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The Impact of Post-tetanic Count on Subsequent Train-of-four During Recovery From Rocuronium

This study has been completed.
Sponsor:
Information provided by:
Maisonneuve-Rosemont Hospital
ClinicalTrials.gov Identifier:
NCT01086176
First received: March 10, 2010
Last updated: April 26, 2010
Last verified: March 2010
History of Changes
  Purpose

The purpose of this study is to see how long does the effect of a post-tetanic facilitation last on subsequent train-of-four. The investigators hypothesis is that the effect last at least 30 minutes.


Condition Intervention
Post-tetanic Count on One Arm, the Other Arm is the Control
 Device: NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex)

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Further study details as provided by Maisonneuve-Rosemont Hospital:

Primary Outcome Measures:
  • The difference at 30 minutes after the post-tetanic count between the TOF% in both arms, we expect a difference of more than 10%

Secondary Outcome Measures:
  • The difference at 30 minutes after the post-tetanic count on the T1% (of the calibrated T1) in both arms, we expect a difference of more than 10%
  • The difference of the slope of recuperation on TOF and T1% after a post-tetanic count vs the control arm that had no tetanic stimulation

Estimated Enrollment: 22
Study Start Date: March 2010
Study Completion Date: April 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patient-control Device: NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex)
on one side, we do a post-tetanic count, on the other side we don't, after, we do train-of-four on both sides and check the difference

  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Poeple having general anesthesia at HMR

Criteria

Inclusion Criteria:

  • Patient having general anesthesia in dorsal decubitus with both arm available for at least an hour and a half

Exclusion Criteria:

  • Age >75 or <18
  • Neuromuscular disease
  • difficult laryngoscopy predicted
  • Allergy to rocuronium
  • Malignant hyperthermia
  • Full stomach
  • Drugs the influence neuromuscular blockers
  • Decision of the clinician to exclude his patient
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01086176

Locations
Canada, Quebec
Hopital Maisonneuve-Rosemont
Montréal, Quebec, Canada, H1T 2M4
Sponsors and Collaborators
Maisonneuve-Rosemont Hospital
  More Information

No publications provided

Responsible Party: Louis-Philippe Fortier MD Msc, HMR
ClinicalTrials.gov Identifier: NCT01086176     History of Changes
Other Study ID Numbers: MaisonneuveRH-09092
Study First Received: March 10, 2010
Last Updated: April 26, 2010
Health Authority: Canada: Health Canada

ClinicalTrials.gov processed this record on May 16, 2013