The Identification of Novel Prognostic Markers in Melanoma
Recruitment status was Recruiting
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Purpose
The purpose of this project is to analyze tumour tissue from a group of subjects with malignant melanoma, who have been treated at the Royal Marsden Hospital.
| Condition |
|---|
|
Malignant Melanoma |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Retrospective |
| Official Title: | Novel Prognostic Markers in Melanoma: a Protocol for the Analysis of Paraffin-embedded Tumour Samples |
- Given that the nature of the research is qualitative, there is no primary outcome measure. [ Designated as safety issue: No ]
| Estimated Enrollment: | 500 |
| Study Start Date: | December 2008 |
| Estimated Study Completion Date: | December 2009 |
| Estimated Primary Completion Date: | December 2009 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| Malignant melanoma tumour tissue |
|
Benign pigmented lesions & other skin cancers
Normal skin, benign melanocytic tumours, and skin cancers from lineages other than melanocytic, to be used as negative controls
|
Detailed Description:
Background - The Royal Marsden Hospital and the Institute of Cancer Research constitute the largest comprehensive cancer centre in Europe. In addition to an in-house drug development program, phase I - phase III clinical trials of novel anti-cancer agents are hosted. In order to investigate the optimal use of novel molecularly targeted agents, access to clinical tumour samples is needed in order to determine which particular cancer type expresses a molecular "signature" that may indicate potential therapeutic utility. Understanding such signatures should accelerate the registration of new drugs for routine cancer therapy; offering the potential of selecting those patients with tumour types most likely to benefit from therapy. Furthermore, new insights into disease biology may be gained.
Main research question/ objective - Are there features of primary melanoma or lymph node metastases that predict subsequent clinical outcome better than existing markers?
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Group of subjects with malignant melanoma, who have been treated at the Royal Marsden Hospital
Inclusion Criteria:
- Diagnosis of melanoma
- Adequate paraffin-embedded material available for analysis.
- Adequate clinical follow-up information
- Written informed consent where applicable
Exclusion Criteria:
- Inadequate paraffin-embedded material available
- Inadequate clinical follow-up information.
Contacts and Locations| Contact: Professor Martin Gore | 02078082198 | martin.gore@rmh.nhs.uk |
| United Kingdom | |
| Royal Marsden NHS Foundation Trust | Recruiting |
| Sutton, Surrey, United Kingdom, SM2 5PT | |
| Principal Investigator: | Professor Martin Gore | Royal Marsden NHS Foundation Trust |
More Information
No publications provided
| Responsible Party: | Professor Martin Gore, Royal Marsden NHS Foundation Trust |
| ClinicalTrials.gov Identifier: | NCT01002560 History of Changes |
| Other Study ID Numbers: | CCR3078 |
| Study First Received: | October 26, 2009 |
| Last Updated: | October 26, 2009 |
| Health Authority: | United Kingdom: Research Ethics Committee |
Keywords provided by Royal Marsden NHS Foundation Trust:
|
Melanoma Novel Prognostic Markers |
Additional relevant MeSH terms:
|
Melanoma Neuroendocrine Tumors Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal |
Neoplasms by Histologic Type Neoplasms Neoplasms, Nerve Tissue Nevi and Melanomas |
ClinicalTrials.gov processed this record on May 23, 2013