Trial record 1 of 1 for:    rtog and 0937
Previous Study | Return to List | Next Study

Radiation Therapy in Treating Patients With Extensive Stage Small Cell Lung Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2014 by Radiation Therapy Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT01055197
First received: January 22, 2010
Last updated: April 21, 2014
Last verified: April 2014
  Purpose

RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. This may be an effective treatment for extensive stage small cell lung cancer.

PURPOSE: This randomized phase II trial is comparing how well radiation therapy to the brain works when given with or without radiation therapy to other areas of the body in treating patients with extensive stage small cell lung cancer.


Condition Intervention Phase
Lung Cancer
Radiation: prophylactic cranial irradiation
Radiation: selective external radiation therapy
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC)

Resource links provided by NLM:


Further study details as provided by Radiation Therapy Oncology Group:

Primary Outcome Measures:
  • Overall survival [ Time Frame: From randomization to date of death or last follow-up. Analysis occurs after all patients have been potentially followed for 12 months. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Comparison of treatment-related adverse events [ Time Frame: From start of treatment to end of follow-up. ] [ Designated as safety issue: Yes ]
  • Patterns of failure [ Time Frame: From randomization to date of death or last follow-up. Analysis occurs after all patients have been potentially followed for 12 months. ] [ Designated as safety issue: No ]
  • Comparison of time to first failure [ Time Frame: From randomization to date of death or last follow-up. Analysis occurs after all patients have been potentially followed for 12 months. ] [ Designated as safety issue: No ]
  • Evaluation of the percentage of the planned radiotherapy dose to each site [ Time Frame: From start to end of radiation therapy. ] [ Designated as safety issue: No ]

Estimated Enrollment: 154
Study Start Date: March 2010
Estimated Primary Completion Date: March 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Arm I
Patients undergo prophylactic cranial irradiation 5 days per week for 2 weeks.
Radiation: prophylactic cranial irradiation
Given 5 days per week for 2 weeks
Experimental: Arm II
Patients undergo prophylactic cranial irradiation as in arm I. Patients also undergo consolidative extracranial radiotherapy to locoregional and residual metastatic disease 5 days per week for 2-3 weeks.
Radiation: prophylactic cranial irradiation
Given 5 days per week for 2 weeks
Radiation: selective external radiation therapy
Given 5 days per week for 2-3 weeks

Detailed Description:

OBJECTIVES:

Primary

  • To compare the 1-year overall median survival rate in patients with extensive stage small cell lung cancer treated with prophylactic cranial irradiation with vs without consolidative extracranial radiotherapy following platinum-based chemotherapy.

Secondary

  • To compare treatment-related adverse events in these patients.
  • To evaluate patterns of failure in these patients.
  • To compare the time to first failure in these patients.
  • To evaluate the percentage of the planned radiotherapy dose given to each site.

OUTLINE: This is a multicenter study. Patients are stratified according to response to prior treatment (complete response vs partial response) and number of metastatic lesions (1 vs 2-3). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo prophylactic cranial irradiation 5 days per week for 2 weeks.
  • Arm II: Patients undergo prophylactic cranial irradiation as in arm I. Patients also undergo consolidative extracranial radiotherapy to locoregional and residual metastatic disease 5 days per week for 2-3 weeks.

After completion of study treatment, patients are followed up at 2 weeks; at 1, 2, 6, 9, and 12 months; every 6 months for 2 years; and then annually thereafter.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically or cytologically confirmed extensive stage small cell lung cancer (SCLC) diagnosed within the past 6 months*

    • Has 1-4 extracranial metastatic lesions NOTE: *Diagnosis made before treatment with chemotherapy
  • Has completed 4-6 courses of platinum-based chemotherapy within the past 8 weeks AND meets the following criteria:

    • Radiographic partial or complete response to chemotherapy in ≥ 1 site of disease according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria (if radiotherapy has been delivered to primary disease with chemotherapy, there must be complete or partial response in ≥ 1 of the sites that has not been treated with radiotherapy)
    • No progression in any site
  • No limited stage SCLC, even if disease progressed
  • No brain or central nervous system (CNS) metastases

PATIENT CHARACTERISTICS:

  • Zubrod performance status 0-2
  • Absolute neutrophil count (ANC) ≥ 1,000/mm^3
  • Platelets ≥ 75,000/mm^3
  • Hemoglobin ≥ 8.0 g/dL (the use of transfusion or other intervention is allowed)
  • Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times upper limit of normal (ULN) (for patients who will receive radiotherapy to the liver)
  • Serum bilirubin < 1.5 times ULN (for patients who will receive radiotherapy to the liver)
  • Serum creatinine < 1.5 times ULN (for patients who will receive radiotherapy to the kidneys)
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No severe, active co-morbidity, defined as any of the following:

    • Acute bacterial or fungal infection requiring IV antibiotics at the time of study registration
    • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of study registration

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • Recovered from prior chemotherapy (i.e., toxicities ≤ grade 1 [except for neuropathy and alopecia])
  • Thoracic radiotherapy administered concurrently with or before chemotherapy for the current diagnosis allowed (these patients will not receive mediastinal radiotherapy per protocol)
  • No prior radiotherapy to the region of this cancer that would result in overlap of radiotherapy fields
  • No concurrent chemotherapy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01055197

  Hide Study Locations
Locations
United States, Arizona
Arizona Oncology - Tucson Recruiting
Tucson, Arizona, United States, 85704
Contact: Curtis F. Mack    520-797-4468      
United States, California
Saint Agnes Cancer Center at Saint Agnes Medical Center Recruiting
Fresno, California, United States, 93720
Contact: Clinical Trials Office - Saint Agnes Cancer Center    559-450-7790    medresearch@samc.com   
Radiological Associates of Sacramento Medical Group, Incorporated Recruiting
Sacramento, California, United States, 95815
Contact: Christopher Jones, MD    916-646-6600      
United States, Colorado
Penrose Cancer Center at Penrose Hospital Recruiting
Colorado Springs, Colorado, United States, 80933
Contact: Clinical Trials Office - Penrose Cancer Center    719-776-5275      
Poudre Valley Radiation Oncology Recruiting
Fort Collins, Colorado, United States, 80528
Contact: Joshua H. Petit    970-482-3328      
United States, Connecticut
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Samir Narayan    860-714-4680      
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus Recruiting
New Britain, Connecticut, United States, 06050
Contact: Clinical Trials Office - George Bray Cancer Center    860-224-5660      
United States, Florida
University of Florida Shands Cancer Center Recruiting
Gainesville, Florida, United States, 32610-0232
Contact: Clinical Trials Office - University of Florida Shands Cancer C    888-254-7581      
Baptist Cancer Institute - Jacksonville Recruiting
Jacksonville, Florida, United States, 32207
Contact: Clinical Trials Office - Baptist Cancer Institute - Jacksonvil    904-202-7051      
Integrated Community Oncology Network at Southside Cancer Center Recruiting
Jacksonville, Florida, United States, 32207
Contact: Douglas W. Johnson, MD    904-202-2273      
Integrated Community Oncology Network Recruiting
Jacksonville Beach, Florida, United States, 32250
Contact: Douglas W. Johnson, MD    904-202-2273      
Baptist Medical Center South Recruiting
Jascksonville, Florida, United States, 32258
Contact: Douglas W. Johnson, MD    904-202-2273      
Integrated Community Oncology Network - Orange Park Recruiting
Orange Park, Florida, United States, 32073
Contact: Douglas W. Johnson, MD    904-202-2273      
M.D. Anderson Cancer Center at Orlando Recruiting
Orlando, Florida, United States, 32806
Contact: Justin Rineer    407-648-3800      
Florida Hospital Cancer Institute at Florida Hospital Orlando Recruiting
Orlando, Florida, United States, 32803-1273
Contact: Clinical Trials Office - Florida Hospital Cancer Institute    407-303-5623      
Florida Cancer Center - Palatka Recruiting
Palatka, Florida, United States, 32177
Contact: Douglas W. Johnson, MD    904-202-2273      
Flagler Cancer Center Recruiting
Saint Augustine, Florida, United States, 32086
Contact: Douglas W. Johnson, MD    904-202-2273      
United States, Georgia
Georgia Cancer Center for Excellence at Grady Memorial Hospital Recruiting
Atlanta, Georgia, United States, 30303
Contact: Liza Stapleford    404-489-9000      
Winship Cancer Institute of Emory University Recruiting
Atlanta, Georgia, United States, 30322
Contact: Clinical Trials Office - Winship Cancer Institute    404-778-1900      
Emory Crawford Long Hospital Recruiting
Atlanta, Georgia, United States, 30308
Contact: Liza Stapleford    404-686-4411      
United States, Illinois
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Recruiting
Chicago, Illinois, United States, 60611-3013
Contact: Clinical Trials Office - Robert H. Lurie Comprehensive Cancer    312-695-1301    cancer@northwestern.edu   
Cancer Institute at St. John's Hospital Recruiting
Springfield, Illinois, United States, 62702
Contact: Cathy L. Clausen, MD    765-646-8358      
United States, Indiana
Saint John's Cancer Center at Saint John's Medical Center Recruiting
Anderson, Indiana, United States, 46016
Contact: Alexander M. Yeh, MD    317-962-3172      
Parkview Regional Cancer Center at Parkview Health Recruiting
Fort Wayne, Indiana, United States, 46805
Contact: Brian K. Chang    260-373-7850      
Radiation Oncology Associates Southwest Recruiting
Fort Wayne, Indiana, United States, 46804
Contact: Brian K. Chang    260-436-4116      
Center for Cancer Care at Goshen General Hospital Recruiting
Goshen, Indiana, United States, 46526
Contact: Clinical Trials Office - Center for Cancer Care at Goshen Gene    574-535-2858      
Community Regional Cancer Care at Community Hospital East Recruiting
Indianapolis, Indiana, United States, 46219
Contact: Shih J. Wei    317-355-5347      
Community Regional Cancer Care at Community Hospital North Recruiting
Indianapolis, Indiana, United States, 46256
Contact: Shih J. Wei    317-621-4300      
United States, Kansas
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160-7357
Contact: Clinical Trials Office - Kansas Masonic Cancer Research Instit    913-588-4709      
Kansas City Cancer Centers - Southwest Recruiting
Overland Park, Kansas, United States, 66210
Contact: Parvesh Kumar, MD    323-865-3072      
United States, Kentucky
Lucille P. Markey Cancer Center at University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536-0093
Contact: Clinical Trials Office - Markey Cancer Center at University of    859-257-3379      
James Graham Brown Cancer Center at University of Louisville Recruiting
Louisville, Kentucky, United States, 40202
Contact: Neal E. Dunlap    502-562-4158      
United States, Maryland
St. Agnes Hospital Cancer Center Recruiting
Baltimore, Maryland, United States, 21229
Contact: Richard S. Hudes, MD    410-368-2965      
United States, Massachusetts
Boston University Cancer Research Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Clinical Trials Office - Boston University Cancer Research Cen    617-638-8265      
United States, Michigan
Hickman Cancer Center at Bixby Medical Center Recruiting
Adrian, Michigan, United States, 49221
Contact: Clinical Trials Office - Hickman Cancer Center at Bixby Medica    517-265-0116      
Henry Ford Macomb Hospital Recruiting
Clinton Township, Michigan, United States, 48038
Contact: Eleanor M. Walker, MD    313-916-1021      
Josephine Ford Cancer Center at Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Eleanor M. Walker, MD    313-916-1021      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Genesys Hurley Cancer Institute    810-762-8057      
Lacks Cancer Center at Saint Mary's Health Care Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D.A. Padula    616-752-5222      
Butterworth Hospital at Spectrum Health Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Gilbert D.A. Padula    616-391-2799      
Van Elslander Cancer Center at St. John Hospital and Medical Center Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Clincial Trials Office - Van Elslander Cancer Center at St. Jo    313-343-3166      
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007-3731
Contact: Clinical Trials Office - West Michigan Cancer Center    269-373-7458      
Mercy Regional Cancer Center at Mercy Hospital Recruiting
Port Huron, Michigan, United States, 48060
Contact: Samir Narayan    810-985-1484      
Seton Cancer Institute at Saint Mary's - Saginaw Recruiting
Saginaw, Michigan, United States, 48601
Contact: Clinical Trials Office - Seton Cancer Institute - Saginaw    989-776-8411      
St. John Macomb Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Samir Narayan    586-573-5757      
United States, Mississippi
University of Mississippi Cancer Clinic Recruiting
Jackson, Mississippi, United States, 39216
Contact: P. G. Shankar Giri    601-984-5590      
United States, Missouri
Cancer Institute of Cape Girardeau, LLC Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Tapan Roy, MD    573-334-2230      
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Parvesh Kumar, MD    323-865-3072      
Kansas City Cancer Centers - South Recruiting
Kansas City, Missouri, United States, 64131
Contact: Parvesh Kumar, MD    323-865-3072      
Barnes-Jewish West County Hospital Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Clifford G Robinson    314-996-8000      
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Clifford G Robinson    314-747-7222      
United States, Nebraska
Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Andrew O. Wahl    402-552-2000      
Methodist Estabrook Cancer Center Recruiting
Omaha, Nebraska, United States, 68114
Contact: Tien-Shew W. Huang    402-354-5890      
United States, Nevada
Renown Institute for Cancer at Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: Daniel W. Weed    775-982-5050      
United States, New Hampshire
Elliot Regional Cancer Center at Elliot Hospital Recruiting
Manchester, New Hampshire, United States, 03103
Contact: Brian R. Knab    603-663-4201      
United States, New Jersey
Frederick R. and Betty M. Smith Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Maria Werner-Wasik, MD    215-955-7679      
Cancer Institute of New Jersey at Cooper - Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Clinical Trials Office - Cancer Institute of New Jersey at Coo    856-325-6757      
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87131-5636
Contact: Clinical Trials Office - University of New Mexico Cancer Cente    505-272-6972      
United States, New York
New York Oncology Hematology, PC at Albany Regional Cancer Care Recruiting
Albany, New York, United States, 12206
Contact: Todd H. Doyle    518-489-2607      
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Clinical Trials Office - Herbert Irving Comprehensive Cancer C    212-305-8615      
NYU Cancer Institute at New York University Medical Center Recruiting
New York, New York, United States, 10016
Contact: Silvia C. Formenti    212-263-6485      
Highland Hospital of Rochester Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen    585-473-2200      
James P. Wilmot Cancer Center at University of Rochester Medical Center Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-275-5345      
United States, North Carolina
Forsyth Regional Cancer Center at Forsyth Medical Center Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact: Clinical Trials Office - Forsyth Regional Cancer Center at For    336-277-8887      
Wake Forest University Comprehensive Cancer Center Recruiting
Winston-Salem, North Carolina, United States, 27157-1096
Contact: Clinical Trials Office - Wake Forest University Comprehensive    336-713-6771      
United States, North Dakota
Trinity CancerCare Center Recruiting
Minot, North Dakota, United States, 58701
Contact: Kevin B. Collins, MD    701-857-3535      
United States, Ohio
McDowell Cancer Center at Akron General Medical Center Recruiting
Akron, Ohio, United States, 44307
Contact: Mitchell L. Fromm, MD    330-344-6448      
Summa Center for Cancer Care at Akron City Hospital Recruiting
Akron, Ohio, United States, 44309-2090
Contact: Clinical Trials Office - Akron City Hospital    330-375-6101      
Barberton Citizens Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: William F. Demas, MD    330-375-3557      
Charles M. Barrett Cancer Center at University Hospital Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Kevin P. Redmond, MD    513-584-9089      
Cleveland Clinic Cancer Center at Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: Clinical Trials Office - Cleveland Clinic Cancer Center at Fai    216-476-9362      
Case Comprehensive Cancer Center Recruiting
Cleveland, Ohio, United States, 44106-5065
Contact: Clinical Trials Office - Case Comprehensive Cancer Center    800-641-2422      
Cleveland Clinic Taussig Cancer Center Recruiting
Cleveland, Ohio, United States, 44195
Contact: Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente    866-223-8100      
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210-1240
Contact: Ohio State University Cancer Clinical Trial Matching Service    866-627-7616    Jamesline@osumc.edu   
Hillcrest Cancer Center at Hillcrest Hospital Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: Mitchell Machtay, MD    215-955-6706      
Lake/University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Mitchell Machtay, MD    215-955-6706      
Southwest General Health Center Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Mitchell Machtay, MD    215-955-6706      
UHHS Chagrin Highlands Medical Center Recruiting
Orange Village, Ohio, United States, 44122
Contact: Mitchell Machtay, MD    215-955-6706      
St. Charles Mercy Hospital Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    419-696-7200      
Parma Community General Hospital Recruiting
Parma, Ohio, United States, 44129
Contact: Clinical Trials Office - Parma Community General Hospital    440-743-4747      
North Coast Cancer Care, Incorporated Recruiting
Sandusky, Ohio, United States, 44870
Contact: Gregory Videtic, MD    216-444-9797      
Flower Hospital Cancer Center Recruiting
Sylvania, Ohio, United States, 43560
Contact: Clinical Trials Office - Flower Hospital Cancer Center    419-824-1842      
St. Anne Mercy Hospital Recruiting
Toledo, Ohio, United States, 43623
Contact: Rex B. Mowat    419-407-2663      
UHHS Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Mitchell Machtay, MD    215-955-6706      
Cleveland Clinic - Wooster Recruiting
Wooster, Ohio, United States, 44691
Contact: Clinical Trials Office - Cleveland Clinic - Wooster    800-862-7798      
United States, Oklahoma
Natalie Warren Bryant Cancer Center at St. Francis Hospital Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Charles E. Stewart    918-494-2273      
United States, Oregon
Three Rivers Community Hospital Recruiting
Grants Pass, Oregon, United States, 97527
Contact: Gordon L. Metz, MD    541-608-4263      
Dubs Cancer Center at Rogue Valley Medical Center Recruiting
Medford, Oregon, United States, 97504
Contact: Gordon L. Metz, MD    541-608-4263      
United States, Pennsylvania
Northeast Radiation Oncology Center Recruiting
Dunmore, Pennsylvania, United States, 18512
Contact: Maria Werner-Wasik, MD    215-955-7679      
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19107-5541
Contact: Clinical Trials Office - Kimmel Cancer Center at Thomas Jeffer    215-955-6084      
United States, South Carolina
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: Clinical Trials Office - Gibbs Regional Cancer Center    800-486-5941      
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Michael J. Swartz    605-719-2360      
United States, Texas
Texas Oncology, PA at Texas Cancer Center - Arlington South Recruiting
Arlington, Texas, United States, 76014
Contact: Berchmans John    817-467-6092      
Texas Oncology, PA at Texas Cancer Center - Denton South Recruiting
Denton, Texas, United States, 76210
Contact: Jeffery D. Morton    940-382-1022      
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital Recruiting
Fort Worth, Texas, United States, 76104
Contact: Stephen D. Sorgen    817-820-4820      
University of Texas Medical Branch Recruiting
Galveston, Texas, United States, 77555-0361
Contact: Clinical Trials Office - University of Texas Medical Branch    409-772-1950      
Memorial Hermann Hospital - Memorial City Recruiting
Houston, Texas, United States, 77024
Contact: Vivek S. Kavadi    713-242-3500      
Longview Cancer Center Recruiting
Longview, Texas, United States, 75601
Contact: Bernard W. Taylor, Jr.    903-757-2122      
Cancer Care Centers of South Texas - Northeast Recruiting
San Antonio, Texas, United States, 78217
Contact: Michael J. Gagnon    210-656-7177      
Texas Oncology, PA at Texas Cancer Center - Sherman Recruiting
Sherman, Texas, United States, 75090
Contact: Mary E. Hebert    903-892-9455      
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land Recruiting
Sugar Land, Texas, United States, 77479
Contact: Vivek S. Kavadi    281-277-5200      
Tyler Cancer Center Recruiting
Tyler, Texas, United States, 75702
Contact: Mark W. Saunders    903-579-9800      
Texas Oncology, PA - Wichita Falls Recruiting
Wichita Falls, Texas, United States, 76310
Contact: Mark S. Lee    940-767-4364      
United States, Wisconsin
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center Recruiting
Madison, Wisconsin, United States, 53792-6164
Contact: Clinical Trials Office - University of Wisconsin Paul P. Carbo    608-262-5223      
Medical College of Wisconsin Cancer Center Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Clinical Trials Office - Medical College of Wisconsin Cancer C    414-805-4380      
Veterans Affairs Medical Center - Milwaukee Recruiting
Milwaukee, Wisconsin, United States, 53295
Contact: Elizabeth M. Gore, MD    414-805-4369      
All Saints Cancer Center at Wheaton Franciscan Healthcare Recruiting
Racine, Wisconsin, United States, 53405
Contact: James H. Taylor, MD    262-687-5000      
Riverview UW Cancer Center at Riverview Hospital Recruiting
Wisconsin Rapids, Wisconsin, United States, 54494
Contact: Steven P. Howard    715-421-7442      
Canada, British Columbia
British Columbia Cancer Agency - Vancouver Cancer Centre Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Robert A. Olson    604-877-6000      
Canada, Ontario
London Regional Cancer Program at London Health Sciences Centre Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Edward W. T. Yu    519-685-8615      
Northeastern Ontario Regional Cancer Centre Recruiting
Sudbury, Ontario, Canada, P3E 5J1
Contact: Andrew Pearce    705-522-6237      
Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Alexander Y. Sun    416-946-2811      
Canada, Saskatchewan
Allan Blair Cancer Centre at Pasqua Hospital Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Arbind Dubey    306-766-2203      
Israel
Rabin Medical Center - Beilinson Campus Recruiting
Petach Tikva, Israel, 49100
Contact: Aaron M. Allen    972-3-937-7377      
Tel-Aviv Sourasky Medical Center Recruiting
Tel Aviv, Israel, 64239
Contact: Ofer Merimsky    972-3-697-4444      
Sponsors and Collaborators
Radiation Therapy Oncology Group
Investigators
Principal Investigator: Elizabeth M. Gore, MD Medical College of Wisconsin
  More Information

Additional Information:
No publications provided

Responsible Party: Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier: NCT01055197     History of Changes
Other Study ID Numbers: RTOG 0937, CDR0000663959, NCI-2011-02008
Study First Received: January 22, 2010
Last Updated: April 21, 2014
Health Authority: United States: Federal Government

Keywords provided by Radiation Therapy Oncology Group:
extensive stage small cell lung cancer

Additional relevant MeSH terms:
Lung Neoplasms
Small Cell Lung Carcinoma
Bronchial Neoplasms
Carcinoma, Bronchogenic
Lung Diseases
Neoplasms
Neoplasms by Site
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms

ClinicalTrials.gov processed this record on October 22, 2014