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| Sponsor: | Third Military Medical University |
|---|---|
| Information provided by (Responsible Party): | Wu Qinan, Third Military Medical University |
| ClinicalTrials.gov Identifier: | NCT00940082 |
Purpose
Objectives: To investigate the cardiac condition of the diabetic patients in our hospital in order to seek for the new diagnostic method of warning its cardiovascular complications in early times.
Methods: 317 diabetic patients in our hospital from January in 2004 to July in 2008 were divided into 2 groups: group A (106 patients whose age ranged from (31-59) and group B (211 patients whose age ranged from (60-90). The height, weight, blood glucose, glycosylated hemoglobin, lipid, blood pressure, course of disease, ejection fraction (EF), fractional shortening(FS), diameter of left ventricle in late diastolic stage(LVEDd), the thickness of the ventricular septa（IVSDand the posterior wall of the right ventricle in late diastolic stage (LVPWd)were recorded respectively. Left ventricular mass index (LVMI), relative wall thickness (RWT) were calculated and High-sensitive C-reactive protein (HsCRP), homocysteine and TNF-α were detected. Multifactor logistic regression was made based on the comparison and contrast between all indexes to analyze the correlations between age and the positive indexes.
| Condition |
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Two-Dimensional Echocardiography |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic |
Take the fasting blood more than 12 hours overnight
| Estimated Enrollment: | 400 |
| Study Start Date: | June 2007 |
| Estimated Study Completion Date: | October 2015 |
| Estimated Primary Completion Date: | September 2015 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
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youth control group
healthy people which ages from 30 to 59
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youth diabetes group
type 1 and type 2 diabetes patients which ages from 30 to 59
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the elderly diabetes group
type 1 and type 2 diabetes patients which ages from 60 to 90
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elderly control group
healthy people which ages from 60 to 90
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Diabetes is one of the commonly seen health hazards in modern times. According to statistics, 70% people with diabetes have died of cardiovascular diseases.
Framingham `s study has proven the increase of the congestive heart-failure (2.4:1 in male patients and5:1 in female patients), which has no association with the age, hypertension, obesity, cardiovascular disease and Hyperlipidemia[1]. Other prospective studies also showed that the patients with diabetes in the early stage may be subject to abnormal echocardiogram and their probabilities of suffering from heart failure in the lifetime and Q-wave and non-Q wave myocardial infarction will be increased[1,2]. Early in 2000, American Heart Association issued a statement that "diabetes is a cardiovascular disease" [3]and in 2007, with reference to the joint guidelines concerning diabetes, pre-diabetes and cardiovascular disease, European Society of Cardiology (ESC) and the European Diabetes Research Institute (ESAD) clearly pointed out that hyperglycemia and cardiovascular disease (CVD) are closely related and the danger of CVD can be raised notably for those whose blood glucose is normal when fasting but tend to increase postprandially[4]. In the pathogenesis study of cardiovascular complications of diabetes, the promotion of oxidative stress and declination of the heart antioxidant reserves have close associations with the cardiovascular complications in animal and human body[5]. A number of cytokines and inflammatory signaling pathways are involved including tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (HsCRP), adiponectin, IL-6, NF-κB[1,6]. Accordingly, this study analyzes the echocardiography, high-sensitivity C-reactive protein and tumor necrosis factor-α of the patients with diabetics in our hospital in order to find early warning indicators of the cardiovascular complications of diabetes and provide prevention and treatment for cardiovascular complications of diabetes.
Eligibility| Ages Eligible for Study: | 18 Years to 95 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
type 1 and type 2 diabetic patients. They have been included in the standard diagnostic criteria for WHO1999 years and those diabetic patients with acute and chronic infection, high blood pressure, special and Gestational diabetic patients have been excluded. (Judgment have been made according to the case history, physical examination, medication, hormone history, blood routine etc) Those repeatedly hospitalized patients were recorded according to the time they took their first related inspection
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Wu Qinan, master | 13452867542 | wqn11@126.com |
| Contact: Chen Bing, doctor | 023 68765217 | wqn1111@yahoo.com.cn |
| China, Chongqing | |
| Endocrine Department, the First Affiliated Hospital of the Third Military Medical University | Recruiting |
| Chongqing, Chongqing, China, 400038 | |
| Contact: qinan wu, master 02368765217 ext 86 wqn11@126.com | |
| Sub-Investigator: qinan wu, master | |
| Study Director: | Chen Bing, doctor | Endocrine Department, the south west Hospital of the Third Military Medical University |
More Information
| Responsible Party: | Wu Qinan, Ethics Committee of Third Military Medical University, Third Military Medical University |
| ClinicalTrials.gov Identifier: | NCT00940082 History of Changes |
| Other Study ID Numbers: | the south west Hospital, Endocrine Department |
| Study First Received: | July 14, 2009 |
| Last Updated: | September 11, 2011 |
| Health Authority: | China: National Natural Science Foundation |
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Diabetes; Echocardiography; High-sensitive C-reactive protein; homocysteine; TNF-α |
