S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2014 by Southwest Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Southwest Oncology Group
ClinicalTrials.gov Identifier:
NCT01097278
First received: March 31, 2010
Last updated: April 4, 2014
Last verified: April 2014
  Purpose

RATIONALE: Cholecalciferol may prevent breast cancer in premenopausal women.

PURPOSE: This randomized phase II trial is studying how well cholecalciferol works in preventing breast cancer in premenopausal women.


Condition Intervention Phase
brca1 Mutation Carrier
brca2 Mutation Carrier
Breast Cancer
Dietary Supplement: cholecalciferol
Other: placebo
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
Official Title: Phase IIB Randomized Controlled Biomarker Modulation Study of Vitamin D in Premenopausal Women at High Risk for Breast Cancer

Resource links provided by NLM:


Further study details as provided by Southwest Oncology Group:

Primary Outcome Measures:
  • Change in mammographic density at 12 months compared to baseline [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Ki-67 as assessed in tissue obtained in breast biopsies at baseline and at 12 months [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 200
Study Start Date: November 2011
Estimated Study Completion Date: July 2015
Estimated Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I
Participants receive oral cholecalciferol once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.
Dietary Supplement: cholecalciferol
Given orally
Active Comparator: Arm II
Participants receive oral placebo once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.
Dietary Supplement: cholecalciferol
Given orally
Other: placebo
Given orally

Detailed Description:

OBJECTIVES:

  • To assess whether mammographic density is reduced in premenopausal women at high risk of breast cancer taking high-dose vitamin D3 (oral cholecalciferol 20,000 IU weekly) vs placebo for 1 year.
  • To assess whether proliferation as measured by Ki-67 staining of breast epithelial cells is reduced in women receiving these treatments.
  • To explore the difference in the expression of other biomarkers (including cleaved caspase-3 [apoptosis marker], ER, vitamin D receptor [VDR], and 1α-hydroxylase) in breast tissue obtained from these women.
  • To assess whether parathyroid hormone, IGF-1, IGFBP-3, 25(OH)D, and 1,25(OH)D serum levels are altered in these women at baseline and at 6 and 12 months.
  • To explore whether a change in mammographic density correlates with polymorphisms in the VDR gene.
  • To assess other sources of vitamin D (sunlight exposure, diet) in these women using a validated questionnaire administered at baseline and at 12 and 24 months.
  • To collect and bank serum, plasma, and breast tissue from these women before and after a 1-year intervention with vitamin D for future biomarker analysis.
  • To assess the toxicity of high-dose cholecalciferol compared to placebo in this setting.

OUTLINE: This is a multicenter study. Participants are stratified according to baseline serum 25(OH)D level (< 20 ng/mL vs 20-32 ng/mL or < 50 nmol/L vs 50-80 nmol/L), baseline mammographic density (11-50% vs > 50%), and designated biopsy site (yes vs no). Participants are randomized to 1 of 2 treatment arms.

  • Arm I: Participants receive oral cholecalciferol once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.
  • Arm II: Participants receive oral placebo once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.

Blood samples are collected at baseline and periodically thereafter for biomarkers and 25(OH)D level. Participants undergo a mammogram at baseline and at 12 months. Participants may also undergo random core-needle breast biopsy at baseline and at 12 months.

Participants complete a questionnaire at baseline and at 12 and 24 months.

After completion of study therapy, participants are followed up at 1 and 12 months.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • At an elevated risk of breast cancer by at least one of the following criteria:

    • Diagnosis of ADH, ALH, lobular carcinoma in situ (LCIS) or resected ductal carcinoma in situ (DCIS) or small invasive breast cancers (pTmi or pT1a N0) if no pior RT, tamoxifen, or systemic breast cancer treatment within 28 days prior to registration OR diagnosis of resected Stage I (T1b-c N0-N1mi) through Stage II breast cancer for which the participant has been disease-free for at least 5 years and has completed all adjuvant treatment OR
    • A known* deleterious mutation in BRCA1, BRCA2, PTEN, or TP53 NOTE: *The participant must be a documented carrier to meet this criterion. If there is a known mutation in a hereditary breast cancer susceptibility gene in a participant's family member, the participant herself must have undergone genetic testing as per NCCN clinical guidelines to be eligible per this criterion.
    • Modified Gail Model/CARE model** risk at 5 years ≥ 1.67% or lifetime risk ≥ 20% by Claus, BRCAPro, Tyrer-Cuzick or IBIS models OR
    • Mammographic density ≥ 50% (heterogenously dense) NOTE: **Risk models are to be used only if there is no known previous diagnosis of resected DCIS or LCIS and there is no known deleterious mutation in BRCA1, BRCA2, PTEN, or TP53.
  • At least one breast available for imaging and biopsy (a previously irradiated breast [i.e., for resected DCIS] is not evaluable for breast imaging or biopsy)
  • Baseline mammogram (performed within 10 days after starting their last menstrual period on a digital mammography machine) that shows either normal or benign findings

    • Baseline mammographic density > 10% based upon the classification system (2 = 11-50%, "scattered fibroglandular densities"; 3 = 51-75%, "heterogeneously dense"; 4 = >75, "extremely dense". Women with a baseline mammographic density of ≤ 10% (1 = ≤ 10% breasts are almost entirely fat)will not be eligible.

PATIENT CHARACTERISTICS:

  • Premenopausal, defined as ≥ 1 of the following criteria:

    • Less than 6 months since the last menstrual period, no prior bilateral oophorectomy, and no use of hormone-replacement therapy
    • Has undergone a prior hysterectomy but no prior bilateral oophorectomy AND follicle-stimulating hormone values measured within the past 28 days are consistent with the normal values for the premenopausal state
  • Zubrod performance status 0-1
  • Serum creatinine ≤ upper limit of normal (ULN)
  • Serum calcium or corrected calcium ≤ ULN
  • Spot urine calcium:creatinine ratio < 0.37 mg/dL
  • INR ≤ 1.5 times ULN+
  • PT and PTT ≤ ULN*
  • Baseline serum 25(OH)D level ≤ 32 ng/mL (or 80 nmol/L)
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No other prior malignancy except for the following:

    • Adequately treated basal cell or squamous cell skin cancer
    • In situ cervical cancer
    • Adequately treated stage I or II (including resected Stage I, T1b-c N0-N1mi through Stage II breast cancer) from which the participant is currently in complete remission
    • Any other cancer (including contralateral breast) for which the participant has been disease-free for ≥ 5 years
  • No history of kidney stones
  • No medical conditions requiring calcium or vitamin D supplementation (i.e., osteoporosis)
  • No known hypersensitivity to vitamin D
  • No known allergy to soy NOTE: +For patients undergoing breast biopsy.

PRIOR CONCURRENT THERAPY:

  • Prior breast reduction surgery allowed

    • No bilateral breast implants
  • More than 1 month since prior surgery or radiotherapy to the breast for resected DCIS
  • At least 28 days since prior tamoxifen
  • Prior anticoagulant therapy allowed provided it is discontinued ≥ 7 days before breast biopsy
  • No concurrent calcium or additional vitamin D supplements

    • Concurrent multivitamins allowed provided that the dose of vitamin D in the multivitamin does not exceed 400 IU daily
  • No concurrent participation in any other clinical trial for the treatment or prevention of cancer unless the participant is no longer receiving the intervention and is in the follow-up phase only (participants must not join such a trial while participating in this study)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01097278

Contacts
Contact: Patricia O'Kane 2106148808 ext 1011 pokane@swog.org
Contact: Dana Sparks, MAT 2106148808 ext 1004 dsparks@swog.org

  Hide Study Locations
Locations
United States, Alabama
Northeast Alabama Regional Medical Center Recruiting
Anniston, Alabama, United States, 36202
Contact: George I. Crawford    256-235-5084      
Principal Investigator: George I. Crawford         
Providence Hospital Recruiting
Mobile, Alabama, United States, 36608
Contact: Thaddeus A. Beeker    877-904-4367      
Principal Investigator: Thaddeus A. Beeker         
United States, Alaska
Alaska Regional Hospital Terminated
Anchorage, Alaska, United States, 99508
Fairbanks Memorial Hospital Active, not recruiting
Fairbanks, Alaska, United States, 99701
United States, Arizona
Arizona Cancer Center at University Medical Center North Recruiting
Tucson, Arizona, United States, 85719
Contact: Joanne M. Jeter    520-626-9008      
Principal Investigator: Joanne M. Jeter         
University of Arizona Health Sciences Center Recruiting
Tucson, Arizona, United States, 85724
Contact: Joanne M. Jeter    520-626-9008      
Principal Investigator: Joanne M. Jeter         
United States, Arkansas
Highlands Oncology Group-Rogers Recruiting
Rogers, Arkansas, United States, 72758
Contact: Joseph T. Beck    800-381-6939      
Principal Investigator: Joseph T. Beck         
United States, California
East Bay Radiation Oncology Center Recruiting
Castro Valley, California, United States, 94546
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Valley Medical Oncology Consultants-Castro Valley Terminated
Castro Valley, California, United States, 94546
John Muir Medical Center-Concord Campus Recruiting
Concord, California, United States, 94520
Contact: Deborah L. Kerlin    925-674-2580      
Principal Investigator: Deborah L. Kerlin         
UC Irvine Health Pacific Breast Care Center Recruiting
Costa Mesa, California, United States, 92627
Contact: David Hsiang    877-827-8839    ucstudy@uci.edu   
Principal Investigator: David Hsiang         
City of Hope Active, not recruiting
Duarte, California, United States, 91010
Epic Care-Dublin Recruiting
Dublin, California, United States, 94568
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Valley Medical Oncology Consultants-Fremont Terminated
Fremont, California, United States, 94538
Breastlink Medical Group Inc Active, not recruiting
Long Beach, California, United States, 90806
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: Agustin A. Garcia    323-865-0451      
Principal Investigator: Agustin A. Garcia         
University of Southern California Recruiting
Los Angeles, California, United States, 90033
Contact: Agustin A. Garcia    323-865-0451      
Principal Investigator: Agustin A. Garcia         
Contra Costa Regional Medical Center Recruiting
Martinez, California, United States, 94553-3156
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
El Camino Hospital Recruiting
Mountain View, California, United States, 94040
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Larry G Strieff MD Medical Corporation Recruiting
Oakland, California, United States, 94609
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Epic Care-Oakland Recruiting
Oakland, California, United States, 94612
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Bay Area Breast Surgeons Inc Recruiting
Oakland, California, United States, 94609
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Alta Bates Summit Medical Center - Summit Campus Recruiting
Oakland, California, United States, 94609
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Tom K Lee Inc Terminated
Oakland, California, United States, 94609
Highland General Hospital Recruiting
Oakland, California, United States, 94602
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Bay Area Tumor Institute CCOP Recruiting
Oakland, California, United States, 94609
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
University of California Medical Center At Irvine-Orange Campus Recruiting
Orange, California, United States, 92868
Contact: David Hsiang    877-827-8839    ucstudy@uci.edu   
Principal Investigator: David Hsiang         
Huntington Memorial Hospital Recruiting
Pasadena, California, United States, 91105
Contact: Jeannie Shen    626-535-2420      
Principal Investigator: Jeannie Shen         
East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill Recruiting
Pleasant Hill, California, United States, 94523
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Valley Medical Oncology Consultants Recruiting
Pleasanton, California, United States, 94588
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
Doctors Medical Center- JC Robinson Regional Cancer Center Recruiting
San Pablo, California, United States, 94806
Contact: James H. Feusner    510-450-7600      
Principal Investigator: James H. Feusner         
John Muir Medical Center Recruiting
Walnut Creek, California, United States, 94598
Contact: Deborah L. Kerlin    925-674-2580      
Principal Investigator: Deborah L. Kerlin         
Presbyterian Intercommunity Hospital Recruiting
Whittier, California, United States, 90602
Contact: Dustin E. Stevenson    562-698-0811      
Principal Investigator: Dustin E. Stevenson         
United States, Colorado
The Medical Center of Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Memorial Hospital Colorado Springs Recruiting
Colorado Springs, Colorado, United States, 80909
Contact: Laura K. Pomerenke    888-785-6789      
Principal Investigator: Laura K. Pomerenke         
Exempla Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Colorado Cancer Research Program CCOP Recruiting
Denver, Colorado, United States, 80224-2522
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Mercy Medical Center Recruiting
Durango, Colorado, United States, 81301
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Regina J. Brown    970-495-8226      
Principal Investigator: Regina J. Brown         
Front Range Cancer Specialists Terminated
Fort Collins, Colorado, United States, 80528
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Anthony Hospital Recruiting
Lakewood, Colorado, United States, 80228
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Littleton Adventist Hospital Recruiting
Littleton, Colorado, United States, 80122
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Sky Ridge Medical Center Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Longmont United Hospital Recruiting
Longmont, Colorado, United States, 80501
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Parker Adventist Hospital Recruiting
Parker, Colorado, United States, 80138
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Saint Mary Corwin Medical Center Recruiting
Pueblo, Colorado, United States, 81004
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Exempla Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Greenwich Hospital Recruiting
Greenwich, Connecticut, United States, 06830
Contact: Laura Lazarus    203-863-3698      
Principal Investigator: Laura Lazarus         
Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Middlesex Hospital Recruiting
Middletown, Connecticut, United States, 06457
Contact: Susanna Hong    860-358-2058      
Principal Investigator: Susanna Hong         
United States, Florida
Florida Hospital Recruiting
Orlando, Florida, United States, 32803
Contact: Lee M. Zehngebot    407-303-5623      
Principal Investigator: Lee M. Zehngebot         
Martin Hospital South Recruiting
Stuart, Florida, United States, 34997
Contact: James J. Vopal    772-288-5858 ext 4      
Principal Investigator: James J. Vopal         
Martin Medical Center Recruiting
Stuart, Florida, United States, 34994
Contact: James J. Vopal    772-288-5858 ext 4      
Principal Investigator: James J. Vopal         
Robert and Carol Weissman Cancer Center at Martin Health Recruiting
Stuart, Florida, United States, 34994
Contact: James J. Vopal    772-288-5858 ext 4      
Principal Investigator: James J. Vopal         
United States, Georgia
Dekalb Medical Center Recruiting
Decatur, Georgia, United States, 30033
Contact: Jayanthi Srinivasiah    404-501-3279      
Principal Investigator: Jayanthi Srinivasiah         
United States, Hawaii
Pali Momi Medical Center Active, not recruiting
Aiea, Hawaii, United States, 96701
Oncare Hawaii Inc-Pali Momi Active, not recruiting
Aiea, Hawaii, United States, 96701
Straub Clinic and Hospital Active, not recruiting
Honolulu, Hawaii, United States, 96813
Kapiolani Medical Center for Women and Children Active, not recruiting
Honolulu, Hawaii, United States, 96826
Queen's Medical Center Active, not recruiting
Honolulu, Hawaii, United States, 96813
Oncare Hawaii Inc-Kuakini Active, not recruiting
Honolulu, Hawaii, United States, 96817
University of Hawaii Active, not recruiting
Honolulu, Hawaii, United States, 96813
Kuakini Medical Center Active, not recruiting
Honolulu, Hawaii, United States, 96817
Oncare Hawaii Inc-POB II Active, not recruiting
Honolulu, Hawaii, United States, 96813
OnCare Hawaii-Liliha Active, not recruiting
Honolulu, Hawaii, United States, 96817-3169
Tripler Army Medical Center Recruiting
Honolulu, Hawaii, United States, 96859
Contact: Jeffrey L. Berenberg    808-586-2979      
Principal Investigator: Jeffrey L. Berenberg         
Castle Medical Center Active, not recruiting
Kailua, Hawaii, United States, 96734
Wilcox Memorial Hospital and Kauai Medical Clinic Active, not recruiting
Lihue, Hawaii, United States, 96766
United States, Idaho
Saint Alphonsus Regional Medical Center Recruiting
Boise, Idaho, United States, 83706
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Saint Luke's Mountain States Tumor Institute Recruiting
Boise, Idaho, United States, 83712
Contact: Paul G. Montgomery    800-845-4624      
Principal Investigator: Paul G. Montgomery         
Saint Luke's Mountain States Tumor Institute - Meridian Recruiting
Meridian, Idaho, United States, 83642
Contact: Paul G. Montgomery    800-845-4624      
Principal Investigator: Paul G. Montgomery         
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint Luke's Mountain States Tumor Institute-Twin Falls Recruiting
Twin Falls, Idaho, United States, 83301
Contact: Paul G. Montgomery    800-845-4624      
Principal Investigator: Paul G. Montgomery         
United States, Illinois
Saint Anthony's Health Terminated
Alton, Illinois, United States, 62002
Saint Joseph Medical Center Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61701
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Advocate Sherman Hospital Withdrawn
Elgin, Illinois, United States, 60123
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Galesburg Cottage Plaza Office Recruiting
Galesburg, Illinois, United States, 61401
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Delnor Community Hospital Terminated
Geneva, Illinois, United States, 60134
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Loyola University Medical Center Withdrawn
Maywood, Illinois, United States, 60153
Illinois CancerCare-Monmouth Recruiting
Monmouth, Illinois, United States, 61462
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Holy Family Medical Center Terminated
Monmouth, Illinois, United States, 61462
Good Samaritan Regional Health Center Recruiting
Mount Vernon, Illinois, United States, 62864
Contact: Jay W. Carlson    888-244-6061    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Mid-Illinois Hematology Oncology Associates Terminated
Normal, Illinois, United States, 61761
Community Cancer Center Foundation Recruiting
Normal, Illinois, United States, 61761
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Ottawa Regional Hospital and Healthcare Center Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois Oncology Research Association CCOP Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Proctor Hospital Terminated
Peoria, Illinois, United States, 61614
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: Nguyet A. Le-Lindqwister    800-793-2262      
Principal Investigator: Nguyet A. Le-Lindqwister         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Central DuPage Hospital Cancer Center Recruiting
Warrenville, Illinois, United States, 60555
Contact: John D. Ayers    630-352-5300      
Principal Investigator: John D. Ayers         
United States, Indiana
Elkhart Clinic Recruiting
Elkhart, Indiana, United States, 46514-2098
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Michiana Hematology Oncology PC-Elkhart Recruiting
Elkhart, Indiana, United States, 46514
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Elkhart General Hospital Recruiting
Elkhart, Indiana, United States, 46515
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Indiana University Medical Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Lida A. Mina    317-274-2552      
Principal Investigator: Lida A. Mina         
Community Howard Regional Health Recruiting
Kokomo, Indiana, United States, 46904
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Indiana University Health La Porte Hospital Recruiting
La Porte, Indiana, United States, 46350
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Saint Joseph Regional Medical Center-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Michiana Hematology Oncology PC-Mishawaka Recruiting
Mishawaka, Indiana, United States, 46545-1470
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Cancer Care Partners LLC Terminated
Mishawaka, Indiana, United States, 46545
Michiana Hematology Oncology PC-Plymouth Recruiting
Plymouth, Indiana, United States, 46563
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Northern Indiana Cancer Research Consortium Recruiting
South Bend, Indiana, United States, 46628
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Michiana Hematology Oncology PC-South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
South Bend Clinic Recruiting
South Bend, Indiana, United States, 46617
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Memorial Hospital of South Bend Recruiting
South Bend, Indiana, United States, 46601
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Michiana Hematology Oncology-PC Westville Recruiting
Westville, Indiana, United States, 46391
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
United States, Iowa
Mercy Medical Center-Sioux City Recruiting
Sioux City, Iowa, United States, 51104
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
Saint Luke's Regional Medical Center Recruiting
Sioux City, Iowa, United States, 51104
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
Cancer Center of Kansas - Chanute Recruiting
Chanute, Kansas, United States, 66720
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Dodge City Recruiting
Dodge City, Kansas, United States, 67801
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - El Dorado Recruiting
El Dorado, Kansas, United States, 67042
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Fort Scott Recruiting
Fort Scott, Kansas, United States, 66701
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Independence Recruiting
Independence, Kansas, United States, 67301
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Providence Medical Center Terminated
Kansas City, Kansas, United States, 66112
Cancer Center of Kansas-Kingman Recruiting
Kingman, Kansas, United States, 67068
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Lawrence Memorial Hospital Recruiting
Lawrence, Kansas, United States, 66044
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Liberal Recruiting
Liberal, Kansas, United States, 67901
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Manhattan Recruiting
Manhattan, Kansas, United States, 66502
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - McPherson Recruiting
McPherson, Kansas, United States, 67460
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Newton Recruiting
Newton, Kansas, United States, 67114
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Saint Luke's South Hospital Recruiting
Overland Park, Kansas, United States, 66213
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Menorah Medical Center Recruiting
Overland Park, Kansas, United States, 66209
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Cancer Center of Kansas - Parsons Recruiting
Parsons, Kansas, United States, 67357
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Kansas City CCOP Recruiting
Prairie Village, Kansas, United States, 66208
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Cancer Center of Kansas - Pratt Recruiting
Pratt, Kansas, United States, 67124
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Salina Recruiting
Salina, Kansas, United States, 67401
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Wellington Recruiting
Wellington, Kansas, United States, 67152
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Associates In Womens Health Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Main Office Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Via Christi Regional Medical Center Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Wichita CCOP Recruiting
Wichita, Kansas, United States, 67214
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas-Wichita Medical Arts Tower Recruiting
Wichita, Kansas, United States, 67208
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
Cancer Center of Kansas - Winfield Recruiting
Winfield, Kansas, United States, 67156
Contact: Shaker R. Dakhil    316-262-4467      
Principal Investigator: Shaker R. Dakhil         
United States, Kentucky
Baptist Health Lexington Recruiting
Lexington, Kentucky, United States, 40503
Contact: Elvis S. Donaldson    859-260-6425      
Principal Investigator: Elvis S. Donaldson         
United States, Louisiana
Hematology/Oncology Clinic LLP Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Hana F. Safah    504-988-6121      
Principal Investigator: Hana F. Safah         
Ochsner Medical Center Recruiting
New Orleans, Louisiana, United States, 70121
Contact: John T. Cole    888-562-4763      
Principal Investigator: John T. Cole         
Tulane University Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Hana F. Safah    504-988-6121      
Principal Investigator: Hana F. Safah         
Louisiana State University Health Sciences Center Shreveport Withdrawn
Shreveport, Louisiana, United States, 71130
United States, Massachusetts
Caritas Saint Elizabeth's Medical Center Recruiting
Brighton, Massachusetts, United States, 02135-2997
Contact: Dorcas D. Chi    617-789-2903      
Principal Investigator: Dorcas D. Chi         
Lahey Hospital and Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Corrine L. Zarwan    781-744-8027      
Principal Investigator: Corrine L. Zarwan         
United States, Michigan
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Michigan Cancer Research Consortium Community Clinical Oncology Program Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Oakwood Hospital Recruiting
Dearborn, Michigan, United States, 48124
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Wayne State University-Karmanos Cancer Institute Recruiting
Detroit, Michigan, United States, 48201
Contact: Sayeh M. Lavasani    313-576-9363      
Principal Investigator: Sayeh M. Lavasani         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Robert A. Chapman    313-916-1784      
Principal Investigator: Robert A. Chapman         
Botsford General Hospital Recruiting
Farmington, Michigan, United States, 48334
Contact: Padmaja V. Venuturumilli    248-551-7695      
Principal Investigator: Padmaja V. Venuturumilli         
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48502
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Genesys Regional Medical Center-West Flint Campus Recruiting
Flint, Michigan, United States, 48532
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Genesys Regional Medical Center Terminated
Grand Blanc, Michigan, United States, 48439
Allegiance Health Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Bronson Methodist Hospital Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Borgess Medical Center Recruiting
Kalamazoo, Michigan, United States, 49001
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Sparrow Hospital Recruiting
Lansing, Michigan, United States, 48912
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Mid-Michigan Medical Center - Midland Terminated
Midland, Michigan, United States, 48670
Lakeland Cancer Specialists Terminated
Niles, Michigan, United States, 49102
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Saint Joseph Mercy Port Huron Recruiting
Port Huron, Michigan, United States, 48060
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
William Beaumont Hospital-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Padmaja V. Venuturumilli    248-551-7695      
Principal Investigator: Padmaja V. Venuturumilli         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
Marie Yeager Cancer Center Recruiting
Saint Joseph, Michigan, United States, 49085
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
Providence Hospital Recruiting
Southfield, Michigan, United States, 48075
Contact: Anibal Drelichman    248-849-5337    jaswinder.grewal@stjohn.org   
Principal Investigator: Anibal Drelichman         
Lakeland Hospital Recruiting
St. Joseph, Michigan, United States, 49085
Contact: Robin T. Zon    574-234-5123      
Principal Investigator: Robin T. Zon         
William Beaumont Hospital - Troy Recruiting
Troy, Michigan, United States, 48098
Contact: Padmaja V. Venuturumilli    248-551-7695      
Principal Investigator: Padmaja V. Venuturumilli         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella    734-712-3456      
Principal Investigator: Philip J. Stella         
United States, Minnesota
Fairview Ridges Hospital Recruiting
Burnsville, Minnesota, United States, 55337
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Fairview-Southdale Hospital Recruiting
Edina, Minnesota, United States, 55435
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hutchinson Area Health Care Recruiting
Hutchinson, Minnesota, United States, 55350
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint John's Hospital - Healtheast Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Abbott-Northwestern Hospital Recruiting
Minneapolis, Minnesota, United States, 55407
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
New Ulm Medical Center Recruiting
New Ulm, Minnesota, United States, 56073
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
North Memorial Medical Health Center Recruiting
Robbinsdale, Minnesota, United States, 55422
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Metro-Minnesota CCOP Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Park Nicollet Clinic - Saint Louis Park Recruiting
Saint Louis Park, Minnesota, United States, 55416
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United Hospital Recruiting
Saint Paul, Minnesota, United States, 55102
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Regions Hospital Recruiting
Saint Paul, Minnesota, United States, 55101
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Saint Francis Regional Medical Center Recruiting
Shakopee, Minnesota, United States, 55379
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Lakeview Hospital Recruiting
Stillwater, Minnesota, United States, 55082
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Ridgeview Medical Center Recruiting
Waconia, Minnesota, United States, 55387
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Rice Memorial Hospital Recruiting
Willmar, Minnesota, United States, 56201
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
Minnesota Oncology and Hematology PA-Woodbury Recruiting
Woodbury, Minnesota, United States, 55125
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United States, Mississippi
Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson    228-809-5292      
Principal Investigator: James E. Clarkson         
United States, Missouri
Central Care Cancer Center-Carrie J Babb Cancer Center Recruiting
Bolivar, Missouri, United States, 65613
Contact: Jay W. Carlson    888-244-6061    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Centerpoint Medical Center LLC Recruiting
Independence, Missouri, United States, 64057
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Mercy Hospital-Joplin Recruiting
Joplin, Missouri, United States, 64804
Contact: Jay W. Carlson    888-244-6061    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
North Kansas City Hospital Terminated
Kansas City, Missouri, United States, 64116
Heartland Hematology and Oncology Associates Incorporated Recruiting
Kansas City, Missouri, United States, 64118
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Research Medical Center Recruiting
Kansas City, Missouri, United States, 64132
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's Hospital of Kansas City Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Luke's East - Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64086
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Liberty Radiation Oncology Clinic Recruiting
Liberty, Missouri, United States, 64068
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint John's Clinic-Rolla-Cancer and Hematology Recruiting
Rolla, Missouri, United States, 65401
Contact: Robert L. Carolla    417-269-4520      
Principal Investigator: Robert L. Carolla         
Phelps County Regional Medical Center Active, not recruiting
Rolla, Missouri, United States, 65401
Heartland Regional Medical Center Recruiting
Saint Joseph, Missouri, United States, 64506
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Joseph Oncology Inc Recruiting
Saint Joseph, Missouri, United States, 64507
Contact: Rakesh Gaur    913-948-5588    aroland@kccop.org   
Principal Investigator: Rakesh Gaur         
Saint Louis-Cape Girardeau CCOP Terminated
Saint Louis, Missouri, United States, 63141
Saint Louis Cancer and Breast Institute-South City Recruiting
Saint Louis, Missouri, United States, 63109
Contact: Bethany G. Sleckman    913-948-5588      
Principal Investigator: Bethany G. Sleckman         
Saint John's Mercy Medical Center Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Bethany G. Sleckman    913-948-5588      
Principal Investigator: Bethany G. Sleckman         
CoxHealth South Hospital Recruiting
Springfield, Missouri, United States, 65807
Contact: Jay W. Carlson    888-244-6061    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Recruiting
Springfield, Missouri, United States, 65802
Contact: Robert L. Carolla    417-269-4520      
Principal Investigator: Robert L. Carolla         
Mercy Hospital Springfield Recruiting
Springfield, Missouri, United States, 65804
Contact: Jay W. Carlson    888-244-6061    sherrijr@iora.org   
Principal Investigator: Jay W. Carlson         
United States, Montana
Montana Cancer Consortium CCOP Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Hematology-Oncology Centers of the Northern Rockies PC Terminated
Billings, Montana, United States, 59102
Saint Vincent Healthcare Recruiting
Billings, Montana, United States, 59101
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Billings Clinic Recruiting
Billings, Montana, United States, 59107-7000
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Cancer Center Terminated
Bozeman, Montana, United States, 59715
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Saint James Community Hospital and Cancer Treatment Center Recruiting
Butte, Montana, United States, 59701
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Great Falls Clinic Terminated
Great Falls, Montana, United States, 59405
Saint Peter's Community Hospital Recruiting
Helena, Montana, United States, 59601
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Glacier Oncology PLLC Terminated
Kalispell, Montana, United States, 59901
Montana Cancer Specialists Active, not recruiting
Missoula, Montana, United States, 59802
Saint Patrick Hospital - Community Hospital Recruiting
Missoula, Montana, United States, 59802
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Good Samaritan Hospital Recruiting
Kearney, Nebraska, United States, 68847
Contact: George K. Bascom    308-865-7963      
Principal Investigator: George K. Bascom         
Nebraska Cancer Research Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
Alegent Health Bergan Mercy Medical Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
Missouri Valley Cancer Consortium CCOP Recruiting
Omaha, Nebraska, United States, 68106
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
Creighton University Medical Center Recruiting
Omaha, Nebraska, United States, 68131
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
Alegent Health Immanuel Medical Center Recruiting
Omaha, Nebraska, United States, 68122
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
Alegent Health Lakeside Hospital Recruiting
Omaha, Nebraska, United States, 68130
Contact: Gamini S. Soori    402-280-4100      
Principal Investigator: Gamini S. Soori         
United States, New Hampshire
Saint Joseph Hospital Recruiting
Nashua, New Hampshire, United States, 03060
Contact: Mary A. Voltz    603-880-3408    carcieri@sjh-nh.org   
Principal Investigator: Mary A. Voltz         
United States, New Mexico
Presbyterian Kaseman Hospital Recruiting
Albuquerque, New Mexico, United States, 87110
Contact: Melanie E. Royce    505-727-8000      
Principal Investigator: Melanie E. Royce         
University of New Mexico Withdrawn
Albuquerque, New Mexico, United States, 87106
University of New Mexico at Lovelace Medical Center Withdrawn
Albuquerque, New Mexico, United States, 87102
United States, New York
Hematology Oncology Associates of Central New York PC-East Syracuse Recruiting
East Syracuse, New York, United States, 13057
Contact: Jeffrey J. Kirshner    315-472-7504      
Principal Investigator: Jeffrey J. Kirshner         
Arnot Ogden Medical Center Withdrawn
Elmira, New York, United States, 14905
Glens Falls Hospital Withdrawn
Glens Falls, New York, United States, 12801
Winthrop University Hospital Recruiting
Mineola, New York, United States, 11501
Contact: Nina D'Abreo    866-946-8476      
Principal Investigator: Nina D'Abreo         
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Katherine D. Crew    212-305-8615      
Principal Investigator: Katherine D. Crew         
Highland Hospital Active, not recruiting
Rochester, New York, United States, 14620
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5830      
Principal Investigator: Jonathan W. Friedberg         
State University of New York Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Jayne R. Charlamb    315-464-5476      
Principal Investigator: Jayne R. Charlamb         
United States, North Carolina
Randolph Hospital Recruiting
Asheboro, North Carolina, United States, 27203
Contact: Peter Rubin    336-832-0821      
Principal Investigator: Peter Rubin         
Presbyterian Hospital Recruiting
Charlotte, North Carolina, United States, 28204
Contact: Justin P. Favaro    704-384-5369      
Principal Investigator: Justin P. Favaro         
Cone Health Cancer Center Recruiting
Greensboro, North Carolina, United States, 27403
Contact: Peter Rubin    336-832-0821      
Principal Investigator: Peter Rubin         
Margaret R Pardee Memorial Hospital Recruiting
Hendersonville, North Carolina, United States, 28791
Contact: James E. Radford    828-696-4716      
Principal Investigator: James E. Radford         
Park Ridge Hospital Breast Health Center Recruiting
Hendersonville, North Carolina, United States, 28792
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Annie Penn Memorial Hospital Recruiting
Reidsville, North Carolina, United States, 27320
Contact: Peter Rubin    336-832-0821      
Principal Investigator: Peter Rubin         
Rutherford Hospital Withdrawn
Rutherfordton, North Carolina, United States, 28139
United States, North Dakota
Trinity Cancer Care Center Recruiting
Minot, North Dakota, United States, 58701
Contact: Stephen N. Makoni    800-862-0005      
Principal Investigator: Stephen N. Makoni         
United States, Ohio
Akron General Medical Center Withdrawn
Akron, Ohio, United States, 44307
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Strecker Cancer Center-Belpre Recruiting
Belpre, Ohio, United States, 45714
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Mount Carmel Health Center West Recruiting
Columbus, Ohio, United States, 43222
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Doctors Hospital Recruiting
Columbus, Ohio, United States, 43228
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Grant Medical Center Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Columbus CCOP Recruiting
Columbus, Ohio, United States, 43215
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Columbus Oncology and Hematology Associates Inc Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Riverside Methodist Hospital Recruiting
Columbus, Ohio, United States, 43214
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Delaware Health Center-Grady Cancer Center Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Summa Health Center at Lake Medina Recruiting
Medina, Ohio, United States, 44256
Contact: Jennifer E. Payne    330-375-6101      
Principal Investigator: Jennifer E. Payne         
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Southern Ohio Medical Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Springfield Regional Medical Center Recruiting
Springfield, Ohio, United States, 45505
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Saint Ann's Hospital Recruiting
Westerville, Ohio, United States, 43081
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
Genesis HealthCare System Recruiting
Zanesville, Ohio, United States, 43701
Contact: John P. Kuebler    614-566-3275      
Principal Investigator: John P. Kuebler         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: William C. Dooley    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: William C. Dooley         
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Legacy Mount Hood Medical Center Active, not recruiting
Gresham, Oregon, United States, 97030
Providence Milwaukie Hospital Recruiting
Milwaukie, Oregon, United States, 97222
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Willamette Falls Medical Center Recruiting
Oregon City, Oregon, United States, 97045
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Legacy Good Samaritan Hospital and Medical Center Active, not recruiting
Portland, Oregon, United States, 97210
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Legacy Emanuel Hospital and Health Center Active, not recruiting
Portland, Oregon, United States, 97227
Western Oncology Research Consortium Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Legacy Meridian Park Hospital Active, not recruiting
Tualatin, Oregon, United States, 97062
United States, Pennsylvania
Phoenixville Hospital Recruiting
Phoenixville, Pennsylvania, United States, 19460
Contact: Carl W. Sharer    610-983-1908      
Principal Investigator: Carl W. Sharer         
United States, South Carolina
AnMed Health Cancer Center Recruiting
Anderson, South Carolina, United States, 29621
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
AnMed Health Hospital Recruiting
Anderson, South Carolina, United States, 29621
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Medical University of South Carolina Withdrawn
Charleston, South Carolina, United States, 29425
Greenville Health System Cancer Institute-Easley Recruiting
Easley, South Carolina, United States, 29640
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
McLeod Regional Medical Center Recruiting
Florence, South Carolina, United States, 29506
Contact: Rajesh Bajaj    843-679-7256      
Principal Investigator: Rajesh Bajaj         
Greenville Memorial Hospital Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Saint Francis Hospital Recruiting
Greenville, South Carolina, United States, 29601
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Institute-Butternut Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Andrews Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Instutite/Greenville CCOP Recruiting
Greenville, South Carolina, United States, 29615
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Self Regional Healthcare Active, not recruiting
Greenwood, South Carolina, United States, 29646
Gibbs Cancer Center-Pelham Active, not recruiting
Greer, South Carolina, United States, 29651
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Cancer Centers of the Carolinas-Greer Medical Oncology Terminated
Greer, South Carolina, United States, 29650
Carolina Blood and Cancer Care Associates PA-Lancaster Recruiting
Lancaster, South Carolina, United States, 29720
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Carolina Blood and Cancer Care Associates PA Recruiting
Rock Hill, South Carolina, United States, 29732
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Jeffrey K. Giguere    864-241-6251      
Principal Investigator: Jeffrey K. Giguere         
Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
Upstate Carolina CCOP Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: James D. Bearden    800-486-5941      
Principal Investigator: James D. Bearden         
United States, Texas
Texas Tech University Health Science Center-Amarillo Recruiting
Amarillo, Texas, United States, 79106
Contact: Rakhshanda L. Rahman    806-354-5411      
Principal Investigator: Rakhshanda L. Rahman         
Baylor University Medical Center Recruiting
Dallas, Texas, United States, 75246
Contact: Michael D. Grant    800-422-9567      
Principal Investigator: Michael D. Grant         
M D Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Contact: Therese B. Bevers    713-792-3245      
Principal Investigator: Therese B. Bevers         
Methodist Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Angel A. Rodriguez    713-790-2700    burton@bcm.edu   
Principal Investigator: Angel A. Rodriguez         
Doctor's Hospital of Laredo Recruiting
Laredo, Texas, United States, 78041
Contact: Gary W. Unzeitig    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Gary W. Unzeitig         
United States, Utah
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Leigh A. Neumayer    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Leigh A. Neumayer         
United States, Washington
Evergreen Hospital Medical Center Active, not recruiting
Kirkland, Washington, United States, 98033
Pacific Medical Center-First Hill Active, not recruiting
Seattle, Washington, United States, 98104
Virginia Mason CCOP Active, not recruiting
Seattle, Washington, United States, 98101
Rockwood Clinic Recruiting
Spokane, Washington, United States, 99220
Contact: Kirk A. Lund    509-755-5800      
Principal Investigator: Kirk A. Lund         
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
Legacy Salmon Creek Hospital Active, not recruiting
Vancouver, Washington, United States, 98686
Compass Oncology Vancouver Recruiting
Vancouver, Washington, United States, 98684
Contact: Alison K. Conlin    503-215-6412      
Principal Investigator: Alison K. Conlin         
United States, West Virginia
Princeton Community Hospital Recruiting
Princeton, West Virginia, United States, 24740
Contact: Rowena Gonzales-Chambers    304-487-7000      
Principal Investigator: Rowena Gonzales-Chambers         
United States, Wisconsin
Mercy Health System Recruiting
Janesville, Wisconsin, United States, 53547
Contact: Emily G. Robinson    800-928-1103      
Principal Investigator: Emily G. Robinson         
Cancer Center of Western Wisconsin Recruiting
New Richmond, Wisconsin, United States, 54017
Contact: Joseph W. Leach    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Joseph W. Leach         
United States, Wyoming
Rocky Mountain Oncology Recruiting
Casper, Wyoming, United States, 82609
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Welch Cancer Center Recruiting
Sheridan, Wyoming, United States, 82801
Contact: Benjamin T. Marchello    800-648-6274      
Principal Investigator: Benjamin T. Marchello         
Sponsors and Collaborators
Southwest Oncology Group
Investigators
Principal Investigator: Katherine D. Crew, MD, MS Columbia University
  More Information

Additional Information:
No publications provided

Responsible Party: Southwest Oncology Group
ClinicalTrials.gov Identifier: NCT01097278     History of Changes
Other Study ID Numbers: S0812, S0812, U10CA037429, NCI-2011-02032
Study First Received: March 31, 2010
Last Updated: April 4, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Southwest Oncology Group:
breast cancer
ductal breast carcinoma in situ
lobular breast carcinoma in situ
BRCA1 mutation carrier
BRCA2 mutation carrier

Additional relevant MeSH terms:
Breast Neoplasms
Breast Diseases
Neoplasms
Neoplasms by Site
Skin Diseases
Cholecalciferol
Bone Density Conservation Agents
Growth Substances
Micronutrients
Pharmacologic Actions
Physiological Effects of Drugs
Vitamins

ClinicalTrials.gov processed this record on October 22, 2014