Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement
This study is ongoing, but not recruiting participants.
Sponsor:
Cancer and Leukemia Group B
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00869206
First received: March 24, 2009
Last updated: April 17, 2012
Last verified: April 2012
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Purpose
RATIONALE: Zoledronic acid may stop the growth of cancer cells in bone and may help relieve some of the symptoms caused by bone metastases. It is not yet known which schedule of zoledronic acid is more effective in treating patients with metastatic cancer that has spread to the bone.
PURPOSE: This randomized phase III trial is studying two different schedules of zoledronic acid to compare how well they work in treating patients with metastatic breast cancer, metastatic prostate cancer, or multiple myeloma with bone involvement.
| Condition | Intervention | Phase |
|---|---|---|
|
Breast Cancer Metastatic Cancer Multiple Myeloma and Plasma Cell Neoplasm Musculoskeletal Complications Pain Prostate Cancer Urinary Complications |
Drug: zoledronic acid |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Randomized, Phase III Study of Standard Dosing Versus Longer Dosing Interval of Zoledronic Acid in Metastatic Cancer |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
Drug Information available for:
Zoledronic acid
U.S. FDA Resources
Further study details as provided by National Cancer Institute (NCI):
Primary Outcome Measures:
- Proportion of patients with ≥ 1 skeletal-related event within 2 years after randomization [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Pain as assessed by the Brief Pain Inventory questionnaire [ Designated as safety issue: No ]
- ECOG performance status [ Designated as safety issue: No ]
- Osteonecrosis of the jaw [ Designated as safety issue: No ]
- Renal dysfunction [ Designated as safety issue: No ]
- Skeletal morbidity rate [ Designated as safety issue: No ]
| Estimated Enrollment: | 1758 |
| Study Start Date: | March 2009 |
| Estimated Primary Completion Date: | May 2015 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: Arm I
Patients receive zoledronic acid IV over ≥ 15 minutes. Courses repeat every 4 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
|
Drug: zoledronic acid
Given IV every 4 weeks or every 12 weeks
|
|
Experimental: Arm II
Patients receive zoledronic acid IV over ≥ 15 minutes. Courses repeat every 12 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
|
Drug: zoledronic acid
Given IV every 4 weeks or every 12 weeks
|
Detailed Description:
OBJECTIVES:
Primary
- To compare the proportion of patients with metastatic breast cancer, metastatic prostate cancer, or multiple myeloma involving bone who experience ≥ 1 skeletal-related event during 2 years of treatment with zoledronic acid administered every 12 weeks vs every 4 weeks.
Secondary
- To compare pain scores of these patients, as assessed by the Brief Pain Inventory questionnaire.
- To compare the functional status (ECOG performance status) of these patients.
- To compare the incidence of osteonecrosis of the jaw in these patients.
- To compare the incidence of renal dysfunction in these patients.
- To compare the skeletal morbidity rate of these patients, defined as the number of skeletal-related events per year.
OUTLINE: This is a multicenter study. Patients are stratified according to tumor type (breast cancer vs prostate cancer vs multiple myeloma), baseline serum creatinine (≤ 1.4 mg/dL vs > 1.4 mg/dL), prior skeletal-related events (no vs yes), and prior oral bisphosphate use (no vs yes). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive zoledronic acid IV over ≥ 15 minutes. Courses repeat every 4 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive zoledronic acid IV over ≥ 15 minutes. Courses repeat every 12 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
Patients complete the Brief Pain Inventory questionnaire at baseline and then every 4 weeks for 2 years.
After completion of study treatment, patients are followed up every 4 weeks for 2 years from registration.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
DISEASE CHARACTERISTICS:
Histologically confirmed diagnosis of one of the following:
- Breast adenocarcinoma
- Prostate adenocarcinoma
- Multiple myeloma
Has ≥ 1 site of bone metastasis or bone involvement by radiologic imaging, including radiography, computed tomography (CT), PET scan, PET/CT scan, magnetic resonance imaging, bone scan, or skeletal survey
- Indeterminate lesions should be confirmed by a second imaging method
No known brain metastases
- Patients who develop brain metastases during the study are allowed to continue study treatment as assigned
PATIENT CHARACTERISTICS:
- ECOG performance status 0-2
- Creatinine clearance ≥ 30 mL/min
- Corrected serum calcium ≥ 8.0 mg/dL and < 11.6 mg/dL
- Not pregnant or nursing
- Negative pregnancy test
PRIOR CONCURRENT THERAPY:
- Prior non-investigational chemotherapy, biologic therapy, and endocrine therapy in the adjuvant or metastatic setting allowed
No prior treatment with IV bisphosphonates
- Prior oral bisphosphonates allowed
- No concurrent oral bisphosphonates
No prior treatment with radiopharmaceuticals
- Prior radioactive iodine allowed
- Prior brachytherapy allowed for patients with prostate cancer
- No prior denosumab
Prior radiotherapy to bone is allowed, provided that at least one site of bone metastasis has not been irradiated and radiation is completed prior to registration
- There should be no plan for radiotherapy to non-irradiated sites of bone metastases
- No concurrent investigational agent(s)
- No concurrent treatment with other agents expected to alter osteoclast activity (e.g., calcitonin, mithramycin, gallium nitrate, or any other bisphosphonate)
Concurrent non-investigational antineoplastic therapies, including antiandrogens, other hormonal agents, cytotoxic chemotherapy agents, and biologic response modifiers allowed
- No concurrent investigational agents
- Concurrent standard radiotherapy to non-bony sites allowed
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00869206
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| United States, Alaska | |
| Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital | |
| Fairbanks, Alaska, United States, 99701 | |
| United States, Arizona | |
| Mayo Clinic Scottsdale | |
| Scottsdale, Arizona, United States, 85259-5499 | |
| United States, California | |
| East Bay Radiation Oncology Center | |
| Castro Valley, California, United States, 94546 | |
| Valley Medical Oncology Consultants - Castro Valley | |
| Castro Valley, California, United States, 94546 | |
| North Bay Cancer Center | |
| Fairfield, California, United States, 94533 | |
| Valley Medical Oncology | |
| Fremont, California, United States, 94538 | |
| Rebecca and John Moores UCSD Cancer Center | |
| La Jolla, California, United States, 92093-0658 | |
| Contra Costa Regional Medical Center | |
| Martinez, California, United States, 94553-3156 | |
| Memorial Medical Center | |
| Modesto, California, United States, 95355 | |
| Camino Medical Group - Treatment Center | |
| Mountain View, California, United States, 94040 | |
| El Camino Hospital Cancer Center | |
| Mountain View, California, United States, 94040 | |
| Leavey Cancer Center at Northridge Hospital Medical Center | |
| Northridge, California, United States, 91328 | |
| Larry G Strieff MD Medical Corporation | |
| Oakland, California, United States, 94609 | |
| CCOP - Bay Area Tumor Institute | |
| Oakland, California, United States, 94609 | |
| Bay Area Breast Surgeons, Incorporated | |
| Oakland, California, United States, 94609 | |
| Highland General Hospital | |
| Oakland, California, United States, 94602 | |
| Alta Bates Summit Medical Center - Summit Campus | |
| Oakland, California, United States, 94609 | |
| Tom K Lee, Incorporated | |
| Oakland, California, United States, 94609 | |
| Palo Alto Medical Foundation | |
| Palo Alto, California, United States, 94301 | |
| Feather River Hospital Cancer Center | |
| Paradise, California, United States, 95969 | |
| Pismo Beach, California, United States, 93449 | |
| Naval Medical Center - San Diego | |
| San Diego, California, United States, 92134 | |
| Veterans Affairs Medical Center - San Diego | |
| San Diego, California, United States, 92161 | |
| Doctors Medical Center - San Pablo Campus | |
| San Pablo, California, United States, 94806 | |
| United States, Colorado | |
| Aurora Presbyterian Hospital | |
| Aurora, Colorado, United States, 80012 | |
| Boulder Community Hospital | |
| Boulder, Colorado, United States, 80301-9019 | |
| Penrose Cancer Center at Penrose Hospital | |
| Colorado Springs, Colorado, United States, 80933 | |
| Memorial Hospital Cancer Center - Colorado Springs | |
| Colorado Springs, Colorado, United States, 80909 | |
| St. Anthony Central Hospital | |
| Denver, Colorado, United States, 80204 | |
| Porter Adventist Hospital | |
| Denver, Colorado, United States, 80210 | |
| Rose Medical Center | |
| Denver, Colorado, United States, 80220 | |
| St. Joseph Hospital | |
| Denver, Colorado, United States, 80218 | |
| Presbyterian - St. Luke's Medical Center | |
| Denver, Colorado, United States, 80218 | |
| CCOP - Colorado Cancer Research Program | |
| Denver, Colorado, United States, 80224-2522 | |
| Swedish Medical Center | |
| Englewood, Colorado, United States, 80110 | |
| Front Range Cancer Specialists | |
| Fort Collins, Colorado, United States, 80528 | |
| Poudre Valley Hospital | |
| Fort Collins, Colorado, United States, 80524 | |
| St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center | |
| Grand Junction, Colorado, United States, 81502 | |
| North Colorado Medical Center | |
| Greeley, Colorado, United States, 80631 | |
| Littleton Adventist Hospital | |
| Littleton, Colorado, United States, 80122 | |
| Sky Ridge Medical Center | |
| Lone Tree, Colorado, United States, 80124 | |
| Hope Cancer Care Center at Longmont United Hospital | |
| Longmont, Colorado, United States, 80501 | |
| McKee Medical Center | |
| Loveland, Colorado, United States, 80539 | |
| Parker Adventist Hospital | |
| Parker, Colorado, United States, 80138 | |
| St. Mary - Corwin Regional Medical Center | |
| Pueblo, Colorado, United States, 81004 | |
| North Suburban Medical Center | |
| Thornton, Colorado, United States, 80229 | |
| Exempla Lutheran Medical Center | |
| Wheat Ridge, Colorado, United States, 80033 | |
| United States, Connecticut | |
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | |
| Hartford, Connecticut, United States, 06105 | |
| Manchester Memorial Hospital | |
| Manchester, Connecticut, United States, 06040 | |
| Middlesex Hospital Cancer Center | |
| Middletown, Connecticut, United States, 06457 | |
| George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus | |
| New Britain, Connecticut, United States, 06050 | |
| United States, Delaware | |
| Tunnell Cancer Center at Beebe Medical Center | |
| Lewes, Delaware, United States, 19958 | |
| CCOP - Christiana Care Health Services | |
| Newark, Delaware, United States, 19713 | |
| United States, District of Columbia | |
| Kaiser Permanente at Capitol Hill Medical Center | |
| Washington, District of Columbia, United States, 20002 | |
| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | |
| Washington, District of Columbia, United States, 20007 | |
| Sibley Memorial Hospital | |
| Washington, District of Columbia, United States, 20016 | |
| United States, Florida | |
| Broward General Medical Center Cancer Center | |
| Fort Lauderdale, Florida, United States, 33316 | |
| Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital | |
| Fort Lauderdale, Florida, United States, 33308 | |
| Mayo Clinic - Jacksonville | |
| Jacksonville, Florida, United States, 32224 | |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | |
| Jupiter, Florida, United States, 33458 | |
| Cancer Center of South Florida Foundation, Incorporated | |
| Lake Worth, Florida, United States, 33461 | |
| CCOP - Mount Sinai Medical Center | |
| Miami Beach, Florida, United States, 33140 | |
| Florida Hospital Cancer Institute at Florida Hospital Orlando | |
| Orlando, Florida, United States, 32803-1273 | |
| Cleveland Clinic Florida - Weston | |
| Weston, Florida, United States, 33331 | |
| United States, Georgia | |
| Phoebe Cancer Center at Phoebe Putney Memorial Hospital | |
| Albany, Georgia, United States, 31701 | |
| Winship Cancer Institute of Emory University | |
| Atlanta, Georgia, United States, 30322 | |
| Veterans Affairs Medical Center - Atlanta (Decatur) | |
| Decatur, Georgia, United States, 30033 | |
| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | |
| Savannah, Georgia, United States, 31403-3089 | |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | |
| Savannah, Georgia, United States, 31405 | |
| United States, Idaho | |
| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | |
| Boise, Idaho, United States, 83706 | |
| Mountain States Tumor Institute at St. Luke's Regional Medical Center | |
| Boise, Idaho, United States, 83712 | |
| St. Joseph Regional Medical Center | |
| Lewiston, Idaho, United States, 83501 | |
| United States, Illinois | |
| Louis A. Weiss Memorial Hospital | |
| Chicago, Illinois, United States, 60640 | |
| Veterans Affairs Medical Center - Chicago Westside Hospital | |
| Chicago, Illinois, United States, 60612 | |
| John H. Stroger, Jr. Hospital of Cook County | |
| Chicago, Illinois, United States, 60612-3785 | |
| University of Illinois Cancer Center | |
| Chicago, Illinois, United States, 60612-7243 | |
| Decatur Memorial Hospital Cancer Care Institute | |
| Decatur, Illinois, United States, 62526 | |
| Evanston Hospital | |
| Evanston, Illinois, United States, 60201-1781 | |
| Leonard C. Ferguson Cancer Center | |
| Freeport, Illinois, United States, 61032 | |
| Veterans Affairs Medical Center - Hines | |
| Hines, Illinois, United States, 60141 | |
| Joliet Oncology-Hematology Associates, Limited - West | |
| Joliet, Illinois, United States, 60435 | |
| La Grange Memorial Hospital | |
| La Grange, Illinois, United States, 60525 | |
| Moline, Illinois, United States, 61265 | |
| Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | |
| Moline, Illinois, United States, 61265 | |
| Hematology Oncology Consultants - Naperville | |
| Naperville, Illinois, United States, 60540 | |
| West Suburban Center for Cancer Care | |
| River Forest, Illinois, United States, 60305 | |
| Regional Cancer Center at Memorial Medical Center | |
| Springfield, Illinois, United States, 62781-0001 | |
| CCOP - Carle Cancer Center | |
| Urbana, Illinois, United States, 61801 | |
| United States, Indiana | |
| St. Francis Hospital and Health Centers - Beech Grove Campus | |
| Beech Grove, Indiana, United States, 46107 | |
| Michiana Hematology-Oncology, PC - Elkhart | |
| Elkhart, Indiana, United States, 46514 | |
| Elkhart General Hospital | |
| Elkhart, Indiana, United States, 46515 | |
| Elkhart Clinic, LLC | |
| Elkhart, Indiana, United States, 46514-2098 | |
| Howard Community Hospital | |
| Kokomo, Indiana, United States, 46904 | |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | |
| La Porte, Indiana, United States, 46350 | |
| Clarian Arnett Cancer Care | |
| Lafayette, Indiana, United States, 47904 | |
| Suniti Medical Corporation | |
| Merrillville, Indiana, United States, 46410 | |
| Saint Anthony Memorial Health Centers | |
| Michigan City, Indiana, United States, 46360 | |
| Michiana Hematology-Oncology, PC - South Bend | |
| Mishawaka, Indiana, United States, 46545-1470 | |
| Saint Joseph Regional Medical Center | |
| Mishawaka, Indiana, United States, 46545-1470 | |
| Michiana Hematology Oncology PC - Plymouth | |
| Plymouth, Indiana, United States, 46563 | |
| Reid Hospital & Health Care Services | |
| Richmond, Indiana, United States, 47374 | |
| Memorial Hospital of South Bend | |
| South Bend, Indiana, United States, 46601 | |
| CCOP - Northern Indiana CR Consortium | |
| South Bend, Indiana, United States, 46601 | |
| Michiana Hematology Oncology PC - La Porte | |
| Westville, Indiana, United States, 46391 | |
| United States, Iowa | |
| McFarland Clinic, PC | |
| Ames, Iowa, United States, 50010 | |
| Bettendorf, Iowa, United States, 52722 | |
| Mercy Regional Cancer Center at Mercy Medical Center | |
| Cedar Rapids, Iowa, United States, 52403 | |
| St. Luke's Hospital | |
| Cedar Rapids, Iowa, United States, 52402 | |
| Iowa Blood and Cancer Care | |
| Cedar Rapids, Iowa, United States, 52402 | |
| Cedar Rapids Oncology Associates | |
| Cedar Rapids, Iowa, United States, 52403 | |
| Medical Oncology and Hematology Associates - West Des Moines | |
| Clive, Iowa, United States, 50325 | |
| Genesis Regional Cancer Center at Genesis Medical Center | |
| Davenport, Iowa, United States, 52803 | |
| John Stoddard Cancer Center at Iowa Lutheran Hospital | |
| Des Moines, Iowa, United States, 50316 | |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | |
| Des Moines, Iowa, United States, 50309 | |
| CCOP - Iowa Oncology Research Association | |
| Des Moines, Iowa, United States, 50309 | |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | |
| Des Moines, Iowa, United States, 50309 | |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | |
| Des Moines, Iowa, United States, 50314 | |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | |
| Des Moines, Iowa, United States, 50314 | |
| Holden Comprehensive Cancer Center at University of Iowa | |
| Iowa City, Iowa, United States, 52242-1002 | |
| Veterans Affairs Medical Center - Iowa City | |
| Iowa City, Iowa, United States, 52246 | |
| Mercy Cancer Center at Mercy Medical Center - North Iowa | |
| Mason City, Iowa, United States, 50401 | |
| McCreery Cancer Center at Ottumwa Regional | |
| Ottumwa, Iowa, United States, 52501 | |
| Mercy Medical Center - Sioux City | |
| Sioux City, Iowa, United States, 51102 | |
| Siouxland Hematology-Oncology Associates, LLP | |
| Sioux City, Iowa, United States, 51101 | |
| St. Luke's Regional Medical Center | |
| Sioux City, Iowa, United States, 51104 | |
| Covenant Cancer Treatment Center | |
| Waterloo, Iowa, United States, 50702 | |
| United States, Kansas | |
| Cancer Center of Kansas, PA - Chanute | |
| Chanute, Kansas, United States, 66720 | |
| Cancer Center of Kansas, PA - Dodge City | |
| Dodge City, Kansas, United States, 67801 | |
| Cancer Center of Kansas, PA - El Dorado | |
| El Dorado, Kansas, United States, 67042 | |
| Cancer Center of Kansas - Fort Scott | |
| Fort Scott, Kansas, United States, 66701 | |
| Cancer Center of Kansas-Independence | |
| Independence, Kansas, United States, 67301 | |
| Cancer Center of Kansas, PA - Kingman | |
| Kingman, Kansas, United States, 67068 | |
| Lawrence Memorial Hospital | |
| Lawrence, Kansas, United States, 66044 | |
| Cancer Center of Kansas, PA - Liberal | |
| Liberal, Kansas, United States, 67901 | |
| Cancer Center of Kansas, PA - Newton | |
| Newton, Kansas, United States, 67114 | |
| Saint Luke's Hospital - South | |
| Overland Park, Kansas, United States, 66213 | |
| Menorah Medical Center | |
| Overland Park, Kansas, United States, 66209 | |
| Cancer Center of Kansas, PA - Parsons | |
| Parsons, Kansas, United States, 67357 | |
| CCOP - Kansas City | |
| Prairie Village, Kansas, United States, 66208 | |
| Cancer Center of Kansas, PA - Pratt | |
| Pratt, Kansas, United States, 67124 | |
| Cancer Center of Kansas, PA - Salina | |
| Salina, Kansas, United States, 67401 | |
| Cotton-O'Neil Cancer Center | |
| Topeka, Kansas, United States, 66606 | |
| Cancer Center of Kansas, PA - Wellington | |
| Wellington, Kansas, United States, 67152 | |
| CCOP - Wichita | |
| Wichita, Kansas, United States, 67214 | |
| Cancer Center of Kansas, PA - Medical Arts Tower | |
| Wichita, Kansas, United States, 67208 | |
| Cancer Center of Kansas, PA - Wichita | |
| Wichita, Kansas, United States, 67214 | |
| Associates in Womens Health, PA - North Review | |
| Wichita, Kansas, United States, 67208 | |
| Via Christi Cancer Center at Via Christi Regional Medical Center | |
| Wichita, Kansas, United States, 67214 | |
| Cancer Center of Kansas, PA - Winfield | |
| Winfield, Kansas, United States, 67156 | |
| United States, Louisiana | |
| Ochsner Health Center - Bluebonnet | |
| Baton Rouge, Louisiana, United States, 70809 | |
| Mary Bird Perkins Cancer Center - Baton Rouge | |
| Baton Rouge, Louisiana, United States, 70809 | |
| Ochsner Health Center - Covington | |
| Covington, Louisiana, United States, 70433 | |
| Medical Center of Louisiana - New Orleans | |
| New Orleans, Louisiana, United States, 70112 | |
| Ochsner Cancer Institute at Ochsner Clinic Foundation | |
| New Orleans, Louisiana, United States, 70121 | |
| CCOP - Ochsner | |
| New Orleans, Louisiana, United States, 70121 | |
| MBCCOP - LSU Health Sciences Center | |
| New Orleans, Louisiana, United States, 70112 | |
| United States, Maine | |
| Harold Alfond Center for Cancer Care | |
| Augusta, Maine, United States, 04330 | |
| CancerCare of Maine at Eastern Maine Medical Center | |
| Bangor, Maine, United States, 04401 | |
| United States, Maryland | |
| Kaiser Permanente at Woodlawn Medical Center | |
| Baltimore, Maryland, United States, 21244 | |
| Union Memorial Hospital | |
| Baltimore, Maryland, United States, 21218 | |
| Good Samaritan Hospital of Maryland | |
| Baltimore, Maryland, United States, 21239 | |
| Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center | |
| Baltimore, Maryland, United States, 21237 | |
| Shore Regional Cancer Center at Memorial Hospital - Easton | |
| Easton, Maryland, United States, 21601 | |
| Union Hospital of Cecil County | |
| Elkton MD, Maryland, United States, 21921 | |
| Kaiser Permanente - Gaithersburg Medical Center | |
| Gaithersburg, Maryland, United States, 20879 | |
| Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility | |
| Largo, Maryland, United States, 20774 | |
| Cancer Institute at St. Joseph Medical Center | |
| Towson, Maryland, United States, 21204 | |
| United States, Massachusetts | |
| Sturdy Memorial Hospital | |
| Attleboro, Massachusetts, United States, 02703 | |
| Tufts Medical Center Cancer Center | |
| Boston, Massachusetts, United States, 02111 | |
| Caritas St. Elizabeth's Medical Center | |
| Brighton, Massachusetts, United States, 02135-2997 | |
| Addison Gilbert Hospital | |
| Gloucester, Massachusetts, United States, 01930 | |
| Caritas Holy Family Hospital | |
| Methuen, Massachusetts, United States, 01844 | |
| Jordan Hospital Club Cancer Center | |
| Plymouth, Massachusetts, United States, 02360 | |
| Commonwealth Hematology-Oncology, PC - Quincy | |
| Quincy, Massachusetts, United States, 02169 | |
| Baystate Regional Cancer Program at D'Amour Center for Cancer Care | |
| Springfield, Massachusetts, United States, 01199 | |
| United States, Michigan | |
| Hickman Cancer Center at Bixby Medical Center | |
| Adrian, Michigan, United States, 49221 | |
| Saint Joseph Mercy Cancer Center | |
| Ann Arbor, Michigan, United States, 48106-0995 | |
| CCOP - Michigan Cancer Research Consortium | |
| Ann Arbor, Michigan, United States, 48106 | |
| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |
| Dearborn, Michigan, United States, 48123-2500 | |
| Green Bay Oncology, Limited - Escanaba | |
| Escanaba, Michigan, United States, 49431 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| Genesys Hurley Cancer Institute | |
| Flint, Michigan, United States, 48503 | |
| Genesys Regional Medical Center | |
| Grand Blanc, Michigan, United States, 48439 | |
| Van Elslander Cancer Center at St. John Hospital and Medical Center | |
| Grosse Pointe Woods, Michigan, United States, 48236 | |
| Dickinson County Healthcare System | |
| Iron Mountain, Michigan, United States, 49801 | |
| Foote Memorial Hospital | |
| Jackson, Michigan, United States, 49201 | |
| Borgess Medical Center | |
| Kalamazoo, Michigan, United States, 49001 | |
| Bronson Methodist Hospital | |
| Kalamazoo, Michigan, United States, 49007 | |
| West Michigan Cancer Center | |
| Kalamazoo, Michigan, United States, 49007-3731 | |
| Sparrow Regional Cancer Center | |
| Lansing, Michigan, United States, 48912-1811 | |
| St. Mary Mercy Hospital | |
| Livonia, Michigan, United States, 48154 | |
| Upper Michigan Cancer Center at Marquette General Hospital | |
| Marquette, Michigan, United States, 49855 | |
| Mercy Memorial Hospital - Monroe | |
| Monroe, Michigan, United States, 48162 | |
| Community Cancer Center of Monroe | |
| Monroe, Michigan, United States, 48162 | |
| Michiana Hematology Oncology PC - Niles | |
| Niles, Michigan, United States, 49120 | |
| St. Joseph Mercy Oakland | |
| Pontiac, Michigan, United States, 48341-2985 | |
| Mercy Regional Cancer Center at Mercy Hospital | |
| Port Huron, Michigan, United States, 48060 | |
| William Beaumont Hospital - Royal Oak Campus | |
| Royal Oak, Michigan, United States, 48073 | |
| Seton Cancer Institute at Saint Mary's - Saginaw | |
| Saginaw, Michigan, United States, 48601 | |
| Lakeside Cancer Specialists, PLLC | |
| Saint Joseph, Michigan, United States, 49085 | |
| Lakeland Regional Cancer Care Center - St. Joseph | |
| St. Joseph, Michigan, United States, 49085 | |
| St. John Macomb Hospital | |
| Warren, Michigan, United States, 48093 | |
| United States, Minnesota | |
| Alexandria, Minnesota, United States, 56308 | |
| MeritCare Bemidji | |
| Bemidji, Minnesota, United States, 56601 | |
| St. Joseph's Medical Center | |
| Brainerd, Minnesota, United States, 56401 | |
| Fairview Ridges Hospital | |
| Burnsville, Minnesota, United States, 55337 | |
| Mercy and Unity Cancer Center at Mercy Hospital | |
| Coon Rapids, Minnesota, United States, 55433 | |
| Duluth Clinic Cancer Center - Duluth | |
| Duluth, Minnesota, United States, 55805-1983 | |
| Miller - Dwan Medical Center | |
| Duluth, Minnesota, United States, 55805 | |
| CCOP - Duluth | |
| Duluth, Minnesota, United States, 55805 | |
| Fairview Southdale Hospital | |
| Edina, Minnesota, United States, 55435 | |
| Mercy and Unity Cancer Center at Unity Hospital | |
| Fridley, Minnesota, United States, 55432 | |
| Hutchinson Area Health Care | |
| Hutchinson, Minnesota, United States, 55350 | |
| Immanuel St. Joseph's | |
| Mankato, Minnesota, United States, 56002 | |
| Minnesota Oncology - Maplewood | |
| Maplewood, Minnesota, United States, 55109 | |
| HealthEast Cancer Care at St. John's Hospital | |
| Maplewood, Minnesota, United States, 55109 | |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | |
| Minneapolis, Minnesota, United States, 55407 | |
| Hennepin County Medical Center - Minneapolis | |
| Minneapolis, Minnesota, United States, 55415 | |
| Humphrey Cancer Center at North Memorial Outpatient Center | |
| Robbinsdale, Minnesota, United States, 55422-2900 | |
| Mayo Clinic Cancer Center | |
| Rochester, Minnesota, United States, 55905 | |
| Coborn Cancer Center | |
| Saint Cloud, Minnesota, United States, 56303 | |
| CentraCare Clinic - River Campus | |
| Saint Cloud, Minnesota, United States, 56303 | |
| CCOP - Metro-Minnesota | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| Park Nicollet Cancer Center | |
| Saint Louis Park, Minnesota, United States, 55416 | |
| United Hospital | |
| Saint Paul, Minnesota, United States, 55102 | |
| St. Francis Cancer Center at St. Francis Medical Center | |
| Shakopee, Minnesota, United States, 55379 | |
| Regions Hospital Cancer Care Center | |
| St. Paul, Minnesota, United States, 55101 | |
| Lakeview Hospital | |
| Stillwater, Minnesota, United States, 55082 | |
| Ridgeview Medical Center | |
| Waconia, Minnesota, United States, 55387 | |
| Willmar Cancer Center at Rice Memorial Hospital | |
| Willmar, Minnesota, United States, 56201 | |
| Minnesota Oncology - Woodbury | |
| Woodbury, Minnesota, United States, 55125 | |
| United States, Mississippi | |
| Memorial Hospital at Gulfport | |
| Gulfport, Mississippi, United States, 39502 | |
| Veterans Affairs Medical Center - Jackson | |
| Jackson, Mississippi, United States, 39216 | |
| Keesler Air Force Base Medical Center | |
| Kessler AFB, Mississippi, United States, 39534 | |
| Regional Cancer Center at Singing River Hospital | |
| Pascagoula, Mississippi, United States, 39581 | |
| United States, Missouri | |
| Central Care Cancer Center at Carrie J. Babb Cancer Center | |
| Bolivar, Missouri, United States, 65613 | |
| Skaggs Cancer Center at Skaggs Regional Medical Center | |
| Branson, Missouri, United States, 65616 | |
| Southeast Cancer Center | |
| Cape Girardeau, Missouri, United States, 63703 | |
| Saint Luke's Hospital | |
| Chesterfield, Missouri, United States, 63017 | |
| Ellis Fischel Cancer Center at University of Missouri - Columbia | |
| Columbia, Missouri, United States, 65203 | |
| Goldschmidt Cancer Center | |
| Jefferson City, Missouri, United States, 65109 | |
| Saint Luke's Cancer Institute at Saint Luke's Hospital | |
| Kansas City, Missouri, United States, 64111 | |
| North Kansas City Hospital | |
| Kansas City, Missouri, United States, 64116 | |
| Parvin Radiation Oncology | |
| Kansas City, Missouri, United States, 64116 | |
| Heartland Hematology Oncology Associates, Incorporated | |
| Kansas City, Missouri, United States, 64118 | |
| Research Medical Center | |
| Kansas City, Missouri, United States, 64132 | |
| Saint Luke's East - Lee's Summit | |
| Lee's Summit, Missouri, United States, 64086 | |
| Phelps County Regional Medical Center | |
| Rolla, Missouri, United States, 65401 | |
| Heartland Regional Medical Center | |
| Saint Joseph, Missouri, United States, 64506 | |
| Saint Joseph Oncology, Incorporated | |
| Saint Joseph, Missouri, United States, 64507 | |
| Missouri Baptist Cancer Center | |
| Saint Louis, Missouri, United States, 63131 | |
| Comprehensive Cancer Care, PC | |
| Saint Louis, Missouri, United States, 63141 | |
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | |
| Saint Louis, Missouri, United States, 63110 | |
| Hulston Cancer Center at Cox Medical Center South | |
| Springfield, Missouri, United States, 65807 | |
| CCOP - Cancer Research for the Ozarks | |
| Springfield, Missouri, United States, 65802 | |
| St. John's Regional Health Center | |
| Springfield, Missouri, United States, 65804 | |
| United States, Montana | |
| Hematology-Oncology Centers of the Northern Rockies - Billings | |
| Billings, Montana, United States, 59102 | |
| CCOP - Montana Cancer Consortium | |
| Billings, Montana, United States, 59101 | |
| St. Vincent Healthcare Cancer Care Services | |
| Billings, Montana, United States, 59101 | |
| Billings Clinic - Downtown | |
| Billings, Montana, United States, 59107-7000 | |
| Bozeman Deaconess Cancer Center | |
| Bozeman, Montana, United States, 59715 | |
| St. James Healthcare Cancer Care | |
| Butte, Montana, United States, 59701 | |
| Sletten Cancer Institute at Benefis Healthcare | |
| Great Falls, Montana, United States, 59405 | |
| Great Falls Clinic - Main Facility | |
| Great Falls, Montana, United States, 59405 | |
| Northern Montana Hospital | |
| Havre, Montana, United States, 59501 | |
| St. Peter's Hospital | |
| Helena, Montana, United States, 59601 | |
| Glacier Oncology, PLLC | |
| Kalispell, Montana, United States, 59901 | |
| Kalispell Regional Medical Center | |
| Kalispell, Montana, United States, 59901 | |
| Kalispell Medical Oncology at KRMC | |
| Kalispell, Montana, United States, 59901 | |
| Montana Cancer Specialists at Montana Cancer Center | |
| Missoula, Montana, United States, 59807-7877 | |
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | |
| Missoula, Montana, United States, 59807 | |
| United States, Nebraska | |
| Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center | |
| Grand Island, Nebraska, United States, 68803 | |
| Good Samaritan Cancer Center at Good Samaritan Hospital | |
| Kearney, Nebraska, United States, 68848-1990 | |
| Cancer Resource Center - Lincoln | |
| Lincoln, Nebraska, United States, 68510 | |
| Callahan Cancer Center at Great Plains Regional Medical Center | |
| North Platte, Nebraska, United States, 69103 | |
| Creighton University Medical Center | |
| Omaha, Nebraska, United States, 68131-2197 | |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | |
| Omaha, Nebraska, United States, 68124 | |
| Immanuel Medical Center | |
| Omaha, Nebraska, United States, 68122 | |
| CCOP - Missouri Valley Cancer Consortium | |
| Omaha, Nebraska, United States, 68106 | |
| Lakeside Hospital | |
| Omaha, Nebraska, United States, 68130 | |
| UNMC Eppley Cancer Center at the University of Nebraska Medical Center | |
| Omaha, Nebraska, United States, 68198-6805 | |
| United States, Nevada | |
| CCOP - Nevada Cancer Research Foundation | |
| Las Vegas, Nevada, United States, 89106 | |
| University Medical Center of Southern Nevada | |
| Las Vegas, Nevada, United States, 89102 | |
| Renown Institute for Cancer at Renown Regional Medical Center | |
| Reno, Nevada, United States, 89502 | |
| Saint Mary's Regional Medical Center | |
| Reno, Nevada, United States, 89503 | |
| Radiation Oncology Associates - Reno | |
| Reno, Nevada, United States, 89509 | |
| United States, New Hampshire | |
| New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | |
| Concord, New Hampshire, United States, 03301 | |
| Seacoast Cancer Center at Wentworth - Douglass Hospital | |
| Dover, New Hampshire, United States, 03820 | |
| Center for Cancer Care at Exeter Hospital | |
| Exeter, New Hampshire, United States, 03833 | |
| New Hampshire Oncology - Hematology, PA - Hooksett | |
| Hooksett, New Hampshire, United States, 03106 | |
| Lakes Region General Hospital | |
| Laconia, New Hampshire, United States, 03246 | |
| Foundation Medical Partners | |
| Nashua, New Hampshire, United States, 03060 | |
| United States, New Jersey | |
| Trinitas Comprehensive Cancer Center at Trinitas Hospital | |
| Elizabeth, New Jersey, United States, 07207 | |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | |
| Marlton, New Jersey, United States, 08053 | |
| Jersey Shore Cancer Center at Jersey Shore University Medical Center | |
| Neptune, New Jersey, United States, 07753 | |
| Fox Chase Virtua Health Cancer Program at Virtua West Jersey | |
| Voorhees, New Jersey, United States, 08043 | |
| Cancer Institute of New Jersey at Cooper - Voorhees | |
| Voorhees, New Jersey, United States, 08043 | |
| United States, New Mexico | |
| University of New Mexico Cancer Center | |
| Albuquerque, New Mexico, United States, 87131-5636 | |
| Lovelace Medical Center - Downtown | |
| Albuquerque, New Mexico, United States, 87102 | |
| Hematology Oncology Associates, PC | |
| Albuquerque, New Mexico, United States, 87106 | |
| United States, New York | |
| Lincoln Medical and Mental Health Center | |
| Bronx, New York, United States, 10451 | |
| Kings County Hospital Center | |
| Brooklyn, New York, United States, 11203 | |
| SUNY Downstate Medical Center | |
| Brooklyn, New York, United States, 11203 | |
| Roswell Park Cancer Institute | |
| Buffalo, New York, United States, 14263-0001 | |
| Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital | |
| Cooperstown, New York, United States, 13326 | |
| CCOP - Hematology-Oncology Associates of Central New York | |
| East Syracuse, New York, United States, 13057 | |
| Elmhurst Hospital Center | |
| Elmhurst, New York, United States, 11373 | |
| Charles R. Wood Cancer Center at Glens Falls Hospital | |
| Glens Falls, New York, United States, 12801 | |
| Queens Cancer Center of Queens Hospital | |
| Jamaica, New York, United States, 11432 | |
| Monter Cancer Center of the North Shore-LIJ Health System | |
| Lake Success, New York, United States, 11042 | |
| Don Monti Comprehensive Cancer Center at North Shore University Hospital | |
| Manhasset, New York, United States, 11030 | |
| CCOP - North Shore University Hospital | |
| Manhasset, New York, United States, 11030 | |
| Long Island Jewish Medical Center | |
| New Hyde Park, New York, United States, 11040 | |
| NYU Cancer Institute at New York University Medical Center | |
| New York, New York, United States, 10016 | |
| New York Weill Cornell Cancer Center at Cornell University | |
| New York, New York, United States, 10021 | |
| Nalitt Cancer Institute at Staten Island University Hospital | |
| Staten Island, New York, United States, 10305 | |
| Veterans Affairs Medical Center - Syracuse | |
| Syracuse, New York, United States, 13210 | |
| Dickstein Cancer Treatment Center at White Plains Hospital Center | |
| White Plains, New York, United States, 10601 | |
| United States, North Carolina | |
| Wayne Memorial Hospital, Incorporated | |
| Goldsboro, North Carolina, United States, 27534 | |
| Leo W. Jenkins Cancer Center at ECU Medical School | |
| Greenville, North Carolina, United States, 27834 | |
| Pardee Memorial Hospital | |
| Hendersonville, North Carolina, United States, 28791 | |
| Kinston Medical Specialists | |
| Kinston, North Carolina, United States, 28501 | |
| FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | |
| Pinehurst, North Carolina, United States, 28374 | |
| Rutherford Hospital | |
| Rutherfordton, North Carolina, United States, 28139 | |
| Iredell Memorial Hospital | |
| Statesville, North Carolina, United States, 28677 | |
| Zimmer Cancer Center at New Hanover Regional Medical Center | |
| Wilmington, North Carolina, United States, 28401 | |
| Forsyth Regional Cancer Center at Forsyth Medical Center | |
| Winston-Salem, North Carolina, United States, 27103 | |
| Wake Forest University Comprehensive Cancer Center | |
| Winston-Salem, North Carolina, United States, 27157-1096 | |
| United States, North Dakota | |
| St. Alexius Medical Center Cancer Center | |
| Bismarck, North Dakota, United States, 58502 | |
| Mid Dakota Clinic, PC | |
| Bismarck, North Dakota, United States, 58501 | |
| Bismarck Cancer Center | |
| Bismarck, North Dakota, United States, 58501 | |
| Medcenter One Hospital Cancer Care Center | |
| Bismarck, North Dakota, United States, 58501 | |
| CCOP - MeritCare Hospital | |
| Fargo, North Dakota, United States, 58122 | |
| MeritCare Broadway | |
| Fargo, North Dakota, United States, 58102 | |
| Roger Maris Cancer Center at MeritCare Hospital | |
| Fargo, North Dakota, United States, 58122 | |
| Altru Cancer Center at Altru Hospital | |
| Grand Forks, North Dakota, United States, 58201 | |
| Trinity CancerCare Center | |
| Minot, North Dakota, United States, 58701 | |
| United States, Ohio | |
| McDowell Cancer Center at Akron General Medical Center | |
| Akron, Ohio, United States, 44307 | |
| Wood County Oncology Center | |
| Bowling Green, Ohio, United States, 43402 | |
| Aultman Cancer Center at Aultman Hospital | |
| Canton, Ohio, United States, 44710-1799 | |
| Adena Regional Medical Center | |
| Chillicothe, Ohio, United States, 45601 | |
| MetroHealth Cancer Care Center at MetroHealth Medical Center | |
| Cleveland, Ohio, United States, 44109 | |
| Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | |
| Columbus, Ohio, United States, 43210-1240 | |
| Riverside Methodist Hospital Cancer Care | |
| Columbus, Ohio, United States, 43214-3998 | |
| Grant Medical Center Cancer Care | |
| Columbus, Ohio, United States, 43215 | |
| Mount Carmel Health - West Hospital | |
| Columbus, Ohio, United States, 43222 | |
| CCOP - Columbus | |
| Columbus, Ohio, United States, 43215 | |
| Doctors Hospital at Ohio Health | |
| Columbus, Ohio, United States, 43228 | |
| Samaritan North Cancer Care Center | |
| Dayton, Ohio, United States, 45415 | |
| David L. Rike Cancer Center at Miami Valley Hospital | |
| Dayton, Ohio, United States, 45409 | |
| CCOP - Dayton | |
| Dayton, Ohio, United States, 45420 | |
| Good Samaritan Hospital | |
| Dayton, Ohio, United States, 45406 | |
| Grandview Hospital | |
| Dayton, Ohio, United States, 45405 | |
| Grady Memorial Hospital | |
| Delaware, Ohio, United States, 43015 | |
| Hematology Oncology Center | |
| Elyria, Ohio, United States, 44035 | |
| Community Cancer Center | |
| Elyria, Ohio, United States, 44035 | |
| Blanchard Valley Medical Associates | |
| Findlay, Ohio, United States, 45840 | |
| Middletown Regional Hospital | |
| Franklin, Ohio, United States, 45005-1066 | |
| Wayne Hospital | |
| Greenville, Ohio, United States, 45331 | |
| Charles F. Kettering Memorial Hospital | |
| Kettering, Ohio, United States, 45429 | |
| Fairfield Medical Center | |
| Lancaster, Ohio, United States, 43130 | |
| Lima Memorial Hospital | |
| Lima, Ohio, United States, 45804 | |
| St. Rita's Medical Center | |
| Lima, Ohio, United States, 45801 | |
| Strecker Cancer Center at Marietta Memorial Hospital | |
| Marietta, Ohio, United States, 45750 | |
| Northwest Ohio Oncology Center | |
| Maumee, Ohio, United States, 43537-1839 | |
| Knox Community Hospital | |
| Mount Vernon, Ohio, United States, 43050 | |
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | |
| Newark, Ohio, United States, 43055 | |
| Fisher-Titus Medical Center | |
| Norwalk, Ohio, United States, 44857 | |
| Toledo Clinic - Oregon | |
| Oregon, Ohio, United States, 43616 | |
| St. Charles Mercy Hospital | |
| Oregon, Ohio, United States, 43616 | |
| Southern Ohio Medical Center Cancer Center | |
| Portsmouth, Ohio, United States, 45662 | |
| North Coast Cancer Care, Incorporated | |
| Sandusky, Ohio, United States, 44870 | |
| Community Hospital of Springfield and Clark County | |
| Springfield, Ohio, United States, 45505 | |
| Flower Hospital Cancer Center | |
| Sylvania, Ohio, United States, 43560 | |
| Mercy Hospital of Tiffin | |
| Tiffin, Ohio, United States, 44883 | |
| Medical University of Ohio Cancer Center | |
| Toledo, Ohio, United States, 43614 | |
| CCOP - Toledo Community Hospital | |
| Toledo, Ohio, United States, 43617 | |
| St. Anne Mercy Hospital | |
| Toledo, Ohio, United States, 43623 | |
| St. Vincent Mercy Medical Center | |
| Toledo, Ohio, United States, 43608 | |
| Toledo Hospital | |
| Toledo, Ohio, United States, 43606 | |
| Toledo Clinic, Incorporated - Main Clinic | |
| Toledo, Ohio, United States, 43623 | |
| UVMC Cancer Care Center at Upper Valley Medical Center | |
| Troy, Ohio, United States, 45373-1300 | |
| Fulton County Health Center | |
| Wauseon, Ohio, United States, 43567 | |
| Mount Carmel St. Ann's Cancer Center | |
| Westerville, Ohio, United States, 43081 | |
| United States Air Force Medical Center - Wright-Patterson | |
| Wright-Patterson Afb, Ohio, United States, 45433-5529 | |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | |
| Xenia, Ohio, United States, 45385 | |
| Genesis - Good Samaritan Hospital | |
| Zanesville, Ohio, United States, 43701 | |
| United States, Oklahoma | |
| LaFortune Cancer Center at St. John Medical Center | |
| Tulsa, Oklahoma, United States, 74104 | |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | |
| Tulsa, Oklahoma, United States, 74136 | |
| United States, Oregon | |
| Clackamas Radiation Oncology Center | |
| Clackamas, Oregon, United States, 97015 | |
| Three Rivers Community Hospital | |
| Grants Pass, Oregon, United States, 97527 | |
| Dubs Cancer Center at Rogue Valley Medical Center | |
| Medford, Oregon, United States, 97504 | |
| Providence Cancer Center at PMCC | |
| Medford, Oregon, United States, 97504 | |
| Providence Milwaukie Hospital | |
| Milwaukie, Oregon, United States, 97222 | |
| Providence Newberg Medical Center | |
| Newberg, Oregon, United States, 97132 | |
| Willamette Falls Hospital | |
| Oregon City, Oregon, United States, 97045 | |
| Kaiser Permanente Health Care - Portland | |
| Portland, Oregon, United States, 97227 | |
| Providence St. Vincent Medical Center | |
| Portland, Oregon, United States, 97225 | |
| Providence Cancer Center at Providence Portland Medical Center | |
| Portland, Oregon, United States, 97213-2967 | |
| CCOP - Columbia River Oncology Program | |
| Portland, Oregon, United States, 97225 | |
| Salem Hospital Regional Cancer Care Services | |
| Salem, Oregon, United States, 97309-5014 | |
| United States, Pennsylvania | |
| Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | |
| Allentown, Pennsylvania, United States, 18105 | |
| Lehigh Valley Hospital - Muhlenberg | |
| Bethlehem, Pennsylvania, United States, 18017 | |
| Bryn Mawr Hospital | |
| Bryn Mawr, Pennsylvania, United States, 19010 | |
| Geisinger Cancer Institute at Geisinger Health | |
| Danville, Pennsylvania, United States, 17822-0001 | |
| Doylestown Hospital Cancer Center | |
| Doylestown, Pennsylvania, United States, 18901 | |
| Delaware County Regional Cancer Center at Delaware County Memorial Hospital | |
| Drexel Hill, Pennsylvania, United States, 19026 | |
| Dale and Frances Hughes Cancer Center at Pocono Medical Center | |
| East Stroudsburg, Pennsylvania, United States, 18301 | |
| Easton Regional Cancer Center at Easton Hospital | |
| Easton, Pennsylvania, United States, 18042 | |
| Geisinger Hazleton Cancer Center | |
| Hazleton, Pennsylvania, United States, 18201 | |
| Lancaster General Hospital | |
| Lancaster, Pennsylvania, United States, 17604 | |
| St. Mary Regional Cancer Center | |
| Langhorne, Pennsylvania, United States, 19047 | |
| Riddle Memorial Hospital Cancer Center | |
| Media, Pennsylvania, United States, 19063 | |
| Cancer Center of Paoli Memorial Hospital | |
| Paoli, Pennsylvania, United States, 19301-1792 | |
| Albert Einstein Cancer Center | |
| Philadelphia, Pennsylvania, United States, 19141 | |
| Joan Karnell Cancer Center at Pennsylvania Hospital | |
| Philadelphia, Pennsylvania, United States, 19107 | |
| Cancer Center at Phoenixville Hospital | |
| Phoenixville, Pennsylvania, United States, 19460 | |
| Veterans Affairs Medical Center - Pittsburgh | |
| Pittsburgh, Pennsylvania, United States, 15240 | |
| Hematology and Oncology Associates of Northeastern Pennsylvania | |
| Scranton, Pennsylvania, United States, 18510 | |
| Mercy Hospital Cancer Center - Scranton | |
| Scranton, Pennsylvania, United States, 18501 | |
| Geisinger Medical Group - Scenery Park | |
| State College, Pennsylvania, United States, 16801 | |
| Chester County Hospital | |
| West Chester, Pennsylvania, United States, 19380 | |
| Jennersville Regional Hospital | |
| West Grove, Pennsylvania, United States, 19390-9499 | |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | |
| Wilkes-Barre, Pennsylvania, United States, 18711 | |
| Lankenau Cancer Center at Lankenau Hospital | |
| Wynnewood, Pennsylvania, United States, 19096 | |
| CCOP - Main Line Health | |
| Wynnewood, Pennsylvania, United States, 19096 | |
| United States, Rhode Island | |
| Miriam Hospital | |
| Providence, Rhode Island, United States, 02906 | |
| Rhode Island Hospital Comprehensive Cancer Center | |
| Providence, Rhode Island, United States, 02903 | |
| Roger Williams Medical Center | |
| Providence, Rhode Island, United States, 02908 | |
| United States, South Carolina | |
| AnMed Cancer Center | |
| Anderson, South Carolina, United States, 29621 | |
| Roper St. Francis Cancer Center at Roper Hospital | |
| Charleston, South Carolina, United States, 29401 | |
| McLeod Regional Medical Center | |
| Florence, South Carolina, United States, 29501 | |
| Carolina Blood and Cancer Care Associates, PA | |
| Lancaster, South Carolina, United States, 29720 | |
| Carolina Blood and Cancer Care | |
| Rock Hill, South Carolina, United States, 29732 | |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | |
| Spartanburg, South Carolina, United States, 29303 | |
| CCOP - Upstate Carolina | |
| Spartanburg, South Carolina, United States, 29303 | |
| Lexington Medical Center | |
| West Columbia, South Carolina, United States, 29169 | |
| United States, South Dakota | |
| Avera Cancer Institute | |
| Sioux Falls, South Dakota, United States, 57105 | |
| Medical X-Ray Center, PC | |
| Sioux Falls, South Dakota, United States, 57105 | |
| Sanford Cancer Center at Sanford USD Medical Center | |
| Sioux Falls, South Dakota, United States, 57117-5039 | |
| United States, Tennessee | |
| Thompson Cancer Survival Center | |
| Knoxville, Tennessee, United States, 37916 | |
| United States, Virginia | |
| Martha Jefferson Hospital Cancer Care Center | |
| Charlottesville, Virginia, United States, 22901 | |
| Medical Oncology and Hematology Associates of North Virginia - Fairfax | |
| Fairfax, Virginia, United States, 22031 | |
| Kaiser Permanente Medical Center - Fair Oaks | |
| Fairfax, Virginia, United States, 22033 | |
| Fredericksburg Oncology, Incorporated | |
| Fredericksburg, Virginia, United States, 22401 | |
| Veterans Affairs Medical Center - Richmond | |
| Richmond, Virginia, United States, 23249 | |
| Virginia Commonwealth University Massey Cancer Center | |
| Richmond, Virginia, United States, 23298-0037 | |
| United States, Washington | |
| Overlake Cancer Center at Overlake Hospital Medical Center | |
| Bellevue, Washington, United States, 98004 | |
| Providence Centralia Hospital | |
| Centralia, Washington, United States, 98531-9027 | |
| Providence Regional Cancer Partnership | |
| Everett, Washington, United States, 98201 | |
| St. Francis Hospital | |
| Federal Way, Washington, United States, 98003 | |
| Cascade Cancer Center at Evergreen Hospital Medical Center | |
| Kirkland, Washington, United States, 98033 | |
| Providence St. Peter Hospital Regional Cancer Center | |
| Olympia, Washington, United States, 98506-5166 | |
| Good Samaritan Cancer Center | |
| Puyallup, Washington, United States, 98372 | |
| Virginia Mason Medical Center | |
| Seattle, Washington, United States, 98101 | |
| Pacific Medical Center | |
| Seattle, Washington, United States, 98104 | |
| CCOP - Virginia Mason Research Center | |
| Seattle, Washington, United States, 98101 | |
| MultiCare Regional Cancer Center at Tacoma General Hospital | |
| Tacoma, Washington, United States, 98405 | |
| Franciscan Cancer Center at St. Joseph Medical Center | |
| Tacoma, Washington, United States, 98405-3004 | |
| Allenmore Hospital | |
| Tacoma, Washington, United States, 98405 | |
| St. Clare Hospital | |
| Tacoma, Washington, United States, 98499 | |
| CCOP - Northwest | |
| Tacoma, Washington, United States, 98405 | |
| Southwest Washington Medical Center Cancer Center | |
| Vancouver, Washington, United States, 98664 | |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | |
| Yakima, Washington, United States, 98902 | |
| United States, West Virginia | |
| St. Mary's Regional Cancer Center at St. Mary's Medical Center | |
| Huntington, West Virginia, United States, 25702 | |
| United States, Wisconsin | |
| Langlade Memorial Hospital | |
| Antigo, Wisconsin, United States, 54409 | |
| Marshfield Clinic - Chippewa Center | |
| Chippewa Falls, Wisconsin, United States, 54729 | |
| Marshfield Clinic Cancer Care at Regional Cancer Center | |
| Eau Claire, Wisconsin, United States, 54701 | |
| Midelfort Clinic - Luther | |
| Eau Claire, Wisconsin, United States, 54703-1510 | |
| Green Bay Oncology, Limited at St. Mary's Hospital | |
| Green Bay, Wisconsin, United States, 54303 | |
| Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | |
| Green Bay, Wisconsin, United States, 54311 | |
| St. Vincent Hospital Regional Cancer Center | |
| Green Bay, Wisconsin, United States, 54307-3508 | |
| St. Mary's Hospital Medical Center - Green Bay | |
| Green Bay, Wisconsin, United States, 54303 | |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | |
| Green Bay, Wisconsin, United States, 54301-3526 | |
| Mercy Regional Cancer Center | |
| Janesville, Wisconsin, United States, 53547 | |
| Gundersen Lutheran Center for Cancer and Blood | |
| La Crosse, Wisconsin, United States, 54601 | |
| Franciscan Skemp Healthcare - La Crosse Campus | |
| La Crosse, Wisconsin, United States, 54601 | |
| Holy Family Memorial Medical Center Cancer Care Center | |
| Manitowoc, Wisconsin, United States, 54221-1450 | |
| Vince Lombardi Cancer Clinic - Marinette | |
| Marinette, Wisconsin, United States, 54143 | |
| Bay Area Cancer Care Center at Bay Area Medical Center | |
| Marinette, Wisconsin, United States, 54143 | |
| Marshfield Clinic - Marshfield Center | |
| Marshfield, Wisconsin, United States, 54449 | |
| Columbia Saint Mary's Hospital - Ozaukee | |
| Mequon, Wisconsin, United States, 53097 | |
| Columbia-Saint Mary's Cancer Care Center | |
| Milwaukee, Wisconsin, United States, 53211 | |
| Marshfield Clinic - Lakeland Center | |
| Minocqua, Wisconsin, United States, 54548 | |
| D.N. Greenwald Center | |
| Mukwonago, Wisconsin, United States, 53149 | |
| Regional Cancer Center at Oconomowoc Memorial Hospital | |
| Oconomowoc, Wisconsin, United States, 53066 | |
| Green Bay Oncology, Limited - Oconto Falls | |
| Oconto Falls, Wisconsin, United States, 54154 | |
| All Saints Cancer Center at Wheaton Franciscan Healthcare | |
| Racine, Wisconsin, United States, 53405 | |
| Ministry Medical Group at Saint Mary's Hospital | |
| Rhinelander, Wisconsin, United States, 54501 | |
| Marshfield Clinic - Indianhead Center | |
| Rice Lake, Wisconsin, United States, 54868 | |
| St. Nicholas Hospital | |
| Sheboygan, Wisconsin, United States, 53081 | |
| Vince Lombardi Cancer Clinic - Sheboygan | |
| Sheboygan, Wisconsin, United States, 53081 | |
| Marshfield Clinic at Saint Michael's Hospital | |
| Stevens Point, Wisconsin, United States, 54481 | |
| Green Bay Oncology, Limited - Sturgeon Bay | |
| Sturgeon Bay, Wisconsin, United States, 54235 | |
| Aurora Medical Center | |
| Summit, Wisconsin, United States, 53066 | |
| Vince Lombardi Cancer Clinic - Two Rivers | |
| Two Rivers, Wisconsin, United States, 54241 | |
| Waukesha Memorial Hospital Regional Cancer Center | |
| Waukesha, Wisconsin, United States, 53188 | |
| University of Wisconcin Cancer Center at Aspirus Wausau Hospital | |
| Wausau, Wisconsin, United States, 54401 | |
| Oncology Alliance, SC - Milwaukee - West | |
| Wauwatosa, Wisconsin, United States, 53226 | |
| Marshfield Clinic - Weston Center | |
| Weston, Wisconsin, United States, 54476 | |
| Marshfield Clinic - Wisconsin Rapids Center | |
| Wisconsin Rapids, Wisconsin, United States, 54494 | |
| Riverview UW Cancer Center at Riverview Hospital | |
| Wisconsin Rapids, Wisconsin, United States, 54494 | |
| United States, Wyoming | |
| Welch Cancer Center at Sheridan Memorial Hospital | |
| Sheridan, Wyoming, United States, 82801 | |
| Puerto Rico | |
| San Juan City Hospital | |
| San Juan, Puerto Rico, 00936 | |
Sponsors and Collaborators
Cancer and Leukemia Group B
Investigators
| Study Chair: | Andrew L. Himelstein, MD | Helen F. Graham Cancer Center at Christiana Hospital |
| Principal Investigator: | Richard L. Schilsky, MD | University of Chicago |
More Information
Additional Information:
No publications provided
| Responsible Party: | Monica M. Bertagnolli, Cancer and Leukemia Group B |
| ClinicalTrials.gov Identifier: | NCT00869206 History of Changes |
| Other Study ID Numbers: | CDR0000637947, CALGB-70604 |
| Study First Received: | March 24, 2009 |
| Last Updated: | April 17, 2012 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
|
pain musculoskeletal complications urinary complications adenocarcinoma of the prostate stage IV breast cancer recurrent breast cancer male breast cancer |
stage IV prostate cancer recurrent prostate cancer stage III multiple myeloma stage I multiple myeloma stage II multiple myeloma refractory multiple myeloma bone metastases |
Additional relevant MeSH terms:
|
Breast Neoplasms Neoplasms Multiple Myeloma Neoplasms, Plasma Cell Plasmacytoma Neoplasm Metastasis Neoplasms, Second Primary Prostatic Neoplasms Neoplasms by Site Breast Diseases Skin Diseases Neoplasms by Histologic Type Hemostatic Disorders Vascular Diseases Cardiovascular Diseases |
Paraproteinemias Blood Protein Disorders Hematologic Diseases Hemorrhagic Disorders Lymphoproliferative Disorders Immunoproliferative Disorders Immune System Diseases Neoplastic Processes Pathologic Processes Genital Neoplasms, Male Urogenital Neoplasms Genital Diseases, Male Prostatic Diseases Zoledronic acid Diphosphonates |
ClinicalTrials.gov processed this record on May 21, 2013