Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Newly Diagnosed, Previously Untreated Multiple Myeloma (ELOQUENT - 1)

This study is currently recruiting participants.
Verified January 2013 by Bristol-Myers Squibb
Sponsor:
Collaborator:
AbbVie
Information provided by (Responsible Party):
Bristol-Myers Squibb
ClinicalTrials.gov Identifier:
NCT01335399
First received: April 13, 2011
Last updated: January 4, 2013
Last verified: January 2013
  Purpose

The purpose of the study is to determine whether the addition of Elotuzumab to Lenalidomide/low-dose Dexamethasone will increase the progression free survival (PFS)


Condition Intervention Phase
Multiple Myeloma
Drug: Lenalidomide
Drug: Dexamethasone
Biological: Elotuzumab (BMS-901608; HuLuc63)
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase 3, Randomized, Open Label Trial of Lenalidomide/Dexamethasone With or Without Elotuzumab in Subjects With Previously Untreated Multiple Myeloma

Resource links provided by NLM:


Further study details as provided by Bristol-Myers Squibb:

Primary Outcome Measures:
  • Progression-free survival (PFS) - Time from randomization to date of first tumor progression or death due to any cause, provided death is not more than 10 weeks after the last tumor assessment. [ Time Frame: Every 4 weeks (-1/+3 days) relative to the first dose of study medication. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Objective Response Rate - The percentage of patients who have a partial or complete response to study therapy. [ Time Frame: All response endpoints assessed every 4 weeks (-1/+3 days). ] [ Designated as safety issue: No ]
  • Overall Survival - The period of time from study entry until the date of death or last known date alive. [ Time Frame: Survival will be assessed every 16 weeks in the Follow Up Phase of the trial. ] [ Designated as safety issue: No ]

Estimated Enrollment: 750
Study Start Date: August 2011
Estimated Study Completion Date: November 2018
Estimated Primary Completion Date: November 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Lenalidomide + Dexamethasone Drug: Lenalidomide
Capsules, Oral, 25 mg, once daily, on Days 1-21, Repeat every 28 days until subject meets criteria for discontinuation of study drug
Other Name: Revlimid®
Drug: Dexamethasone
Tablets, Oral, 40 mg, weekly, on Days 1, 8, 15, 22, Repeat every 28 days until subject meets criteria for discontinuation of study drug
Other Names:
  • Decadron®
  • Dexamethasone Intensol®
  • Dexpak®
  • Taperpak®
Experimental: Lenalidomide + Dexamethasone + Elotuzumab Drug: Lenalidomide
Capsules, Oral, 25 mg, once daily, on Days 1-21, Repeat every 28 days until subject meets criteria for discontinuation of study drug
Other Name: Revlimid®
Drug: Dexamethasone
Tablets, Oral, 28 mg, once daily, on Days 1, 8, 15, 22 (cycles 1&2) ; Days 1 &15 (cycles 3-18); Day 1 (cycle 19 and beyond), Repeat every 28 days until subject meets criteria for discontinuation of study drug
Other Names:
  • Decadron®
  • Dexamethasone Intensol®
  • Dexpak®
  • Taperpak®
Drug: Dexamethasone
Tablets, Oral, 40 mg, once daily, on Days 8 & 22 (cycles 3-18); Days 8, 15, 22 (cycle 19 and beyond), Repeat every 28 days until subject meets criteria for discontinuation of study drug
Other Names:
  • Decadron®
  • Dexamethasone Intensol®
  • Dexpak®
  • Taperpak®
Drug: Dexamethasone
Solution, Intravenous (IV), 8 mg, Once daily, on Days 1, 8, 15, 22 (cycles 1&2) ; Days 1 &15 (cycles 3-18); Day 1 (cycle 19 and beyond), Repeat every 28 days until subject meets criteria for discontinuation of study drug
Other Names:
  • Decadron®
  • Dexamethasone Intensol®
  • Dexpak®
  • Taperpak®
Biological: Elotuzumab (BMS-901608; HuLuc63)
Solution, Intravenous (IV), 10 mg/kg, weekly, on Days 1, 8, 15, 22 (cycles 1&2); Days 1 and 15 (cycles 3-18), Repeat every 28 days until subject meets criteria for discontinuation of study drug
Biological: Elotuzumab (BMS-901608; HuLuc63)
Solution, Intravenous (IV), 20 mg/kg, Day 1 (cycle 19 and beyond), Repeat every 28 days until subject meets criteria for discontinuation of study drug

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Subjects who are newly diagnosed with symptomatic Multiple Myeloma (MM) and who:

    • have not received any prior systemic anti-myeloma therapy AND
    • have measurable disease AND
    • are not candidates for high-dose therapy plus stem-cell transplantation (SCT) because of age (≥ 65 years) or coexisting conditions. Refusal to undergo high dose therapy with SCT is NOT sufficient for entry onto CA204006 for a subject < 65 years old. There must be a comorbidity that prevents SCT for a subject < 65 years old

Exclusion Criteria:

  • Subjects with non-secretory or oligo-secretory or free light-chain only myeloma
  • Smoldering MM, defined as asymptomatic MM with absence of lytic bone lesions
  • Monoclonal Gammopathy of Undetermined Significance (MGUS)
  • Active plasma cell leukemia
  • Known Human Immunodeficiency Virus (HIV) infection or active hepatitis A, B, or C
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01335399

Contacts
Contact: For participation information at a USA site use a phone number below. For site information outside the USA please email: Clinical.Trials@bms.com
Contact: First line of email MUST contain NCT# & Site#. Only trial sites that are recruiting have contact information at this time.

  Hide Study Locations
Locations
United States, Alabama
Birmingham Hematology & Oncology Associates Llc Recruiting
Birmingham, Alabama, United States, 35213
Contact: Kevin S Windsor, Site 1628     205-592-5077        
United States, Arizona
Acrc/Arizona Clinical Research Center, Inc. Recruiting
Tucson, Arizona, United States, 85715
Contact: Manuel R Modiano, Site 1644     520-290-2510        
United States, California
Local Institution Not yet recruiting
Bakersfield, California, United States, 93309
Contact: , Site 1618            
Alta Bates Summit Comprehensive Cancer Center Recruiting
Berkeley, California, United States, 94704
Contact: Rajesh Behl, Site 1602     510-204-6401        
Compassionate Cancer Care Medical Group Inc Recruiting
Corona, California, United States, 92879
Contact: Haresh S Jhangiani, Site 1668     951-371-2411        
Compassionate Cancer Care Medical Group Inc Recruiting
Corona, California, United States, 92879
Contact: Haresh S Jhangiani, Site 1636     951-371-2411        
Marin Cancer Care, Inc Recruiting
Greenbrae, California, United States, 94904
Contact: Peter D. Eisenberg, Site 1616     415-925-5000        
Local Institution Not yet recruiting
Los Angeles, California, United States, 90095
Contact: Site 1660            
Medical Oncology Care Associates Recruiting
Orange, California, United States, 92868
Contact: Birbal Bhaskar, Site 1673     714-541-6622        
Sharp Clinical Oncology Research Recruiting
San Diego, California, United States, 92123
Contact: Rajesh Belani, Site 1613     858-939-5062        
United States, Connecticut
Yale University School Of Medicine Recruiting
New Haven, Connecticut, United States, 06520
Contact: Madhav V Dhodapkar, Site 1621     203-785-2604        
United States, District of Columbia
Washington Cancer Institute At Washington Hospital Center Recruiting
Washington, District of Columbia, United States, 20010
Contact: Joseph P Catlett, Site 1612     202-877-8839        
United States, Florida
Cancer Care Centers Of Florida Recruiting
Brooksville, Florida, United States, 34613
Contact: Raju Rao, Site 1617     352-596-1401        
Florida Cancer Specialists Recruiting
Fort Myers, Florida, United States, 33916
Contact: James Andrew Jr Reeves, Site 1648     239-275-6400        
Integrated Community Oncology Network Recruiting
Jacksonville, Florida, United States, 32256
Contact: Mehdi M Moezi, Site 1623     904-272-3139        
Cancer Care Centers Of Florida Recruiting
New Port Richey, Florida, United States, 34652
Contact: Kapisthalam S. Kumar, Site 1625     727-842-2795        
Florida Cancer Specialists Recruiting
St. Petersburg, Florida, United States, 33705
Contact: Peter Acs, Site 1649     352-332-3900        
Palm Beach Cancer Institute Recruiting
West Palm Beach, Florida, United States, 33401
Contact: Shachar Peles, Site 1611     561-366-4112        
United States, Georgia
Local Institution Not yet recruiting
Atlanta, Georgia, United States, 30322
Contact: Site 1630            
United States, Illinois
The University Of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Cara Rosenbaum, Site 1607     773-702-0167        
Local Institution Not yet recruiting
Chicago, Illinois, United States, 60612
Contact: Site 1635            
United States, Indiana
Investigative Clinical Research Of Indiana, Llc Recruiting
Indianapolis, Indiana, United States, 46260
Contact: Robert F Manges, Site 1669     317-297-2208        
Michiana Hematology Oncology, P.C. Recruiting
Mishawaka, Indiana, United States, 46545
Contact: Jose A Bufill, Site 1656     574-234-5123        
United States, Iowa
University Of Iowa Hospitals And Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Raymond Hohl, Site 1633     319-356-8110        
United States, Kentucky
Local Institution Not yet recruiting
Lexington, Kentucky, United States, 40503
Contact: Site 1674            
Local Institution Not yet recruiting
Louisville, Kentucky, United States, 40207
Contact: Site 1683            
Local Institution Not yet recruiting
Pikeville, Kentucky, United States, 41501
Contact: , Site 1666            
United States, Louisiana
Cancer Center Of Acadiana At Lafayette General Recruiting
Lafayette, Louisiana, United States, 70503
Contact: Luis A Meza, Site 1646     337-289-8400        
Local Institution Not yet recruiting
Shreveport, Louisiana, United States, 71103
Contact: Site 1652            
United States, Maryland
Greater Baltimore Medical Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: , Site 1676     443-849-2000        
Harry & Jeanette Weinberg Cancer Institute Recruiting
Baltimore, Maryland, United States, 21237
Contact: Stephen Noga, Site 1650     443-777-7452        
United States, Massachusetts
Dana-Farber Cancer Institute Recruiting
Boston, Massachusetts, United States, 02215
Contact: Jacob Laubach, Site 1619     617-632-2104        
Local Institution Not yet recruiting
Burlington, Massachusetts, United States, 01805
Contact: Site 1606            
United States, Michigan
Local Institution Not yet recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Site 1603            
University Of Michigan Recruiting
Ann Arbor, Michigan, United States, 49109
Contact: Mark Kaminski, Site 1681     734-939-5310        
Henry Ford Health System Recruiting
Detroit, Michigan, United States, 48202
Contact: Philip Kuriakose, Site 1604     313-916-1784        
United States, Missouri
Columbia Comprehensive Cancer Care Clinic Recruiting
Jefferson City, Missouri, United States, 65109
Contact: Ali Khojasteh, Site 1667     573-556-7788        
Mercy Medical Research Institute Recruiting
Springfield, Missouri, United States, 65807
Contact: Viran Roger Holden, Site 1651     417-820-8099        
Washington University School Of Medicine Recruiting
St. Louis, Missouri, United States, 63110
Contact: Keith Stockerl-Goldstein, Site 1645     314-454-8304        
United States, New York
Local Institution Not yet recruiting
New York, New York, United States, 10016
Contact: Site 1622            
Local Institution Not yet recruiting
New York, New York, United States, 10003
Contact: , Site 1699            
St. Luke'S Roosevelt Hospital Center Recruiting
New York, New York, United States, 10019
Contact: Peter Wiernik, Site 1692     212-636-3334        
St. Luke'S-Roosevelt Hospital Center Recruiting
New York, New York, United States, 10019
Contact: Peter Wiernik, Site 1615     212-636-3338        
Local Institution Not yet recruiting
New York, New York, United States, 10065
Contact: Site 1689            
Stony Brook University Medical Center Recruiting
Stony Brook, New York, United States, 11794-8151
Contact: Michael W Schuster, Site 1671     631-444-3577        
United States, North Carolina
Mecklenburg Medical Group Recruiting
Charlotte, North Carolina, United States, 28204
Contact: David W Miller, Site 1605     704-302-9040        
Piedmont Hematology Oncology Associates, Pa Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact: Franklin L. Chen, Site 1610     336-277-8887        
United States, Ohio
Cleveland Clinic Recruiting
Cleveland, Ohio, United States, 44195
Contact: Christy Stotler, Site 1608     216-444-0293        
Benson, Md, Don Recruiting
Columbus, Ohio, United States, 43210
Contact: Don Benson, Site 1638     740-296-8508        
Local Institution Not yet recruiting
Middletown, Ohio, United States, 45042
Contact: Site 1690            
United States, Oklahoma
Cancer Care Associates Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Charles M Strnad, Site 1655     918-499-2000        
United States, Pennsylvania
Local Institution Not yet recruiting
Bethlehem, Pennsylvania, United States, 18015
Contact: Site 1665            
Local Institution Not yet recruiting
Pittsburgh, Pennsylvania, United States, 15224
Contact: Site 1647            
Local Institution Not yet recruiting
Pittsburgh, Pennsylvania, United States, 15240
Contact: , Site 1679            
United States, South Carolina
Charleston Hematology Oncology Associates, Pa Recruiting
Charleston, South Carolina, United States, 29414
Contact: George F. Geils Jr, Site 1629     843-577-6957        
Local Institution Not yet recruiting
Greenville, South Carolina, United States, 29615
Contact: Site 1624            
United States, Tennessee
Tennessee Cancer Specialists Recruiting
Knoxville, Tennessee, United States, 37909
Contact: Tracy W. Dobbs, Site 1600     865-934-2670        
Tennessee Oncology, Pllc Recruiting
Nashville, Tennessee, United States, 37203
Contact: Jesus Berdeja, Site 1627     615-986-7600        
United States, Texas
Cancer Specialists Of South Texas, Pa Recruiting
Corpus Christi, Texas, United States, 78412
Contact: Aftab Mahmood, Site 1634     361-993-3456        
The University Of Texas Md Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Contact: Jatin Shah, Site 1614     713-792-2817        
Northwest Cancer Center Recruiting
Houston, Texas, United States, 77090
Contact: Laurent Gressot, Site 1642     281-440-5006        
United States, Virginia
Hematology-Oncology Associates Of Fredricksburg, Inc Recruiting
Fredricksburg, Virginia, United States, 22408
Contact: Christopher Vaughn, Site 1657     540-371-0079        
Virginia Commonwealth University Recruiting
Richmond, Virginia, United States, 23298
Contact: Beata Holkova, Site 1620     804-628-2581        
United States, Washington
Local Institution Not yet recruiting
Seattle, Washington, United States, 98108
Contact: Site 1640            
Fred Hutchinson Cancer Research Center Recruiting
Seattle, Washington, United States, 98109
Contact: William Bensinger, Site 1631     206-667-4933        
United States, West Virginia
Edwards Comprehensive Cancer Center Recruiting
Huntington, West Virginia, United States, 25701
Contact: Rajesh Sehgal, Site 1601     304-399-6610        
United States, Wisconsin
Gundersen Clinic, Ltd Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Craig E Cole, Site 1653     608-782-7300        
Local Institution Not yet recruiting
Madison, Wisconsin, United States, 53792
Contact: Site 1609            
Dean Clinic-Hematology And Oncology Recruiting
Madison, Wisconsin, United States, 53717
Contact: Amit Sanyal, Site 1663     608-410-2700        
Australia, New South Wales
Local Institution Recruiting
Waratah, New South Wales, Australia, 2298
Contact: Site 3607            
Local Institution Recruiting
Westmead, New South Wales, Australia, 2145
Contact: Site 3610            
Australia, Queensland
Local Institution Recruiting
Herston, Queensland, Australia, 4029
Contact: Site 3609            
Local Institution Recruiting
South Brisbane, Queensland, Australia, 4101
Contact: Site 3608            
Australia, South Australia
Local Institution Recruiting
Adelaide, South Australia, Australia, 5011
Contact: Site 3606            
Local Institution Recruiting
Adelaide, South Australia, Australia, 5000
Contact: Site 3612            
Australia, Victoria
Local Institution Recruiting
Fitzroy, Victoria, Australia, 3065
Contact: Site 3601            
Local Institution Recruiting
Frankston, Victoria, Australia, 3199
Contact: Site 3602            
Local Institution Recruiting
Heidelberg Melbourne, Victoria, Australia, 3084
Contact: Site 3603            
Local Institution Recruiting
Wodonga, Victoria, Australia, 3690
Contact: Site 3604            
Australia, Western Australia
Local Institution Recruiting
Nedlands, Western Australia, Australia, 6009
Contact: Site 3611            
Local Institution Recruiting
Perth, Western Australia, Australia, 6000
Contact: Site 3605            
Australia
Local Institution Recruiting
Canberra, Australia, 2605
Contact: Site 3600            
Austria
Local Institution Recruiting
Innsbruck, Austria, 6020
Contact: Site 4051            
Local Institution Recruiting
Linz, Austria, 4020
Contact: Site 4052            
Local Institution Recruiting
Rankweil, Austria, 6830
Contact: Site 4054            
Local Institution Recruiting
Wels, Austria, 4600
Contact: Site 4053            
Local Institution Recruiting
Wien, Austria, 1090
Contact: Site 4050            
Belgium
Local Institution Recruiting
Brussels, Belgium, 1020
Contact: Site 4160            
Local Institution Recruiting
Brussels, Belgium, 1090
Contact: Site 4156            
Local Institution Recruiting
Brussels, Belgium, 1000
Contact: Site 4152            
Local Institution Recruiting
Brussles, Belgium, 1200
Contact: Site 4157            
Local Institution Recruiting
Charleroi, Belgium, 6000
Contact: Site 4154            
Local Institution Recruiting
Edegem-Antwerp, Belgium, 2650
Contact: Site 4155            
Local Institution Recruiting
Haine St Paul, Belgium, 7100
Contact: Site 4159            
Local Institution Recruiting
Leuven, Belgium, 3000
Contact: Site 4158            
Local Institution Recruiting
Liege, Belgium, 4000
Contact: Site 4150            
Local Institution Recruiting
Roeselare, Belgium, 8800
Contact: Site 4153            
Local Institution Recruiting
Yvoir, Belgium, 5530
Contact: Site 4151            
Canada, Alberta
Local Institution Recruiting
Calgary, Alberta, Canada, T2N 2T9
Contact: Site 2601            
Local Institution Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Site 2600            
Canada, Manitoba
Local Institution Not yet recruiting
Winnipeg, Manitoba, Canada, R3E 0V9
Contact: Site 2602            
Canada, New Brunswick
Local Institution Recruiting
Saint John, New Brunswick, Canada, E2L 4L2
Contact: Site 2611            
Canada, Nova Scotia
Local Institution Recruiting
Halifax, Nova Scotia, Canada, B3H 2Y9
Contact: Site 2610            
Canada, Ontario
Local Institution Recruiting
London, Ontario, Canada, N6A 5W9
Contact: Site 2606            
Local Institution Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Site 2612            
Local Institution Not yet recruiting
Weston, Ontario, Canada, M9N 1N8
Contact: Site 2608            
Canada, Quebec
Local Institution Not yet recruiting
Greenfield Park, Quebec, Canada, J4V 2H1
Contact: Site 2603            
Local Institution Recruiting
Montral, Quebec, Canada, H3A 1A1
Contact: Site 2607            
Local Institution Not yet recruiting
Montreal, Quebec, Canada, H1T 2M4
Contact: Site 2605            
Canada, Saskatchewan
Local Institution Recruiting
Saskatoon, Saskatchewan, Canada, S7N 4H4
Contact: Site 2604            
Czech Republic
Local Institution Recruiting
Hradec Kralove, Czech Republic, 500 05
Contact: Site 4252            
Local Institution Recruiting
Praha 10, Czech Republic, 100 34
Contact: Site 4250            
Local Institution Not yet recruiting
Praha 2, Czech Republic, 128 08
Contact: Site 4251            
Germany
Local Institution Recruiting
Aschaffenburg, Germany, 63739
Contact: Site 4565            
Local Institution Recruiting
Berlin, Germany, 12200
Contact: Site 4550            
Local Institution Recruiting
Chemnitz, Germany, 09113
Contact: Site 4555            
Local Institution Recruiting
Dresden, Germany, 01307
Contact: Site 4562            
Local Institution Recruiting
Hamm, Germany, 59071
Contact: Site 4552            
Local Institution Recruiting
Heidelberg, Germany, 69120
Contact: Site 4553            
Local Institution Recruiting
Jena, Germany, 07747
Contact: Site 4560            
Local Institution Recruiting
Koln, Germany, 50937
Contact: Site 4563            
Local Institution Recruiting
Mainz, Germany, 55131
Contact: Site 4554            
Local Institution Recruiting
Munchen, Germany, 81377
Contact: Site 4561            
Local Institution Recruiting
Munster, Germany, 48149
Contact: Site 4558            
Local Institution Recruiting
Offenbach, Germany, 63069
Contact: Site 4551            
Local Institution Recruiting
Stuttgart, Germany, 70376
Contact: Site 4556            
Local Institution Recruiting
Tuebingen, Germany, 72076
Contact: Site 4564            
Local Institution Recruiting
Ulm, Germany, 89081
Contact: Site 4559            
Greece
Local Institution Recruiting
Athens, Greece, 11528
Contact: Site 4651            
Local Institution Not yet recruiting
Athens, Greece, 11527
Contact: Site 4653            
Local Institution Recruiting
Ioannina, Greece, 45500
Contact: Site 4650            
Local Institution Recruiting
Larissa, Greece, 41110
Contact: Site 4652            
Local Institution Recruiting
Patras, Greece, 26504
Contact: Site 4654            
Hungary
Local Institution Recruiting
Budapest, Hungary, 1122
Contact: Site 4754            
Local Institution Terminated
Budapest, Hungary, 1097
Local Institution Terminated
Debrecen, Hungary, 4032
Local Institution Terminated
Gyor, Hungary, 9024
Local Institution Terminated
Szeged, Hungary, 6720
Ireland
Local Institution Recruiting
Co Galway, Galway, Ireland
Contact: Site 4851            
Local Institution Recruiting
Dublin, Ireland, 7
Contact: Site 4852            
Local Institution Recruiting
Dublin, Ireland, 8
Contact: Site 4850            
Israel
Local Institution Recruiting
Afula, Israel, 18101
Contact: Site 4950            
Local Institution Recruiting
Ashkelon, Israel, 78278
Contact: Site 4956            
Local Institution Recruiting
Jerusalem, Israel, 91120
Contact: Site 4951            
Local Institution Recruiting
Nahariya, Israel, 22100
Contact: Site 4954            
Local Institution Recruiting
Petah Tikva, Israel, 49100
Contact: Site 4952            
Local Institution Recruiting
Rehovot, Israel, 76100
Contact: Site 4953            
Local Institution Recruiting
Tel Aviv, Israel, 64239
Contact: Site 4957            
Local Institution Recruiting
Zerifin, Israel, 70300
Contact: Site 4955            
Italy
Local Institution Recruiting
Ancona, Italy, 60126
Contact: Site 5067            
Local Institution Not yet recruiting
Bari, Italy, 70124
Contact: Site 5065            
Local Institution Recruiting
Bergamo, Italy, 24128
Contact: Site 5053            
Local Institution Recruiting
Bologna, Italy, 40138
Contact: Site 5070            
Local Institution Not yet recruiting
Catania, Italy, 95124
Contact: Site 5060            
Local Institution Recruiting
Firenze, Italy, 50134
Contact: Site 5066            
Local Institution Recruiting
Genova, Italy, 16132
Contact: Site 5050            
Local Institution Not yet recruiting
Giovanni Rotondo, Italy, 71013
Contact: Site 5059            
Local Institution Not yet recruiting
Lecce, Italy, 73100
Contact: Site 5061            
Local Institution Recruiting
Meldola, Italy, 47014
Contact: Site 5057            
Local Institution Recruiting
Milano, Italy, 20132
Contact: Site 5069            
Local Institution Recruiting
Monza, Italy, 20052
Contact: Site 5052            
Local Institution Recruiting
Napoli, Italy, 80131
Contact: Site 5068            
Local Institution Recruiting
Napoli, Italy, 80131
Contact: Site 5062            
Local Institution Recruiting
Palermo, Italy, 90146
Contact: Site 5055            
Local Institution Recruiting
Ravenna, Italy, 47923
Contact: Site 5063            
Local Institution Recruiting
Rimini, Italy, 47923
Contact: Site 5064            
Local Institution Recruiting
Roma, Italy, 00144
Contact: Site 5058            
Local Institution Recruiting
Roma, Italy, 00161
Contact: Site 5056            
Local Institution Recruiting
Roma, Italy, 00168
Contact: Site 5054            
Local Institution Recruiting
Torino, Italy, 10126
Contact: Site 5051            
Poland
Local Institution Recruiting
Bialystok, Poland, 15-276
Contact: Site 5250            
Local Institution Recruiting
Chorzow, Poland, 41-500
Contact: Site 5252            
Local Institution Not yet recruiting
Gdansk, Poland, 80-211
Contact: Site 5254            
Local Institution Not yet recruiting
Lodz, Poland, 93-510
Contact: Site 5258            
Local Institution Recruiting
Lublin, Poland, 20-081
Contact: Site 5257            
Local Institution Recruiting
Poznan, Poland, 60-569
Contact: Site 5259            
Local Institution Not yet recruiting
Szczecin, Poland, 70-111
Contact: Site 5255            
Local Institution Recruiting
Warsaw, Poland, 02-776
Contact: Site 5260            
Local Institution Recruiting
Warsaw, Poland, 02-106
Contact: Site 5256            
Local Institution Recruiting
Warszawa, Poland, 02-507
Contact: Site 5253            
Local Institution Recruiting
Wroclaw, Poland, 50-367
Contact: Site 5251            
Puerto Rico
Local Institution Recruiting
Ponce, Puerto Rico, 00716
Contact: Site 7600            
Local Institution Not yet recruiting
San Juan, Puerto Rico, 00918
Contact: Site 7602            
Romania
Local Institution Recruiting
Brasov, Romania, 500326
Contact: Site 5356            
Local Institution Recruiting
Bucaresti, Romania, 030171
Contact: Site 5350            
Local Institution Recruiting
Bucuresti, Romania, 020125
Contact: Site 5355            
Local Institution Recruiting
Bucuresti, Romania, 050098
Contact: Site 5353            
Local Institution Recruiting
Bucuresti, Romania, 22328
Contact: Site 5352            
Local Institution Recruiting
Lasi, Romania, 700106
Contact: Site 5351            
Russian Federation
Local Institution Not yet recruiting
Moscow, Russian Federation, 115478
Contact: Site 5451            
Local Institution Recruiting
Samara, Russian Federation, 443095
Contact: Site 5453            
Local Institution Not yet recruiting
St Petersburg, Russian Federation, 197089
Contact: Site 5452            
Local Institution Not yet recruiting
St. Petersburg, Russian Federation, 197022
Contact: Site 5450            
Spain
Local Institution Recruiting
Badalona-Barcelona, Spain, 08916
Contact: Site 5552            
Local Institution Recruiting
Barcelona, Spain, 08041
Contact: Site 5555            
Local Institution Recruiting
Madrid, Spain, 28007
Contact: Site 5551            
Local Institution Recruiting
Madrid, Spain, 28041
Contact: Site 5554            
Local Institution Recruiting
Madrid, Spain, 28006
Contact: Site 5553            
Local Institution Recruiting
Salamanca, Spain, 37007
Contact: Site 5550            
Local Institution Recruiting
San Sebastian, Spain, 20014
Contact: Site 5557            
Local Institution Recruiting
Toledo, Spain, 45004
Contact: Site 5556            
Switzerland
Local Institution Recruiting
Bern, Switzerland, 3010
Contact: Site 5751            
Local Institution Recruiting
St Gallen, Switzerland, 9007
Contact: Site 5750            
Local Institution Recruiting
Zurich, Switzerland, 8028
Contact: Site 5753            
Local Institution Recruiting
Zurich, Switzerland, 8091
Contact: Site 5752            
Turkey
Local Institution Not yet recruiting
Adana, Balcali, Turkey, 01330
Contact: Site 5855            
Local Institution Not yet recruiting
Izmir, Bornova, Turkey, 35100
Contact: Site 5853            
Local Institution Not yet recruiting
Istanbul, Capa, Turkey, 34340
Contact: Site 5852            
Local Institution Not yet recruiting
Ankara, Demetevier, Turkey, 06310
Contact: Site 5850            
Local Institution Not yet recruiting
Ankara, Dikimevi, Turkey, 06620
Contact: Site 5851            
Local Institution Not yet recruiting
Izmir, Inciralti, Turkey, 35340
Contact: Site 5854            
Local Institution Not yet recruiting
Gaziantep, Turkey, 27310
Contact: Site 5856            
United Kingdom
Local Institution Not yet recruiting
Belfast, Antrim, United Kingdom, BT9 7AB
Contact: Site 5951            
Local Institution Recruiting
London, Greater London, United Kingdom, NW3 2QG
Contact: Site 5955            
Local Institution Not yet recruiting
London, Greater London, United Kingdom, SE5 9RS
Contact: Site 5953            
Local Institution Recruiting
London, Greater London, United Kingdom, NW1 2PG
Contact: Site 5952            
Local Institution Recruiting
London, Greater London, United Kingdom, EC1A 7BE
Contact: Site 5950            
Local Institution Recruiting
London, United Kingdom, HA1 3UJ
Contact: Site 5954            
Sponsors and Collaborators
Bristol-Myers Squibb
AbbVie
Investigators
Study Director: Bristol-Myers Squibb Bristol-Myers Squibb
  More Information

Additional Information:
No publications provided

Responsible Party: Bristol-Myers Squibb
ClinicalTrials.gov Identifier: NCT01335399     History of Changes
Other Study ID Numbers: CA204-006, 2010-022445-20
Study First Received: April 13, 2011
Last Updated: January 4, 2013
Health Authority: Australia: Department of Health and Ageing Therapeutic Goods Administration
Australia: National Health and Medical Research Council
Austria: Federal Office for Safety in Health Care
Belgium: The Federal Public Service (FPS) Health, Food Chain Safety and Environment
Canada: Health Canada
Czech Republic: State Institute for Drug Control
Germany: Federal Institute for Drugs and Medical Devices
Germany: Paul-Ehrlich-Institut
Germany: Federal Office for Radiation Protection
Germany: Ministry of Health
Greece: Ethics Committee
Greece: National Organization of Medicines
Hungary: National Institute of Pharmacy
Ireland: Irish Medicines Board
Israel: Israeli Health Ministry Pharmaceutical Administration
Italy: Ministry of Health
Italy: National Bioethics Committee
Italy: National Institute of Health
Italy: National Monitoring Centre for Clinical Trials - Ministry of Health
Italy: The Italian Medicines Agency
Poland: National Institute of Medicines
Poland: Ministry of Health
Poland: Ministry of Science and Higher Education
Poland: Office for Registration of Medicinal Products, Medical Devices and Biocidal Products
Romania: National Medicines Agency
Romania: Ministry of Public Health
Russia: Ethics Committee
Russia: Ministry of Health of the Russian Federation
Russia: FSI Scientific Center of Expertise of Medical Application
Spain: Spanish Agency of Medicines
Switzerland: Federal Office of Public Health
Switzerland: Swissmedic
Turkey: Ministry of Health
United Kingdom: Medicines and Healthcare Products Regulatory Agency
United States: Food and Drug Administration

Keywords provided by Bristol-Myers Squibb:
Newly Diagnosed
Previously Untreated

Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Neoplasms by Histologic Type
Neoplasms
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Paraproteinemias
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Lymphoproliferative Disorders
Immunoproliferative Disorders
Immune System Diseases
Dexamethasone acetate
Dexamethasone
Dexamethasone 21-phosphate
Lenalidomide
Thalidomide
BB 1101
Anti-Inflammatory Agents
Therapeutic Uses
Pharmacologic Actions
Antiemetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Central Nervous System Agents
Gastrointestinal Agents
Glucocorticoids

ClinicalTrials.gov processed this record on May 22, 2013