-85-44254   
Principal Investigator: Rainer Fietkau, Prof. Dr. med.         
Dr. Senchkenbergisches Institut fur Neuroonkologie Recruiting
Frankfurt, Germany, D-60528
Contact: Joachim P Steinbach, Prof Dr. Med    49(0)69 6301 87710   
Contact: Oliver Baehr, Dr. Med    +49 (0)69 6301 87710   
Principal Investigator: Joachim P Steinbach, Prof Dr. Med         
University Hospital Hamburg Kopf und Neurozentrum Recruiting
Hamburg, Germany, 20246
Contact: Manfred Westphal, MD    0049/40 7410 53750   
Contact: Nils O Schmidt, MD    0049/40 7410 22421   
Principal Investigator: Manfred Westphal, MD         
Universitaetsklinikum Heidelberg, Neurologische Klinik, IM Neuenheimer Feld 672 Not yet recruiting
Heidelberg, Germany, 69120
Contact: Wolfgang Wick, Prof. MD    +0049 6221 56 7075   
Contact: Antje Wick, Dr.    +0049 6221 56 7484   
Principal Investigator: Wolfgang Wick, Prof. Dr.         
University Medical Centre Recruiting
Kiel, Germany, 24105
Contact: Brigitte Hirschhausen    +49 431 597 8807 ext 4907   
Contact: Nils Warneke, MD    +49 431 597 8807 ext 8550   
Principal Investigator: Maximilian Mehdorn, MD         
Universitaetsklinikum Muenster Recruiting
Muenster, Germany, 48149
Contact: Oliver Grauer, MD PhD    0049 251 83 46814   
Contact: Johannes Wolfer, MD    0049 251 83 43236   
Principal Investigator: Oliver Grauer, MD PhD         
LMU Munich Recruiting
Munich, Germany, D-81377
Contact: Oliver Schnell, Dr    +49 (0)89 7095-0   
Contact: Christoph Barth    +49(0)89 7095-3548/6548   
Principal Investigator: Oliver Schnell, Dr         
NNA Recruiting
Athens, Attiki, Greece, 11521
Contact: Panagiotis Papadopoulos, MD, PhD    +302107261374   
Principal Investigator: Panagiotis Papadopoulos, MD, PhD         
"HYGEIA" Hospital Recruiting
Marousi, District of Attica, Greece, 151 23
Contact: Evangelia Razi, MD, PhD    30 210 6867165   
Contact: Theodoros Poufos    306932713266   
Principal Investigator: Evangelia Razi, MD, PhD         
Országos Onkológiai Intézet Sugárterápiás Osztály Recruiting
Budapest, Hungary, 1122
Contact: József Lövey, MD, Prof    +36 20 455 3579   
Contact: Ágnes SC Sarai    +36 70 255 9869   
Principal Investigator: József Lövey, MD. Prof         
Debreceni Egyetem Orvos- és Egészségtudományi Centrum Onkológiai Intézet Recruiting
Debrecen, Hungary, 4032
Contact: Zsolt Horvath, Prof. Dr    3606304913443   
Contact: Angéla Tóth    36 30 240 8966   
Principal Investigator: Zsolt Horvath, Dr         
Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Sugárterápiás Osztály Recruiting
Miskolc, Hungary, 3526
Contact: Katalin Molnár, Dr    36 30 203 2489   
Contact: Jolan Fodor    36 30 222 5287   
Principal Investigator: Katalin Molnár, MD         
Pécsi Tudományegyetem Általános Orvostudományi Kar Recruiting
Pécs, Hungary, 7624
Contact: László Mangel, MD    +36 30 245 7110   
Contact: Judit Kalincsak, MD    +36 30 987 2059   
Principal Investigator: László Mangel, MD         
Szegedi Tudományegyetem Onkoterápiás Klinika Recruiting
Szeged, Hungary, 6720
Contact: Katalin Hideghéty    36 30 292 1638   
Contact: Agnes Dobi, MD    36 30 527 7025   
Principal Investigator: Katalin Hideghéty, MD, PhD         
Vas Megyei Markusovszky Lajos Általános Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktatókórház Nonprofit Zrt Recruiting
Szombathely, Hungary, 9700
Contact: Miklós Wenczl, MD    +36 30 600 3359   
Contact: Gergő Padányi, MD    +36 20 392 8442   
Principal Investigator: Miklós Wenczl, MD         
City Cancer Centre, Vijayawada Terminated
Vijayawada, Andhra Pradesh, India, 520002
HCG - Bangalore Institute of Oncology, Bangalore Active, not recruiting
Bengaluru, Karnataka, India, 560027
Amrita Institute of Medical Sciences and Research Centre, Kochi Terminated
Kochi, Kerala, India, 682 026
Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram Terminated
Thiruvananthapuram, Kerala, India, 695 011
Marathwada Regional Cancer Centre and Research Institute - Government Terminated
Aurangabad, Maharashtra, India, 431001
Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute Terminated
Andheri-West, Mumbai, India, 400 053
Tata Memorial Hospital , Mumbai Terminated
Parel, Mumbai, India, 400012
Indraprastha Apollo Hospital, New Delhi Terminated
Jasola Viha, New Delhi, India, 110076
Sahyadri Hospitals Limited Active, not recruiting
Erandauame, Pune, India, 411004
Dr. Rai Memorial Medical Centre, Chennai Terminated
Chennai, Tamil Nadu, India, 600018
HCG Shanti Mukand Hospital - Curie Cancer Centre, Delhi Terminated
Delhi, India, 110092
Soroka University M.C. Recruiting
Beer-Sheva, Israel, 84101
Contact: Konstantin Lavrenkov, Dr    +972 (0) 86244127   
Contact: Nataly Israeli    +972 (0) 547377077   
Principal Investigator: Konstantin Lavrenkov, Dr         
Rambam Health Care Campus Recruiting
Haifa, Israel, 3109601
Contact: Tzahala Tzuk Shina, Dr    +972-4-8543022   
Contact: Marina Hefetz    +972-4-8542811   
Principal Investigator: Tzahala Tzuk Shina, Dr         
Hadassah Medical Center Recruiting
Jerusalem, Israel, 91120
Contact: Alexander Lossos, MD    +972-50-8946874   
Contact: Edward Linetsky, MD    +972-50-7874581   
Principal Investigator: Alexander Lossos, MD         
SHEBA Medical Center Recruiting
Tel Hashomer, Israel, 52126
Contact: Leor Zach, MD    972-3-530-8402   
Contact: Ayelet Huri    972-3-530-7033   
Principal Investigator: Leor Zach, MD         
Tel-Aviv Sourasky Medical Center Recruiting
Tel-Aviv, Israel, 64239
Contact: Deborah T Blumenthal, MD    +972 3 6974273   
Contact: Noa Nunberg    972 3 6973105   
Principal Investigator: Deborah T Blumenthal, MD         
UO Oncologie Medica Dipartimento Oncologico Recruiting
Bologna, Italy, 40139
Contact: Alba Brandes, MD    +390516225697   
Contact: Enrico Franceschi, MD    +390516225796   
Principal Investigator: Alba Brandes, MD         
Fondazione IRCCS Instituto Neurologico Carlo Besta Recruiting
Milano, Italy, 20133
Contact: Gaetano Finocchiaro, MD    +39 02 23942454   
Contact: Marica Eoli, MD    +39 02 23942285   
Principal Investigator: Gaetano Finocchiaro, MD         
Sacred Heart Catholic University Recruiting
Rome, Italy, 00168
Contact: Silvia Chiesa, MD    +39 33 84 35 7241   
Contact: Mario Balducci, MD    +39 33 84 35 4743   
Principal Investigator: Mario Balducci, MD         
Universita e AO Citta delia Scienza, Universita Di Torino Recruiting
Torino, Italy, 10126
Contact: Riccardo Soffietti, MD    +39 011 633 4904   
Contact: Roberta Ruda, MD    +39 011 633 4904   
Principal Investigator: Riccardo Soffietti, MD         
Grupo Médico Camino S.C. Recruiting
Mexico, D.F, Mexico, 03310
Contact: Freddy Guillermo Castro Farfán, MD    52 (55) 4168 9873   
Principal Investigator: Freddy Guillermo Castro Farfán, MD         
Hospital Civil de Guadalajara "Fray Antonio Alcalde" Recruiting
Guadalajara, Jalisco, Mexico, 34000
Contact: Francisco Javier Ramírez Godínez,, MD    52 33 36 140482   
Principal Investigator: Francisco Javier Ramírez Godínez,, MD         
Ensayos Clínicos y Medicina de Alta Especialidad, S.C. Recruiting
Culiacán, Sinaloa, Mexico, 80020
Contact: José Ángel Félix Torrontegui, MD    52 667 758 7952   
Contact: Elmer Lopez Meza    52 1 667 189 0432   
Principal Investigator: José Ángel Félix Torrontegui, MD         
Servicios Medicos de Investigacion Clinica Sc Recruiting
Durango, Mexico, 34000
Contact: Jesús López Hernández,, MD    52 618 1858977   
Contact: Monica Montaño Alva    52 618 1858970   
Principal Investigator: Jesús López Hernández, MD         
Hospital Central "Ignacio Morones Prieto" Recruiting
San Luis Potosí, Mexico, 78240
Contact: Ildefonso Rodríguez Leyva, MD    52 444 817 6692   
Contact: Rocio Rodríguez Leyva, MD    52 1 4442043616   
Principal Investigator: Ildefonso Rodríguez Leyva, MD         
Medisch Centrum Haaglanden Recruiting
The Hague, Zuid Holland, Netherlands, 2512 VA
Contact: Maaike J Vos, MD    +31 7033 02 508   
Contact: Ellen Gortmaker    +31 7033 02 183   
Principal Investigator: Maaike Vos, MD         
VUMC Recruiting
Amsterdam, Netherlands, 1081HV
Contact: Myra van Linde, MD    +31 (0) 20 4444 321   
Principal Investigator: Myra van Linde, MD         
Radboud University Nijmegen Medical Center Recruiting
Nijmegen, Netherlands, 6525 GA
Contact: Sasja Mulder, MD    +31 24 3655388   
Contact: Johanna Gijtenbeek, MD, PhD.    +31 24 3616600   
Principal Investigator: Sasja Mulder, MD         
New Zealand
Christchurch Hospital Recruiting
Christchurch Central, Christchurch, New Zealand, 8011
Contact: Bridget A Robinson, BMed Sci MBChB FRACP    64-3-394-0020   
Contact: Anne Smith, BA, RN    64-3-364-0368   
Principal Investigator: Bridget A Robinson, BMed Sci MBChB FRACP         
Palmerston North Hospital Recruiting
Roslyn, Palmerston North, New Zealand, 4414
Contact: Alice Mazengarb    64 6350 8099   
Contact: Susan Newlands         
Principal Investigator: Claire Hardie, BSc (Hons) MBChB MRCP FRCR         
Waikato Hospital, Regional Cancer Centre Recruiting
Hamilton, Waikato District, New Zealand, 3240
Contact: Michael R Tills, MBChB DRACR    64-7-839-8976   
Contact: Jenny Boyd, RN    64-7-839-8976      
Principal Investigator: Michael Tills, MBChB DRACR         
Waikato Hospital, Regional Cancer Center Recruiting
Hamilton, Waikato Distric, New Zealand, 3240
Contact: Jenny Boyd    64-7-839-8976   
Principal Investigator: Ziad Thotathil, MBChB, DRACR         
Hospital Almanzor Aguinaga Asenjo Recruiting
Chiclayo, Peru
Contact: Rodrigo Auqui, MD    (+51) 979-928-159   
Principal Investigator: Rodrigo Auqui, MD         
Instituto Oncologico Miraflores Recruiting
Lima, Peru, Lima 18
Contact: PEDRO RIOS    (51) 990899299   
Principal Investigator: Fernando Salas, MD         
Oncosalud Recruiting
Lima, Peru, Lima 41
Contact: Carlos O Munive, MD    (+51) 964-646451   
Principal Investigator: Carlos O Munive, MD         
Clinica Ricardo Palma Recruiting
Lima, Peru, Lima 27
Contact: Wuilbert Rodriguez, MD    (+51) 993-513-544   
Principal Investigator: Wuilbert Rodriguez, MD         
Clinica Anglo Americana Recruiting
Lima, Peru, Lima 27
Contact: Claudia Lozada, MD    (+51) 997-921-444   
Principal Investigator: Claudia Lozada, MD         
Institut Catala d Oncologia Recruiting
LaHospitalet de Lubregat, Catalonia, Spain, 08908
Contact: Miguel Gil-Gil, MD    +34 93 260 7744   
Contact: Carlos Mesia-Barroso    +34 93 260 7744   
Principal Investigator: Manuel Gil-Gil, MD         
Dra. Sonia Del Barco Berron, ICO Girona Avda, Recruiting
Franca, Girona, Spain, 17007
Contact: Sonia Del Barco Berron, MD    972225834   
Contact: Begona M Castillo    972225828   
Principal Investigator: Sonia Del Barco Berron, MD         
Hospital Clinic Recruiting
Barcelona, Spain, 8036
Contact: Estela Pineda, MD    +93 2275402   
Contact: Teresa Vilelle    +93 2275400 ext 2811      
Principal Investigator: Estela Pineda, MD         
ICO Badalona-Hospital Germans Trias i Pujol Recruiting
Barcelonia, Spain, 08916
Contact: Carmen Balana, MD    +34 93 497 89 24/5   
Principal Investigator: Carmen Balana, MD         
Hospital 12 de Octubre Recruiting
Madrid, Spain, 28041
Contact: Juan Manuel Sepulveda Sanchez, Dr    +34913908003   
Contact: Jessica Gonzalez    +34913908339      
Principal Investigator: Juan Manuel Sepulveda Sanchez, Dr         
Kantonsspital Aarau Medizinische Onkologie Tellstrasse Recruiting
Aarau, AG, Switzerland, 5001
Contact: Christoph Mamot, MD    ++41 62 838 60 53   
Contact: Moosmann Peter, MD    ++41 62 838 60 53   
Principal Investigator: Christoph Mamot, MD         
CHUV, Centre Hospitalier Universitaire Vaudois Recruiting
Lausanne, VD, Switzerland, 1011
Contact: Andreas F Hottinger, MD, PhD    +41 21 314 0168   
Contact: Krisztian Homicsko, MD, PhD    +41 21 3140155   
Principal Investigator: Andreas F Hottinger, MD, PhD         
Oncology Institute of Southern Switzerland (IOSI) Recruiting
Bellinzona, Switzerland, 6500
Contact: Jolanda de Jong, SRn    +41 91 811 8945   
Contact: Gianfranco Pesce, MD    +41 91 811 8673   
Principal Investigator: Gianfranco Pesce, MD         
Inselspital, Universitatsspital Bern, Universitatsklinik fur Medizinische Onkologie, Freiburgstrasse Recruiting
Bern, Switzerland, 3010
Contact: Andrea Schmid, MD    +41 31 632 41 15   
Contact: Martin Dave Berger, MD    +41 31 632 41 15   
Principal Investigator: Andrea Schmid, MD         
Hopitaux Universitaires de Geneve-HUG-Centre d'Oncologie Recruiting
Geneva, Switzerland, 1211
Contact: Pierre-Yves Dietrich, MD, PhD.    +41 22 372 32 70   
Contact: Denis Migliorini, MD    +41 79 553 44 17   
Principal Investigator: Pierre-Yves Dietrich, MD, PhD.         
Brain Tumor Center, University Hospital Zurich Recruiting
Zurich, Switzerland, 8091
Contact: Michael Weller, MD    +41 44 2555500   
Contact: Patrick Roth, MD    +41 44 25551111   
Principal Investigator: Michael Weller, MD         
National Cheng Kung University Hospital Recruiting
Tainan City, Bei District, Taiwan, 704
Contact: E-Jian Lee, M.D. PhD    886- 6-2353535 ext 5204   
Principal Investigator: E-Jian Lee, M.D. PhD         
Kaohsiung Chang Gung Memorial Hospital Recruiting
Kaohsiung, Taiwan, 83301
Contact: Jih-Tsun Ho, MD    886- 7-731-7123 ext 8011   
Principal Investigator: Jih-Tsun Ho, MD         
Chang Gung Memorial Hospital Linkou Branch Recruiting
Taichung, Taiwan, 40705
Contact: Cheng-Neng Chang, MD    886- 3-328-1200   
Contact: Pei-Ru Chung    886-910-385-772   
Principal Investigator: Cheng-Neng Chang, MD         
Taichung Veterans General Hospital Recruiting
Taichung, Taiwan, 40705
Contact: Wen-Yu Cheng, MD    886- 4-2359-2525 ext 5081   
Principal Investigator: Wen-Yu Cheng         
Chi Mei Medical Center Recruiting
Tainan City - Yongkang District, Taiwan, 710
Contact: Chin-Hong Chang, MD    886 6-2812811 ext 57112   
Principal Investigator: Chang Chin-Hong         
Tri-Service General Hospital Recruiting
Taipei city - Neihu District, Taiwan, 00114
Contact: Hsin-I Ma, MD, PhD    886- 2-87927177   
Principal Investigator: Hsin-I Ma         
National Taiwan University Hospital Withdrawn
Taipei City - Zhongzheng Dist, Taiwan, 00100
Siriraj Hospital Recruiting
Bangkoknoi, Bangkok, Thailand, 10700
Contact: Sith Sathornsumetee, MD    66 81 812 7830   
Contact: Montira Engchuan    66 81 7210116   
Principal Investigator: Sith Sathornsumetee, MD         
King Chulalongkorn Memorial Hospital Recruiting
Patumwan, Bankok, Thailand, 10330
Contact: Iyavut Thaipisuttikul, MD    66 81 938 7087   
Contact: Jeeratheep Laporn    66 86 887 5599   
Principal Investigator: Iyavut Thaipisuttikul, MD         
Maharaj Nakorn Chiang Mai Hospital Recruiting
Amphoe Muang, Chiang Mai, Thailand, 50200
Contact: Kanokwan Watcharasaksilp, MD    66 816 811 910   
Contact: Karaket Sukchanchai    66 86 198 9939   
Principal Investigator: Kanokwan Watcharasaksilp, MD         
Songkhlanagarind Hospital Recruiting
Hat Yai, Songkla, Thailand, 90110
Contact: Arunee Dechaphunkul, MD    66 81 535 4282   
Contact: Jakkaphan Rattanaphan    669 4421 6142   
Principal Investigator: Arunee Dechaphunkul, MD         
United Kingdom
Royal Marsden NHS Foundation Trust Recruiting
Sutton, Surrey, United Kingdom, SM2 5PT
Contact: Kathy Greenwood    0208-661-3300   
Contact: Dana Plumer    0208-661-3877   
Principal Investigator: Frank Saran, MD, FRCR         
The Bristol Haematology and Oncology Centre Recruiting
Bristol, United Kingdom, BS2 8ED
Contact: Kirsten Hopkins, MD    44 0117 342 3008   
Principal Investigator: Kirsten Hopkins, MD         
Edinburgh Cancer Centre Western General Hospital Recruiting
Edinburgh, United Kingdom, EH4 2XU
Contact: Sara Erridge, Dr.    +44 (0) 131 537 1052   
Principal Investigator: Sara Erridge, Dr         
Beatson West of Scotland Cancer Centrel Terminated
Glasgow, United Kingdom, G12 0NY
Guy's and St Thomas' NHS, Westminister Bridge Road Recruiting
London, United Kingdom, SE17EH
Contact: Kelly Radford, RN    020 7188 2020   
Contact: Harriet Jones    0207188 7188   
Principal Investigator: Ronald Beaney, MD         
Nottingham City Hospital Recruiting
Nottingham, United Kingdom, NG5 1PB
Contact: Karen Foweraker, Dr    +44 0115969 1169   
Contact: Leanne Alder    +44 0115 969 1169   
Sponsors and Collaborators
Celldex Therapeutics
  More Information

Additional Information:
No publications provided

Responsible Party: Celldex Therapeutics Identifier: NCT01480479     History of Changes
Other Study ID Numbers: CDX110-04
Study First Received: November 21, 2011
Last Updated: August 6, 2014
Health Authority: United States: Food and Drug Administration
United States: Institutional Review Board

Keywords provided by Celldex Therapeutics:
Small cell
Giant cell
Brain Cancer
Brain Tumor
EGFR variant III

Additional relevant MeSH terms:
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Antineoplastic Agents
Therapeutic Uses processed this record on September 18, 2014