Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) - Full Text View

Sponsor:	University of California, Irvine
Collaborator:	Mainz University
Information provided by:	University of California, Irvine
ClinicalTrials.gov Identifier:	NCT00610402

Purpose

Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life.

Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma.

These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.

Condition
Sturge - Weber Syndrome (SWS)

Study Type:	Observational
Study Design:	Case-Only, Prospective
Official Title:	Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)

Resource links provided by NLM:

Genetics Home Reference related topics: hypohidrotic ectodermal dysplasia

MedlinePlus related topics: Glaucoma

U.S. FDA Resources

Further study details as provided by University of California, Irvine:

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

blood sample tear drop sample

Enrollment:	57
Study Start Date:	July 2007
Study Completion Date:	June 2008
Primary Completion Date:	July 2007 (Final data collection date for primary outcome measure)

Detailed Description:

The ocular antibody profile in patients with SWS is unknown.The researchers want to study on blood and tear drop samples from patients with SWS to determine the incidence of ocular antibodies in patients with this syndrome.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

community sample

Criteria

Inclusion Criteria:

Male and female volunteers with SWS of all ages

Exclusion Criteria:

Volunteers without SWS

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00610402

Locations

United States, California
Beckman Laser Institute Medical clinic
Irvine, California, United States, 92612

Sponsors and Collaborators

University of California, Irvine

Mainz University

Investigators

Principal Investigator:

John S Nelson, M.D,PhD

Beckman Laser Institute University of California Irvine

More Information

No publications provided

Responsible Party:	Beckman Laser Institute, University of California, Irvine ( J. Stuart Nelson, M.D., Ph.D. Associate Director and Medical Director at the Beckman Laser Institute and Medical Clinic )
Study ID Numbers:	NIH-LAMMP P41-RR01192
Study First Received:	January 25, 2008
Last Updated:	March 13, 2009
ClinicalTrials.gov Identifier:	NCT00610402 History of Changes
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:

Angiomatosis
Klippel-Trenaunay-Weber Syndrome
Brain Diseases
Cerebrovascular Disorders
Pathologic Processes
Sturge-Weber Syndrome
Syndrome
Neoplasms, Vascular Tissue
Hemangioma
Abnormalities, Multiple
Brain Ischemia
Cardiovascular Diseases
Congenital Abnormalities
Ectodermal Dysplasia

Skin Diseases, Genetic
Neurocutaneous Syndromes
Disease
Neoplasms by Histologic Type
Skin Diseases
Stroke
Nervous System Diseases
Vascular Diseases
Skin Abnormalities
Central Nervous System Diseases
Brain Stem Infarctions
Neoplasms
Genetic Diseases, Inborn
Brain Infarction

ClinicalTrials.gov processed this record on November 27, 2009