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Eating Behavior in Adolescents
This study is currently recruiting participants.
Verified June 2011 by National Institutes of Health Clinical Center (CC)

First Received on March 7, 2008.   Last Updated on December 22, 2011   History of Changes
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00631644
  Purpose

This study will explore the eating habits of adolescents and determine if eating behavior is linked to genetics.

Healthy adolescents between 13 and 17 years of age may be eligible for this study. Candidates come to the NIH Clinical Center at 8:00 AM to be screened with the following:

  • Medical history and brief physical examination, including height, weight, and body fat measurements. Body fat is measured using a device called a Bod Pod. The adolescent sits inside the device for about 5 minutes and the machine determines body fat by measuring air movement. The adolescent must wear a tight-fitting swimsuit for this test.
  • Urine test to look for sugar or protein in the urine and to test for pregnancy in females.
  • Blood tests for routine chemistries and for gene studies related to eating behaviors.
  • Questionnaires and interviews about the adolescent's general health and eating habits.
  • Acclimatization to test meal conditions for the study. The adolescent is given a breakfast shake to drink.

Participants come to the NIH Clinical Center at 10:30 AM for laboratory meal testing. At this visit, the adolescent does the following:

  • Eats food from a buffet of everyday foods that most kids eat.
  • Fills out questionnaires.
  • Tastes and rates the flavor of a variety of snack foods.

Condition
Overweight
Eating Behavior
Binge Eating

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Eating Behavior in Adolescents

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 350
Study Start Date: March 2008
Detailed Description:

Little is known about the eating behaviors that place adolescents at heightened risk for overweight. In the proposed study, we aim to investigate the role that eating behaviors and genes may play in the development of overweight. Participants will be adolescent girls and boys from a racially/ethnically diverse sample of adolescents from the DC Metro community. Adolescent eating behavior will be observed during laboratory test meals. Adolescents will be provided with a large buffet of foods or a standard meal and instructed to eat until you are no longer hungry. Thirty minutes later, they will taste and rate a variety of highly palatable snack foods. Blood tests will be conducted to examine genes related to eating behavior. Assessments also will include affective states, degree of hunger, degree of fullness, body image satisfaction, disordered eating attitudes and behaviors, and measures of interpersonal interactions.

  Eligibility

Ages Eligible for Study:   13 Years to 17 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

Volunteers will qualify for participation in the study if they meet the following criteria:

  1. Age 13-17 years.
  2. Good general health as indicated by medical history and physical examination.
  3. Negative urine glucose and normal electrolytes, hepatic, and thyroid function.
  4. For the fMRI portion only: right handedness (required for standardization of responses).
  5. For the fMRI portion only: female.
  6. For the fMRI portion only: overweight (BMI greater than or equal to 85th percentile for age and sex).

EXCLUSION CRITERIA:

Volunteers will be excluded if they have any of the following:

  1. Medical problem likely to affect caloric intake.
  2. History of any condition including psychiatric disorders in either child or their responsible parent that in the opinion of the investigators would impede competence to sign consent, interfere with adherence to procedures, or possibly hinder completion of the study.
  3. Pregnancy.
  4. Use of medication likely to affect caloric intake.
  5. History of significant neurological injury or insult.
  6. For the fMRI portion only: braces (or other metal) that would interfere with the fMRI procedure.
  7. For the fMRI portion only: non-native English speakers (required for standardization of responses).
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00631644

Contacts
Contact: Patient Recruitment and Public Liaison Office (800) 411-1222 prpl@mail.cc.nih.gov
Contact: TTY 1-866-411-1010

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Sub-Investigator: Patient Recruitment and Public Liaison Office (PRPL) For more information at the NIH Clinical Center contact            
Sponsors and Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  More Information

Additional Information:
NIH Clinical Center Detailed Web Page  This link exits the ClinicalTrials.gov site

Publications:
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006 Apr 5;295(13):1549-55.
Barros A. [Individual impression spoon from self polymerising plastics] Zahnarztl Prax. 1967 Jan 1;18(1):1. German. No abstract available.
Taylor ED, Theim KR, Mirch MC, Ghorbani S, Tanofsky-Kraff M, Adler-Wailes DC, Brady S, Reynolds JC, Calis KA, Yanovski JA. Orthopedic complications of overweight in children and adolescents. Pediatrics. 2006 Jun;117(6):2167-74.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Shomaker LB, Tanofsky-Kraff M, Zocca JM, Courville A, Kozlosky M, Columbo KM, Wolkoff LE, Brady SM, Crocker MK, Ali AH, Yanovski SZ, Yanovski JA. Eating in the absence of hunger in adolescents: intake after a large-array meal compared with that after a standardized meal. Am J Clin Nutr. 2010 Oct;92(4):697-703. Epub 2010 Aug 18.

ClinicalTrials.gov Identifier: NCT00631644     History of Changes
Other Study ID Numbers: 080085, 08-CH-0085
Study First Received: March 7, 2008
Last Updated: December 22, 2011
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Adolescents
Eating Behavior
Eating in the Absence of Hunger
Disordered Eating
Food Intake
 Macronutrient Composition
Obesity
Adolescent
Healthy Volunteer
HV

Additional relevant MeSH terms:
Bulimia
Bulimia Nervosa
Binge-Eating Disorder
Overweight
Hyperphagia
 Signs and Symptoms, Digestive
Signs and Symptoms
Eating Disorders
Mental Disorders
Body Weight

ClinicalTrials.gov processed this record on February 09, 2012



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