Setup Variation in the Supraclavicular Lymph Nodes Treatment in Breast Cancer Patients

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
M.D. Anderson Cancer Center
ClinicalTrials.gov Identifier:
NCT00658281
First received: April 8, 2008
Last updated: January 27, 2014
Last verified: January 2014
  Purpose

The goal of this clinical research study is to use the On Board Imager kilovoltage (OBI KV) system and cone beam computed tomography (CBCT) scanning or CT-on-rail system to look at how well a routine device called an electronic portal imaging device (EPID) can set up a patient to receive radiation therapy on the lymph nodes in the neck.


Condition Intervention
Breast Cancer
Procedure: CBCT Scan
Procedure: OBI KV Imaging

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: A Pilot Study of Setup Variation in the Supraclavicular Lymph Nodes Treatment in Breast Cancer Patients Using On-Board Imaging System With Linear Accelerator

Resource links provided by NLM:


Further study details as provided by M.D. Anderson Cancer Center:

Primary Outcome Measures:
  • System Failure (defined as 2 or more disagreements between the EPID and either OBI systems or CT-on-rail from among the 5 evaluations for a particular patient) [ Time Frame: CBCT scanning and OBI R or CT-on-rial system, 5 evaluations per patient, during 5-week radiation treatment period ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: March 2008
Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
OBI KV System + CBCT Scanning
Breast cancer patient radiation treatment set up using OBI KV system and CBCT scanning or CT-on-rail system to verify standard EPID for positioning.
Procedure: CBCT Scan
Cone Beam Computed Tomography (CBCT) scan performed once a week.
Procedure: OBI KV Imaging
On Board Imager kilovoltage (OBI KV) Imaging performed once a week.

  Hide Detailed Description

Detailed Description:

The Study Imaging Techniques for Radiation Treatment Planning:

The standard way to set up a patient to receive radiation therapy on the lymph nodes in the neck is by using an EPID, which uses high-energy X-rays to make images to see if the patient's body positioning for radiation therapy is correct or not. It is important for the doctors to see the position of the patient's lower neck so that radiation can be delivered to the right place.

The position of the patient's body during radiation therapy is typically checked once a week using an EPID or a similar device. While the patient is lying on the treatment table, the EPID system takes the necessary images. In this study, along with using an EPID, researchers will use the OBI KV system and CBCT scanning, in order to look at how well the standard EPID is describing the patient's neck position.

OBI KV imaging is designed to make images using low-energy X-rays, and the images are considered reasonably clear and easy for the doctors to read. CBCT scanning uses low-energy X-rays that let the doctors see the lymph nodes in the lower neck. Unlike regular CT scanning, CBCT scanning does not require "contrast" material to be used.

Since all 3 of the pieces of equipment (the EPID, OBI KV, and CBCT systems) are built into the same treatment machine, you will not need to move for the extra pieces of equipment that are being used in this study. You will lay very still, as usual, and the images will all be taken in a row.

Screening Tests:

The study doctor will review your medical chart to decide if you are eligible to take part in this study. If you are found to be eligible and you agree to take part, you will then begin the normal radiation treatment planning process. You will sign a separate consent form that will describe the radiation therapy and EPID procedures in more detail, as well as their risks.

During the treatment period when you are receiving radiation treatments once a day for 5 weeks, you will have CBCT scanning and OBI KV imaging performed once a week.

Before you receive radiation treatment, while you are lying on the treatment table, the EPID will be used. After that, the OBI KV and CBCT devices will rotate around you to take the images for this study. During the radiation therapy treatment, the EPID, OBI KV, and CBCT scans will be performed once a week, on the same day if possible. Sometimes the EPID and OBI KV scans will be performed during the same treatment, while the CBCT scan may be performed during another treatment that same week. It should take about 30 minutes to finish taking both the OBI KV and CBCT images.

The results of the CBCT scanning and OBI KV imaging will not, in any way, be used to plan your radiation therapy.

Length of Study Participation:

After your 5-week radiation treatment period, your participation in this study will be over.

This is an investigational study. The EPID is commercially available and FDA approved for use in setting up a patient to receive radiation therapy. OBI KV imaging and CBCT scanning are also commercially available and FDA approved for use in this purpose, but they are not typically used. What is experimental in this study is using additional procedures (OBI KV imaging and CBCT scanning) to check how reliably the EPID can set up a patient to receive radiation therapy on the lymph nodes in the neck.

Up to 30 evaluable patients will take part in this study. All will be enrolled at M. D. Anderson.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients diagnosed with breast cancer.

Criteria

Inclusion Criteria:

  1. Histologically confirmed carcinoma of the breast.
  2. AJCC Stage I-III, or locally recurrent breast cancer
  3. Planned for radiation treatment of the supraclavicular and axillary apex nodal beds using a SCV field
  4. Age greater than or equal to 18 years, since classic breast cancer is a disease of adults
  5. Able to understand the current trial and give informed consent

Exclusion Criteria:

  1. Has bilateral breast cancer requiring radiation to both breasts due to anatomic constraints on planning CT
  2. inflammatory carcinoma due to altered treatment schedule
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00658281

Locations
United States, Texas
UT MD Anderson Cancer Center
Houston, Texas, United States, 77030
Sponsors and Collaborators
M.D. Anderson Cancer Center
Investigators
Principal Investigator: Xiaochun Wang, PhD M.D. Anderson Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: M.D. Anderson Cancer Center
ClinicalTrials.gov Identifier: NCT00658281     History of Changes
Other Study ID Numbers: 2007-0132
Study First Received: April 8, 2008
Last Updated: January 27, 2014
Health Authority: United States: Institutional Review Board

Keywords provided by M.D. Anderson Cancer Center:
Breast Cancer
On Board Imager Kilovoltage
Cone Beam Computed Tomography
Electronic Portal Imaging Device
Lymph Nodes
CBCT
OBI KV

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases

ClinicalTrials.gov processed this record on July 22, 2014