Inclusion Criteria:

• Body mass index (BMI) between 19 and 32 kg/m2, inclusive
• Women of non-child-bearing potential or practicing birth control
• Have a normal electrocardiogram (ECG)
• Be in good health, in the opinion of the investigator
• Be sufficiently alert to understand and communicate intelligibly with the study staff (i.e., patients must be able to perform all study procedures)
• Agree to limit their methylxanthine consumption throughout the study to 2 methylxanthine-containing substances
• Agree to refrain from ingesting products containing grapefruit, quinine, or Seville orange during the study
• Agree to refrain from ingesting antacids during the study
• Agree to refrain from ingesting alcohol during the study
• Have signed an informed consent document indicating that the study has been explained to them and they are willing to participate in the study.

Exclusion Criteria:

• History of significant renal, hepatic, gastrointestinal, hematologic, pulmonary, metabolic, thyroid, or other chronic disease
• Significant cardiovascular disease, including a history of myocardial infarction within the past 2 years, cerebrovascular accident, clinically significant cardiac valvular disease, unstable angina, significantly abnormal ECG, arrhythmia, or congestive cardiac failure
• History of significant psychiatric disorders including schizophrenia, psychosis, panic disorder, major depression, suicidal attempt or other major affective disorders or current dysthymia. If possible, the investigator shall attempt to confirm the presence or absence of past psychiatric history with subject's primary care physician
• History of raised intraocular pressure, glaucoma, or otherwise at risk for acute narrow-angle glaucoma
• Demonstrate significant active physical disease, acute or chronic, within 7 days before the start of the study
• Liver enzymes (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) outside the normal limits
• Women who wish to become pregnant within 2 months following discontinuation of the study drug, or who are breast-feeding
• Require or have taken any prescription medications within 2 weeks before dosing
• Use of any over-the-counter medications (including aspirin, antacids, vitamins, and herbal supplements (e.g., diuretic tea that may have an impact on renal function) within 7 days before dosing until the end of the study
• Use of hormonal contraceptives (including oral, implanted, intrauterine device, and patch) or hormonal replacement therapy within 3 months before start of screening until 2 months after study completion
• Use of a carbonic anhydrase inhibitor for any reason within 2 weeks before the start of screening
• History of alcohol or drug abuse
• Testing positive for HIV antibody, Hepatitis B antigen, or Hepatitis C antibody
• Abnormal clinical laboratory values, unless reviewed and approved by the Sponsor's medical monitor
• Use of any nicotine-containing products, including tobacco products (e.g., cigarettes, cigars, or chewing tobacco) in the 3 months before start of screening until the end of the study
• History of kidney stones
• Family history (first-degree relatives) of kidney stones that are not established to be due to a known cause (e.g., hyperparathyroidism, medication)
• History of lactic acidosis or chronic metabolic acidosis
• History of hereditary or acquired neurologic disease (e.g., epilepsy or significant brain trauma)
• Malignancy or a history of a malignancy within 5 years before start of screening, other than treated basal cell carcinomas of the skin
• Known contraindication or hypersensitivity to topiramate or heparin
• Use of any medications that are known P-450 enzyme inducers or inhibitors (e.g., cimetidine or rifampin), within 3 months before dosing. (See Attachment 6, Listing of Medications That Are Known Cytochrome P-450 Enzyme Inducers or Inhibitors)
• Any significant condition that in the opinion of the investigator could interfere in the patient's participation or completion of the study
• Have received an experimental drug or used an experimental medical device within 30 days before screening
• Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator