Is Carotid Intima-media Thickness Affected by A1C Variability?

This study has been completed.
Sponsor:
Information provided by:
Yonsei University
ClinicalTrials.gov Identifier:
NCT00842972
First received: February 11, 2009
Last updated: September 14, 2009
Last verified: September 2009
  Purpose

This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.


Condition
Type 2 Diabetes
A1C Variability

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Yonsei University:

  Eligibility

Ages Eligible for Study:   34 Years to 79 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

typeII, Fluroscopy in carotid once a year during 2 years.

Criteria

Inclusion Criteria:

  • type II
  • fluoroscopy in carotid once a year during 2 years

Exclusion Criteria:

  • type 1 diabetes
  • history or clinical evidence of coronary artery disease or cerebral or peripheral vascular disease
  • the presence of albuminuria (defined as 24 hour urine albumin excretion ≥ 30 mg)
  • renal dysfunction (defined as creatinine blood level ≥ 2.0 mg/dL)
  • hepatic dysfunction (defined as alanine aminotransferase and/or aspartate aminotransferase blood level ≥ 3 × upper normal limit)
  • smoking within the past 3 months prior to commencement of the study
  • use of any medication likely to alter IMT such as calcium channel blocker, thiazolidinedione, antiplatelet agent (clopidogrel, cilostazol)
  • use of glucocorticoid
  • pregnancy
  • severe concomitant disease such as cancer
  • infection
  • Cushing's syndrome
  • acromegaly, or any other disorder likely to alter glycemia
  • primary hypercholesterolemia
  • hypothyroidism or hyperthyroidism
  • use of any hormonal drugs
  • alcoholism or drug abuse
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Ahn, Chul Woo, Gangnam Severance Hospital
ClinicalTrials.gov Identifier: NCT00842972     History of Changes
Other Study ID Numbers: 3-2006-0005
Study First Received: February 11, 2009
Last Updated: September 14, 2009
Health Authority: Korea: Food and Drug Administration

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on April 17, 2014