Trial record 1 of 1 for:    RTOG 1005
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Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery

This study is currently recruiting participants.
Verified December 2013 by Radiation Therapy Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT01349322
First received: May 5, 2011
Last updated: December 19, 2013
Last verified: December 2013
  Purpose

RATIONALE: It is not yet know whether higher per daily radiation therapy is equally as effective as standard per daily radiation therapy in treating breast cancer.

PURPOSE: This randomized phase III trial studies how well an accelerated course of higher per daily radiation therapy with concomitant boost works compared to standard per daily radiation therapy with a sequential boost in treating patients with early-stage breast cancer that was removed by surgery.


Condition Intervention Phase
Breast Cancer
Radiation: Whole breast irradiation delivered by 3-dimensional conformal radiation therapy or intensity modulated radiation therapy
Radiation: Higher per daily radiation therapy
Radiation: Concurrent boost radiotherapy
Radiation: Standard per daily radiation therapy
Radiation: Sequential boost radiotherapy
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Trial of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer

Resource links provided by NLM:


Further study details as provided by Radiation Therapy Oncology Group:

Primary Outcome Measures:
  • Local control [ Time Frame: From randomization to the date of first local failure or last follow-up. Analysis occurs after 245 local failures have been reported. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Overall survival [ Time Frame: From randomization to date of death due to any cause or last follow-up. ] [ Designated as safety issue: No ]
  • Disease-free survival [ Time Frame: From randomization to date of local-regional disease recurrence, distant metastases, second primary, death due to any cause or last follow-up. ] [ Designated as safety issue: No ]
  • Distant disease-free survival [ Time Frame: From randomization to date of distant metastases, second primary, death due to any cause or last follow-up. ] [ Designated as safety issue: No ]
  • Changes in breast-related symptoms and side effects and cosmesis [ Time Frame: From randomization to three years. ] [ Designated as safety issue: No ]
  • Correlation between dose-volume data and both adverse events and efficacy [ Time Frame: From randomization to end of follow-up. ] [ Designated as safety issue: No ]
  • Treatment cost of accelerated course of hypofractionated WBI versus standard WBI with a sequential boost [ Time Frame: From randomization to end of treatment. ] [ Designated as safety issue: No ]

Estimated Enrollment: 2312
Study Start Date: May 2011
Estimated Primary Completion Date: August 2020 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm I
Patients undergo standard whole-breast radiotherapy (WBI) comprising intensity-modulated radiation therapy (IMRT) or three-dimensional conformal radiotherapy (3D-CRT) 5 days a week for 3-5 weeks followed by a sequential radiotherapy boost to the lumpectomy area 5 days a week for 1-1½ weeks in the absence of disease progression or unacceptable toxicity.
Radiation: Whole breast irradiation delivered by 3-dimensional conformal radiation therapy or intensity modulated radiation therapy
Patients undergo whole breast radiotherapy by 3D-CRT or IMRT
Radiation: Standard per daily radiation therapy
Patients undergo standard per daily radiation therapy
Radiation: Sequential boost radiotherapy
Patients undergo sequential boost radiotherapy
Experimental: Arm II
Patients undergo accelerated hypofractionated WBI comprising IMRT or 3D-CRT with a concurrent boost to the lumpectomy area 5 days a week for 3 weeks in the absence of disease progression or unacceptable toxicity.
Radiation: Whole breast irradiation delivered by 3-dimensional conformal radiation therapy or intensity modulated radiation therapy
Patients undergo whole breast radiotherapy by 3D-CRT or IMRT
Radiation: Higher per daily radiation therapy
Patients undergo higher per daily radiation therapy
Radiation: Concurrent boost radiotherapy
Patients undergo concurrent boost radiotherapy

Detailed Description:

OBJECTIVES:

Primary

  • To determine whether an accelerated course of hypofractionated whole-breast irradiation (WBI) including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be non-inferior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients.

Secondary

  • To determine whether breast-related symptoms and cosmesis from accelerated WBI that is hypofractionated (in only 3 weeks) with a concomitant boost is non-inferior to standard WBI with sequential boost.
  • To determine whether the risk of late cardiac toxicity in patients with left-sided breast cancer treated with hypofractionation will be non-inferior to conventional fractionated radiation therapy (RT) based upon analysis of radiation dosimetry from CT-based treatment planning and NTCP calculations.
  • To determine whether CT-based conformal methods intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) for WBI are feasible in a multi-institutional setting following lumpectomy in early-stage breast cancer patients and whether dose-volume analyses can be established to assess treatment adequacy and likelihood of toxicity.
  • To determine that cosmetic results and breast-related symptoms 3 years after hypofractionated breast radiation with concomitant boost will not be inferior to that obtained 3 years after WBI with sequential boost.
  • To determine whether future correlative studies can identify individual gene expressions and biological host factors associated with toxicity and/or local recurrence from standard and hypofractionated WBI.
  • If shown to be non-inferior, to then determine if accelerated course of hypofractionated WBI including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be superior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients.
  • To determine whether treatment costs for hypofractionated WBI with concomitant boost are not higher than WBI with sequential boost.

OUTLINE: This is a multicenter study. Patients are stratified according to age (< 50 vs. ≥ 50 years), prior chemotherapy (yes vs. no), estrogen-receptor status (+ vs. -), and histology grade (1-2 vs. 3). Patients are randomized to 1 of 2 treatment arms. Treatment begins within 9 weeks of last surgery or chemotherapy delivery.

  • Arm I: Patients undergo standard whole-breast radiotherapy (WBI) comprising intensity-modulated radiation therapy (IMRT) or three-dimensional conformal radiotherapy (3D-CRT) 5 days a week for 3-5 weeks followed by a sequential radiotherapy boost to the lumpectomy area 5 days a week for 1-1½ weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.
  • Arm II: Patients undergo accelerated hypofractionated WBI comprising IMRT or 3D-CRT with a concurrent boost to the lumpectomy area 5 days a week for 3 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.

Patients' tissue samples may be collected for future research studies.

After completion of study therapy, patients are followed at 1 month, at 6 months, and then yearly.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Pathologically proven diagnosis of breast cancer resected by lumpectomy and whole-breast irradiation (WBI) with boost without regional nodal irradiation planned
  • Must meet one of the following three criteria:

    • pStage I or II breast cancer AND at least one of the following:

      • Age < 50 years or
      • Positive axillary nodes or
      • Lymphovascular space invasion (LVI) or
      • At least 2 close resection margins (> 0 mm to ≤ 2 mm) or
      • One close resection margin and extensive in-situ component (EIC) or
      • Focally positive resection margins or
      • Non-hormone-sensitive breast cancer (estrogen and progesterone receptor negative (ER- and PR-) or
      • Grade III histology or
      • Oncotype recurrence score > 25 or
    • pStage 0 breast cancer with nuclear grade 3 ductal carcinoma in situ (DCIS) and patient age < 50 years or
  • If multifocal breast cancer, then it must have been resected through a single lumpectomy incision with negative margins
  • Breast-conserving surgery with margins defined as follows:

    • Negative margins defined as no tumor at the resected specimen edge
    • Close resection margins > 0 mm to ≤ 2 mm as follows:

      • One close resection margin and EIC
      • Two or more close resection margins
    • A focally positive resection margin
  • Allowable options for mandatory axillary staging include:

    • Sentinel node biopsy alone (if sentinel node is negative, pN0, pN0[IHC-,+])
    • Sentinel node biopsy alone, OR followed by axillary node dissection, for clinically node-negative patients as described below:

      • Microscopic sentinel node (SN) positive (pN1mic)
      • One or two SNs positive (pN1) without extracapsular extension
      • Negative SN biopsy after neoadjuvant chemotherapy
    • Axillary node dissection is required following SN biopsy with a minimum total of 6 axillary nodes if any of the following exist:

      • For > 2 positive SN
      • Any positive SN biopsy after neoadjuvant chemotherapy
      • For clinically (by either imaging or examination) T3 disease
      • For extracapsular extension
    • Axillary dissection alone (with a minimum of 6 axillary nodes)
  • CT-imaging of the ipsilateral breast within 28 days of study entry for the radiation treatment planning.

    • Must be able to delineate on CT scan the extent of the target lumpectomy cavity for boost (placement of surgical clips to assist in treatment planning of the boost is strongly recommended)
  • No clinical evidence for distant metastases, based upon the following minimum diagnostic workup:

    • History/physical examination, including breast exam (inspection and palpation of the breasts) and documentation of weight and Zubrod Performance Status of 0-2 within 28 days prior to study entry
    • A mammogram of both right and left breast within only 1 time point of 90 days of the diagnostic biopsy establishing the diagnosis
  • No prior invasive or in-situ carcinoma of the breast (prior LCIS is eligible)
  • No American Joint Committee on Cancer (AJCC) pathologic T4, N2 or N3, or M1 breast cancer
  • Must not have two or more breast cancers that are not resectable through a single lumpectomy incision
  • Must not be DCIS and ≥ 50 years old
  • Must not be DCIS only (without an invasive component), nuclear grade 1 or 2 and < 50 years old
  • No suspicious unresected microcalcification, densities, or palpable abnormalities (in the ipsilateral or contralateral breast) unless biopsied and found to be benign
  • No non-epithelial breast malignancies such as sarcoma or lymphoma
  • No Paget disease of the nipple
  • No male breast cancer
  • Breast implants allowed

PATIENT CHARACTERISTICS:

  • ANC ≥ 1,800/mm³
  • Platelet count ≥ 75,000/mm³
  • Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL is acceptable)
  • Negative urine or serum pregnancy test within 14 days of study entry
  • Women of childbearing potential must not be pregnant or nursing and willing to use medically acceptable form of contraception during radiotherapy
  • No prior invasive non-breast malignancy (except non-melanomatous skin cancer or carcinoma in situ of the cervix) unless disease free for a minimum of 5 years prior to study entry
  • No severely active co-morbidity, defined as follows:

    • Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
    • Transmural myocardial infarction within the past 6 months
    • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
    • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration
    • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol
    • Acquired Immune-Deficiency Syndrome (AIDS) based upon current CDC definition

      • HIV testing is not required for entry into this protocol
  • No active systemic lupus, erythematosus, or any history of scleroderma or dermatomyositis with active rash
  • Medical, psychiatric, or other condition that would prevent the patient from receiving the protocol therapy or providing informed consent

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • Study entry must be within 50 days of last breast/axillary surgery and/or last chemotherapy
  • No treatment plan that includes regional-node radiotherapy
  • No prior radiotherapy to the breast or prior radiation to the region of the ipsilateral breast that would result in overlap of radiation therapy fields
  • No intention to administer concurrent chemotherapy for current breast cancer
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01349322

  Hide Study Locations
Locations
United States, Alabama
The Kirklin Clinic at Acton Road Recruiting
Birmingham, Alabama, United States, 35243
Contact: Ruby F. Meredith    205-934-0309      
Principal Investigator: Ruby F. Meredith         
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Ruby F. Meredith    205-934-0309      
Principal Investigator: Ruby F. Meredith         
United States, Arizona
21st Century Oncology-Scottsdale Recruiting
Scottsdale, Arizona, United States, 85251
Contact: Steven E. Finkelstein    215-574-3173      
Principal Investigator: Steven E. Finkelstein         
Mayo Clinic in Arizona Recruiting
Scottsdale, Arizona, United States, 85259
Contact: Ivy A. Petersen    507-538-7623      
Principal Investigator: Ivy A. Petersen         
Arizona Oncology Associates-West Orange Grove Recruiting
Tucson, Arizona, United States, 85704
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
University of Arizona Health Sciences Center Recruiting
Tucson, Arizona, United States, 85724
Contact: Victor J. Gonzalez    520-626-9008      
Principal Investigator: Victor J. Gonzalez         
United States, California
Auburn Radiation Oncology Center Recruiting
Auburn, California, United States, 95603
Contact: Christopher U. Jones    916-646-8300      
Principal Investigator: Christopher U. Jones         
Marshall Radiation Oncology Center Recruiting
Cameron Park, California, United States, 95682
Contact: Christopher U. Jones    916-646-8300      
Principal Investigator: Christopher U. Jones         
Mercy San Juan Medical Center Recruiting
Carmichael, California, United States, 95608
Contact: Christopher U. Jones    916-646-8300      
Principal Investigator: Christopher U. Jones         
Enloe Medical Center Recruiting
Chico, California, United States, 95926
Contact: Grace E. Yuh    530-332-3808      
Principal Investigator: Grace E. Yuh         
City of Hope Recruiting
Duarte, California, United States, 91010
Contact: Nayana L. Vora    800-826-4673    becomingapatient@coh.org   
Principal Investigator: Nayana L. Vora         
Moores University of California San Diego Cancer Center Recruiting
LA Jolla, California, United States, 92093
Contact: Loren K. Mell    858-822-5354    cancercto@ucsd.edu   
Principal Investigator: Loren K. Mell         
University of Southern California Recruiting
Los Angeles, California, United States, 90033-0804
Contact: Quynh N. Nguyen    323-865-0451      
Principal Investigator: Quynh N. Nguyen         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: Eugene I. Chung    323-865-0451      
Principal Investigator: Eugene I. Chung         
Cedars-Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Christiane M. Burnison    310-423-8965      
Principal Investigator: Christiane M. Burnison         
Kaiser Permanente Oakland-Broadway Recruiting
Oakland, California, United States, 94611
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Rancho Cordova Cancer Center Recruiting
Rancho Cardova, California, United States, 95670
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Rohnert Park Cancer Center Recruiting
Rohnert Park, California, United States, 94928
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
The Permanente Medical Group-Roseville Radiation Oncology Recruiting
Roseville, California, United States, 95678
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Roseville Radiation Oncology Center Recruiting
Roseville, California, United States, 95661
Contact: Christopher U. Jones    916-646-8300      
Principal Investigator: Christopher U. Jones         
UC Davis Comprehensive Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Jyoti S. Mayadev    916-734-3089      
Principal Investigator: Jyoti S. Mayadev         
Radiological Associates of Sacramento Recruiting
Sacramento, California, United States, 95815
Contact: Christopher U. Jones    916-646-8300      
Principal Investigator: Christopher U. Jones         
Santa Clara Valley Medical Center Active, not recruiting
San Jose, California, United States, 95128
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Radiation Oncology Cancer Treatment Center Withdrawn
Santa Clara, California, United States, 95051
City of Hope- South Pasadena Cancer Center Recruiting
South Pasadena, California, United States, 91030
Contact: Nayana L. Vora    800-826-4673    becomingapatient@coh.org   
Principal Investigator: Nayana L. Vora         
Kaiser Permanente Cancer Treatment Center Recruiting
South San Francisco, California, United States, 94080
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Solano Radiation Oncology Center Recruiting
Vacaville, California, United States, 95687
Contact: Christopher U. Jones    916-646-8300      
Principal Investigator: Christopher U. Jones         
United States, Colorado
University of Colorado Cancer Center - Anschutz Cancer Pavilion Recruiting
Aurora, Colorado, United States, 80045
Contact: Rachel A. Rabinovitch    720-848-0650      
Principal Investigator: Rachel A. Rabinovitch         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Alan T. Monroe    888-785-6789      
Principal Investigator: Alan T. Monroe         
United States, District of Columbia
Washington Hospital Center Recruiting
Washington, District of Columbia, United States, 20010
Contact: Pamela D. Randolph-Jackson    202-877-8839      
Principal Investigator: Pamela D. Randolph-Jackson         
United States, Florida
John Fitzgerald Kennedy Medical Center Recruiting
Atlantis, Florida, United States, 33462
Contact: Georges F. Hatoum    866-574-5124    Sylvester@emergingmed.com   
Principal Investigator: Georges F. Hatoum         
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach Active, not recruiting
Deerfield Beach, Florida, United States, 33442
University of Florida Recruiting
Gainesville, Florida, United States, 32610
Contact: Romaine C. Nichols    877-686-6009      
Principal Investigator: Romaine C. Nichols         
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224-9980
Contact: Ivy A. Petersen    507-538-7623      
Principal Investigator: Ivy A. Petersen         
Edna Williams Cancer Center at the Baptist Cancer Institute Recruiting
Jacksonville, Florida, United States, 32207
Contact: Cynthia S. Anderson    904-202-7051      
Principal Investigator: Cynthia S. Anderson         
University of Florida Health Science Center Recruiting
Jacksonville, Florida, United States, 32209
Contact: Romaine C. Nichols    877-686-6009      
Principal Investigator: Romaine C. Nichols         
Cancer Specialists of North Florida-Baptist South Recruiting
Jascksonville, Florida, United States, 32258
Contact: Cynthia S. Anderson    904-202-7051      
Principal Investigator: Cynthia S. Anderson         
University of Miami Miller School of Medicine-Sylvester Cancer Center Recruiting
Miami, Florida, United States, 33136
Contact: Cristiane Takita    866-574-5124    Sylvester@emergingmed.com   
Principal Investigator: Cristiane Takita         
M D Anderson Cancer Center- Orlando Recruiting
Orlando, Florida, United States, 32806
Contact: Tomas Dvorak    321-841-7246      
Principal Investigator: Tomas Dvorak         
Cancer Specialists of North Florida-Putnam Recruiting
Palatka, Florida, United States, 32177
Contact: Cynthia S. Anderson    904-202-7051      
Principal Investigator: Cynthia S. Anderson         
Cancer Specialists of North Florida-Saint Augustine Recruiting
Saint Augustine, Florida, United States, 32086
Contact: Cynthia S. Anderson    904-202-7051      
Principal Investigator: Cynthia S. Anderson         
H. Lee Moffitt Cancer Center and Research Institute Withdrawn
Tampa, Florida, United States, 33612
United States, Georgia
Emory University Recruiting
Atlanta, Georgia, United States, 30322
Contact: Mylin A. Torres    404-778-1868      
Principal Investigator: Mylin A. Torres         
Grady Health System Recruiting
Atlanta, Georgia, United States, 30303
Contact: Mylin A. Torres    404-778-1868      
Principal Investigator: Mylin A. Torres         
Northside Hospital Recruiting
Atlanta, Georgia, United States, 30342
Contact: Henry D. Cline    404-303-3355      
Principal Investigator: Henry D. Cline         
Piedmont Hospital Recruiting
Atlanta, Georgia, United States, 30309
Contact: Adam W. Nowlan    404-425-7943    phri@piedmont.org   
Principal Investigator: Adam W. Nowlan         
Northside Hospital-Forsyth Recruiting
Cumming, Georgia, United States, 30041
Contact: Henry D. Cline    404-303-3355      
Principal Investigator: Henry D. Cline         
Memorial Health University Medical Center Recruiting
Savannah, Georgia, United States, 31403
Contact: John R. Duttenhaver    912-350-8568      
Principal Investigator: John R. Duttenhaver         
Saint Joseph's-Candler Health System Recruiting
Savannah, Georgia, United States, 31405
Contact: John A. Pablo    912-819-5704      
Principal Investigator: John A. Pablo         
United States, Hawaii
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Paul A. DeMare    808-545-8548      
Principal Investigator: Paul A. DeMare         
United States, Idaho
Saint Alphonsus Regional Medical Center Recruiting
Boise, Idaho, United States, 83706
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
United States, Illinois
University of Chicago Comprehensive Cancer Center Recruiting
Chicago, Illinois, United States, 60637-1470
Contact: Steven J. Chmura    773-834-7424      
Principal Investigator: Steven J. Chmura         
Illinois Masonic Medical Center Recruiting
Chicago, Illinois, United States, 60657
Contact: Santosh V. Yajnik    847-384-3621      
Principal Investigator: Santosh V. Yajnik         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
LC Ferguson Cancer Center Recruiting
Freeport, Illinois, United States, 61032
Contact: Lauren Q. Shapiro    877-405-6866      
Principal Investigator: Lauren Q. Shapiro         
Loyola University Medical Center Active, not recruiting
Maywood, Illinois, United States, 60153
Community Cancer Center Foundation Recruiting
Normal, Illinois, United States, 61761
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Saint John's Hospital Recruiting
Springfield, Illinois, United States, 62702
Contact: Cathy L. Clausen    217-525-5666    diana.weyhenmeyer@st-johns.org   
Principal Investigator: Cathy L. Clausen         
Carle Foundation - Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Ronald A. Sapiente    800-446-5532      
Principal Investigator: Ronald A. Sapiente         
Central DuPage Hospital Cancer Center Recruiting
Warrenville, Illinois, United States, 60555
Contact: Christy M. Kesslering    630-352-5300      
Principal Investigator: Christy M. Kesslering         
United States, Indiana
Saint John's Health System Cancer Center Recruiting
Anderson, Indiana, United States, 46016
Contact: Alexander M. Yeh    765-646-8358      
Principal Investigator: Alexander M. Yeh         
IU Health West Recruiting
Avon, Indiana, United States, 46123
Contact: Peter A. Johnstone    317-274-2552      
Principal Investigator: Peter A. Johnstone         
Indiana University Health Goshen Center for Cancer Care Recruiting
Goshen, Indiana, United States, 46526
Contact: James A. Wheeler    574-535-2858      
Principal Investigator: James A. Wheeler         
Community Regional Cancer Care-North Recruiting
Indianapolis, Indiana, United States, 46256
Contact: Shih J. Wei    800-777-7775      
Principal Investigator: Shih J. Wei         
IU Health Methodist Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Alexander M. Yeh    765-646-8358      
Principal Investigator: Alexander M. Yeh         
Community Regional Cancer Care-East Radiation Oncology Recruiting
Indianapolis, Indiana, United States, 46219
Contact: Shih J. Wei    800-777-7775      
Principal Investigator: Shih J. Wei         
Indiana University Medical Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Alexander M. Yeh    765-646-8358      
Principal Investigator: Alexander M. Yeh         
Michiana Hematology Oncology PC-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: David A. Hornback    800-284-7370      
Principal Investigator: David A. Hornback         
IU Health Ball Memorial Hospital Recruiting
Muncie, Indiana, United States, 47303
Contact: Yunjie X. Lin    765-751-5850    alpatterson@medicalconsultantspc.com   
Principal Investigator: Yunjie X. Lin         
United States, Iowa
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Finley Hospital Active, not recruiting
Dubuque, Iowa, United States, 52001
United States, Kansas
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City Cancer Centers-Southwest Recruiting
Overland Park, Kansas, United States, 66210
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City CCOP Recruiting
Prairie Village, Kansas, United States, 66208
Contact: Rakesh Gaur    913-948-5588    amy.krushelniski@hcahealthcare.com   
Principal Investigator: Rakesh Gaur         
Stormont-Vail Regional Health Center Active, not recruiting
Topeka, Kansas, United States, 66604
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536
Contact: Jonathan M. Feddock    859-257-3379      
Principal Investigator: Jonathan M. Feddock         
Owensboro Mercy Medical Center Recruiting
Owensboro, Kentucky, United States, 42303
Contact: Samuel R. Faught    270-688-3691    shawns@omhs.org   
Principal Investigator: Samuel R. Faught         
United States, Louisiana
Tulane University Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Michael J. Burdick    504-988-6121      
Principal Investigator: Michael J. Burdick         
United States, Maryland
Saint Agnes Hospital Recruiting
Baltimore, Maryland, United States, 21229
Contact: Richard S. Hudes    410-368-2910      
Principal Investigator: Richard S. Hudes         
University of Maryland Greenebaum Cancer Center Recruiting
Baltimore, Maryland, United States, 21201-1595
Contact: Steven J. Feigenberg    800-888-8823      
Principal Investigator: Steven J. Feigenberg         
Central Maryland Radiation Oncology in Howard County Recruiting
Columbia, Maryland, United States, 21044
Contact: Steven J. Feigenberg    800-888-8823      
Principal Investigator: Steven J. Feigenberg         
Tate Cancer Center Recruiting
Glen Burnie, Maryland, United States, 21061
Contact: Steven J. Feigenberg    800-888-8823      
Principal Investigator: Steven J. Feigenberg         
Peninsula Regional Medical Center Recruiting
Salisbury, Maryland, United States, 21801
Contact: Matthew L. Snyder    866-922-6237      
Principal Investigator: Matthew L. Snyder         
United States, Massachusetts
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Lisa A. Kachnic    617-638-8265      
Principal Investigator: Lisa A. Kachnic         
Massachusetts General Hospital Cancer Center Recruiting
Boston, Massachusetts, United States, 02114
Contact: Alphonse G. Taghian    877-726-5130      
Principal Investigator: Alphonse G. Taghian         
Lowell General Hospital Recruiting
Lowell, Massachusetts, United States, 01854
Contact: Jeffrey D. Goldstein    978-788-7084    ghincks@lowellgeneral.org   
Principal Investigator: Jeffrey D. Goldstein         
North Shore Medical Center Cancer Center Recruiting
Peabody, Massachusetts, United States, 01960
Contact: Alphonse G. Taghian    877-726-5130      
Principal Investigator: Alphonse G. Taghian         
United States, Michigan
Henry Ford Macomb Hospital Active, not recruiting
Clinton Township, Michigan, United States, 48038
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Eleanor M. Walker    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Wayne State University Active, not recruiting
Detroit, Michigan, United States, 48202
21st Century Oncology-Farmington Hills Recruiting
Farmington Hills, Michigan, United States, 48334
Contact: Jeffrey D. Forman    248-858-6215      
Principal Investigator: Jeffrey D. Forman         
Saint Mary's Health Care Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D. Padula    616-685-5225      
Principal Investigator: Gilbert D. Padula         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Northern Michigan Regional Hospital Recruiting
Petoskey, Michigan, United States, 49770
Contact: Peter S. Armstrong    800-248-6777      
Principal Investigator: Peter S. Armstrong         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
William Beaumont Hospital Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Frank A. Vicini    248-551-7695      
Principal Investigator: Frank A. Vicini         
United States, Minnesota
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Daniel A. Nikcevich    888-203-7267      
Principal Investigator: Daniel A. Nikcevich         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Ivy A. Petersen    507-538-7623      
Principal Investigator: Ivy A. Petersen         
CentraCare Clinic Recruiting
Saint Cloud, Minnesota, United States, 56303
Contact: Barbi L. Kaplan-Frenkel    877-229-4907    coborncancercenter@centracare.com   
Principal Investigator: Barbi L. Kaplan-Frenkel         
United States, Mississippi
Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson    228-809-5292      
Principal Investigator: James E. Clarkson         
United States, Missouri
Cape Radiation Oncology Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Tapan Roy    866-334-2230    sfmc@sfmc.net   
Principal Investigator: Tapan Roy         
Saint Luke's Hospital Recruiting
Chesterfield, Missouri, United States, 63017
Contact: Donald F. Busiek    314-205-6936      
Principal Investigator: Donald F. Busiek         
Kansas City Cancer Center - South Recruiting
Kansas City, Missouri, United States, 64131
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Barnes West County Hospital Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Imran Zoberi    800-600-3606    info@ccadmin.wustl.edu   
Principal Investigator: Imran Zoberi         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Imran Zoberi    800-600-3606    info@ccadmin.wustl.edu   
Principal Investigator: Imran Zoberi         
Siteman Cancer Center - Saint Peters Recruiting
Saint Peters, Missouri, United States, 63376
Contact: Imran Zoberi    800-600-3606    info@ccadmin.wustl.edu   
Principal Investigator: Imran Zoberi         
United States, Montana
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Methodist Estabrook Cancer Center Recruiting
Omaha, Nebraska, United States, 68114
Contact: Tien-Shew W. Huang    402-354-5144      
Principal Investigator: Tien-Shew W. Huang         
The Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Andrew O. Wahl    800-999-5465      
Principal Investigator: Andrew O. Wahl         
United States, Nevada
Radiation Oncology Centers of Las Vegas - Tonopah Recruiting
Las Vegas, Nevada, United States, 89106
Contact: Raul T. Meoz    702-731-8274      
Principal Investigator: Raul T. Meoz         
Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: Daniel W. Weed    775-982-4400      
Principal Investigator: Daniel W. Weed         
Saint Mary's Regional Medical Center Recruiting
Reno, Nevada, United States, 89503
Contact: Kathleen (Katie) B. Legarza    775-770-7410      
Principal Investigator: Kathleen (Katie) B. Legarza         
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Alan C. Hartford    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: Alan C. Hartford         
United States, New Jersey
Memorial Sloan Kettering Cancer Center at Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Preeti K. Parhar    212-639-5007      
Principal Investigator: Preeti K. Parhar         
Ocean Medical Center Recruiting
Brick, New Jersey, United States, 08724
Contact: Douglas A. Miller    732-206-8384      
Principal Investigator: Douglas A. Miller         
Monmouth Medical Center Recruiting
Long Branch, New Jersey, United States, 07740
Contact: Mitchell F. Weiss    732-923-7689      
Principal Investigator: Mitchell F. Weiss         
Morristown Memorial Hospital Recruiting
Morristown, New Jersey, United States, 07962
Contact: Mona Karim    973-971-5900      
Principal Investigator: Mona Karim         
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Recruiting
Mount Holly, New Jersey, United States, 08060
Contact: Lemuel S. Ariaratnam    888-847-8823      
Principal Investigator: Lemuel S. Ariaratnam         
Jersey Shore Medical Center Recruiting
Neptune, New Jersey, United States, 07753
Contact: Douglas A. Miller    732-206-8384      
Principal Investigator: Douglas A. Miller         
Saint Peter's University Hospital Recruiting
New Brunswick, New Jersey, United States, 08901
Contact: Hemangini Shah    732-745-8600 ext 6163    kcovert@saintpetersuh.com   
Principal Investigator: Hemangini Shah         
Capital Health Medical Center-Hopewell Recruiting
Pennington, New Jersey, United States, 08534
Contact: Shirnett K. Williamson    800-255-3440      
Principal Investigator: Shirnett K. Williamson         
Riverview Medical Center/Booker Cancer Center Recruiting
Red Bank, New Jersey, United States, 07701
Contact: Douglas A. Miller    732-206-8384      
Principal Investigator: Douglas A. Miller         
Sparta Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Pramila R. Anne    215-955-6084      
Principal Investigator: Pramila R. Anne         
Community Medical Center Recruiting
Toms River, New Jersey, United States, 08755
Contact: David J. D'Ambrosio    732-818-3882      
Principal Investigator: David J. D'Ambrosio         
Virtua West Jersey Hospital Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Lemuel S. Ariaratnam    888-847-8823      
Principal Investigator: Lemuel S. Ariaratnam         
United States, New Mexico
University of New Mexico Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Thomas M. Schroeder    505-272-6972      
Principal Investigator: Thomas M. Schroeder         
Memorial Medical Center - Las Cruces Recruiting
Las Cruces, New Mexico, United States, 88011
Contact: Sagus Sampath    505-272-6972      
Principal Investigator: Sagus Sampath         
United States, New York
Saint Peters Hospital-Albany Recruiting
Albany, New York, United States, 12208
Contact: Duncan E. Savage    518-525-1547      
Principal Investigator: Duncan E. Savage         
New York Oncology Hematology PC - Albany Recruiting
Albany, New York, United States, 12206
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263
Contact: David M. Mattson    877-275-7724      
Principal Investigator: David M. Mattson         
Memorial Sloan-Kettering Cancer Center at Suffolk Recruiting
Commack, New York, United States, 11725
Contact: Preeti K. Parhar    212-639-5007      
Principal Investigator: Preeti K. Parhar         
Mary Imogene Bassett Hospital Recruiting
Cooperstown, New York, United States, 13326
Contact: Joy E. Anderson    607-547-6965    jennifer.victory@bassett.org   
Principal Investigator: Joy E. Anderson         
Hematology Oncology Associates of Central New York PC Recruiting
East Syracuse, New York, United States, 13057
Contact: Dennis J. Kotlove    315-472-7504      
Principal Investigator: Dennis J. Kotlove         
Cayuga Medical Center Active, not recruiting
Ithaca, New York, United States, 14850
North Shore-LIJ Health System CCOP Recruiting
Manhasset, New York, United States, 11030
Contact: Lucille N. Lee    516-562-3467      
Principal Investigator: Lucille N. Lee         
Long Island Jewish Medical Center Recruiting
New Hyde Park, New York, United States, 11040
Contact: Lucille N. Lee    516-562-3467      
Principal Investigator: Lucille N. Lee         
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Daniela Gidea-Addeo    212-305-8615      
Principal Investigator: Daniela Gidea-Addeo         
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Preeti K. Parhar    212-639-5007      
Principal Investigator: Preeti K. Parhar         
Hudson Valley Oncology Associates Active, not recruiting
Poughkeepsie, New York, United States, 12601
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
University Radiation Oncology Recruiting
Rochester, New York, United States, 14626
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Memorial Sloan-Kettering Cancer Center Rockville Centre Recruiting
Rockville Centre, New York, United States, 11570
Contact: Preeti K. Parhar    212-639-5007      
Principal Investigator: Preeti K. Parhar         
Memorial Sloan-Kettering Cancer Center at Phelps Recruiting
Sleepy Hollow, New York, United States, 10591
Contact: Preeti K. Parhar    212-639-5007      
Principal Investigator: Preeti K. Parhar         
Staten Island University Hospital Recruiting
Staten Island, New York, United States, 10305
Contact: Philip M. Vigneri    718-226-8888      
Principal Investigator: Philip M. Vigneri         
Stony Brook University Medical Center Active, not recruiting
Stony Brook, New York, United States, 11794
United States, North Carolina
Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27710
Contact: Janet K. Horton    888-275-3853      
Principal Investigator: Janet K. Horton         
The Coleman Radiation Center-Carteret General Hospital Recruiting
Morehead City, North Carolina, United States, 28557
Contact: Michael A. Papagikos    910-251-1839      
Principal Investigator: Michael A. Papagikos         
CarolinaEast Health System-Medical Center Recruiting
New Bern, North Carolina, United States, 28560
Contact: Michael A. Papagikos    910-251-1839      
Principal Investigator: Michael A. Papagikos         
South Atlantic Radiation Oncology Recruiting
Supply, North Carolina, United States, 28462
Contact: Michael A. Papagikos    910-251-1839      
Principal Investigator: Michael A. Papagikos         
New Hanover Regional Medical Center Recruiting
Wilmington, North Carolina, United States, 28401
Contact: Michael A. Papagikos    910-251-1839      
Principal Investigator: Michael A. Papagikos         
New Hanover Radiation Oncology Center Recruiting
Wilmington, North Carolina, United States, 28401
Contact: Michael A. Papagikos    910-251-1839      
Principal Investigator: Michael A. Papagikos         
United States, North Dakota
Altru Cancer Center Recruiting
Grand Forks, North Dakota, United States, 58201
Contact: Grant R. Seeger    701-780-6520      
Principal Investigator: Grant R. Seeger         
United States, Ohio
Akron General Medical Center Recruiting
Akron, Ohio, United States, 44307
Contact: Mitchel L. Fromm    330-344-6348      
Principal Investigator: Mitchel L. Fromm         
Summa Akron City Hospital Recruiting
Akron, Ohio, United States, 44304
Contact: Charles A. Kunos    800-641-2422      
Principal Investigator: Charles A. Kunos         
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Charles A. Kunos    800-641-2422      
Principal Investigator: Charles A. Kunos         
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: John P. Kuebler    502-361-8496      
Principal Investigator: John P. Kuebler         
University of Cincinnati Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Kevin P. Redmond    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Kevin P. Redmond         
The Christ Hospital Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Cornelia M. McCluskey    513-585-2859      
Principal Investigator: Cornelia M. McCluskey         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Janice A. Lyons    800-641-2422      
Principal Investigator: Janice A. Lyons         
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Julia R. White    866-627-7616    osu@emergingmed.com   
Principal Investigator: Julia R. White         
Cleveland Clinic Cancer Center Independence Recruiting
Independence, Ohio, United States, 44131
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Janice A. Lyons    800-641-2422      
Principal Investigator: Janice A. Lyons         
UHHS-Chagrin Highlands Medical Center Recruiting
Orange Village, Ohio, United States, 44122
Contact: Janice A. Lyons    800-641-2422      
Principal Investigator: Janice A. Lyons         
Parma Community General Hospital Recruiting
Parma, Ohio, United States, 44129
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
Robinson Radiation Oncology Recruiting
Ravenna, Ohio, United States, 44266
Contact: Mitchel L. Fromm    330-344-6348      
Principal Investigator: Mitchel L. Fromm         
North Coast Cancer Care Recruiting
Sandusky, Ohio, United States, 44870
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
Cleveland Clinic Cancer Center-Strongsville Recruiting
Strongsville, Ohio, United States, 44136
Contact: Rahul D. Tendulkar    866-223-8100      
Principal Investigator: Rahul D. Tendulkar         
UHHS-Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Janice A. Lyons    800-641-2422      
Principal Investigator: Janice A. Lyons         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Terence S. Herman    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Terence S. Herman         
Natalie W Bryant Cancer Center Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Charles E. Stewart    918-494-2200      
Principal Investigator: Charles E. Stewart         
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Willamette Valley Cancer Center Recruiting
Eugene, Oregon, United States, 97401
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Providence Medford Medical Center Recruiting
Medford, Oregon, United States, 97504
Contact: Gordon L. Metz    541-789-6176      
Principal Investigator: Gordon L. Metz         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
United States, Pennsylvania
Abington Memorial Hospital Active, not recruiting
Abington, Pennsylvania, United States, 19001
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Paul B. Gilman    484-476-2649    wellenbachj@mlhs.org   
Principal Investigator: Paul B. Gilman         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822-2001
Contact: Thomas J. Gergel    570-271-5251      
Principal Investigator: Thomas J. Gergel         
Pocono Medical Center Recruiting
East Stroudsburg, Pennsylvania, United States, 18301
Contact: Pramila R. Anne    215-955-6084      
Principal Investigator: Pramila R. Anne         
The Regional Cancer Center Recruiting
Erie, Pennsylvania, United States, 16505
Contact: Andrew T. Figura    814-838-0448    mhaynes@trcc.org   
Principal Investigator: Andrew T. Figura         
Adams Cancer Center Recruiting
Gettysburg, Pennsylvania, United States, 17325
Contact: Amit B. Shah    877-441-7957      
Principal Investigator: Amit B. Shah         
Cherry Tree Cancer Center Recruiting
Hanover, Pennsylvania, United States, 17331
Contact: Amit B. Shah    877-441-7957      
Principal Investigator: Amit B. Shah         
Lancaster General Hospital Recruiting
Lancaster, Pennsylvania, United States, 17604
Contact: Jeffery S. Eshleman    717-544-5511      
Principal Investigator: Jeffery S. Eshleman         
Saint Mary Medical and Regional Cancer Center Recruiting
Langhorne, Pennsylvania, United States, 19047
Contact: Robert E. Reilly    215-710-4585      
Principal Investigator: Robert E. Reilly         
Holy Redeemer Hospital and Medical Center Recruiting
Meadowbrook, Pennsylvania, United States, 19046
Contact: Pallav Mehta    215-938-3551      
Principal Investigator: Pallav Mehta         
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Paul B. Gilman    484-476-2649    wellenbachj@mlhs.org   
Principal Investigator: Paul B. Gilman         
Hospital of The University of Pennsylvania Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Gary M. Freedman    215-728-4790      
Principal Investigator: Gary M. Freedman         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Pramila R. Anne    215-955-6084      
Principal Investigator: Pramila R. Anne         
Saint Joseph Medical Center Recruiting
Reading, Pennsylvania, United States, 19605
Contact: Leonard C. Tuanquin    610-378-2336    kevinkeller@catholichealth.net   
Principal Investigator: Leonard C. Tuanquin         
Reading Hospital and Medical Center Recruiting
West Reading, Pennsylvania, United States, 19612
Contact: Albert Yuen    610-988-9323      
Principal Investigator: Albert Yuen         
Lankenau Hospital Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Paul B. Gilman    484-476-2649    wellenbachj@mlhs.org   
Principal Investigator: Paul B. Gilman         
York Hospital Recruiting
York, Pennsylvania, United States, 17405
Contact: Amit B. Shah    877-441-7957      
Principal Investigator: Amit B. Shah         
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Jennifer L. Harper    843-792-9321      
Principal Investigator: Jennifer L. Harper         
Cancer Centers of the Carolinas - Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville CCOP Recruiting
Greenville, South Carolina, United States, 29615
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Cancer Centers of the Carolinas-Greer Radiation Oncology Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
The Radiation Oncology Center-Hilton Head/Bluffton Recruiting
Hilton Head Island, South Carolina, United States, 29926
Contact: John A. Pablo    912-819-5704      
Principal Investigator: John A. Pablo         
Cancer Centers of the Carolinas - Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Cancer Centers of the Carolinas - Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: Patricia C. Griffin    800-486-5941      
Principal Investigator: Patricia C. Griffin         
Lexington Medical Center Recruiting
West Columbia, South Carolina, United States, 29169
Contact: Quillin G. Davis    803-936-8050      
Principal Investigator: Quillin G. Davis         
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Michael J. Swartz    605-716-3982    research@rcrh.org   
Principal Investigator: Michael J. Swartz         
Avera Cancer Institute Recruiting
Sioux Falls, South Dakota, United States, 57105
Contact: James H. Simon    800-657-4377    Jan.Healy@avera.org   
Principal Investigator: James H. Simon         
United States, Texas
Texas Oncology-Arlington South Recruiting
Arlington, Texas, United States, 76014
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology PA - Bedford Recruiting
Bedford, Texas, United States, 76022
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Ann E. Spangler    214-648-7097      
Principal Investigator: Ann E. Spangler         
Texas Oncology-Denton South Recruiting
Denton, Texas, United States, 76210
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Brooke Army Medical Center Recruiting
Fort Sam Houston, Texas, United States, 78234
Contact: Bronwyn R. Stall    210-916-4837      
Principal Investigator: Bronwyn R. Stall         
The Klabzuba Cancer Center Recruiting
Fort Worth, Texas, United States, 76104
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Memorial Hermann Memorial City Medical Center Recruiting
Houston, Texas, United States, 77024
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Baylor Medical Center at Irving Active, not recruiting
Irving, Texas, United States, 75061
Texas Oncology - Lewisville Recruiting
Lewisville, Texas, United States, 75067
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
West Texas Cancer Center Active, not recruiting
Odessa, Texas, United States, 79761
Texas Oncology - Round Rock Cancer Center Recruiting
Round Rock, Texas, United States, 78681
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Cancer Care Centers of South Texas- Northeast Recruiting
San Antonio, Texas, United States, 78217
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229-3900
Contact: Richard L. Crownover    210-567-0653    che@uthscsa.edu   
Principal Investigator: Richard L. Crownover         
Texas Cancer Center-Sherman Recruiting
Sherman, Texas, United States, 75090
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology Cancer Center Sugar Land Recruiting
Sugar Land, Texas, United States, 77479
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology-Wichita Falls Texoma Cancer Center Recruiting
Wichita Falls, Texas, United States, 76310
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
United States, Utah
Logan Regional Hospital Recruiting
Logan, Utah, United States, 84321
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84157
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
McKay-Dee Hospital Center Recruiting
Ogden, Utah, United States, 84403
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Matthew M. Poppe    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Matthew M. Poppe         
United States, Vermont
Norris Cotton Cancer Center-North Active, not recruiting
Saint Johnsbury, Vermont, United States, 05819
United States, Virginia
Inova Alexandria Hospital Recruiting
Alexandria, Virginia, United States, 22304
Contact: Jane Grayson    703-776-2580    research@inova.org   
Principal Investigator: Jane Grayson         
Inova Fairfax Hospital Active, not recruiting
Falls Church, Virginia, United States, 22042
Augusta Health Cancer Center Active, not recruiting
Fishersville, Virginia, United States, 22939
Rockingham Memorial Hospital Hahn Cancer Center Recruiting
Harrisonburg, Virginia, United States, 22801
Contact: Heather Anne W. Morgan    540-689-7000      
Principal Investigator: Heather Anne W. Morgan         
Virginia Commonwealth University Recruiting
Richmond, Virginia, United States, 23298
Contact: Douglas W. Arthur    804-628-1939      
Principal Investigator: Douglas W. Arthur         
United States, Washington
Saint Francis Hospital Recruiting
Federal Way, Washington, United States, 98003
Contact: Huong T. Pham    800-354-9527      
Principal Investigator: Huong T. Pham         
Skagit Valley Hospital Recruiting
Mount Vernon, Washington, United States, 98274
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
Virginia Mason CCOP Recruiting
Seattle, Washington, United States, 98101
Contact: Huong T. Pham    800-354-9527      
Principal Investigator: Huong T. Pham         
Cancer Care Northwest Recruiting
Spokane, Washington, United States, 99218
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Cancer Care Northwest - Spokane South Recruiting
Spokane, Washington, United States, 99202
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Wenatchee Valley Medical Center Recruiting
Wenatchee, Washington, United States, 98801
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
United States, West Virginia
Edwards Comprehensive Cancer Center Recruiting
Huntington, West Virginia, United States, 25701
Contact: Maria R. Tria Tirona    304-399-6617      
Principal Investigator: Maria R. Tria Tirona         
West Virginia University Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Geraldine M. Jacobson    304-293-2745    sfilburn@hsc.wvu.edu   
Principal Investigator: Geraldine M. Jacobson         
Wheeling Hospital Recruiting
Wheeling, West Virginia, United States, 26003
Contact: Jondavid Pollock    304-243-6442      
Principal Investigator: Jondavid Pollock         
United States, Wisconsin
Appleton Medical Center Recruiting
Appleton, Wisconsin, United States, 54911
Contact: Michael E. Ray    920-380-1500      
Principal Investigator: Michael E. Ray         
Beloit Memorial Hospital Recruiting
Beloit, Wisconsin, United States, 53511
Contact: Bethany M. Anderson    877-405-6866      
Principal Investigator: Bethany M. Anderson         
Central Wisconsin Cancer Program Recruiting
Fond Du Lac, Wisconsin, United States, 54935
Contact: Timothy P. Korytko    800-494-2927      
Principal Investigator: Timothy P. Korytko         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Gregory M. Cooley    920-433-8889      
Principal Investigator: Gregory M. Cooley         
Saint Mary's Hospital Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Gregory M. Cooley    920-433-8889      
Principal Investigator: Gregory M. Cooley         
UW Cancer Center Johnson Creek Recruiting
Johnson Creek, Wisconsin, United States, 53038
Contact: Bethany M. Anderson    877-405-6866      
Principal Investigator: Bethany M. Anderson         
Mayo Clinic Health System-Franciscan Healthcare Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: David J. Schwartz    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: David J. Schwartz         
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Collin D. Driscoll    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Collin D. Driscoll         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Bethany M. Anderson    877-405-6866      
Principal Investigator: Bethany M. Anderson         
Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Gregory M. Cooley    920-433-8889      
Principal Investigator: Gregory M. Cooley         
Community Memorial Hospital Recruiting
Menomonee Falls, Wisconsin, United States, 53051
Contact: Adam D. Currey    414-805-4380      
Principal Investigator: Adam D. Currey         
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Mitchell H. Pincus    800-252-2990      
Principal Investigator: Mitchell H. Pincus         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Julia R. White    866-627-7616    osu@emergingmed.com   
Principal Investigator: Julia R. White         
Wheaton Franciscan Cancer Care - All Saints Recruiting
Racine, Wisconsin, United States, 53405
Contact: James H. Taylor    414-874-4541    Kelli.holton@wfhc.org   
Principal Investigator: James H. Taylor         
Vince Lombardi Cancer Clinic-Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: David C. Rohde    800-252-2990      
Principal Investigator: David C. Rohde         
Door County Cancer Center Recruiting
Sturgeon Bay, Wisconsin, United States, 54235-1495
Contact: Gregory M. Cooley    920-433-8889      
Principal Investigator: Gregory M. Cooley         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: David C. Rohde    800-252-2990      
Principal Investigator: David C. Rohde         
Waukesha Memorial Hospital Recruiting
Waukesha, Wisconsin, United States, 53188
Contact: Wingate F. Clapper    262-928-7632      
Principal Investigator: Wingate F. Clapper         
Aspirus Regional Cancer Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Darryl R. Barton    877-405-6866      
Principal Investigator: Darryl R. Barton         
Aurora West Allis Medical Center Recruiting
West Allis, Wisconsin, United States, 53227
Contact: Mitchell H. Pincus    800-252-2990      
Principal Investigator: Mitchell H. Pincus         
Canada, Alberta
Cross Cancer Institute Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Zsolt Gabos    780-432-8500      
Principal Investigator: Zsolt Gabos         
Canada, Ontario
Grand River Regional Cancer Centre at Grand River Hospital Recruiting
Kitchener, Ontario, Canada, N2G 1G3
Contact: Darindra D. Gopaul    519-749-4300ext2307      
Principal Investigator: Darindra D. Gopaul         
London Regional Cancer Program Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Tracy L. Sexton    519-685-8600      
Principal Investigator: Tracy L. Sexton         
The Ottawa Hospital Cancer Centre (Ottawa Health Research Institute) Civic Campus Recruiting
Ottawa, Ontario, Canada, K1Y 4E9
Contact: Samy El-Sayed    613-761-4395    info@ohri.ca   
Principal Investigator: Samy El-Sayed         
Irving Greenberg Family Cancer Centre Recruiting
Ottawa, Ontario, Canada, K2H 8P4
Contact: Samy El-Sayed    613-761-4395    info@ohri.ca   
Principal Investigator: Samy El-Sayed         
Windsor Regional Cancer Centre Recruiting
Windsor, Ontario, Canada, N8W 2X3
Contact: Khalid J. Hirmiz    519-253-5253      
Principal Investigator: Khalid J. Hirmiz         
Canada, Quebec
CHUM - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Sophie Lavertu    514-890-8000ext23611    sylvie.beaudoin.chum@ssss.gouv.qc.ca   
Principal Investigator: Sophie Lavertu         
Hopital Maisonneuve-Rosemont Recruiting
Montreal, Quebec, Canada, H1T 2M4
Contact: Michael Yassa    514-252-3400ext3329      
Principal Investigator: Michael Yassa         
McGill University Department of Oncology Recruiting
Montreal, Quebec, Canada, H2W 1S6
Contact: Tarek Hijal    514-934-1934ext42953    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: Tarek Hijal         
CHUQ - Pavilion Hotel-Dieu de Quebec Recruiting
Quebec City, Quebec, Canada, G1R 2J6
Contact: Isabelle Germain    418-525-4444      
Principal Investigator: Isabelle Germain         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Asim Amjad    306-766-2213      
Principal Investigator: Asim Amjad         
Switzerland
Kantonsspital Aarau AG-Canton Hospital Recruiting
Aarau, Switzerland, 5001
Contact: Stephan B. Bodis    215-574-3173      
Principal Investigator: Stephan B. Bodis         
Sponsors and Collaborators
Radiation Therapy Oncology Group
Investigators
Principal Investigator: Frank A. Vicini, MD, FACR Botsford Cancer Center
Study Chair: Gary M. Freedman, MD University of Pennsylvania
Study Chair: Julia R. White, MD Ohio State University
Study Chair: Douglas W. Arthur, MD Virginia Commonwealth University
  More Information

Additional Information:
No publications provided

Responsible Party: Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier: NCT01349322     History of Changes
Other Study ID Numbers: RTOG 1005, NCI-2011-02669, CDR0000700069
Study First Received: May 5, 2011
Last Updated: December 19, 2013
Health Authority: United States: Federal Government

Keywords provided by Radiation Therapy Oncology Group:
stage IA breast cancer
stage IB breast cancer
stage II breast cancer
estrogen receptor-negative breast cancer
estrogen receptor-positive breast cancer
progesterone receptor-negative breast cancer
progesterone receptor-positive breast cancer
ductal breast carcinoma in situ

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases

ClinicalTrials.gov processed this record on April 17, 2014