Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by Radiation Therapy Oncology Group
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier:
NCT00956007
First received: August 8, 2009
Last updated: May 28, 2014
Last verified: May 2014
  Purpose

RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective when given alone or together with cetuximab in treating patients with head and neck cancer that has been removed by surgery.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer.


Condition Intervention Phase
Head and Neck Cancer
Biological: cetuximab
Radiation: intensity-modulated radiation therapy
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer

Resource links provided by NLM:


Further study details as provided by Radiation Therapy Oncology Group:

Primary Outcome Measures:
  • Overall survival [ Time Frame: From randomization to date of death or last follow-up. Analysis occurs after 372 events have been reported. ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Adverse events (dysphagia, xerostomia, and skin toxicity) according to CTCAE, v. 4 and their relationships with patient-reported outcomes at 3, 12, and 24 months [ Time Frame: From start of treatment to 2 years after end of treatment. ] [ Designated as safety issue: Yes ]
  • Other acute adverse events (≤ 90 days from start of radiotherapy [RT]) according to CTCAE, v. 4 [ Time Frame: From start of treatment to 90 days. ] [ Designated as safety issue: Yes ]
  • Other late adverse events (> 90 days from start of RT) according to CTCAE, v. 4 [ Time Frame: From 90 days after start of treatment to last follow-up. ] [ Designated as safety issue: Yes ]
  • Disease-free survival [ Time Frame: From randomization to date of failure (local, regional or distant progression or death) or last follow-up. Analysis occurs at the same time as the primary outcome. ] [ Designated as safety issue: No ]
  • Loco-regional control [ Time Frame: From randomization to date of failure (local or regional progression or distant progression or death) or last follow-up. Analysis occurs at the same time as the primary outcome. ] [ Designated as safety issue: No ]
  • Quality of life as measured by Functional Assessment of Cancer Therapy-Head & Neck (FACT-HN) and EuroQol (EQ-5D) at baseline and at 3, 12, and 24 months [ Time Frame: From randomization to 2 years. ] [ Designated as safety issue: No ]
  • Xerostomia as measured by University of Michigan Xerostomia-Related Quality of Life Scale (XeQOLS) at baseline and at 3, 12, and 24 months [ Time Frame: From randomization to 2 years. ] [ Designated as safety issue: Yes ]
  • Swallowing as measured by the normalcy of diet subscale of the Performance Status Scale for Head and Neck Cancer (PSS-HN) at baseline and at 3, 12, and 24 months [ Time Frame: From randomization to 2 years. ] [ Designated as safety issue: No ]
  • Skin toxicity as measured by the Dermatology Life Quality Index (DLQI) at baseline and at 3, 12, and 24 months [ Time Frame: From randomization to 2 years. ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 700
Study Start Date: November 2009
Estimated Primary Completion Date: August 2021 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm I: Intensity-Modulated Radiotherapy
Patients undergo intensity-modulated radiotherapy (IMRT) once daily 5 days a week for 6 weeks in the absence of disease progression or unacceptable toxicity.
Radiation: intensity-modulated radiation therapy
Patients undergo radiotherapy.
Experimental: Arm II: IMRT plus cetuximab
Patients undergo IMRT as in arm I. Patients also receive cetuximab IV over 1-2 hours once weekly beginning at least 5 days prior to the start of IMRT and continuing for 4 weeks after the completion of IMRT (for a total of 11 doses) in the absence of disease progression or unacceptable toxicity.
Biological: cetuximab
Given IV
Radiation: intensity-modulated radiation therapy
Patients undergo radiotherapy.

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed squamous cell carcinoma (including variants, such as verrucous carcinoma, spindle cell carcinoma, or carcinoma not otherwise specified) of the head and neck, including the following subtypes:

    • Oral cavity
    • Oropharynx
    • Larynx
  • Clinical stage T1, N1-2, M0 OR T2-4a, N0-2, M0 disease based on the following diagnostic workup within the past 8 weeks:

    • General history and physical examination by a Radiation Oncologist and/or Medical Oncologist
    • Chest x-ray or chest CT scan (with or without contrast) or chest CT/PET scan (with or without contrast)
  • Must have undergone gross total resection of the primary tumor with curative intent within the past 7 weeks with surgical pathology demonstrating ≥ 1 of the following criteria for "intermediate" risk of recurrence:

    • Perineural invasion
    • Lymphovascular invasion
    • Single lymph node > 3 cm or ≥ 2 lymph nodes (all < 6 cm) (no extracapsular extension)
    • Close margin(s) of resection, defined as cancer extending to within 5 mm of a surgical margin, and/or an initially focally positive margin that is subsequently superseded by intraoperative negative margins (similarly, patients whose tumors had focally positive margins in the main specimen but negative margins from re-excised samples in the region of the positive margin are eligible)
    • Pathologically confirmed T3 or T4a primary tumor
    • T2 oral cavity cancer with > 5 mm depth of invasion
  • No positive margin(s) (defined as tumor present at the cut or inked edge of the tumor), nodal extracapsular extension, and/or gross residual disease after surgery

PATIENT CHARACTERISTICS:

  • Zubrod performance status 0-1
  • Absolute granulocyte count ≥ 1,500/mm³
  • Platelet count ≥ 100,000/mm³
  • Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention allowed)
  • Total bilirubin < 2 times upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 times ULN
  • Serum creatinine < 2 times ULN OR creatinine clearance ≥ 50 mL/min
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No other invasive malignancy within the past 3 years, except for nonmelanomatous skin cancer or previously treated carcinoma in situ of the breast, oral cavity, or cervix
  • No simultaneous primary or bilateral tumors
  • No severe, active co-morbidity, including any of the following:

    • Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
    • Transmural myocardial infarction within the past 6 months
    • Acute bacterial or fungal infection requiring IV antibiotics at the time of study registration
    • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy
    • Idiopathic pulmonary fibrosis or other severe interstitial lung disease that requires oxygen therapy or is thought to have required oxygen therapy within the past year
    • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
    • AIDS based on current Centers for Disease Control (CDC) definition
    • Grade 3-4 electrolyte abnormalities according to CTCAE, v. 4, including any of the following:

      • Serum calcium (ionized or adjusted for albumin) < 7 mg/dL or > 12.5 mg/dL*
      • Glucose < 40 mg/dL or > 250 mg/dL
      • Magnesium < 0.9 mg/dL or > 3 mg/dL*
      • Potassium < 3.5 mmol/L or > 6 mmol/L*
      • Sodium < 130 mmol/L or > 155 mmol/L* NOTE: *Despite intervention to normalize levels.
  • No prior allergic reaction to cetuximab

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • No prior systemic chemotherapy or anti-epidermal growth factor (EGF) therapy for this cancer

    • Prior chemotherapy or anti-EGF therapy for a different cancer allowed
  • No prior radiotherapy to the region of the study cancer that would result in overlap of radiotherapy fields
  • No concurrent amifostine as a radioprotector
  • No concurrent granulocyte colony-stimulating factor or erythropoietin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00956007

  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Sharon A. Spencer    205-934-0309      
Principal Investigator: Sharon A. Spencer         
United States, Arizona
Arizona Oncology Associates-West Orange Grove Recruiting
Tucson, Arizona, United States, 85704
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
United States, California
Sutter Cancer Centers Radiation Oncology Services-Auburn Recruiting
Auburn, California, United States, 95603
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Recruiting
Cameron Park, California, United States, 95682
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
Mercy San Juan Medical Center Recruiting
Carmichael, California, United States, 95608
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
City of Hope Active, not recruiting
Duarte, California, United States, 91010
UC San Diego Moores Cancer Center Active, not recruiting
LA Jolla, California, United States, 92093
University of Southern California/Norris Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Eugene I. Chung    323-865-0451      
Principal Investigator: Eugene I. Chung         
Kaiser Permanente Los Angeles Medical Center Recruiting
Los Angeles, California, United States, 90027
Contact: Michael R. Girvigian    626-564-3455      
Principal Investigator: Michael R. Girvigian         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: Eugene I. Chung    323-865-0451      
Principal Investigator: Eugene I. Chung         
Memorial Medical Center Recruiting
Modesto, California, United States, 95355
Contact: Jorge A. Garcia-Young    209-572-7116      
Principal Investigator: Jorge A. Garcia-Young         
Bay Area Tumor Institute CCOP Active, not recruiting
Oakland, California, United States, 94609
Pomona Valley Hospital Medical Center Active, not recruiting
Pomona, California, United States, 91767
The Permanente Medical Group-Roseville Radiation Oncology Active, not recruiting
Roseville, California, United States, 95678
Sutter Cancer Centers Radiation Oncology Services-Roseville Recruiting
Roseville, California, United States, 95661
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
Radiological Associates of Sacramento Withdrawn
Sacramento, California, United States, 95815
Sutter General Hospital Recruiting
Sacramento, California, United States, 95816
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
University of California at Davis Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Allen M. Chen    916-734-3089      
Principal Investigator: Allen M. Chen         
Mercy General Hospital Radiation Oncology Center Terminated
Sacramento, California, United States, 95819
Saint Helena Hospital Recruiting
Saint Helena, California, United States, 94574
Contact: David J. Tate    707-967-3698      
Principal Investigator: David J. Tate         
UCSF-Mount Zion Recruiting
San Francisco, California, United States, 94115
Contact: Sue S. Yom    877-827-3222      
Principal Investigator: Sue S. Yom         
Kaiser Permanente Medical Center - Santa Clara Active, not recruiting
Santa Clara, California, United States, 95051
Stanford University Hospitals and Clinics Active, not recruiting
Stanford, California, United States, 94305
Sutter Cancer Centers Radiation Oncology Services-Vacaville Recruiting
Vacaville, California, United States, 95687
Contact: Christopher U. Jones    916-454-6500    cancerinfo@sutterhealth.org   
Principal Investigator: Christopher U. Jones         
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
University of Colorado Cancer Center - Anschutz Cancer Pavilion Recruiting
Aurora, Colorado, United States, 80045
Contact: David Raben    720-848-0650      
Principal Investigator: David Raben         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Porter Adventist Hospital Recruiting
Denver, Colorado, United States, 80210
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Littleton Recruiting
Littleton, Colorado, United States, 80120
Contact: Keren Sturtz    888-785-6789      
Principal Investigator: Keren Sturtz         
United States, Connecticut
Saint Vincent's Medical Center Recruiting
Bridgeport, Connecticut, United States, 06606
Contact: Christopher M. Iannuzzi    203-576-6329    twhite@stvincents.org   
Principal Investigator: Christopher M. Iannuzzi         
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Roy H. Decker    203-785-5702      
Principal Investigator: Roy H. Decker         
William Backus Hospital Recruiting
Norwich, Connecticut, United States, 06360
Contact: Dennis E. Slater    860-886-8362      
Principal Investigator: Dennis E. Slater         
United States, Delaware
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Adam Raben    302-733-6227      
Principal Investigator: Adam Raben         
United States, Florida
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach Recruiting
Deerfield Beach, Florida, United States, 33442
Contact: Michael A. Samuels    866-574-5124    Sylvester@emergingmed.com   
Principal Investigator: Michael A. Samuels         
Mayo Clinic in Florida Recruiting
Jacksonville, Florida, United States, 32224-9980
Contact: Robert L. Foote    507-538-7623      
Principal Investigator: Robert L. Foote         
Edna Williams Cancer Center at the Baptist Cancer Institute Withdrawn
Jacksonville, Florida, United States, 32207
Cancer Specialists of North Florida-Southside Withdrawn
Jacksonville, Florida, United States, 32207
Cancer Specialists of North Florida-Beaches Withdrawn
Jacksonville Beach, Florida, United States, 32250
Cancer Specialists of North Florida-Baptist South Withdrawn
Jascksonville, Florida, United States, 32258
University of Miami Miller School of Medicine-Sylvester Cancer Center Recruiting
Miami, Florida, United States, 33136
Contact: Michael A. Samuels    866-574-5124    Sylvester@emergingmed.com   
Principal Investigator: Michael A. Samuels         
Baptist Hospital of Miami Recruiting
Miami, Florida, United States, 33176
Contact: Andre A. Abitbol    800-599-2456    cancerinfo@baptisthealth.net   
Principal Investigator: Andre A. Abitbol         
Cancer Specialists of North Florida-Orange Park Withdrawn
Orange Park, Florida, United States, 32073
UF Cancer Center at Orlando Health Recruiting
Orlando, Florida, United States, 32806
Contact: Rafael R. Manon    321-841-7246      
Principal Investigator: Rafael R. Manon         
Florida Hospital Recruiting
Orlando, Florida, United States, 32803
Contact: Robert J. Sollaccio    407-303-5623      
Principal Investigator: Robert J. Sollaccio         
Cancer Specialists of North Florida-Putnam Withdrawn
Palatka, Florida, United States, 32177
Cancer Specialists of North Florida-Saint Augustine Withdrawn
Saint Augustine, Florida, United States, 32086
United States, Georgia
Emory University/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Jonathan J. Beitler    404-778-1868      
Principal Investigator: Jonathan J. Beitler         
Atlanta VA Medical Center Active, not recruiting
Decatur, Georgia, United States, 30033
Northeast Georgia Medical Center Recruiting
Gainesville, Georgia, United States, 30501
Contact: Frank G. Lake    770-219-8800    cancerpatient.navigator@nghs.com   
Principal Investigator: Frank G. Lake         
Memorial Health University Medical Center Recruiting
Savannah, Georgia, United States, 31403
Contact: Aaron W. Pederson    912-350-8568      
Principal Investigator: Aaron W. Pederson         
Saint Joseph's-Candler Health System Recruiting
Savannah, Georgia, United States, 31405
Contact: John A. Pablo    912-819-5704      
Principal Investigator: John A. Pablo         
United States, Hawaii
Queen's Medical Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Paul A. DeMare    808-545-8548      
Principal Investigator: Paul A. DeMare         
The Cancer Center of Hawaii-Liliha Recruiting
Honolulu, Hawaii, United States, 96817
Contact: Paul A. DeMare    808-545-8548      
Principal Investigator: Paul A. DeMare         
University of Hawaii Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Paul A. DeMare    808-545-8548      
Principal Investigator: Paul A. DeMare         
United States, Idaho
Saint Alphonsus Regional Medical Center Recruiting
Boise, Idaho, United States, 83706
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
United States, Illinois
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Lawrence E. Feldman    312-355-3046      
Principal Investigator: Lawrence E. Feldman         
John H Stroger Jr Hospital of Cook County Recruiting
Chicago, Illinois, United States, 60612-3785
Contact: Fred R. Rosen    312-864-6000      
Principal Investigator: Fred R. Rosen         
NorthShore University HealthSystem-Evanston Hospital Active, not recruiting
Evanston, Illinois, United States, 60201
Ingalls Memorial Hospital Recruiting
Harvey, Illinois, United States, 60426
Contact: Sulochana D. Yalavarthi    708-915-4673    clinicaltrials@ingalls.org   
Principal Investigator: Sulochana D. Yalavarthi         
Hines Veterans Administration Hospital Recruiting
Hines, Illinois, United States, 60141
Contact: Cheryl M. Czerlanis    708-226-4357      
Principal Investigator: Cheryl M. Czerlanis         
Loyola University Medical Center Active, not recruiting
Maywood, Illinois, United States, 60153
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781-0001
Contact: James L. Wade    217-876-4740    kcheek@dmhhs.org   
Principal Investigator: James L. Wade         
Saint John's Hospital Recruiting
Springfield, Illinois, United States, 62702
Contact: Cathy L. Clausen    217-525-5666    diana.weyhenmeyer@st-johns.org   
Principal Investigator: Cathy L. Clausen         
Carle Cancer Center Active, not recruiting
Urbana, Illinois, United States, 61801
United States, Indiana
Radiation Oncology Associates PC Recruiting
Fort Wayne, Indiana, United States, 46804
Contact: Brian K. Chang    260-373-8888    parkviewresearch@parkview.com   
Principal Investigator: Brian K. Chang         
Parkview Hospital Randallia Recruiting
Fort Wayne, Indiana, United States, 46805
Contact: Brian K. Chang    260-373-8888    parkviewresearch@parkview.com   
Principal Investigator: Brian K. Chang         
IU Health Goshen Center for Cancer Care Withdrawn
Goshen, Indiana, United States, 46526
Community Regional Cancer Care-East Radiation Oncology Recruiting
Indianapolis, Indiana, United States, 46219
Contact: Shih J. Wei    317-621-7104      
Principal Investigator: Shih J. Wei         
Community Regional Cancer Care-North Recruiting
Indianapolis, Indiana, United States, 46256
Contact: Shih J. Wei    317-621-7104      
Principal Investigator: Shih J. Wei         
IU Health Methodist Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Alexander M. Yeh    765-646-8358      
Principal Investigator: Alexander M. Yeh         
IU Health Ball Memorial Hospital Recruiting
Muncie, Indiana, United States, 47303
Contact: Yunjie X. Lin    765-751-5850    alpatterson@medicalconsultantspc.com   
Principal Investigator: Yunjie X. Lin         
United States, Iowa
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Robert J. Behrens    888-244-6061    sherrijr@iora.org   
Principal Investigator: Robert J. Behrens         
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Mark C. Smith    800-237-1225      
Principal Investigator: Mark C. Smith         
Siouxland Hematology Oncology Associates Recruiting
Sioux City, Iowa, United States, 51101
Contact: Donald B. Wender    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
United States, Kentucky
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536
Contact: Mahesh R. Kudrimoti    859-257-3379      
Principal Investigator: Mahesh R. Kudrimoti         
The James Graham Brown Cancer Center at University of Louisville Recruiting
Louisville, Kentucky, United States, 40202
Contact: Shiao Y. Woo    866-530-5516      
Principal Investigator: Shiao Y. Woo         
United States, Louisiana
Mary Bird Perkins Cancer Center Recruiting
Baton Rouge, Louisiana, United States, 70809
Contact: Robert W. Veith    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Robert W. Veith         
Touro Infirmary Recruiting
New Orleans, Louisiana, United States, 70115
Contact: Robert W. Veith    504-568-2428    emede1@lsuhsc.edu   
Principal Investigator: Robert W. Veith         
Tulane University Health Sciences Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: William R. Robinson    504-988-6121      
Principal Investigator: William R. Robinson         
United States, Maine
Central Maine Medical Center Active, not recruiting
Lewiston, Maine, United States, 04240
United States, Maryland
University of Maryland/Greenebaum Cancer Center Active, not recruiting
Baltimore, Maryland, United States, 21201
Peninsula Regional Medical Center Recruiting
Salisbury, Maryland, United States, 21801
Contact: Matthew L. Snyder    866-922-6237      
Principal Investigator: Matthew L. Snyder         
United States, Massachusetts
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Minh T. Truong    617-638-8265      
Principal Investigator: Minh T. Truong         
Tufts Medical Center Active, not recruiting
Boston, Massachusetts, United States, 02111
Lahey Hospital and Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Francis W. Nugent    781-744-8027      
Principal Investigator: Francis W. Nugent         
United States, Michigan
University of Michigan Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Avraham Eisbruch    800-865-1125      
Principal Investigator: Avraham Eisbruch         
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
Oakwood Hospital Recruiting
Dearborn, Michigan, United States, 48124
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
Wayne State University/Karmanos Cancer Institute Recruiting
Detroit, Michigan, United States, 48201
Contact: Harold E. Kim    313-576-9363      
Principal Investigator: Harold E. Kim         
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Eleanor M. Walker    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Raymond S. Lord    269-373-7458      
Principal Investigator: Raymond S. Lord         
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Samir Narayan    734-712-3456      
Principal Investigator: Samir Narayan         
United States, Minnesota
Mercy Hospital Recruiting
Coon Rapids, Minnesota, United States, 55433
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
Saint Luke's Hospital of Duluth Recruiting
Duluth, Minnesota, United States, 55805
Contact: Steven R. Bonin    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Steven R. Bonin         
Unity Hospital Recruiting
Fridley, Minnesota, United States, 55432
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
Minnesota Oncology Hematology PA-Maplewood Recruiting
Maplewood, Minnesota, United States, 55109
Contact: Paul W. Sperduto    952-993-1517    MMCCOP@parknicollet.com   
Principal Investigator: Paul W. Sperduto         
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Robert L. Foote    507-538-7623      
Principal Investigator: Robert L. Foote         
Regions Hospital Active, not recruiting
Saint Paul, Minnesota, United States, 55101
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Shankar P. Giri    601-815-6700      
Principal Investigator: Shankar P. Giri         
Singing River Hospital Recruiting
Pascagoula, Mississippi, United States, 39581
Contact: James E. Clarkson    228-809-5292      
Principal Investigator: James E. Clarkson         
United States, Missouri
Cape Radiation Oncology Terminated
Cape Girardeau, Missouri, United States, 63703
University of Missouri - Ellis Fischel Recruiting
Columbia, Missouri, United States, 65212
Contact: Donald C. Doll    573-882-7440      
Principal Investigator: Donald C. Doll         
Kansas City Cancer Centers - North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Kansas City Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Parvesh Kumar    913-588-4709      
Principal Investigator: Parvesh Kumar         
Siteman Cancer Center-South County Recruiting
Saint Louis, Missouri, United States, 63129
Contact: Wade L. Thorstad    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Wade L. Thorstad         
Saint John's Mercy Medical Center Active, not recruiting
Saint Louis, Missouri, United States, 63141
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Wade L. Thorstad    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Wade L. Thorstad         
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: Alan P. Lyss    800-392-0936      
Principal Investigator: Alan P. Lyss         
Barnes-Jewish West County Hospital Recruiting
Saint Louis, Missouri, United States, 63141
Contact: Wade L. Thorstad    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Wade L. Thorstad         
Saint Louis University Hospital Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Bruce J. Walz    314-977-4440      
Principal Investigator: Bruce J. Walz         
Siteman Cancer Center - Saint Peters Recruiting
Saint Peters, Missouri, United States, 63376
Contact: Wade L. Thorstad    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Wade L. Thorstad         
Mercy Hospital Springfield Active, not recruiting
Springfield, Missouri, United States, 65804
CoxHealth South Hospital Active, not recruiting
Springfield, Missouri, United States, 65807
United States, Nebraska
Saint Elizabeth Regional Medical Center Recruiting
Lincoln, Nebraska, United States, 68510
Contact: Kevin Yiee    402-483-2827      
Principal Investigator: Kevin Yiee         
The Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Weining K. Zhen    402-559-8555    llarson@unmc.edu   
Principal Investigator: Weining K. Zhen         
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Tien-Shew W. Huang    402-354-5144      
Principal Investigator: Tien-Shew W. Huang         
United States, Nevada
Renown Regional Medical Center Recruiting
Reno, Nevada, United States, 89502
Contact: Michael C. Hardacre    775-982-4400      
Principal Investigator: Michael C. Hardacre         
United States, New Hampshire
Exeter Hospital Active, not recruiting
Exeter, New Hampshire, United States, 03833
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Alan C. Hartford    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: Alan C. Hartford         
United States, New Jersey
Memorial Sloan Kettering Cancer Center at Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Nancy Y. Lee    212-639-7202      
Principal Investigator: Nancy Y. Lee         
Cooper Hospital University Medical Center Recruiting
Camden, New Jersey, United States, 08103
Contact: Gregory J. Kubicek    856-325-6757      
Principal Investigator: Gregory J. Kubicek         
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Recruiting
Mount Holly, New Jersey, United States, 08060
Contact: Lemuel S. Ariaratnam    888-847-8823      
Principal Investigator: Lemuel S. Ariaratnam         
Saint Peter's University Hospital Recruiting
New Brunswick, New Jersey, United States, 08901
Contact: Gopal R. Desai    732-745-8600 ext 6163    kcovert@saintpetersuh.com   
Principal Investigator: Gopal R. Desai         
UMDNJ - New Jersey Medical School Active, not recruiting
Newark, New Jersey, United States, 07103
Sparta Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Rita S. Axelrod    215-955-6084      
Principal Investigator: Rita S. Axelrod         
MD Anderson Cancer Center at Cooper-Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Gregory J. Kubicek    856-325-6757      
Principal Investigator: Gregory J. Kubicek         
United States, New Mexico
University of New Mexico Recruiting
Albuquerque, New Mexico, United States, 87106
Contact: Benny J. Liem    505-272-6972      
Principal Investigator: Benny J. Liem         
United States, New York
New York Oncology Hematology PC - Albany Recruiting
Albany, New York, United States, 12206
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Maimonides Medical Center Recruiting
Brooklyn, New York, United States, 11219
Contact: Jay S. Cooper    718-765-2500      
Principal Investigator: Jay S. Cooper         
Sands Cancer Center Recruiting
Canandiaqua, New York, United States, 14424
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Memorial Sloan Kettering Cancer Center Commack Recruiting
Commack, New York, United States, 11725
Contact: Nancy Y. Lee    212-639-7202      
Principal Investigator: Nancy Y. Lee         
Mary Imogene Bassett Hospital Withdrawn
Cooperstown, New York, United States, 13326
Memorial Sloan-Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Nancy Y. Lee    212-639-7202      
Principal Investigator: Nancy Y. Lee         
Beth Israel Medical Center Recruiting
New York, New York, United States, 10003
Contact: Kenneth S. Hu    212-844-6286      
Principal Investigator: Kenneth S. Hu         
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Highland Hospital Recruiting
Rochester, New York, United States, 14620
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
University Radiation Oncology Recruiting
Rochester, New York, United States, 14626
Contact: Yuhchyau Chen    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Memorial Sloan-Kettering Cancer Center Rockville Centre Recruiting
Rockville Centre, New York, United States, 11570
Contact: Nancy Y. Lee    212-639-7202      
Principal Investigator: Nancy Y. Lee         
Memorial Sloan-Kettering Cancer Center at Sleepy Hallow Recruiting
Sleepy Hollow, New York, United States, 10591
Contact: Nancy Y. Lee    212-639-7202      
Principal Investigator: Nancy Y. Lee         
United States, North Carolina
Mission Hospital-Memorial Campus Recruiting
Asheville, North Carolina, United States, 28801
Contact: Christopher H. Chay    828-213-4150      
Principal Investigator: Christopher H. Chay         
University of North Carolina Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Bhishamjit S. Chera    877-668-0683    cancerclinicaltrials@med.unc.edu   
Principal Investigator: Bhishamjit S. Chera         
Wayne Radiation Oncology Active, not recruiting
Goldsboro, North Carolina, United States, 27534
Kinston Medical Specialists PA Recruiting
Kinston, North Carolina, United States, 28501
Contact: Peter R. Watson    252-559-2200      
Principal Investigator: Peter R. Watson         
Cancer Centers of North Carolina Terminated
Raleigh, North Carolina, United States, 27607
Wake Forest University Health Sciences Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Kathryn M. Greven    336-713-6771      
Principal Investigator: Kathryn M. Greven         
United States, North Dakota
Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    701-234-6161      
Principal Investigator: Preston D. Steen         
United States, Ohio
Akron General Medical Center Recruiting
Akron, Ohio, United States, 44307
Contact: Mitchel L. Fromm    330-344-6348      
Principal Investigator: Mitchel L. Fromm         
Summa Akron City Hospital/Cooper Cancer Center Recruiting
Akron, Ohio, United States, 44304
Contact: Charles A. Kunos    330-375-6101      
Principal Investigator: Charles A. Kunos         
Summa Barberton Hospital Recruiting
Barberton, Ohio, United States, 44203
Contact: Charles A. Kunos    330-375-6101      
Principal Investigator: Charles A. Kunos         
Mercy Medical Center Recruiting
Canton, Ohio, United States, 44708
Contact: Edward J. Walsh    888-293-4673      
Principal Investigator: Edward J. Walsh         
Geaugra Hospital Recruiting
Chardon, Ohio, United States, 44024
Contact: Min Yao    800-641-2422      
Principal Investigator: Min Yao         
University of Cincinnati Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Kevin P. Redmond    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Kevin P. Redmond         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: David J. Adelstein    866-223-8100      
Principal Investigator: David J. Adelstein         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Min Yao    800-641-2422      
Principal Investigator: Min Yao         
Cleveland Clinic Cancer Center/Fairview Hospital Recruiting
Cleveland, Ohio, United States, 44111
Contact: David J. Adelstein    866-223-8100      
Principal Investigator: David J. Adelstein         
MetroHealth Medical Center Withdrawn
Cleveland, Ohio, United States, 44109
Ohio State University Medical Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Maura L. Gillison    866-627-7616    osu@emergingmed.com   
Principal Investigator: Maura L. Gillison         
Mercy Cancer Center-Elyria Recruiting
Elyria, Ohio, United States, 44035
Contact: Min Yao    800-641-2422      
Principal Investigator: Min Yao         
Cleveland Clinic Cancer Center Independence Recruiting
Independence, Ohio, United States, 44131
Contact: David J. Adelstein    866-223-8100      
Principal Investigator: David J. Adelstein         
Hillcrest Hospital Cancer Center Recruiting
Mayfield Heights, Ohio, United States, 44124
Contact: David J. Adelstein    866-223-8100      
Principal Investigator: David J. Adelstein         
Summa Health Center at Lake Medina Recruiting
Medina, Ohio, United States, 44256
Contact: Charles A. Kunos    330-375-6101      
Principal Investigator: Charles A. Kunos         
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Min Yao    800-641-2422      
Principal Investigator: Min Yao         
Southwest General Health Center Ireland Cancer Center Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Min Yao    800-641-2422      
Principal Investigator: Min Yao         
UHHS-Chagrin Highlands Medical Center Active, not recruiting
Orange Village, Ohio, United States, 44122
Saint Charles Hospital Recruiting
Oregon, Ohio, United States, 43616
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
Robinson Radiation Oncology Recruiting
Ravenna, Ohio, United States, 44266
Contact: Mitchel L. Fromm    330-344-6348      
Principal Investigator: Mitchel L. Fromm         
North Coast Cancer Care Active, not recruiting
Sandusky, Ohio, United States, 44870
Cleveland Clinic Cancer Center-Strongsville Active, not recruiting
Strongsville, Ohio, United States, 44136
Flower Hospital Recruiting
Sylvania, Ohio, United States, 43560
Contact: Rex B. Mowat    517-265-0116      
Principal Investigator: Rex B. Mowat         
University Pointe Recruiting
West Chester, Ohio, United States, 45069
Contact: Kevin P. Redmond    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Kevin P. Redmond         
UHHS-Westlake Medical Center Recruiting
Westlake, Ohio, United States, 44145
Contact: Min Yao    800-641-2422      
Principal Investigator: Min Yao         
Cleveland Clinic Wooster Specialty Center Recruiting
Wooster, Ohio, United States, 44691
Contact: David J. Adelstein    866-223-8100      
Principal Investigator: David J. Adelstein         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Terence S. Herman    405-271-4272    julie-traylor@ouhsc.edu   
Principal Investigator: Terence S. Herman         
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Willamette Valley Cancer Center Recruiting
Eugene, Oregon, United States, 97401
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Oregon Health and Science University Active, not recruiting
Portland, Oregon, United States, 97239
Portland Veterans Administration Medical Center Recruiting
Portland, Oregon, United States, 97239
Contact: Neil D. Gross    503-494-1080    trials@ohsu.edu   
Principal Investigator: Neil D. Gross         
Western Oncology Research Consortium Recruiting
Portland, Oregon, United States, 97213
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Legacy Good Samaritan Hospital and Medical Center Withdrawn
Portland, Oregon, United States, 97210
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Salem Hospital Recruiting
Salem, Oregon, United States, 97301
Contact: Matthew S. Gordon    503-561-2618      
Principal Investigator: Matthew S. Gordon         
United States, Pennsylvania
Lehigh Valley Hospital Recruiting
Allentown, Pennsylvania, United States, 18105
Contact: Eliot L. Friedman    610-402-2273      
Principal Investigator: Eliot L. Friedman         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822-2001
Contact: Thomas J. Gergel    570-271-5251      
Principal Investigator: Thomas J. Gergel         
Northeast Radiation Oncology Center Recruiting
Dunmore, Pennsylvania, United States, 18512
Contact: Rita S. Axelrod    215-955-6084      
Principal Investigator: Rita S. Axelrod         
Pocono Medical Center Recruiting
East Stroudsburg, Pennsylvania, United States, 18301
Contact: Rita S. Axelrod    215-955-6084      
Principal Investigator: Rita S. Axelrod         
The Regional Cancer Center Withdrawn
Erie, Pennsylvania, United States, 16505
Adams Cancer Center Recruiting
Gettysburg, Pennsylvania, United States, 17325
Contact: Amit B. Shah    877-441-7957      
Principal Investigator: Amit B. Shah         
Cherry Tree Cancer Center Recruiting
Hanover, Pennsylvania, United States, 17331
Contact: Amit B. Shah    877-441-7957      
Principal Investigator: Amit B. Shah         
Saint Mary Medical and Regional Cancer Center Active, not recruiting
Langhorne, Pennsylvania, United States, 19047
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Rita S. Axelrod    215-955-6084      
Principal Investigator: Rita S. Axelrod         
Albert Einstein Medical Center Active, not recruiting
Philadelphia, Pennsylvania, United States, 19141
Fox Chase Cancer Center Recruiting
Philadelphia, Pennsylvania, United States, 19111
Contact: Thomas J. Galloway    215-728-4790      
Principal Investigator: Thomas J. Galloway         
University of Pennsylvania/Abramson Cancer Center Terminated
Philadelphia, Pennsylvania, United States, 19104
Reading Hospital Recruiting
West Reading, Pennsylvania, United States, 19611
Contact: Albert Yuen    610-988-9323      
Principal Investigator: Albert Yuen         
WellSpan Health-York Hospital Recruiting
York, Pennsylvania, United States, 17405
Contact: Amit B. Shah    877-441-7957      
Principal Investigator: Amit B. Shah         
United States, South Carolina
AnMed Health Cancer Center Recruiting
Anderson, South Carolina, United States, 29621
Contact: Patricia C. Griffin    800-486-5941      
Principal Investigator: Patricia C. Griffin         
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Anand K. Sharma    843-792-9321      
Principal Investigator: Anand K. Sharma         
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
Greenville Health System Cancer Institute/Greenville CCOP Active, not recruiting
Greenville, South Carolina, United States, 29615
Gibbs Cancer Center-Pelham Recruiting
Greer, South Carolina, United States, 29651
Contact: Patricia C. Griffin    800-486-5941      
Principal Investigator: Patricia C. Griffin         
Spartanburg Regional Medical Center Recruiting
Spartanburg, South Carolina, United States, 29303
Contact: Patricia C. Griffin    800-486-5941      
Principal Investigator: Patricia C. Griffin         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-241-6251      
Principal Investigator: David L. Grisell         
United States, South Dakota
Rapid City Regional Hospital Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Michael J. Swartz    605-716-3982    research@rcrh.org   
Principal Investigator: Michael J. Swartz         
Sanford Cancer Center-Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Miroslaw A. Mazurczak    605-328-1367      
Principal Investigator: Miroslaw A. Mazurczak         
United States, Tennessee
Wellmont Holston Valley Hospital and Medical Center Recruiting
Kingsport, Tennessee, United States, 37660
Contact: Asheesh Shipstone    423-578-8538      
Principal Investigator: Asheesh Shipstone         
Vanderbilt-Ingram Cancer Center Recruiting
Nashville, Tennessee, United States, 37232
Contact: Anthony J. Cmelak    800-811-8480      
Principal Investigator: Anthony J. Cmelak         
United States, Texas
Texas Oncology-Austin Midtown Recruiting
Austin, Texas, United States, 78705
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology - South Austin Cancer Center Recruiting
Austin, Texas, United States, 78745
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology - Central Austin Cancer Center Recruiting
Austin, Texas, United States, 78731
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology PA - Bedford Active, not recruiting
Bedford, Texas, United States, 76022
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390
Contact: Lucien A. Nedzi    214-648-7097      
Principal Investigator: Lucien A. Nedzi         
Texas Oncology-Denton South Recruiting
Denton, Texas, United States, 76210
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
The Klabzuba Cancer Center Recruiting
Fort Worth, Texas, United States, 76104
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
M D Anderson Cancer Center Recruiting
Houston, Texas, United States, 77030
Contact: Erich M. Sturgis    713-792-3245      
Principal Investigator: Erich M. Sturgis         
Ben Taub General Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Mark D. Bonnen    713-798-1354    burton@bcm.edu   
Principal Investigator: Mark D. Bonnen         
Memorial Hermann Memorial City Medical Center Recruiting
Houston, Texas, United States, 77024
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology-Seton Williamson Recruiting
Round Rock, Texas, United States, 78665
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology - Round Rock Cancer Center Recruiting
Round Rock, Texas, United States, 78681
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Ying Li    210-567-0653    che@uthscsa.edu   
Principal Investigator: Ying Li         
Cancer Care Centers of South Texas- Northeast Active, not recruiting
San Antonio, Texas, United States, 78217
Texas Cancer Center-Sherman Recruiting
Sherman, Texas, United States, 75090
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology Cancer Center Sugar Land Recruiting
Sugar Land, Texas, United States, 77479
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Texas Oncology-Wichita Falls Texoma Cancer Center Active, not recruiting
Wichita Falls, Texas, United States, 76310
United States, Utah
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84157
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Ying J. Hitchcock    801-581-4477    clinical.trials@hci.utah.edu   
Principal Investigator: Ying J. Hitchcock         
LDS Hospital Recruiting
Salt Lake City, Utah, United States, 84143
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
Utah Cancer Specialists-Salt Lake City Recruiting
Salt Lake City, Utah, United States, 84106
Contact: Vilija N. Avizonis    801-507-3950      
Principal Investigator: Vilija N. Avizonis         
United States, Virginia
University of Virginia Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Paul W. Read    434-243-6143      
Principal Investigator: Paul W. Read         
Sentara Cancer Institute at Sentara CarePlex Hospital Recruiting
Hampton, Virginia, United States, 23666
Contact: Scott S. Williams    757-388-2406      
Principal Investigator: Scott S. Williams         
Sentara Hospitals Recruiting
Norfolk, Virginia, United States, 23507
Contact: Scott S. Williams    757-388-2406      
Principal Investigator: Scott S. Williams         
Virginia Commonwealth University Recruiting
Richmond, Virginia, United States, 23298
Contact: Harry D. Bear    804-628-1939      
Principal Investigator: Harry D. Bear         
Hunter Holmes McGuire Veterans Administration Medical Center Active, not recruiting
Richmond, Virginia, United States, 23249
Sentara Virginia Beach General Hospital Recruiting
Virginia Beach, Virginia, United States, 23454
Contact: Scott S. Williams    757-388-2406      
Principal Investigator: Scott S. Williams         
United States, Washington
Harrison Medical Center Active, not recruiting
Bremerton, Washington, United States, 98310
Tri-Cities Cancer Center Recruiting
Kennewick, Washington, United States, 99336
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
Skagit Valley Hospital Recruiting
Mount Vernon, Washington, United States, 98274
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
Cancer Care Northwest-North Spokane Recruiting
Spokane, Washington, United States, 99218
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Cancer Care Northwest - Spokane South Recruiting
Spokane, Washington, United States, 99202
Contact: Vivek S. Kavadi    281-277-5200      
Principal Investigator: Vivek S. Kavadi         
Northwest CCOP Active, not recruiting
Tacoma, Washington, United States, 98405
Compass Oncology Vancouver Active, not recruiting
Vancouver, Washington, United States, 98684
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Matthew C. Solhjem    503-215-6412      
Principal Investigator: Matthew C. Solhjem         
Wenatchee Valley Medical Center Recruiting
Wenatchee, Washington, United States, 98801
Contact: George E. Laramore    206-616-8289      
Principal Investigator: George E. Laramore         
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Manish Monga    304-293-2745    sfilburn@hsc.wvu.edu   
Principal Investigator: Manish Monga         
Wheeling Hospital Recruiting
Wheeling, West Virginia, United States, 26003
Contact: Jondavid Pollock    304-243-6442      
Principal Investigator: Jondavid Pollock         
United States, Wisconsin
Langlade Hospital and Cancer Center Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Darryl R. Barton    877-405-6866      
Principal Investigator: Darryl R. Barton         
Fox Valley Hematology and Oncology Recruiting
Appleton, Wisconsin, United States, 54911-3496
Contact: Robert R. Kohl    920-433-8889      
Principal Investigator: Robert R. Kohl         
Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Gregory M. Cooley    920-699-3500    lynda.persico@uwmf.wisc.edu   
Principal Investigator: Gregory M. Cooley         
Gundersen Lutheran Recruiting
La Crosse, Wisconsin, United States, 54601
Contact: Collin D. Driscoll    608-775-2385    cancerctr@gundluth.org   
Principal Investigator: Collin D. Driscoll         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Paul M. Harari    877-405-6866      
Principal Investigator: Paul M. Harari         
Bay Area Medical Center Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Gregory M. Cooley    920-699-3500    lynda.persico@uwmf.wisc.edu   
Principal Investigator: Gregory M. Cooley         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Christopher J. Schultz    414-805-4380      
Principal Investigator: Christopher J. Schultz         
Clement J. Zablocki VA Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53295
Contact: Elizabeth M. Gore    888-469-6614      
Principal Investigator: Elizabeth M. Gore         
Door County Cancer Center Recruiting
Sturgeon Bay, Wisconsin, United States, 54235-1495
Contact: Gregory M. Cooley    920-699-3500    lynda.persico@uwmf.wisc.edu   
Principal Investigator: Gregory M. Cooley         
Aspirus Regional Cancer Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Darryl R. Barton    877-405-6866      
Principal Investigator: Darryl R. Barton         
Canada, Alberta
Cross Cancer Institute Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Rufus A. Scrimger    780-432-8500      
Principal Investigator: Rufus A. Scrimger         
Canada, Manitoba
CancerCare Manitoba Active, not recruiting
Winnipeg, Manitoba, Canada, R3E 0V9
Canada, Newfoundland and Labrador
Doctor H. Bliss Murphy Cancer Centre Terminated
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Canada, Nova Scotia
QEII Health Sciences Centre/Capital District Health Authority Withdrawn
Halifax, Nova Scotia, Canada, B3H 1V8
Canada, Ontario
London Regional Cancer Program Active, not recruiting
London, Ontario, Canada, N6A 4L6
Ottawa Health Research Institute-General Division Recruiting
Ottawa, Ontario, Canada, K1H 1C4
Contact: Samy El-Sayed    613-761-4395    info@ohri.ca   
Principal Investigator: Samy El-Sayed         
The Ottawa Hospital Cancer Centre (Ottawa Health Research Institute) Civic Campus Withdrawn
Ottawa, Ontario, Canada, K1Y 4E9
Health Sciences North Recruiting
Sudbury, Ontario, Canada, P3E 5J1
Contact: Adam K. Andronowski    706-522-6237ext2401    japaquette@hrsrh.on.ca   
Principal Investigator: Adam K. Andronowski         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: John (Joon-Hyung) Kim    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: John (Joon-Hyung) Kim         
Canada, Quebec
CHUM - Hopital Notre-Dame Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Edith J. Filion    514-890-8000ext23611    sylvie.beaudoin.chum@ssss.gouv.qc.ca   
Principal Investigator: Edith J. Filion         
McGill University Department of Oncology Recruiting
Montreal, Quebec, Canada, H2W 1S6
Contact: George Shenouda    514-934-1934ext42953    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: George Shenouda         
CHUQ - Pavilion Hotel-Dieu de Quebec Active, not recruiting
Quebec City, Quebec, Canada, G1R 2J6
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Chang S. Wang    819-820-6480    crcinformation.chus@ssss.gouv.qc.ca   
Principal Investigator: Chang S. Wang         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Evgeny Sadikov    306-766-2213      
Principal Investigator: Evgeny Sadikov         
China, Hong Kong
Chinese University of Hong Kong-Prince of Wales Hospital Recruiting
Shatin, Hong Kong, China, OX1 3UJ
Contact: Michael K. Kam    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Michael K. Kam         
Saudi Arabia
King Faisal Specialist Hospital and Research Centre Recruiting
Riyadh, Saudi Arabia, 11211
Contact: Nasser M. Al Rajhi    011-966-1-464-7272 ext 38005      
Principal Investigator: Nasser M. Al Rajhi         
Sponsors and Collaborators
Radiation Therapy Oncology Group
Investigators
Study Chair: Mitchell Machtay, MD University Hospitals Seidman Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier: NCT00956007     History of Changes
Obsolete Identifiers: NCT01311063
Other Study ID Numbers: RTOG 0920, CDR0000651536, NCI-2011-00878
Study First Received: August 8, 2009
Last Updated: May 28, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Radiation Therapy Oncology Group:
stage III squamous cell carcinoma of the larynx
stage III verrucous carcinoma of the larynx
stage IV squamous cell carcinoma of the larynx
stage IV verrucous carcinoma of the larynx
stage III squamous cell carcinoma of the lip and oral cavity
stage IV squamous cell carcinoma of the lip and oral cavity
stage III verrucous carcinoma of the oral cavity
stage IV verrucous carcinoma of the oral cavity
stage III squamous cell carcinoma of the oropharynx
stage IV squamous cell carcinoma of the oropharynx
tongue cancer

Additional relevant MeSH terms:
Head and Neck Neoplasms
Neoplasms by Site
Neoplasms
Cetuximab
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on July 26, 2014