Trial record 1 of 1 for:    NSABP and B-46
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A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Genentech
US Oncology Research
Information provided by (Responsible Party):
National Surgical Adjuvant Breast and Bowel Project (NSABP)
ClinicalTrials.gov Identifier:
NCT00887536
First received: April 23, 2009
Last updated: March 11, 2014
Last verified: March 2014
  Purpose

The main purpose of this study is to learn if adding bevacizumab to standard treatment with chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) for early stage HER2-negative breast cancer will prevent breast cancer from returning. A second purpose of this study is to learn if adding bevacizumab to treatment with chemotherapy will help women with HER2-negative breast cancer live longer. The researchers also want to learn about the side effects of the combination of drugs used in this study.


Condition Intervention Phase
Breast Cancer
Drug: bevacizumab
Drug: docetaxel
Drug: doxorubicin
Drug: cyclophosphamide
Drug: pegfilgrastim
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Resource links provided by NLM:


Further study details as provided by National Surgical Adjuvant Breast and Bowel Project (NSABP):

Primary Outcome Measures:
  • Invasive disease-free survival(IDFS)relative to the TAC chemotherapy regimen alone [ Time Frame: Every 12 months until recurrence ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Invasive disease-free survival (IDFS) relative to the TAC chemotherapy regimen [ Time Frame: Every 12 months until recurrence ] [ Designated as safety issue: No ]
  • Disease-free survival (DFS-DCIS) relative to the TC alone regimen [ Time Frame: Every 12 months until recurrence ] [ Designated as safety issue: No ]
  • Overall survival (OS) relative to the TC alone regimen [ Time Frame: Every 12 months from randomization until death from any cause ] [ Designated as safety issue: No ]
  • OS relative to the TAC regimen [ Time Frame: Every 12 months from randomization until death from any cause ] [ Designated as safety issue: No ]
  • Recurrence-free interval (RFI) relative to the TC alone regimen [ Time Frame: Every 12 months, from randomization to local, regional, or distant recurrence ] [ Designated as safety issue: No ]
  • RFI relative to the TAC regimen [ Time Frame: Every 12 months, from randomization to local, regional, or distant recurrence ] [ Designated as safety issue: No ]
  • Develop molecular predictive markers for the degree of benefit from TCB over TC or TAC [ Time Frame: 6 years ] [ Designated as safety issue: No ]
  • Provide the efficacy data from Group 1 patients and Group 2 patients enrolled in B-46-I/07132 to US Oncology Research, Inc. (USOR) for a planned combined analysis with efficacy data from patients receiving the same regimens in the USOR 06-090 trial [ Time Frame: 10 years ] [ Designated as safety issue: No ]
  • Toxicity associated with each of the regimens [ Time Frame: Every 6 months ] [ Designated as safety issue: Yes ]
  • Determine the role of topoisomerase II alpha (TOP2A) in prognosis and prediction of degree of benefit from TAC over TC [ Time Frame: 6 years ] [ Designated as safety issue: No ]
  • Develop predictive markers for benefit from doxorubicin [ Time Frame: 6 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 3900
Study Start Date: May 2009
Estimated Study Completion Date: January 2022
Estimated Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Group 1: TAC then pegfilgrastim
docetaxel, doxorubicin, cyclophosphamide, and pegfilgrastim/filgrastim
Drug: docetaxel
docetaxel 75 mg/m2 IV every 21 days for 6 cycles
Other Name: T
Drug: doxorubicin
doxorubicin 50 mg/m2 IV every 21 days for 6 cycles
Other Name: A
Drug: cyclophosphamide

Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles

Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles

Other Name: C
Drug: pegfilgrastim
pegfilgrastim 6 mg subcutaneous (SC) Day 2 every 21 days for 6 cycles [filgrastim (Neupogen®) 5 mcg/kg Days 2-10 may be given in lieu of pegfilgrastim (Neulasta®), but pegfilgrastim is preferred.]
Active Comparator: Group 2: TC
docetaxel and cyclophosphamide
Drug: docetaxel
docetaxel 75 mg/m2 IV every 21 days for 6 cycles
Other Name: T
Drug: cyclophosphamide

Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles

Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles

Other Name: C
Experimental: Group 3: TC + bevacizumab
docetaxel, cyclophosphamide, and bevacizumab
Drug: bevacizumab
bevacizumab 15 mg/kg IV every 21 days for 6 cycles followed by bevacizumab 15 mg/kg IV every 21 days until 1 year following the first dose of bevacizumab
Drug: docetaxel
docetaxel 75 mg/m2 IV every 21 days for 6 cycles
Other Name: T
Drug: cyclophosphamide

Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles

Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles

Other Name: C

Detailed Description:

The B-46-I/07132 study, a multicenter, open-label, randomized Phase III, adjuvant therapy trial, will compare the value of adding bevacizumab to a non-anthracycline-based chemotherapy regimen relative to the same chemotherapy without bevacizumab and relative to an anthracycline-based chemotherapy regimen in women with resected node-positive or high-risk node-negative, HER2-negative breast cancer. This trial will determine whether the addition of bevacizumab to a regimen of docetaxel and cyclophosphamide (TCB) improves invasive disease-free survival relative to docetaxel and cyclophosphamide alone (TC). A secondary aim will be to determine whether the addition of bevacizumab to TC improves invasive disease-free survival compared to a regimen of docetaxel, doxorubicin, and cyclophosphamide (TAC). Other secondary aims include whether TCB improves disease-free survival, overall survival, and recurrence-free interval relative to TC alone and to TAC. The toxicities of the three regimens will also be compared.

Patients in the B-46-I/07132 study will be randomized to one of three treatment regimens: Group 1 patients will receive 6 cycles of TAC administered every 21 days (docetaxel 75 mg/m2, doxorubicin 50 mg/m2, and cyclophosphamide 500 mg/m2); Group 2 patients will receive 6 cycles of TC administered every 21 days (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2); and Group 3 patients will receive 6 cycles of TCB every 21 days with bevacizumab therapy continuing every 21 days after completion of chemotherapy until 1 year following the first dose (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2, and bevacizumab 15 mg/kg). Primary prophylaxis with pegfilgrastim or filgrastim is required for Group 1 patients (optional for patients in Groups 2 and 3). Patients will also receive adjuvant radiation therapy as clinically indicated and endocrine therapy for hormone receptor-positive tumors.

Tumor samples will be submitted for correlative science studies to evaluate predictors of study therapy benefit. Submission of a tumor sample is a study requirement for all patients.

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must be female.
  • The patient must be greater than or equal to 18 years of age and less than or equal to 70 years of age.
  • The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
  • The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
  • The breast cancer must be HER2-negative based on current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. If the result of the in situ hybridization testing (FISH, chromagen in situ hybridization (CISH), or other) is equivocal, the patient is eligible if there is no plan to administer HER2-targeted therapy.
  • All of the following staging criteria (according to the 6th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: ER negative and PgR negative; or Pathologic tumor size greater than 2.0 cm; or T1c (pathologic tumor size greater than 1.0 cm but less than or equal to 2.0 cm) and ER positive (PgR status may be positive or negative) and either Oncotype DX® Recurrence Score of greater than or equal to 25 or grade 3 histology.
  • Patients must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy).
  • For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and DCIS as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures must be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection.)
  • For patients who undergo mastectomy, margins must be histologically free of invasive tumor and DCIS.
  • Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi, or pN1b; Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; or Axillary lymphadenectomy without SN isolation procedure.
  • The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days.
  • Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed. (Either a core biopsy or surgical resection specimen can be used for ER/PgR testing.)
  • The most recent postoperative blood counts must meet the following criteria: Absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3; platelet count must be greater than or equal to 100,000/mm3; and hemoglobin must be greater than or equal to 10 g/dL.
  • The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests: total bilirubin must be less than or equal to upper limits of normal (ULN)for the lab unless the patient has a bilirubin elevation less than ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to 1.5 x ULN for the lab. Alkaline phosphatase and aspartate transaminase (AST) may not both be greater than the ULN. For example, if the alkaline phosphatase is greater than the ULN but less than or equal to 2.5 x ULN, then the AST must be less than or equal to the ULN. If the AST is greater than the ULN but less than or equal to 1.5 x ULN, then the alkaline phosphatase must be less than or equal to ULN.
  • Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan) does not demonstrate metastatic disease and the requirements for adequate hepatic function are met.
  • Patients with alkaline phosphatase that is greater than ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT, or PET scan does not demonstrate metastatic disease.
  • The most recent postoperative serum creatinine must be less than or equal to ULN for the lab.
  • A urine sample must be tested for proteinuria by the dipstick method. Eligibility must be based on the most recent postoperative test result(s) performed within 6 weeks prior to randomization. Urine dipstick must indicate 0-1+ protein. If dipstick reading is greater than or equal to 2+, a 24-hour urine specimen must be collected and must demonstrate less than 1 gram of protein.
  • Left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or multigated acquisition (MUGA) scan must be performed within 90 days prior to randomization. The LVEF must be greater than or equal to 50% regardless of the facility's lower limits of normal (LLN).

Exclusion Criteria:

  • T4 tumors including inflammatory breast cancer.
  • Definitive clinical or radiologic evidence of metastatic disease.
  • Synchronous or metachronous contralateral invasive breast cancer. (Patients with synchronous and/or metachronous contralateral DCIS are eligible.)
  • Any history of ipsilateral invasive breast cancer or ipsilateral DCIS.
  • History of non-breast malignancies within 5 years prior to randomization, except for the following: carcinoma in situ of the cervix, colorectal carcinoma in situ, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
  • Previous therapy with anthracyclines, taxanes, or bevacizumab for any malignancy.
  • Chemotherapy administered for the currently diagnosed breast cancer prior to randomization.
  • Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.)
  • Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy. Patients are eligible if these medications are discontinued prior to randomization.
  • Active hepatitis B or hepatitis C with abnormal liver function tests.
  • Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to 1) Active cardiac disease: angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis, 2) History of cardiac disease: myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function; history of documented congestive heart failure (CHF); and documented cardiomyopathy.
  • Uncontrolled hypertension defined as systolic BP greater than 150 mmHg or diastolic BP greater than 90 mmHg, with or without anti-hypertensive medication. Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.
  • History of hypertensive crisis or hypertensive encephalopathy.
  • History of transient ischemic attack (TIA) or cerebrovascular accident (CVA).
  • History of any arterial thrombotic event within 12 months prior to randomization.
  • Symptomatic peripheral vascular disease.
  • Intrinsic lung disease resulting in dyspnea.
  • Unstable diabetes mellitus.
  • Active infection or chronic infection requiring suppressive antibiotics.
  • History of a major organ allograft or condition requiring chronic immunosuppression, e.g., kidney, liver, lung, heart, bone marrow transplant, or autoimmune diseases. (Patients who have received corneal transplants, cadaver skin, or bone transplants are eligible.)
  • Any significant bleeding within 180 days prior to randomization, exclusive of menorrhagia in premenopausal women.
  • Non-healing wound, skin ulcers, or incompletely healed bone fracture.
  • Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to the planned start of study therapy.
  • Anticipation of need for major surgical procedures during study therapy and for at least 3 months following completion of bevacizumab.
  • Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before randomization.
  • History of GI perforation, abdominal fistulae, or intra-abdominal abscess.
  • Known bleeding diathesis or coagulopathy.
  • Requirement for therapeutic doses of coumadin or equivalent.
  • Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI Common Terminology Criteria for Adverse Events (CTCAE) v3.0.
  • Conditions that would prohibit administration of corticosteroids.
  • Chronic daily treatment with corticosteroids (dose of greater than or equal to 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids).
  • History of hypersensitivity reaction to drugs formulated with polysorbate 80.
  • Pregnancy or lactation at the time of study entry.
  • Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
  • Use of any investigational product within 4 weeks prior to randomization.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00887536

  Hide Study Locations
Locations
United States, Alabama
Birmingham Hematology and Oncology
Bessemer, Alabama, United States, 35022
Birmingham Hematology and Oncology
Birmingham, Alabama, United States, 35205
Birmingham Hematology and Oncology - Pilot
Birmingham, Alabama, United States, 35235
Birmingham Hematology and Oncology - Princeton
Birmingham, Alabama, United States, 35211
Birmingham Hematology and Oncology - Montclair
Birmingham, Alabama, United States, 35213
Birmingham Hematology and Oncology - Brookwood
Birmingham, Alabama, United States, 35209
Clearview Cancer Institute- Huntsville
Huntsville, Alabama, United States, 35805
United States, Arizona
Northern Arizona Hematology & Onclogy Associates
Flagstaff, Arizona, United States, 86001
Arizona Oncolocy (CASA-Green Valley)
Green Valley, Arizona, United States, 85614
Arizona Oncology (CASA- Oro Valley)
Oro Valley, Arizona, United States, 85737
Hematology Oncology Associates
Phoenix, Arizona, United States, 85012
Northern Arizona Hematology & Oncology Associates
Prescott Valley, Arizona, United States, 86314
Arizona Oncology (CASA-Safford)
Safford, Arizona, United States, 85546
Hematology Oncology Associates
Scottsdale, Arizona, United States, 85258
Northern Arizona Hematology & Oncology Associates
Sedona, Arizona, United States, 86336
Arizona Oncology Associates - Carondelet
Tucson, Arizona, United States, 85710
Arizona Oncology - CASA St. Mary's
Tucson, Arizona, United States, 85745
Arizona Oncology (CASA-Office Only)
Tucson, Arizona, United States, 85715
Arizona Oncology Associates - Rudasill
Tucson, Arizona, United States, 85704
Arizona Oncology (CASA-Craycroft)
Tucson, Arizona, United States, 85712
United States, California
Central Hematology/Oncology Medical Group, Inc.
Alhambra, California, United States, 91801
Kaiser Permanente Deer Valley Med Center
Antioch, California, United States, 94531
Comp Blook and Cancer Center
Bakersfield, California, United States, 93309
Southwest Cancer Care (E. Grand)
Escondido, California, United States, 92025
Kaiser Permanente Fremont
Fremont, California, United States, 94538
St. Jude Heritage Healthcare
Fullerton, California, United States, 92835
Kaiser Permanente Medical Center - Hayward
Hayward, California, United States, 94545
Pacific Shores Medical Group
Huntington Beach, California, United States, 92648
Southern California Permanente Medical Group
Irvine, California, United States, 92618
Wilshire Oncology Medical Group (Business Office)
La Verne, California, United States, 91750
Antelope Valley Cancer Center
Lancaster, California, United States, 93534
Pacific Shores Medical Group
Long Beach, California, United States, 90813
Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center
Long Beach, California, United States, 90806
Todd Cancer Institute at Long Beach Memorial Med Cent
Long Beach, California, United States, 90806
Pacific Shores Medical Group
Los Alamitos, California, United States, 90720
TORI- N Valley Hematology Oncology Med Group
Mission Hills, California, United States, 91345
TORI - Oncology Care Medical Assoc.
Montebello, California, United States, 90640
Southwest Cancer Care (Medical Center)
Murrieta, California, United States, 92562
NValley Hematology/Oncology Medical Group
Northridge, California, United States, 91325
Kaiser Permanente-Oakland
Oakland, California, United States, 94611
St. Joseph Hospital
Orange, California, United States, 92868
Ventura County Hematology-Oncology Specialists
Oxnard, California, United States, 93030
Stanford University Medical Center
Palo Alto, California, United States, 94304
Kaiser Permanente Medical Center - Redwood City
Redwood City, California, United States, 94063
Kaiser Permanente Medical Center - Richmond
Richmond, California, United States, 94801
Kaiser Permanente Roseville
Roseville, California, United States, 95678
Sutter Roseville Medical Center
Roseville, California, United States, 95661
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, United States, 95825
Sutter Medical Center
Sacramento, California, United States, 95816
Kaiser Permanente-San Diego
San Diego, California, United States, 92120
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, United States, 94115
TORI - Oncology Care Med Assoc
San Gabriel, California, United States, 91776
Kaiser Permanente San Rafael
San Rafael, California, United States, 94903
Santa Barbara II (Samsum Clinic) - TORI
Santa Barbara, California, United States, 93105
Santa Barbara Hematology Oncology Medical Group
Santa Barbara, California, United States, 93105
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
Santa Clara, California, United States, 95051
Central Coast Medical Oncology Corporation
Santa Maria, California, United States, 93454
Kaiser Permanente Medical Center - Santa Rosa
Santa Rosa, California, United States, 95403
Kaiser Permanente Santa Teresa
Santa Teresa, California, United States, 95119
Santa Barbara Hematology/Oncology Medical Group, Inc
Solvang, California, United States, 93463
Kaiser Permanente, South Sacramento
South Sacramento, California, United States, 95823
Kaiser Permanente-South San Francisco
South San Francisco, California, United States, 94080
Kaiser Permanente Medical Facility - Stockton
Stockton, California, United States, 95210
Olive View/UCLA Medical Center
Sylmar, California, United States, 91342
Kaiser Permanente Medical Center Vacaville
Vacaville, California, United States, 95688
Kaiser Permanente Medical Center - Vallejo
Vallejo, California, United States, 94589
Kaiser Permanente Medical Center - Walnut Creek
Walnut Creek, California, United States, 94596
Westlake Infusion Center
Westlake Village, California, United States, 91361
Trivalley Oncology Hematology
Westlake Village, California, United States, 91361
TORI - Oncology Care Med Assoc
Whittier, California, United States, 90602
United States, Colorado
Rocky Mountain Cancer Center
Aurora, Colorado, United States, 80012
Medical Center of Aurora
Aurora, Colorado, United States, 80012
Rocky Mountain Cancer Centers - Boulder
Boulder, Colorado, United States, 80303
Rocky Mountain Cancer Center - CO Springs
Colorado Springs, Colorado, United States, 80909
Rocky Mountain Cancer Center at the Pivillion- Fontanero
Colorado Springs, Colorado, United States, 80907
Penrose/St. Francis Healthcare System
Colorado Springs, Colorado, United States, 80907
Rocky Mountain Cancer Center - 9th Avenue
Denver, Colorado, United States, 80220
Rocky Mountain Cancer Center - Midtown
Denver, Colorado, United States, 80218
University of Colorado
Denver, Colorado, United States, 80262
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Kaiser Permanente-Franklin
Denver, Colorado, United States, 80205
CCOP - Colorado Cancer Research Program, Inc.
Denver, Colorado, United States, 80209-5031
Rocky Mountain Cancer Center - Rose
Denver, Colorado, United States, 80220
Exempla St. Joseph Hospital
Denver, Colorado, United States, 80218
Shaw Regional Cancer Center
Edwards, Colorado, United States, 81632
Swedish Medical Center
Englewood, Colorado, United States, 80110
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Front Range Cancer Specialists
Fort Collins, Colorado, United States, 80524
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, United States, 81502
St. Mary's Hospital and Medical Center
Grand Junction, Colorado, United States, 81502-1628
North Colorado Medical Center
Greeley, Colorado, United States, 80631
Kaiser Permanente Rock Creek
Lafayette, Colorado, United States, 80026
Rocky Mountain Cancer Center
Lakewood, Colorado, United States, 80228
Rocky Mountain Cancer Center - Dry Creek
Littleton, Colorado, United States, 80120-4413
Rocky Mountain Cancer Center- Sky Ridge
Lone Tree, Colorado, United States, 80124
Rocky Mountain Cancer Center - Longmont
Longmont, Colorado, United States, 80501
McKee Medical Center
Loveland, Colorado, United States, 80539
Rocky Mountain Cancer Center
Parker, Colorado, United States, 80138
Rocky Mountain Cancer Centers
Thornton, Colorado, United States, 80260
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, United States, 80033
United States, Connecticut
University of Connecticut
Farmington, Connecticut, United States, 06032
Hartford Hospital
Hartford, Connecticut, United States, 06102-5037
United States, District of Columbia
Sibley Memorial Hospital
Washington, District of Columbia, United States, 20016
Washington Regional Cancer Center
Washington, District of Columbia, United States, 20010
United States, Florida
SCRI - Florida Cancer Specialists- Bonita Springs
Bonita Springs, Florida, United States, 34135
SCRI - Florida Cancer Specialists - Bradenton
Bradenton, Florida, United States, 34209
Florida Cancer Specialists
Brandon, Florida, United States, 33511
SCRI Florida Cancer Specialists - Cape Coral (811)
Cape Coral, Florida, United States, 33990
SCRI Florida Cancer Specialists - Cape Coral (1708)
Cape Coral, Florida, United States, 33914
Morton Plant Mease Health Care
Clearwater, Florida, United States, 33756
SCRI Florida Cancer Specialists - Englewood
Englewood, Florida, United States, 33990
Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
SCRI Florida Cancer Specialists- Fort Myers (Veronica)
Fort Myers, Florida, United States, 33916
SCRI Florida Cancer Specialists - Ft. Myers (Broadway)
Fort Myers, Florida, United States, 33908
SCRI Florida Cancer Specialists - Fort Myers (Hampshire)
Fort Myers, Florida, United States, 33908
University of Florida Shands Cancer Center
Gainesville, Florida, United States, 32610-0232
Florida Cancer Institute - New Hope
Hudson, Florida, United States, 34667
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States, 32207
Integrated Community Oncology Network (ICON)
Jacksonville, Florida, United States, 32207
TORI-ICON St.Aug
Jacksonville, Florida, United States, 32258
TORI-ICON - Shircl
Jacksonville, Florida, United States, 32204
CCOP, Jupiter Medical Cener
Jupiter, Florida, United States, 33458
Ocala Oncology Center - Lady Lake
Lady Lake, Florida, United States, 32159
Melbourne International Medicine Associates
Melbourne, Florida, United States, 32901
Advanced Medical Specialists- Sunset
Miami, Florida, United States, 33143
Advanced Medical Specialties - AMS
Miami, Florida, United States, 33133
Advanced Medical Specialties - N. Kendall (STE 905E)
Miami, Florida, United States, 33176
Advanced Medical Specialties - N Kendall (STE 300E)
Miami, Florida, United States, 33176
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
SCRI Florida Cancer Specialists - Naples (Goodlette)
Naples, Florida, United States, 34102
SCRI Florida Cancer Specialists - Naples (Pine)
Naples, Florida, United States, 34119
Florida Cancer Institute - New Hope
New Port Richey, Florida, United States, 34655
Ocala Oncology Center
Ocala, Florida, United States, 34478
Cancer Centers of Florida, P.A.
Ocoee, Florida, United States, 34761
Tori-Icon
Orange Park, Florida, United States, 32073
Florida Hospital
Orlando, Florida, United States, 32803
MD Anderson Cancer Center
Orlando, Florida, United States, 32806
Cancer Centers of Florida, P.A.
Orlando, Florida, United States, 32806
SCRI - Florida Cancer Specialists - Port Charlotte
Port Charlotte, Florida, United States, 33980
SCRI Florida Cancer Specialists - Sarasota (Cattleman)
Sarasota, Florida, United States, 34232
SCRI- Florida Cancer Specialists - Sarasota
Sarasota, Florida, United States, 34236
Tori-Icon
St. Augustine, Florida, United States, 32086
SCRI - Florida Cancer Specialists - Armenia
Tampa, Florida, United States, 33603
SCRI - Florida Cancer Specialists - Tampa
Tampa, Florida, United States, 33607
SCRI Florida Cancer Specilaists - Venice
Venice, Florida, United States, 34292
SCRI Florida Cancer Specialists - Venice (Tamiami)
Venice, Florida, United States, 34285
Cancer Centers of Florida, P.A.
Winter Park, Florida, United States, 32789
United States, Georgia
Phoebe Putney Memorial Hospital
Albany, Georgia, United States, 31703
Northwest Georgia Oncology Centers
Austell, Georgia, United States, 30106
Northwest Georgia Oncology Centers
Carrollton, Georgia, United States, 30117
Dublin Hematology/Oncology
Dublin, Georgia, United States, 31021
Suburban Hematology-Oncology Associates
Lawrenceville, Georgia, United States, 30045
Northwest Georgia Oncology Centers
Marietta, Georgia, United States, 30060
SCRI Chattanooga Oncol & Hematol Assoc, PC - Ringgold
Ringgold, Georgia, United States, 30736
Memorial Health University Medical Center
Savannah, Georgia, United States, 31404
United States, Hawaii
Kaiser Permanente Hawaii - Moanalua Med Center
Honolulu, Hawaii, United States, 96819
University of Hawaii
Honolulu, Hawaii, United States, 96813
United States, Illinois
Cancer Care & Hematology Specialists of Chicagoland
Arlington, Illinois, United States, 60005
Rush University Medical Center
Chicago, Illinois, United States, 60612
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States, 62526
CCOP NorthShore University HealthSystem
Evanston, Illinois, United States, 60201
Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, United States, 60521
Edward Hospital
Naperville, Illinois, United States, 60566
Cancer Care & Hematology Specialists of Chicagoland
Niles, Illinois, United States, 60714
Advocate Lutheran General Cancer Care Center
Park Ridge, Illinois, United States, 60068-1174
Carle Foundation Hospital
Urbana, Illinois, United States, 61801
Carle Cancer Center, CCOP
Urbana, Illinois, United States, 61801
Cancer Care and Hematology Specialists of Chicagoland
Winfield, Illinois, United States, 60190
United States, Indiana
Central Indiana Cancer Centers
Carmel, Indiana, United States, 46032
Central Indiana Cancer Centers
Fishers, Indiana, United States, 46037
Central Indiana Cancer Centers
Greenfield, Indiana, United States, 46140
Central Indiana Cancer Centers
Indianapolis, Indiana, United States, 46219
Central Indiana Cancer Centers (E. County)
Indianapolis, Indiana, United States, 46227
St. Vincent Hospital and Health Care Center
Indianapolis, Indiana, United States, 46260
Clarian Arnett Cancer Care
Lafayette, Indiana, United States, 47904
Community Hospital
Munster, Indiana, United States, 46321
United States, Iowa
Genesis Medical Center
Davenport, Iowa, United States, 52803
Finley Hospital
Dubuque, Iowa, United States, 52001-6314
University of Iowa
Iowa City, Iowa, United States, 52242
Mercy Medical Center - Sioux City
Sioux City, Iowa, United States, 51101
St. Luke's Regional Medical Center
Sioux City, Iowa, United States, 51101
Siouxland Hematology-Oncology Associates
Sioux City, Iowa, United States, 51101
Covenant Cancer Treatment Center
Waterloo, Iowa, United States, 50702
United States, Kansas
Kansas Cty Cancer Center - West
Kansas City, Kansas, United States, 66112
Kansas City Cancer Center (CBO)
Overland Park, Kansas, United States, 66210
Kansas CityCancer Centers - Southwest
Overland Park, Kansas, United States, 66210
Menorah Medical Center
Overland Park, Kansas, United States, 66209
Kansas City Cancer Center, Shawnee Mission
Shawnee Mission, Kansas, United States, 66204
United States, Kentucky
SCRI Oncology Hematology Care, Inc. Crestview Hills (CVH)
Crestview Hills, Kentucky, United States, 41017
University of Kentucky Medical Center
Lexington, Kentucky, United States, 40536
Consultants in Blood Disorders and Cancer
Louisville, Kentucky, United States, 40207
NortonHealtcare Inc.
Louisville, Kentucky, United States, 40202
United States, Louisiana
Christus St. Frances Cabrini Hospital
Alexandria, Louisiana, United States, 71301
Baton Rouge General Medical Center
Baton Rouge, Louisiana, United States, 70806
Tulane University Medical Center
New Orleans, Louisiana, United States, 70112
United States, Maine
Eastern Maine Medical Center
Bangor, Maine, United States, 04401
United States, Maryland
Mercy Medical Center
Baltimore, Maryland, United States, 21202
Greater Baltimore Medical Center
Baltimore, Maryland, United States, 21204
Franklin Square Hospital Center
Baltimore, Maryland, United States, 21237
St. Joseph's Medical Center
Baltimore, Maryland, United States, 21204-7582
SCRI - Center for Cancer and Blood Disorders
Bethesda, Maryland, United States, 20817
Suburban Hospital
Bethesda, Maryland, United States, 20817
Chevy Chase Healthcare Management, LLC
Chevy Chase, Maryland, United States, 20815
Maryland Oncology Hematology PA
Columbia, Maryland, United States, 21044
Frederick Memorial Hospital
Frederick, Maryland, United States, 21701
Alliance Hematology Oncology PA
Owings Mills, Maryland, United States, 21117
Penisula Regional Medical Center
Salisbury, Maryland, United States, 21801
Holy Cross Hospital
Silver Spring, Maryland, United States, 20910
Alliance Hematology Oncology PA
Westminster, Maryland, United States, 21157
United States, Massachusetts
Saint Anne's Hospital
Fall River, Massachusetts, United States, 02721
Berkshire Hematology Oncology, P.C.
Pittsfield, Massachusetts, United States, 01201
United States, Michigan
CCOP, St. Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106
Bay Regional Medical Center
Bay City, Michigan, United States, 48706
CCOP - Oakwood Hospital and Medical Center
Dearborn, Michigan, United States, 48123-2500
CCOP - St. John Hospital and Medical Center
Detroit, Michigan, United States, 48236-2172
Henry Ford Health System
Detroit, Michigan, United States, 48202
Michigan State University
East Lansing, Michigan, United States, 48824
CCOP - Hurley Medical Center
Flint, Michigan, United States, 48503
CCOP - Genesys Regional Hospital
Flint, Michigan, United States, 48503
McLaren Regional Medical Center
Flint, Michigan, United States, 48532
CCOP - Allegiance Health
Jackson, Michigan, United States, 49201
Borgess Medical Center
Kalamazoo, Michigan, United States, 49001
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
Ingham Regional Medical Center - Lansing
Lansing, Michigan, United States, 48910-0817
CCOP, Sparrow Health System
Lansing, Michigan, United States, 48910
Lapeer Regional Hospital
Lapeer, Michigan, United States, 48446
CCOP - St. Mary Mercy Hospital - Livonia
Livonia, Michigan, United States, 48154
Marquette General Hospital
Marquette, Michigan, United States, 49855
Mount Clemens Regional Medical Center
Mt. Clemens, Michigan, United States, 48043
Memorial Healthcare
Owosso, Michigan, United States, 48867
CCOP - St. Joseph Mercy Hospital - Oakland
Pontiac, Michigan, United States, 48341
CCOP - St. Joseph Mercy Port Huron
Port Huron, Michigan, United States, 48060
CCOP, William Beaumont Hospital
Royal Oak, Michigan, United States, 48073
CCOP, St. Mary's Medical Center
Saginaw, Michigan, United States, 48601
Providence Hospital - Southfield
Southfield, Michigan, United States, 48075-9975
CCOP, St. John Macomb Hospital
Warren, Michigan, United States, 48093
United States, Minnesota
Minnesota Oncology Hematology-Burnsville
Burnsville, Minnesota, United States, 55337
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
St. Luke's Hospital
Duluth, Minnesota, United States, 55802
Minnesota Oncology Hematology-Edina
Edina, Minnesota, United States, 55435
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Unity Hospital
Fridley, Minnesota, United States, 55432
St. John's Hospital Northeast/HealthEast, Inc.
Maplewood, Minnesota, United States, 55109
Minnesota Oncology Hematology PA - Maplewood
Maplewood, Minnesota, United States, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Minnesota Oncology Hematology-Minneapolis
Minneapolis, Minnesota, United States, 55404
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55415
North Memorial Health Care
Robbinsdale, Minnesota, United States, 55422
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
Park Nicollet Health Services
St. Louis Park, Minnesota, United States, 55416
Minnesota Hematology Oncology-St. Paul
St. Paul, Minnesota, United States, 55102
Regions Hospital Cancer Care Center
St. Paul, Minnesota, United States, 55101
Minnesota Oncology Hematology
Woodbury, Minnesota, United States, 55125
United States, Missouri
Missouri Cancer Associates
Columbia, Missouri, United States, 65201
University of Missouri-Ellis Fischel
Columbia, Missouri, United States, 65203
Kansas City Cancer Center - Central
Kansas City, Missouri, United States, 64111
Kansas City Cancer Center - South
Kansas City, Missouri, United States, 64131
Kansas City Cancer Center - North
Kansas City, Missouri, United States, 64154
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
Research Medical Center
Kansas City, Missouri, United States, 64132
Saint Luke's Hospital
Kansas City, Missouri, United States, 64111
Research Medical Center
Kansas City, Missouri, United States, 64131
Kansas City Cancer Centers - East
Lee's Summit, Missouri, United States, 64064
St. Louis University Health Sciences Center
Saint Louis, Missouri, United States, 63110-0250
United States, Nebraska
St. Elizabeth Community Health Center
Lincoln, Nebraska, United States, 68510
Nebraska Cancer Research Center
Lincoln, Nebraska, United States, 68510
Alegent Health Immanuel Medical Center
Omaha, Nebraska, United States, 68122
CCOP, Missouri Valley Cance Consortium
Omaha, Nebraska, United States, 68131
Creighton University Cancer Center
Omaha, Nebraska, United States, 68131
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Alegent Health Midlands Hospital
Papillion, Nebraska, United States, 68046
United States, Nevada
Comprehensive Cancer Centers of Nevada (Siena)
Henderson, Nevada, United States, 89052
Comprehensive Cancer Centers of Nevada (Wigwam)
Henderson, Nevada, United States, 89074
US Oncology West Region Office (Horizon Ridge)
Henderson, Nevada, United States, 89052
Comprehensive Cancer Centers of Nevada (Twain)
Las Vegas, Nevada, United States, 89169
Comprehensive Cancer Centers of Nevada (Peak Dr.)
Las Vegas, Nevada, United States, 89128
Comprehensive Cancer Centers of Nevada (Southern Hills)
Las Vegas, Nevada, United States, 89148
Renown Regional Medical Center
Reno, Nevada, United States, 89502
United States, New Jersey
Cancer Institute of New Jersey at Hamilton
Hamilton, New Jersey, United States, 08690
Hematology-Oncology Associates of NNJ, PA
Morristown, New Jersey, United States, 07960
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08901
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Saint Clare's Center at Parsippany Commons
Parsippany, New Jersey, United States, 07054
Somerset Medical Center
Somerville, New Jersey, United States, 08876
Sparta Cancer Center
Sparta, New Jersey, United States, 07871
United States, New Mexico
New Mexico Cancer Care Associates
Santa Fe, New Mexico, United States, 87505
United States, New York
New York Oncology Hematology PC-Albany
Albany, New York, United States, 12206
New York Oncology Hematology, PC at Albany Medical Center
Albany, New York, United States, 12208
Amsterdam Community Cancer Program
Amsterdam, New York, United States, 12010
Interlakes Oncology Hematology PC
Brockport, New York, United States, 14420
Interlakes Oncology & Hematology, P.C.
Canandaigua, New York, United States, 14424
Interlakes Oncology Hematology PC
Geneva, New York, United States, 14456
Cancer Center at Glens Falls Hospital
Glens Falls, New York, United States, 12801
New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program
Hudson, New York, United States, 12534
New York Oncology Hematology, PC
Latham, New York, United States, 12110
CCOP - North Shore University Hospital
Manhasset, New York, United States, 11030
CCOP, Long Island Jewish Medical Center
New Hyde Park, New York, United States, 11040
New York University School of Medicine
New York, New York, United States, 10016
New York Oncology Hematology PC
Rexford, New York, United States, 12148
Interlakes Oncology Hematology PC- Long Pond
Rochester, New York, United States, 14626
Interlakes Oncology Hematology PC - White Spruce
Rochester, New York, United States, 14623
University Hospital and Medical Center - SUNY Stony Brook
Stonybrook, New York, United States, 11794
Troy Cancer Treatment Program
Troy, New York, United States, 12180
United States, North Carolina
Alamance Regional Medical Center
Burlington, North Carolina, United States, 27217
Cancer Centers of North Carolina
Cary, North Carolina, United States, 27518
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
CCOP Carolinas HealthCare System
Charlotte, North Carolina, United States, 28232-2861
Presbyterian Hospital
Charlotte, North Carolina, United States, 28233
Regional Cancer Care, PA
Durham, North Carolina, United States, 27704
Virginia Oncology Associates
Elizabeth City, North Carolina, United States, 27909
Cape Fear Valley Medical Center Cancer Center
Fayetteville, North Carolina, United States, 28302-2000
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, United States, 27534
CCOP, Moses Cone Health System-Regional CA Cntr
Greensboro, North Carolina, United States, 27401
East Carolina University
Greenville, North Carolina, United States, 27834
Margaret R. Pardee Memorial Hospital
Hendersonville, North Carolina, United States, 28791
High Point Regional Hospital
High Point, North Carolina, United States, 27261
Cancer Centers of North Carolina- North Raleigh
Raleigh, North Carolina, United States, 27614
Cancer Centers of North Carolina
Raleigh, North Carolina, United States, 27607
CCOP Forsyth Memorial Hospital
Winston-Salem, North Carolina, United States, 27103
United States, North Dakota
Innovis Health
Fargo, North Dakota, United States, 58103
United States, Ohio
Akron City Hospital
Akron, Ohio, United States, 44304
Aultman Hospital
Canton, Ohio, United States, 44710
SCRI Oncology Hematology Care, Inc. Cincinnati (WST)
Cincinnati, Ohio, United States, 45248
SCRI Oncology Hematology Care, Inc. - Cincinnati (TFT)
Cincinnati, Ohio, United States, 45219
SCRI Oncology Hematology Care, Inc - Cincinnati (BAM)
Cincinnati, Ohio, United States, 45242
SCRI Oncology Hematlogy Care, Inc. - Cincinnati (RPR)
Cincinnati, Ohio, United States, 45238
SCRI Oncology Hematology Care, Inc. - Cincinnati (KWD)
Cincinnati, Ohio, United States, 45236
SCRI Oncology Hematology Care, Inc - Cincinnati (AND)
Cincinnati, Ohio, United States, 45230
Good Samaritan Hospital
Dayton, Ohio, United States, 45408
CCOP - Dayton
Dayton, Ohio, United States, 45429
HemOnc Care, Inc.
Fairfield, Ohio, United States, 45014
Atrium Medical Center - Middletown Regional Hosp
Franklin, Ohio, United States, 45005-1066
Wayne Hospital
Greenville, Ohio, United States, 45331
SCRI Oncology Hematology Care, Inc. - Hamilton (HAM)
Hamilton, Ohio, United States, 45013
Kettering Medical Center
Kettering, Ohio, United States, 45429
Greater Dayton Cancer Center
Kettering, Ohio, United States, 45409
Upper Valley Medical Center
Troy, Ohio, United States, 45373
Clinton Memorial Hospital
Wilmington, Ohio, United States, 45177
SCRI Oncology Hematology Care, Inc. - Wilmington (WLM)
Wilmington, Ohio, United States, 45177
United States, Oregon
St. Charles Medical Center - Bend
Bend, Oregon, United States, 97701
Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, United States, 97401
Northwest Cancer Specialists-Portland
Portland, Oregon, United States, 97213
Northwest Cancer Specialists- Rose Qtr
Portland, Oregon, United States, 97227
Northwest Cancer Specialists- St. Vincent
Portland, Oregon, United States, 97225
Providence Medical Center
Portland, Oregon, United States, 97213
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Williamette Valley Cancer Institute and Research Center
Springfield, Oregon, United States, 97477
Celilo Center for Cancer Care
The Dalles, Oregon, United States, 97058
Northwest Cancer Specialists-Tualatin
Tualatin, Oregon, United States, 97062
United States, Pennsylvania
Geisinger Clinic
Danville, Pennsylvania, United States, 17882-2111
Oncology Hematology Associates of Northern PA
Dubois, Pennsylvania, United States, 15801
Pocono Medical Center
E. Stroudsburg, Pennsylvania, United States, 18301
Ephrata Community Hopital
Ephrata, Pennsylvania, United States, 17522-1002
Geisinger Hazleton Cancer Center
Hazleton, Pennsylvania, United States, 18201
Medical Oncology Associates
Kingston, Pennsylvania, United States, 18704
Riddle Memorial Hospital
Media, Pennsylvania, United States, 19063
Rittenhouse Hematology/Oncology
Philadelphia, Pennsylvania, United States, 19107
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Albert Einstein Healthcare Network
Philadelphia, Pennsylvania, United States, 19141-3098
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15232-1305
Allegheny General Hospital/Allegheny-Singer Research Institute
Pittsburgh, Pennsylvania, United States, 15212
Hematology and Oncology Associates of NEPA
Scranton, Pennsylvania, United States, 18501
Scranton Hematology Oncology
Scranton, Pennsylvania, United States, 18510
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, United States, 16801
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
Upland, Pennsylvania, United States, 19013
Reading Hospital and Medical Center
West Reading, Pennsylvania, United States, 19611
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States, 18711
United States, South Carolina
AnMed Health Cancer Center
Anderson, South Carolina, United States, 29621
Medical University of South Carolina
Charleston, South Carolina, United States, 29425-0721
Roper Hosp & Med Asso (Care Alliance Health)
Charleston, South Carolina, United States, 29401
SCRI - South Carolina Oncology Associates - Stoneridge
Columbia, South Carolina, United States, 29210
Cancer Centers of the Carolinas Easley, SC
Easley, South Carolina, United States, 29640
Georgetown Hospital System
Georgetown, South Carolina, United States, 29440
Cancer Centers of the Carolinas-W. Faris Road
Greenville, South Carolina, United States, 29605
Cancer Centers of the Carolinas (International)
Greenville, South Carolina, United States, 29615
Cancer Centers of the Carolinas (Butternut)
Greenville, South Carolina, United States, 29605
Cancer Centers of the Carolinas - Seneca
Seneca, South Carolina, United States, 29672
Spartanburg Regional Healthcare System
Spartanburg, South Carolina, United States, 29303
Cancer Centers of the Carolinas - Spartanburg
Spartanburg, South Carolina, United States, 29307
United States, South Dakota
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
CCOP, Sanford Cancer Center - Oncology Clinic
Sioux Falls, South Dakota, United States, 57105
Avera McKenna Hospital
Sioux Falls, South Dakota, United States, 57101
United States, Tennessee
SCRI Chattanooga Oncol & Hematol Assoc, PC - Chattanooga
Chattanooga, Tennessee, United States, 37404
SCRI Tennessee Oncology - PLLC Franklin
Franklin, Tennessee, United States, 37067
SCRI Tennessee Oncology- Gallatin
Gallatin, Tennessee, United States, 37066
SCRI Tennessee Oncology, PLLC Hermitage
Hermitage, Tennessee, United States, 37076
SCRI Chattanooga Oncol & Hematol Assoc, PC Hixson
Hixson, Tennessee, United States, 37404
CCOP Holston Valley Medical Center
Kingsport, Tennessee, United States, 37662
SCRI Tennessee Oncology Lebanon
Lebanon, Tennessee, United States, 37087
SCRI Tennessee Oncology Murfreesboro
Murfreesboro, Tennessee, United States, 37130
SCRI Tennessee Oncology, PLLC (Harding)
Nashville, Tennessee, United States, 37205
SCRI - Tennessee Oncology PLLC
Nashville, Tennessee, United States, 37203
SCRI - Tennessee Oncology PLLC
Nashville, Tennessee, United States, 37211
SCRI Tennessee Onclogy, PLLC (Dickerson)
Nashville, Tennessee, United States, 37207
SCRI Tennessee Oncology, PLLC (Wallace)
Nashville, Tennessee, United States, 37211
Tennessee Oncology
Shelbyville, Tennessee, United States, 37160
SCRI Tennessee Oncology, PLLC Smyrna
Smyrna, Tennessee, United States, 37167
United States, Texas
Texas Cancer Center - Abilene South
Abilene, Texas, United States, 79606-5208
Texas Oncology PA - Amarillo
Amarillo, Texas, United States, 79106
Texas Onclogy - Arlington South
Arlington, Texas, United States, 76014
Texas Oncology PA - Arlington North
Arlington, Texas, United States, 76012
South Austin Cancer Center
Austin, Texas, United States, 78745
Southwest Regional Cancer Center- North
Austin, Texas, United States, 78759
Texas Oncology Cancer Center - Balcones
Austin, Texas, United States, 78731
Texas Oncology Central Austin
Austin, Texas, United States, 78705
Texas Oncology North Austin- Renfert
Austin, Texas, United States, 78759
Mamie McFaddin Ward Cancer Center
Beaumont, Texas, United States, 77702-1449
Edwards Cancer Center - Bedford
Bedford, Texas, United States, 76022
Texas Oncology PA - Harris HEB
Bedford, Texas, United States, 76022
Texas Oncology, PA - Cedar Park
Cedar Park, Texas, United States, 78613
Methodist Charlton Cancer Center
Dallas, Texas, United States, 75237
Texas Oncology- Sammons CC
Dallas, Texas, United States, 75246
Texas Oncology PA- Presbyterian
Dallas, Texas, United States, 75231-4400
Texas Cancer Center at Medical City
Dallas, Texas, United States, 75230-2510
Texas Cancer Center
Denton, Texas, United States, 76210
El Paso Cancer Treatment Center - West
El Paso, Texas, United States, 79902
El Paso Cancer Treatment Center - East
El Paso, Texas, United States, 79915
Southwest Fort Worth Cancer Center
Fort Worth, Texas, United States, 76132
Texas Oncology at Klabzuba
Fort Worth, Texas, United States, 76104
Texas Oncology - 8th Avenue
Fort Worth, Texas, United States, 76104
Texas Oncology PA - 12th Avenue
Fort Worth, Texas, United States, 76104
San Antonio Tumor and Blood Clinic
Fredericksburg, Texas, United States, 78624
Texas Oncology PA
Garland, Texas, United States, 75042-5788
Texas Oncology
Grapevine, Texas, United States, 76051
Texas Oncology PA - Frostwood
Houston, Texas, United States, 77024
MD Anderson Cancer Center
Houston, Texas, United States, 77030
San Antonio Tumor and Blood Clinic
Kerrville, Texas, United States, 78028
Texas Oncology PA Las Cruces
Las Cruces, Texas, United States, 88011
Lake Vista Cancer Center
Lewisville, Texas, United States, 75067
Longview Cancer Center
Longview, Texas, United States, 75601
Joe Arrington Cancer Research & Treatment Center
Lubbock, Texas, United States, 79410
South Texas Cancer Center - McAllen
McAllen, Texas, United States, 78503
Texas Cancer Center of Mesquite
Mesquite, Texas, United States, 75150
Allison Cancer Center
Midland, Texas, United States, 79701
HOAST - New Braunfels
New Braunfels, Texas, United States, 78130
Texas Oncology - Odessa
Odessa, Texas, United States, 79761
Paris Regional Cancer Center
Paris, Texas, United States, 75460-5004
North Texas Regional Cancer Center
Plano, Texas, United States, 75075
Texas Oncology Plano West Cancer Center
Plano, Texas, United States, 75093
Texas Oncology - Round Rock Cancer Center
Round Rock, Texas, United States, 78681
Texas Oncology Seton Williamson
Round Rock, Texas, United States, 78665
San Antonio Tumor and Blood Clinic - M.Oak
San Antonio, Texas, United States, 78258-3912
University of Texas Health Science Center
San Antonio, Texas, United States, 78284-7842
HOAST - Medical Drive
San Antonio, Texas, United States, 78229
Cancer Care Centers of South Texas- Brooklyn
San Antonio, Texas, United States, 78212
Cancer Care Centers of South Texas - Loop 410
San Antonio, Texas, United States, 78217
Texas Oncology - San Marcos
San Marcos, Texas, United States, 78666
Texas Cancer Center
Sherman, Texas, United States, 75090-0504
Texas Oncology Cancer Center - Sugar Land
Sugar Land, Texas, United States, 77479
US Oncology
The Woodlands, Texas, United States, 77380
Tyler Cancer Center
Tyler, Texas, United States, 75702
Texas Oncology Cancer Care and Research Center
Waco, Texas, United States, 76712
Texas Oncology - Clear Lake
Webster, Texas, United States, 77598
South Texas Cancer Clinic
Weslaco, Texas, United States, 78596
Texoma Cancer Center
Wichita Falls, Texas, United States, 76310
United States, Utah
Sandra L. Maxwell Cancer Center
Cedar City, Utah, United States, 84720
McKay-Dee Hospital Center
Ogden, Utah, United States, 84403
Utah Valley Regional Medical Center - Provo
Provo, Utah, United States, 84604
Dixie Regional Medical Center - East Campus
Saint George, Utah, United States, 84770
LDS Hospital
Salt Lake City, Utah, United States, 84143
Huntsman Cancer Inst. at the University of Utah- Salt Lake City
Salt Lake City, Utah, United States, 84132
United States, Vermont
Southwestern Regional Cancer Center (SWORD)
Bennington, Vermont, United States, 05201
United States, Virginia
Arlington Fairfax Hematology Oncology
Arlington, Virginia, United States, 22205
Virginia Oncology Associates - Medical Pkwy
Chesapeake, Virginia, United States, 23320
Oncology and Hematology Associates of SW VA, Inc
Christiansburg, Virginia, United States, 24073
Fair Oaks Office
Fairfax, Virginia, United States, 22033
Fairfax Northern VA Hematology-Oncology PC
Fairfax, Virginia, United States, 22031
Fairfax-Northern Virginia Hematology-Oncology PC
Gainesville, Virginia, United States, 20155
Virginia Oncology Associates
Hampton, Virginia, United States, 23606
Fairfax-Northern Virginia Hematology-Oncology PC
Leesburg, Virginia, United States, 20176
SCRI Virginia Cancer Institute (Flank)
Mechanicsville, Virginia, United States, 23116
SCRI Virginia Cancer Institute
Midlothian, Virginia, United States, 23114
Virginia Oncology Associates
Newport News, Virginia, United States, 23606
Virginia Oncology Associates - Lake Wright
Norfolk, Virginia, United States, 23502
MBCCOP, Virginia Commonwealth University
Richmond, Virginia, United States, 23298
SCRI Virginia Cancer Institute (6605)
Richmond, Virginia, United States, 23226
SCRI Virginia Cancer Institute (1401)
Richmond, Virginia, United States, 23235
Oncology and Hematology Associates of SW VA, Inc
Roanoke, Virginia, United States, 24014
Oncology and Hematology Associates of SW VA, Inc
Salem, Virginia, United States, 24153
Virginia Oncology Associates
Virginia Beach, Virginia, United States, 23456
Virginia Oncology Associates
Williamsburg, Virginia, United States, 23188
Fairfax Northern Virginia Hematology-Oncology - Winchester
Winchester, Virginia, United States, 22601
Fairfax-Northern Virginia Hematology-Oncology PC
Woodbridge, Virginia, United States, 22191
Oncology and Hematology Associates of SW VA, Inc
Wytheville, Virginia, United States, 24382
United States, Washington
Highline Medical Oncology
Burien, Washington, United States, 98166
Puget Sound Cancer Center- Edmonds
Edmonds, Washington, United States, 98026
Columbia Basin Hematology and Oncology
Kennewick, Washington, United States, 99336
Puget Sound Cancer Center - Seattle
Seattle, Washington, United States, 98133
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109-1024
Rockwood Clinic Cancer Treatment Center
Spokane, Washington, United States, 99204-2967
Cancer Care Northwest-South
Spokane, Washington, United States, 99202
Cancer Care Northwest- Valley - Mission
Spokane, Washington, United States, 99216
Evergreen Hematology & Oncology (Farwell)
Spokane, Washington, United States, 99218
Cancer Care Northwest-North - Holland
Spokane, Washington, United States, 99218
Cancer Care Northwest-Radiation Therapy (XRT)
Spokane, Washington, United States, 99204
Northwest Cancer Specialists-136th Ave
Vancouver, Washington, United States, 98684
Northwest Cancer Specialists-134th St.
Vancouver, Washington, United States, 98686
Yakima Valley Memorial Hospital - North Star Lodge
Yakima, Washington, United States, 98902
United States, West Virginia
Raleigh Regional Cancer Center
Beckley, West Virginia, United States, 25801
CAMC Health Education & Research Institute, Inc.
Charleston, West Virginia, United States, 25304
West Virginia University Hospitals Inc.
Morgantown, West Virginia, United States, 26506-9162
Camden-Clark Memorial Hospital
Parkersburg, West Virginia, United States, 26101
Wheeling Hospital
Wheeling, West Virginia, United States, 26003
United States, Wisconsin
Marshfield Clinic Chippewa Falls Center
Chippewa, Wisconsin, United States, 54729
Marshfield Clinic Regional CA Cntr - Sacred Heart Hospital
Eau Claire, Wisconsin, United States, 54701
CCOP, St. Mary's Hospital Medical Center
Green Bay, Wisconsin, United States, 54303
CCOP, St. Vincent Hospital
Green Bay, Wisconsin, United States, 54301
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, United States, 54449
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53201-0342
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Marshfield Clinic Minocqua Center
Minocqua, Wisconsin, United States, 54548
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States, 54904
Marshfield Clinic at James Beck Cancer Center
Rhinelander, Wisconsin, United States, 54501
Marshfield Clinic Rice Lake Center
Rice Lake, Wisconsin, United States, 54868
Marshfield Clinic Cancer Care at St. Michael's Hospital
Stevens Point, Wisconsin, United States, 54481
Aspirus Regional Cancer Center
Wausau, Wisconsin, United States, 54401
Aurora Women's Pavilion of Aurora West Allis Medical Center
West Allis, Wisconsin, United States, 53227
CCOP Marshfield Clinic - Weston Center
Weston, Wisconsin, United States, 54476
Marshfield Clinic Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, United States, 54494
Ireland
Bon Secours Hospital
Cork, CK, Ireland
Letterkenny General Hospital
Letterkenny, DL, Ireland
Mater Private Hospital
Dublin, DN, Ireland, 7
St James' Hospital
Dublin, Ireland, DN8
St. Vincent's University Hospital
Dublin, Ireland, DN4
Beaumont Hospital
Dublin, Ireland, 9
Mater Misericordiae
Dublin, Ireland, DN7
St. James' Hospital
Dublin, Ireland, DN8
University College Hospital
Galway, Ireland, GY
Sligo General Hospital
Sligo, Ireland, CO Sligo
Waterford Regional Hospital
Waterford, Ireland, 0009
Sponsors and Collaborators
National Surgical Adjuvant Breast and Bowel Project (NSABP)
Genentech
US Oncology Research
Investigators
Principal Investigator: Norman Wolmark, MD NSABP Foundation, Inc.
  More Information

No publications provided

Responsible Party: National Surgical Adjuvant Breast and Bowel Project (NSABP)
ClinicalTrials.gov Identifier: NCT00887536     History of Changes
Other Study ID Numbers: NSABP B-46-I, USOR 07132
Study First Received: April 23, 2009
Last Updated: March 11, 2014
Health Authority: United States: Food and Drug Administration
United States: Institutional Review Board
Ireland: Irish Medicines Board
Ireland: Research Ethics Committee

Keywords provided by National Surgical Adjuvant Breast and Bowel Project (NSABP):
National Surgical Adjuvant Breast and Bowel Project (NSABP)
Taxotere
Docetaxel
Doxorubicin
Cyclophosphamide
Bevacizumab
Breast Neoplasms
Adenocarcinoma
Breast Diseases
Carcinoma
HER2 negative
Node negative
High risk node positive
Adjuvant Therapy

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases
Cyclophosphamide
Liposomal doxorubicin
Docetaxel
Bevacizumab
Doxorubicin
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Antirheumatic Agents
Therapeutic Uses
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Antibiotics, Antineoplastic
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Angiogenesis Inhibitors
Angiogenesis Modulating Agents

ClinicalTrials.gov processed this record on August 28, 2014