American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS)
This study is currently recruiting participants.
Verified January 2013 by University of Oxford
Sponsor:
University of Oxford
Collaborators:
American College of Rheumatology
The European League Against Rheumatism (EULAR)
The Vasculitis foundation
Information provided by (Responsible Party):
University of Oxford
ClinicalTrials.gov Identifier:
NCT01066208
First received: February 9, 2010
Last updated: January 2, 2013
Last verified: January 2013
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Purpose
Vasculitis is group of diseases where inflammation of blood vessels is the common feature. Patients typically present with fever, fatigue, weakness and muscle and joint aches. These symptoms are very common among many different diseases, not just vasculitis. A clustering of other symptoms, physical examination findings, blood tests, radiology and biopsy help make the diagnosis. There are currently no criteria to help doctors make a diagnosis of vasculitis when a patient presents with these non specific symptoms and they are reliant on previous experience and disease definitions. One of the aims of this project is to develop diagnostic criteria for the primary systemic vasculitides (granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, Churg Strauss syndrome, polyarteritis nodosa, giant cell arteritis, Takayasu arteritis). We, the investigators, will do this by studying a large group of patients with vasculitis and comparing them to a large group of patients that present in a similar way, but do not have vasculitis. By comparing the 2 groups we will create a list of items to differentiate between vasculitis and 'vasculitis mimics'.
We also aim to update the current classification criteria. Classification criteria are used to group patients into different types of vasculitis, once a diagnosis of vasculitis has been made, and are useful for studying patients in clinical trials with similar or identical diseases. The current classification criteria (American college of Rheumatology 1990 criteria) were developed 20 years ago, before the availability of some important diagnostic tests (e.g. antineutrophil cytoplasmic antibodies [ANCA]), and are now not consistent with some of the current disease definitions. Therefore to progress future research in vasculitis, it is important that the classification criteria are updated. We will recruit 260 patients with each of the 6 types of vasculitis and compare them with 1300 controls (patients with the 5 other types of vasculitis), in order to determine the optimal combination of symptoms, signs and investigations that classify each person into the appropriate group.
| Condition |
|---|
|
Wegener's Granulomatosis Microscopic Polyangiitis Churg Strauss Syndrome Polyarteritis Nodosa Giant Cell Arteritis Takayasu Arteritis |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | ACR/EULAR Endorsed Study to Develop New Diagnostic and Classification Criteria for Primary Systemic Vasculitis |
Resource links provided by NLM:
MedlinePlus related topics:
Giant Cell Arteritis
Polymyalgia Rheumatica
Vasculitis
Wegener's Granulomatosis
U.S. FDA Resources
Further study details as provided by University of Oxford:
Primary Outcome Measures:
- Develop new diagnostic and classification criteria for ANCA associated vasculitis and polyarteritis nodosa [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Patients may be given the option of having blood, urine or other tissue obtained as part of their routine care retained for use in future ethically approved studies. They may also be asked to provide additional blood to be stored for this purpose. This component is an optional extra, and does not form part of the main study.
| Estimated Enrollment: | 3588 |
| Study Start Date: | January 2011 |
| Estimated Study Completion Date: | December 2013 |
| Estimated Primary Completion Date: | June 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
WG classification
Patients with Wegener's granulomatosis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
MPA classification
Patients with microscopic polyangiitis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
CSS classification
Patients with Churg Strauss syndrome. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
PAN classification
Patients with polyarteritis nodosa. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
Control Classification
For each of the diseases being evaluated (WG, MPA, CSS, PAN, GCA, TAK), patients with the other 5 diseases will be the control group. Within these groups, 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
WG diagnostic
Patients with a new presentation of Wegener's granulomatosis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
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MPA diagnostic
Patients with a new presentation of microscopic polyangiitis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
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CSS diagnostic
Patients with a new presentation of Churg Strauss syndrome. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
|
|
PAN diagnostic
Patients with a new presentation of polyarteritis nodosa. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
|
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Control diagnostic
Patients without vasculitis, but presenting with similar features to the 6 different types of vasculitis being studied. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
|
|
GCA classification
Patients with giant cell arteritis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
TAK classification
Patients with Takayasu arteritis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Classification criteria.
|
|
GCA diagnostic
Patients with a new diagnosis of giant cell arteritis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
|
|
TAK diagnostic
Patients with a new diagnosis of Takayasu arteritis. 1st half of these patients will be assigned to the development cohort and the second half to the validation cohort. Diagnostic criteria.
|
Show Detailed Description Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Patients with primary systemic vasculitis or a mimic of these diseases seen in participating secondary or tertiary care centres in Europe, USA, Mexico, Japan, Asia, Australasia.
Criteria
Inclusion Criteria for Classification criteria:
- Adult patients aged >18 years. There is no upper age limit.
- Ability to give informed consent. If the patient is unable to give informed consent as a result of death or physical incapacity, then informed assent from next of kin.
- Presumed diagnosis of a primary systemic vasculitis.
Exclusion criteria for classification criteria:
- Patients < 18 years of age.
- Inability to provide informed consent.
- Hepatitis B or C
- Co-morbidities that explain the clinical symptoms and signs on which the diagnosis of vasculitis is made. E.g. infection, tumour, other inflammatory condition, etc.
Inclusion criteria for diagnostic criteria:
- Adult patients aged >18 years. There is no upper age limit.
- Ability to give informed consent. If the patient is unable to give informed consent as a result of death or physical incapacity, then informed assent from next of kin.
- Suspected diagnosis of a primary systemic vasculitis
Inclusion criteria for controls group for diagnostic criteria:
- Adult patients aged >18 years. There is no upper age limit.
- Ability to give informed consent. If the patient is unable to give informed consent as a result of death or physical incapacity, then informed assent from next of kin.
- Patients presenting to secondary care with one of the following clinical presentations: I.Multi-system disease. Presentation of disease with at least 2 organs involved. II.Pulmonary-renal syndrome. Defined as haemoptysis / pulmonary haemorrhage with acute renal impairment. III.Acute renal failure IV.Acute respiratory distress. V.Chronic upper airways symptoms and signs. VI.Inflammatory polyarthritis. VII.Fever of unknown origin. VIII.Acute or chronic abdominal pain IX.Hypertension. X.Referred to secondary care with suspicion of vasculitis but confirmed not to have vasculitis. XII.New onset headache. XIII.Jaw or tongue pain. XIV.Sudden visual loss. XV.Limb claudication. XVI.Aortic aneurysm >5cm.
Exclusion Criteria for diagnostic criteria:
- Patients under the age of 18
- Patient or next of kin unable or unwilling to provide informed consent or assent.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01066208
Hide Study Locations
Contacts
| Contact: Raashid A Luqmani | +44 1865 738106 | raashid.luqmani@ndorms.ox.ac.uk |
| Contact: Anthea Craven | anthea.craven@ndorms.ox.ac.uk |
Hide Study LocationsLocations
| United States, California | |
| Cedars-Sinai Medical Center, LA | Recruiting |
| Los Angeles, California, United States, 90048 | |
| Contact: Michael Weisman Weisman@cshs.org | |
| Principal Investigator: Michael Weisman | |
| University of California, San Francisco | Recruiting |
| San Francisco, California, United States, 94143-0500 | |
| Contact: Sharon Chung sharon.chung@ucsf.edu | |
| Principal Investigator: Sharon Chung | |
| United States, Illinois | |
| Rush University Medical Center, Chicago | Recruiting |
| Chicago, Illinois, United States, 60612 | |
| Contact: Tony Sreih antoine.sreih@rush.edu | |
| Principal Investigator: Tony Sreih | |
| United States, Maryland | |
| University of Maryland | Recruiting |
| Baltimore, Maryland, United States, 21201 | |
| Contact: Jamal Mikdashi jmikdash@umaryland.edu | |
| Principal Investigator: Jamal Mikdashi | |
| United States, Massachusetts | |
| Vasculitis Center, Boston University School of Medicine | Recruiting |
| Boston, Massachusetts, United States, 02118 | |
| Contact: Peter Grayson peter.grayson@bmc.org | |
| Principal Investigator: Peter Grayson | |
| United States, Minnesota | |
| Mayo Clinic | Recruiting |
| Rochester, Minnesota, United States, 55905 | |
| Contact: Eric Matteson matteson.eric@mayo.edu | |
| Principal Investigator: Eric Matteson | |
| United States, New York | |
| New York University Langone Medical Centre | Not yet recruiting |
| New York, New York, United States, 10016 | |
| Contact: Yusuf Yazici yusuf.yazici@nyumc.org | |
| Principal Investigator: Yusuf Yazici | |
| United States, North Carolina | |
| University of North Carolina | Not yet recruiting |
| Chapel Hill, North Carolina, United States, 27599-7525 | |
| Contact: Charles Jennette jcj@med.unc.edu | |
| Principal Investigator: Charles Jennette | |
| Principal Investigator: Ronald Falk | |
| United States, Ohio | |
| Cleveland Clinic | Recruiting |
| Cleveland, Ohio, United States, 44195 | |
| Contact: Carol Langford LANGFOC@ccf.org | |
| Principal Investigator: Leonard Calabrese | |
| United States, Pennsylvania | |
| University of Pennsylvania | Recruiting |
| Philadelphia, Pennsylvania, United States, 19104 | |
| Contact: Peter A Merkel pmerkel@upenn.edu | |
| Principal Investigator: Peter A Merkel | |
| University of Pittsburgh | Recruiting |
| Pittsburgh, Pennsylvania, United States, 15261 | |
| Contact: Kim Liang liangkp@upmc.edu | |
| Principal Investigator: Kim Liang | |
| United States, Utah | |
| University Medical Center | Not yet recruiting |
| Salt Lake City, Utah, United States, 84132-0002 | |
| Contact: Curry Koening curry.koening@hsc.utah.edu | |
| Principal Investigator: Curry Koening | |
| Argentina | |
| Hospital Interzonal San Juan Bautista | Recruiting |
| San Fernando del Valle de Catamarca, Catamarca, Argentina | |
| Contact: Sergio Toloza sergiotol@yahoo.com | |
| Principal Investigator: Sergio Toloza | |
| Ramos Mejia Hospital, University of Buenos Aires | Recruiting |
| Buenos Aires, Argentina, C1221ADC | |
| Contact: Eduardo Kerzberg eduardomariok@gmail.com | |
| Principal Investigator: Eduardo Kerzberg | |
| Australia, Australian Capital Territory | |
| ANU Medical Centre | Recruiting |
| Canberra, Australian Capital Territory, Australia | |
| Contact: Paul Gatenby paul-gatenby@anu.edu.au | |
| Principal Investigator: Paul Gatenby | |
| Australia, Queensland | |
| Royal Brisbane and Women's Hospital | Recruiting |
| Herston, Queensland, Australia, 4029 | |
| Contact: Dwarakanathan Ranganathan Dwarakanathan_Ranganathan@health.qld.gov.au | |
| Principal Investigator: Dwarakanathan Ranganathan | |
| Belgium | |
| University Hospitals Leuven | Recruiting |
| Leuven, Belgium | |
| Contact: Daniel Blockmans Daniel.Blockmans@uz.kuleuven.ac.be | |
| Principal Investigator: Daniel Blockmans | |
| Canada, Manitoba | |
| University of Manitoba | Recruiting |
| Winnipeg, Manitoba, Canada, R3A 1M4 | |
| Contact: Navjot Dhindsa ndhindsa@hsc.mb.ca | |
| Principal Investigator: Navjot Dhindsa | |
| Canada, Ontario | |
| St Joseph's Healthcare | Recruiting |
| Hamilton, Ontario, Canada | |
| Contact: Nader Khalidi naderkhalidi@sympatico.ca | |
| Principal Investigator: Nader Khalidi | |
| University of Ottawa | Recruiting |
| Ottawa, Ontario, Canada, K1N 6N5 | |
| Contact: Nataliya Milman nmilman@Ottawahospital.on.ca | |
| Principal Investigator: Nataliya Milman | |
| Mount Sinai Hospital, Toronto | Recruiting |
| Toronto, Ontario, Canada, ON M5T 2S8 | |
| Contact: Simon Carette Simon.Carette@uhn.on.ca | |
| Principal Investigator: Simon Carette | |
| Canada | |
| University of Calgary | Not yet recruiting |
| Calgary, Canada | |
| Contact: Michael Walsh mwwalsh@ucalgary.ca | |
| Principal Investigator: Michael Walsh | |
| St Joseph's Healthcare London, Ontario | Recruiting |
| Ontario, Canada | |
| Contact: Lillian Barra | |
| Principal Investigator: Lillian Barra | |
| Czech Republic | |
| General University Hospital | Recruiting |
| Prague, Czech Republic | |
| Contact: Vladamir Tesar | |
| Principal Investigator: Vladamir Tesar | |
| Denmark | |
| Rigshospitalet | Recruiting |
| Copenhagen, Denmark | |
| Contact: Neils Rasmussen nrasent@dadlnet.dk | |
| Principal Investigator: Niels Rasmussen | |
| Principal Investigator: Bo Baslund | |
| France | |
| Cochin Hospital, Université Paris-descartes | Not yet recruiting |
| Paris, France, 75679 | |
| Contact: Loic Guillevin loic.guillevin@wanadoo.fr | |
| Principal Investigator: Loic Guillevin | |
| Germany | |
| Universitätsklinikum Jena | Recruiting |
| Jena, Germany, 07743 Jena | |
| Contact: Thomas Neumann Thomas.Neumann@med.uni-jena.de | |
| Principal Investigator: Thomas Neumann | |
| University of Schleswig-Holstein | Recruiting |
| Luebeck, Germany | |
| Contact: Julia Holle hollejulia@hotmail.com | |
| Principal Investigator: Julia Holle | |
| Universitätsklinikum Münster | Recruiting |
| Münster, Germany, 48149 | |
| Contact: Cord Sunderkötter Cord.Sunderkoetter@ukmuenster.de | |
| Principal Investigator: Cord Sunderkötter | |
| Kreiskliniken Esslingen | Recruiting |
| Plochingen, Germany, 73207 | |
| Contact: Bernhard Hellmich b.hellmich@kk-es.de | |
| Principal Investigator: Bernhard Hellmich | |
| University Hospital Tübingen | Recruiting |
| Tübingen, Germany, D-72076 | |
| Contact: Joerg Henes joerg.henes@med.uni-tuebingen.de | |
| Principal Investigator: Joerg Henes | |
| India | |
| Postgraduate Institute of Medical Education and Research, Chandigarh | Recruiting |
| Chandigarh, India, Pin- 160 012 | |
| Contact: Aman Sharma pgimer-chd@nic.in | |
| Principal Investigator: Aman Sharma | |
| Ireland | |
| St. Vincent's University Hospital, Dublin | Recruiting |
| Dublin 4, Ireland | |
| Contact: Eamonn Molloy E.Molloy@st-vincents.ie | |
| Principal Investigator: Eamonn Molloy | |
| Italy | |
| University of Parma | Recruiting |
| Parma, Italy | |
| Contact: Augusto Vaglio augusto.vaglio@virgilio.it | |
| Principal Investigator: Augusto Vaglio | |
| Arcispedale Santa Maria Nuova | Recruiting |
| Reggio Emilia, Italy | |
| Contact: Carlo Salvarani Carlo.Salvarani@asmn.re.it | |
| Principal Investigator: Carlo Salvarani | |
| Santa Maria Nuova Hospital, Reggio Emilia | Recruiting |
| Reggio Emilia, Italy, 42123 | |
| Contact: Carlo Salvarani Carlo.Salvarani@asmn.re.it | |
| Principal Investigator: Carlo Salvarani | |
| Japan | |
| Tsukuba University Hospital | Recruiting |
| Tsukuba, Ibaraki Prefecture, Japan, 305-8576 | |
| Contact: Kunihiro Yamagata | |
| Principal Investigator: Kunihiro Yamagata | |
| Miyazaki University Hospital | Recruiting |
| Miyazaki City, Miyazaki Prefecture, Japan, 889-1692 | |
| Contact: Shouichi Fujimoto | |
| Principal Investigator: Shouichi Fujimoto | |
| Saitama Medical University | Recruiting |
| Kawagoe, Saitama Prefecture, Japan, 350-8550 | |
| Contact: Koichi Amano amanokoi@saitama-med.ac.jp | |
| Principal Investigator: Koichi Amano | |
| Kyorin University Hospital | Recruiting |
| Mitaka, Tokyo Prefecture, Japan, 181-8611 | |
| Contact: Yoshihiro Arimura | |
| Principal Investigator: Yoshihiro Arimura | |
| Chiba University | Recruiting |
| Chiba, Japan, 260-8670 | |
| Contact: Kazuo Suzuki ksuzuki@faculty.chiba-u.jp | |
| Principal Investigator: Kazuo Suzuki | |
| Kagawa University Hospital | Recruiting |
| Kagawa, Japan, 761-0793 | |
| Contact: Hiroaki Dobashi | |
| Principal Investigator: Hiroaki Dobashi | |
| St. Marianna University Hospital | Recruiting |
| Kanagawa, Japan, 216-8511 | |
| Contact: Hidehiro Yamada guriko@marianna-u.ac.jp | |
| Principal Investigator: Hidehiro Yamada | |
| Kanazawa University Hospital | Recruiting |
| Kanazawa, Japan, 920-8641 | |
| Contact: Takashi Wada twada@medf.m.kanazawa-u.ac.jp | |
| Principal Investigator: Takashi Wada | |
| Okayama University Hospital | Recruiting |
| Okayama, Japan, 700-8558 | |
| Contact: Hirofumi Makino | |
| Principal Investigator: Hirofumi Makino | |
| Kitano Hospital | Recruiting |
| Osaka, Japan | |
| Contact: Eri Muso | |
| Principal Investigator: Eri Muso | |
| Juntendo University Koshigaya Hospital | Recruiting |
| Saitama, Japan, 343-0032 | |
| Contact: Shigeto Kobayashi | |
| Principal Investigator: Shigeto Kobayashi | |
| Jichi Medical University Hospital | Recruiting |
| Tochigi-ken, Japan, 3311-1 Yakushiji | |
| Contact: Wako Yumura | |
| Principal Investigator: Wako Yumura | |
| University Tokyo Hospital | Recruiting |
| Tokyo, Japan, 113-8655 | |
| Contact: Junichi Hirahashi jhirahashi-tky@umin.ac.jp | |
| Principal Investigator: Junichi Hirahashi | |
| Mexico | |
| Instituto Nacional de Enfermedades Respiratorias | Not yet recruiting |
| Mexico City, Mexico, 14000 | |
| Contact: Luis Felipe Flores-Suárez felipe98@prodigy.net.mx | |
| Principal Investigator: Luis Felipe Flores-Suárez | |
| Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Recruiting |
| Mexico City, Mexico | |
| Contact: Andrea Hinojosa | |
| Principal Investigator: Andrea Hinojosa | |
| Netherlands | |
| VU University Medical Center | Not yet recruiting |
| Amsterdam, Netherlands, 6Z 165 | |
| Contact: Maarten Boers mboers56@xs4all.nl | |
| Principal Investigator: Maarten Boers | |
| University Medical Center Groningen | Recruiting |
| Groningen, Netherlands, 30.001 | |
| Contact: Abraham Rutgers a.rutgers@umgc.nl | |
| Principal Investigator: Abraham Rutgers | |
| New Zealand | |
| University of Otago, Christchurch | Recruiting |
| Christchurch, Canterbury, New Zealand, 8011 | |
| Contact: Lisa Stamp Lisa.Stamp@cdhb.govt.nz | |
| Principal Investigator: Lisa Stamp | |
| Auckland District Health Board | Recruiting |
| Auckland, New Zealand | |
| Contact: Ravi Suppiah | |
| Principal Investigator: Ravi Suppiah | |
| Waikato District Health Board | Recruiting |
| Hamilton, New Zealand, 3240 | |
| Contact: Vicky Quincey vicki.quincey@waikatodhb.health.nz | |
| Principal Investigator: Vicky Quincey | |
| Norway | |
| Hospital of Southern Norway | Recruiting |
| Kristiansand, Norway, Post box 416, 4605 | |
| Contact: Andreas Diamantopoulos +47 38073155 andreas.diamantopoulos@sshf.no | |
| Principal Investigator: Andreas Diamantopoulos | |
| The University Hospital of Northern Norway, Tromsø | Recruiting |
| Tromsø, Norway, 9038 | |
| Contact: Emilio Besada Emilio.Besada@unn.no | |
| Principal Investigator: Emilio Besada | |
| Poland | |
| University of Jagiellonian | Recruiting |
| Kraków, Poland, 31-007 | |
| Contact: Jan Sznajd jsznajd@gmail.com | |
| Principal Investigator: Jan Sznajd | |
| Portugal | |
| Santa Maria Hospital, Lisbon | Recruiting |
| Lisbon, Portugal, 1649-035 | |
| Contact: Ruth Geraldes ruth.geraldes@netcabo.pt | |
| Principal Investigator: Ruth Geraldes | |
| Slovenia | |
| University Medical Centre Ljubljana | Recruiting |
| Ljubljana, Slovenia, 1000 | |
| Contact: Alojzija Hočevar alojzija.hocevar@siol.net | |
| Principal Investigator: Alojzija Hočevar | |
| Spain | |
| Clinic Barcelona Hospital Universitari | Not yet recruiting |
| Barcelona, Catalonia, Spain | |
| Contact: Maria Cid MCCID@clinic.ub.es | |
| Principal Investigator: Maria Cid | |
| Sri Lanka | |
| University of Colombo | Recruiting |
| Columbo 8, Sri Lanka | |
| Contact: Inoshi Atukorala inoshi.atu@gmail.com | |
| Principal Investigator: Inoshi Atukorala | |
| Sweden | |
| Lund University | Recruiting |
| Lund, Sweden, SE-221 85 | |
| Contact: Aladdin Mohammad aladdin.mohammad@med.lu.se | |
| Principal Investigator: Mårten Segelmark | |
| Switzerland | |
| University Hospital Basel | Recruiting |
| Basel, Switzerland, 4031 | |
| Contact: Thomas Daikeler tdaikeler@uhvs.ch | |
| Principal Investigator: Thomas Daikeler | |
| Immunologie-Zentrum Zurich | Not yet recruiting |
| Zurich, Switzerland | |
| Contact: Thomas Hauser hauser@immunologie-zentrum.ch | |
| Principal Investigator: Thomas Hauser | |
| Turkey | |
| Haydarpasa Education and Research Hospital | Not yet recruiting |
| Istanbul, Turkey | |
| Contact: Hasan Yazici hyazici@attglobal.net | |
| Principal Investigator: Hasan Yazici | |
| Marmara University Medical School | Recruiting |
| Istanbul, Turkey, 34668 | |
| Contact: Haner Direskeneli hanerdireskeneli@gmail.com | |
| Principal Investigator: Haner Direskeneli | |
| Istanbul University, Cerrahpasa Medical School | Recruiting |
| Istanbul, Turkey, 34098 | |
| Contact: Gulen Hatemi gulen.hatemi@yahoo.com | |
| Principal Investigator: Gulen Hatemi | |
| Istanbul University, Istanbul Medical School | Recruiting |
| Istanbul, Turkey | |
| Contact: Sevil Kamali sevilkamali@hotmail.com | |
| Principal Investigator: Sevil Kamali | |
| United Kingdom | |
| Queen's Hospital | Recruiting |
| Romford, Essex, United Kingdom, RM7 0AG | |
| Contact: Kuntal Chakravarty kuntal@talk21.com | |
| Principal Investigator: Kuntal Chakravarty | |
| Southend University Hospital NHS Trust | Recruiting |
| Westcliff-on-Sea, Essex, United Kingdom, SS0 0RY | |
| Contact: Bhaskar Dasgupta Bhaskar.Dasgupta@southend.nhs.uk | |
| Principal Investigator: Bhaskar Dasgupta | |
| Aberdeen Royal Infirmary | Recruiting |
| Aberdeen, Scotland, United Kingdom, AB25 2ZN | |
| Contact: Neil Basu neilbasu@nhs.net | |
| Principal Investigator: Neil Basu | |
| Ipswich Hospital NHS Trust | Recruiting |
| Ipswich, Suffolk, United Kingdom | |
| Contact: Richard Watts richard.watts2@mac.com | |
| Principal Investigator: Richard Watts | |
| University of Birmingham | Not yet recruiting |
| Birmingham, United Kingdom | |
| Contact: Matthew Morgan m.d.morgan@bham.ac.uk | |
| Principal Investigator: Caroline Savage | |
| Addenbrooke's Hospital | Not yet recruiting |
| Cambridge, United Kingdom | |
| Contact: David Jayne david.jayne@addenbrookes.nhs.uk | |
| Principal Investigator: David Jayne | |
| Norfolk and Norwich University Hospital | Recruiting |
| Norwich, United Kingdom, NR4 7UY | |
| Contact: Laura Harper LAURA.HARPER@nnuh.nhs.uk | |
| Principal Investigator: Chetan Mukhtyar | |
| Nottingham University Hospitals NHS Trust (QMC) | Recruiting |
| Nottingham, United Kingdom, NG7 2UH | |
| Contact: Peter Lanyon Peter.Lanyon@nuh.nhs.uk | |
| Principal Investigator: Peter Lanyon | |
| Oxford University Hospitals NHS Trust (The Churchill Hospital) | Recruiting |
| Oxford, United Kingdom, OX3 7LE | |
| Contact: Rachel Hoyles rachel.hoyles@ouht.nhs.uk | |
| Principal Investigator: Rachel Hoyles | |
| Nuffield Orthopaedic Centre | Recruiting |
| Oxford, United Kingdom, OX3 7LD | |
| Contact: Raashid Luqmani raashid.luqmani@noc.nhs.uk | |
| Principal Investigator: Raashid Luqmani | |
| Sub-Investigator: Joanna Robson | |
| Royal Berkshire NHS Trust | Recruiting |
| Reading, United Kingdom, RG1 5AN | |
| Contact: Oliver Flossmann 0118 3225308 oliver.flossman@royalberkshire.nhs.uk | |
| Principal Investigator: Oliver Flossmann | |
| Southampton University Hospitals NHS Trust | Recruiting |
| Southampton, United Kingdom, SO16 6YD | |
| Contact: Christopher Edwards cedwards@soton.ac.uk | |
| Principal Investigator: Christopher Edwards | |
Sponsors and Collaborators
University of Oxford
American College of Rheumatology
The European League Against Rheumatism (EULAR)
The Vasculitis foundation
Investigators
| Principal Investigator: | Raashid A Luqmani, DM, FRCP(E) | University of Oxford, United Kingdom |
| Principal Investigator: | Peter Merkel, MD, MPH | University of Pennsylvania |
| Principal Investigator: | Richard Watts, DM, FRCP | University of East Anglia |
More Information
Additional Information:
Publications:
| Responsible Party: | University of Oxford |
| ClinicalTrials.gov Identifier: | NCT01066208 History of Changes |
| Other Study ID Numbers: | ACREULAR001 |
| Study First Received: | February 9, 2010 |
| Last Updated: | January 2, 2013 |
| Health Authority: | United Kingdom: Research Ethics Committee |
Keywords provided by University of Oxford:
|
Classification criteria Diagnostic criteria |
Additional relevant MeSH terms:
|
Arteritis Churg-Strauss Syndrome Polyarteritis Nodosa Takayasu Arteritis Aortic Arch Syndromes Giant Cell Arteritis Polymyalgia Rheumatica Vasculitis Wegener Granulomatosis Systemic Vasculitis Microscopic Polyangiitis Vascular Diseases Cardiovascular Diseases Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Granuloma |
Lymphoproliferative Disorders Lymphatic Diseases Autoimmune Diseases Immune System Diseases Skin Diseases, Vascular Skin Diseases Aortic Diseases Vasculitis, Central Nervous System Autoimmune Diseases of the Nervous System Nervous System Diseases Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Muscular Diseases Musculoskeletal Diseases |
ClinicalTrials.gov processed this record on May 16, 2013