BEATRICE Study: A Study of Avastin (Bevacizumab) Adjuvant Therapy in Triple Negative Breast Cancer.
This study is ongoing, but not recruiting participants.
Sponsor:
Hoffmann-La Roche
Information provided by (Responsible Party):
Hoffmann-La Roche
ClinicalTrials.gov Identifier:
NCT00528567
First received: September 11, 2007
Last updated: February 4, 2013
Last verified: February 2013
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Purpose
This 2 arm open-label study will evaluate the efficacy and safety of the addition of Avastin (bevacizumab) to standard adjuvant therapy in patients with triple negative breast cancer. Patients will be randomized to receive either standard chemotherapy (anthracycline +/- taxane or taxane only), or standard chemotherapy given concurrently with 1 year of Avastin (5mg/kg/week dosing equivalent i.v.). The anticipated time on study treatment is 3-12 months, and the target sample size is 500+ individuals.
| Condition | Intervention | Phase |
|---|---|---|
|
Breast Cancer |
Drug: bevacizumab [Avastin] Drug: Standard adjuvant chemotherapy |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | An Open Label 2-arm Study to Evaluate the Impact of Adjuvant Bevacizumab on Invasive Disease Free Survival in Triple Negative Breast Cancer |
Resource links provided by NLM:
Genetics Home Reference related topics:
breast cancer
Drug Information available for:
Bevacizumab
U.S. FDA Resources
Further study details as provided by Hoffmann-La Roche:
Primary Outcome Measures:
- Invasive disease-free survival [ Time Frame: Event driven ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Overall survival, breast cancer-free interval, disease-free interval, distant disease-free survival. [ Time Frame: Event driven. ] [ Designated as safety issue: No ]
- AEs, and laboratory parameters. [ Time Frame: Throughout study ] [ Designated as safety issue: No ]
| Enrollment: | 2587 |
| Study Start Date: | December 2007 |
| Estimated Study Completion Date: | January 2015 |
| Estimated Primary Completion Date: | January 2015 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: 1 |
Drug: bevacizumab [Avastin]
5mg/kg / week dosing equivalent iv
Drug: Standard adjuvant chemotherapy
As prescribed
|
| Active Comparator: 2 |
Drug: Standard adjuvant chemotherapy
As prescribed
|
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- adult patients, >=18 years of age;
- operable primary invasive breast cancer;
- completed definitive loco-regional surgery;
- primary tumor centrally confirmed as triple negative.
Exclusion Criteria:
- locally advanced breast cancers;
- previous breast cancer history;
- clinically significant cardiovascular disease.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00528567
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| United States, Alabama | |
| Huntsville, Alabama, United States, 35805 | |
| Mobile, Alabama, United States, 36604 | |
| United States, Arkansas | |
| Fayetteville, Arkansas, United States, 72703 | |
| United States, California | |
| Bakersfield, California, United States, 93309 | |
| Fountain Valley, California, United States, 92708 | |
| Greenbrae, California, United States, 94904 | |
| Los Angeles, California, United States, 90057 | |
| Pleasant Hill, California, United States, 94523 | |
| United States, Connecticut | |
| Fairfield, Connecticut, United States, 06824 | |
| Stamford, Connecticut, United States, 06902 | |
| United States, District of Columbia | |
| Washington, District of Columbia, United States, 20010 | |
| United States, Florida | |
| Gainesville, Florida, United States, 32605 | |
| Orlando, Florida, United States, 32806 | |
| Tamarac, Florida, United States, 33321 | |
| United States, Georgia | |
| Atlanta, Georgia, United States, 30318 | |
| Augusta, Georgia, United States, 30901 | |
| Lawrenceville, Georgia, United States, 30046 | |
| United States, Illinois | |
| Niles, Illinois, United States, 60714 | |
| United States, Iowa | |
| Iowa City, Iowa, United States, 52242 | |
| Waterloo, Iowa, United States, 50702 | |
| United States, Maryland | |
| Baltimore, Maryland, United States, 21237 | |
| Baltimore, Maryland, United States, 21215 | |
| Rockville, Maryland, United States, 20850-3348 | |
| United States, Michigan | |
| Brownstown, Michigan, United States, 48183 | |
| Kalamazoo, Michigan, United States, 49007 | |
| Southfield, Michigan, United States, 48075-3707 | |
| United States, Missouri | |
| Kansas City, Missouri, United States, 64111 | |
| St Louis, Missouri, United States, 63141 | |
| United States, New Jersey | |
| Long Branch, New Jersey, United States, 07740 | |
| United States, New York | |
| Bronx, New York, United States, 10469 | |
| United States, North Carolina | |
| Hickory, North Carolina, United States, 28602 | |
| Winston-salem, North Carolina, United States, 27103 | |
| United States, Ohio | |
| Cincinnati, Ohio, United States, 45242 | |
| Columbus, Ohio, United States, 43235 | |
| Middletown, Ohio, United States, 45042 | |
| United States, South Carolina | |
| Columbia, South Carolina, United States, 29210 | |
| United States, Tennessee | |
| Chattanooga, Tennessee, United States, 37404 | |
| Germantown, Tennessee, United States, 38138 | |
| Nashville, Tennessee, United States, 37203 | |
| United States, Texas | |
| Austin, Texas, United States, 78759 | |
| Dallas, Texas, United States, 75234 | |
| United States, Vermont | |
| Rutland, Vermont, United States, 05701 | |
| United States, Virginia | |
| Abingdon, Virginia, United States, 24211 | |
| Richmond, Virginia, United States, 23230 | |
| Argentina | |
| Buenos Aires, Argentina, C1405DCS | |
| Rosario, Argentina, S2002KDS | |
| Australia | |
| Brisbane, Australia, 4104 | |
| Brisbane, Australia, 4006 | |
| Camperdown, Australia, 2050 | |
| East Bentleigh, Australia, VIC 3165 | |
| Fitzroy, Australia, 3065 | |
| Geelong, Australia, 3220 | |
| Heidelberg, Australia, 3084 | |
| Kurralta Park, Australia, 5035 | |
| Malvern, Australia, 3144 | |
| Nambour, Australia, 4560 | |
| Parkville, Australia, 3052 | |
| Perth, Australia, 6000 | |
| Perth, Australia, 6008 | |
| Port Macquarie, Australia, 2444 | |
| St. Leonards, Australia, 2065 | |
| Sydney, Australia, 2065 | |
| Sydney, Australia, 2031 | |
| Sydney, Australia, 2060 | |
| Sydney, Australia, 2139 | |
| Wahroonga, Australia, 2076 | |
| Waratah, Australia, 2298 | |
| Wodonga, Australia, 3690 | |
| Wollongong, Australia, 2500 | |
| Austria | |
| Bludesch, Austria, 6712 | |
| Graz, Austria, 8036 | |
| Innsbruck, Austria, 6020 | |
| Krems, Austria, 4560 | |
| Leoben, Austria, 8700 | |
| Linz, Austria, 4020 | |
| Salzburg, Austria, 5020 | |
| Wels, Austria, 4600 | |
| Wien, Austria, 1090 | |
| Wien, Austria, 1130 | |
| Wiener Neustadt, Austria, 2700 | |
| Wolfsberg, Austria, 9400 | |
| Belgium | |
| Baudour, Belgium, 7331 | |
| Bruxelles, Belgium, 1090 | |
| Hasselt, Belgium, 3500 | |
| Namur, Belgium, 5000 | |
| Sint-niklaas, Belgium, 9100 | |
| Tournai, Belgium, 7500 | |
| Wilrijk, Belgium, 2610 | |
| Bosnia and Herzegovina | |
| Sarajevo, Bosnia and Herzegovina, 71000 | |
| Brazil | |
| Goiania, Brazil, 74075-040 | |
| Ijui, Brazil, 98700-000 | |
| JAU, Brazil, 17210-120 | |
| Porto Alegre, Brazil, 90035-903 | |
| Porto Alegre, Brazil, 90430-090 | |
| Porto Alegre, Brazil, 91350-200 | |
| Rio de Janeiro, Brazil, 22260-020 | |
| Santo Andre, Brazil, 09060-870 | |
| Sao Paulo, Brazil, 05403 | |
| Sao Paulo, Brazil, 01209-010 | |
| Sao Paulo, Brazil, 1401000 | |
| Sao Paulo, Brazil, 01317-000 | |
| Sorocaba, Brazil, 18030-245 | |
| Canada, Alberta | |
| Edmonton, Alberta, Canada, T6G 1Z2 | |
| Canada, British Columbia | |
| Surrey, British Columbia, Canada, V3V 1Z2 | |
| Vancouver, British Columbia, Canada, V5Z 4E6 | |
| Canada, Manitoba | |
| Winnipeg, Manitoba, Canada, R2H 2A6 | |
| Canada, New Brunswick | |
| Moncton, New Brunswick, Canada, E1C 6Z8 | |
| Canada, Newfoundland and Labrador | |
| St. John's, Newfoundland and Labrador, Canada, A1B 3V6 | |
| Canada, Nova Scotia | |
| Halifax, Nova Scotia, Canada, B3H 2Y9 | |
| Canada, Ontario | |
| Kingston, Ontario, Canada, K7L 5P9 | |
| Kitchener, Ontario, Canada, N2G 1G3 | |
| London, Ontario, Canada, N6A 4L6 | |
| Mississauga, Ontario, Canada, L5M 2N1 | |
| Oshawa, Ontario, Canada, L1G 2B9 | |
| Ottawa, Ontario, Canada, K1H 8L6 | |
| Sudbury, Ontario, Canada, P3E 5J1 | |
| Toronto, Ontario, Canada, M9N 1N8 | |
| Toronto, Ontario, Canada, M4N 3M5 | |
| Toronto, Ontario, Canada, M5G 2M9 | |
| Windsor, Ontario, Canada, N8W 2X3 | |
| Canada, Quebec | |
| Greenfield Park, Quebec, Canada, J4V 2H1 | |
| Montreal, Quebec, Canada, H1T 2M4 | |
| Montreal, Quebec, Canada, H2W 1S6 | |
| Canada, Saskatchewan | |
| Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
| Canada | |
| Quebec, Canada, G1S 4L8 | |
| China | |
| Beijing, China, 100021 | |
| Beijing, China, 100071 | |
| Beijing, China, 100032 | |
| Beijing, China, 100853 | |
| Changchun, China, 130012 | |
| Chengdu, China, 610041 | |
| Fuzhou, China, 350025 | |
| Guangzhou, China, 510060 | |
| Hang Zhou, China, 310022 | |
| Shanghai, China, 200032 | |
| Suzhou, China, 215006 | |
| Tianjin, China, 300060 | |
| Wuhan, China, 430030 | |
| Zhejiang, China, 310003 | |
| Costa Rica | |
| San Jose, Costa Rica, 10103 | |
| Czech Republic | |
| Brno, Czech Republic, 656 53 | |
| Novy Jicin, Czech Republic, 741 01 | |
| Olomouc, Czech Republic, 775 20 | |
| Pardubice, Czech Republic, 532 03 | |
| Praha, Czech Republic, 150 06 | |
| Finland | |
| Tampere, Finland, 33520 | |
| Turku, Finland, 20521 | |
| France | |
| Angers, France, 49933 | |
| Bayonne, France, 64100 | |
| Besancon, France, 25030 | |
| Bobigny, France, 93009 | |
| Bordeaux, France, 33077 | |
| Brest, France, 29609 | |
| Clermont Ferrand, France, 63050 | |
| Colmar, France, 68024 | |
| Grenoble, France, 38100 | |
| La Chaussee St Victor, France, 41260 | |
| Le Mans, France, 72000 | |
| Lille, France, 59000 | |
| Lille, France, 59020 | |
| Limoges, France, 87039 | |
| Marseille, France, 13285 | |
| Montbeliard, France, 25209 | |
| Montpellier, France, 34298 | |
| Mougins, France, 6250 | |
| Nancy, France, 54100 | |
| Neuilly Sur Seine, France, 92200 | |
| Paris, France, 75010 | |
| Paris, France, 75908 | |
| Paris, France, 75231 | |
| Rouen, France, 76038 | |
| Saint-cloud, France, 92210 | |
| Senlis, France, 60309 | |
| Strasbourg, France, 67010 | |
| Toulon, France, 83056 | |
| Tours, France, 37044 | |
| Germany | |
| Berlin, Germany, 10317 | |
| Berlin, Germany, 14195 | |
| Bielefeld, Germany, 33604 | |
| Bonn, Germany, 53111 | |
| Chemnitz, Germany, 09116 | |
| Coburg, Germany, 96450 | |
| Dortmund, Germany, 44137 | |
| Dresden, Germany, 01307 | |
| Düsseldorf, Germany, 40225 | |
| Frankfurt Am Main, Germany, 60389 | |
| Freiburg, Germany, 79106 | |
| Georgsmarienhütte, Germany, 49124 | |
| Greifswald, Germany, 17475 | |
| Hamburg, Germany, 20246 | |
| Hamburg, Germany, 20357 | |
| Heidelberg, Germany, 69115 | |
| Herne, Germany, 44625 | |
| Kassel, Germany, 34117 | |
| Kiel, Germany, 24105 | |
| Koeln, Germany, 50924 | |
| Krefeld, Germany, 47805 | |
| Leipzig, Germany, 04129 | |
| Lemgo, Germany, 32657 | |
| Lüneburg, Germany, 21339 | |
| Magdeburg, Germany, 39108 | |
| Marburg, Germany, 35043 | |
| München, Germany, 81925 | |
| Münster, Germany, 48149 | |
| Offenbach, Germany, 63069 | |
| Offenburg, Germany, 77654 | |
| Recklinghausen, Germany, 45657 | |
| Rosenheim, Germany, 83022 | |
| Stade, Germany, 21680 | |
| Trier, Germany, 54290 | |
| Tübingen, Germany, 72076 | |
| ULM, Germany, 89075 | |
| WEIßENFELS, Germany, 06667 | |
| Wiesbaden, Germany, 65199 | |
| Witten, Germany, 58452 | |
| Greece | |
| Heraklion, Greece, 71110 | |
| Patras, Greece, 26500 | |
| Thessaloniki, Greece, 56429 | |
| Hong Kong | |
| Hong Kong, Hong Kong | |
| Hong Kong, Hong Kong, 852 | |
| Israel | |
| Haifa, Israel, 31096 | |
| Jerusalem, Israel, 91120 | |
| Kfar Saba, Israel, 44281 | |
| Petach Tikva, Israel, 49100 | |
| Ramat-gan, Israel, 52621 | |
| Rehovot, Israel, 76100 | |
| Tel Aviv, Israel, 64239 | |
| Italy | |
| Aviano, Italy, 33081 | |
| Bari, Italy, 70126 | |
| Bergamo, Italy, 24128 | |
| Brescia, Italy, 25123 | |
| Brindisi, Italy, 72100 | |
| Candiolo, Italy, 10060 | |
| Cattolica, Italy, 47841 | |
| Cesena, Italy, 47023 | |
| Fano, Italy, 61032 | |
| Genova, Italy, 16142 | |
| Lecce, Italy, 73100 | |
| Lido Di Camaiore, Italy, 55043 | |
| Livorno, Italy, 57100 | |
| Lugo, Italy | |
| Mantova, Italy, 46100 | |
| Noale, Italy, 30033 | |
| Padova, Italy, 35128 | |
| Palermo, Italy, 90146 | |
| Parma, Italy, 43100 | |
| Pavia, Italy, 27100 | |
| Potenza, Italy, 85100 | |
| Ravenna, Italy, 48100 | |
| Rimini, Italy, 47037 | |
| Roma, Italy, 00161 | |
| Roma, Italy, 00158 | |
| Roma, Italy, 00144 | |
| Rozzano, Italy, 20089 | |
| San Giovanni Rotondo, Italy, 71013 | |
| Sassari, Italy, 07100 | |
| Taormina, Italy, 98039 | |
| Treviglio, Italy, 24047 | |
| Vecchiazzano, Italy, 47100 | |
| Japan | |
| Aichi, Japan, 464-8681 | |
| Ehime, Japan, 791-0280 | |
| Fukuoka, Japan, 811-1395 | |
| Kyoto, Japan, 606-8507 | |
| Osaka, Japan, 540-0006 | |
| Saitama, Japan, 350-1298 | |
| Tokyo, Japan, 135-8550 | |
| Tokyo, Japan, 104-8560 | |
| Tokyo, Japan, 104-0045 | |
| Tokyo, Japan, 113-8677 | |
| Korea, Republic of | |
| Kyunggi-do, Korea, Republic of, 411-769 | |
| Seoul, Korea, Republic of, 110-744 | |
| Seoul, Korea, Republic of, 138-736 | |
| Seoul, Korea, Republic of, 135-170 | |
| Seoul, Korea, Republic of, 137-702 | |
| Macedonia, The Former Yugoslav Republic of | |
| Skopje, Macedonia, The Former Yugoslav Republic of, 1000 | |
| Malaysia | |
| Kelantan, Malaysia | |
| Penang, Malaysia, 11200 | |
| Petaling Jaya, Selangor, Malaysia, 46050 | |
| Selangor, Malaysia, 47500 | |
| Mexico | |
| Leon, Mexico, 37000 | |
| Monterrey, Mexico, 64020 | |
| Netherlands | |
| Delftzijl, Netherlands, 9934 JD | |
| Den Helder, Netherlands, 1782GZ | |
| Groningen, Netherlands, 9713 GZ | |
| Tilburg, Netherlands, 5042 AD | |
| New Zealand | |
| Auckland, New Zealand | |
| Wellington, New Zealand, 6002 | |
| Peru | |
| Lima, Peru, 11 | |
| Philippines | |
| Cebu, Philippines, 6000 | |
| Quezon City, Philippines, 1114 | |
| Poland | |
| Elblag, Poland, 82-300 | |
| Lodz, Poland, 93-509 | |
| Lublin, Poland, 20-090 | |
| Lublin, Poland, 20-081 | |
| Poznan, Poland, 61-878 | |
| Warsaw, Poland, 61485 | |
| Warszawa, Poland, 02-781 | |
| Portugal | |
| Coimbra, Portugal, 3000-075 | |
| Lisboa, Portugal, 1099-023 | |
| Lisboa, Portugal, 1649-035 | |
| Romania | |
| Bucharest, Romania, 022328 | |
| Cluj Napoca, Romania, 400015 | |
| Russian Federation | |
| Chelyabinsk, Russian Federation, 454 087 | |
| Ekaterinburg, Russian Federation, 620905 | |
| Ivanovo, Russian Federation, 153040 | |
| Kazan, Russian Federation, 420111 | |
| Kazan, Russian Federation, 420029 | |
| Moscow, Russian Federation, 115478 | |
| Moscow, Russian Federation, 117837 | |
| Moscow, Russian Federation, 121356 | |
| Obninsk, Russian Federation, 249036 | |
| Persochnysaint-petersburg, Russian Federation, 197758 | |
| Ryazan, Russian Federation, 390011 | |
| Samara, Russian Federation, 443066 | |
| St Petersburg, Russian Federation | |
| UFA, Russian Federation, 450054 | |
| Serbia | |
| Belgrade, Serbia, 11000 | |
| Sremska Kamenica, Serbia, 21204 | |
| Singapore | |
| Singapore, Singapore, 119228 | |
| Singapore, Singapore, 169610 | |
| South Africa | |
| Bloemfontein, South Africa, 9301 | |
| Durban, South Africa, 4001 | |
| Johannesburg, South Africa, 2196 | |
| Pietermaritzburg, South Africa, 3201 | |
| Pretoria, South Africa, 0181 | |
| Pretoria, South Africa, 0002 | |
| Spain | |
| Barcelona, Spain, 08003 | |
| Barcelona, Spain, 08035 | |
| Burgos, Spain, 09005 | |
| Gijon, Spain, 33394 | |
| Girona, Spain, 17007 | |
| La Laguna, Spain, 38320 | |
| Madrid, Spain, 28222 | |
| Madrid, Spain, 28034 | |
| Madrid, Spain, 28046 | |
| Madrid, Spain, 28041 | |
| Madrid, Spain, 28033 | |
| Malaga, Spain, 29010 | |
| Mataro, Spain, 08304 | |
| Málaga, Spain, 29010 | |
| Navarra, Spain, 31008 | |
| Palma de Mallorca, Spain, 07014 | |
| Pontevedra, Spain, 36002 | |
| Terrassa, Spain, 08221 | |
| Valencia, Spain, 41014 | |
| Valencia, Spain, 46017 | |
| Zaragoza, Spain, 50009 | |
| Sweden | |
| Eskilstuna, Sweden, 63188 | |
| Gaevle, Sweden, 80187 | |
| Lund, Sweden, 22185 | |
| Malmoe, Sweden, 20502 | |
| Umea, Sweden, 90185 | |
| Uppsala, Sweden, 751 85 | |
| Switzerland | |
| Aarau, Switzerland, 5001 | |
| Basel, Switzerland, 4031 | |
| Bern, Switzerland, 3010 | |
| Chur, Switzerland, 7000 | |
| Thun, Switzerland, 3600 | |
| Winterthur, Switzerland, 8401 | |
| Zürich, Switzerland, 8008 | |
| Taiwan | |
| Changhua, Taiwan, 500 | |
| Kaohsiung, Taiwan, 813 | |
| Kaohsiung, Taiwan, 807 | |
| Tainan, Taiwan, 704 | |
| Taipei, Taiwan, 112 | |
| Taipei, Taiwan, 114 | |
| Taipei, Taiwan, 100 | |
| Taoyuan, Taiwan, 333 | |
| Thailand | |
| Bangkok, Thailand, 10400 | |
| Bangkok, Thailand, 10700 | |
| Chiang Mai, Thailand, 50200 | |
| Songkhla, Thailand, 90110 | |
| United Kingdom | |
| Belfast, United Kingdom, BT9 7AB | |
| Birmingham, United Kingdom, B15 2TT | |
| Bournemouth, United Kingdom, BH7 7DW | |
| Brighton, United Kingdom, BN2 5BE | |
| Bristol, United Kingdom, BS2 8ED | |
| Cambridge, United Kingdom, CB2 2QQ | |
| Cardiff, United Kingdom, CF14 2TL | |
| Chelsmford, United Kingdom, CM1 7ET | |
| Colchester, United Kingdom, CO3 3NB | |
| Dundee, United Kingdom, DD1 9SY | |
| Edinburgh, United Kingdom, EH4 2XU | |
| Epping, United Kingdom, CM16 6TN | |
| Exeter, United Kingdom, EX2 5DW | |
| Glasgow, United Kingdom, G12 0YN | |
| Guildford, United Kingdom, GU2 5XX | |
| Huddersfield, United Kingdom, HD3 3EA | |
| Ipswich, United Kingdom, IP4 5PD | |
| Leeds, United Kingdom, LS9 7TF | |
| London, United Kingdom, NW3 2QG | |
| London, United Kingdom, SE1 9RT | |
| London, United Kingdom, W2 1NY | |
| London, United Kingdom, EC1 A7BE | |
| Manchester, United Kingdom, M20 4BX | |
| Merseyside, United Kingdom, CH63 45Y | |
| Newcastle Upon Tyne, United Kingdom, NE4 6BE | |
| Northwood, United Kingdom, HA6 2RN | |
| Peterborough, United Kingdom, PE 3 9GZ | |
| Sheffield, United Kingdom, S1O 2SJ | |
| Southampton, United Kingdom, SO16 6YD | |
| Stoke-on-trent, United Kingdom, ST4 7LN | |
| Truro, United Kingdom, TR1 3LJ | |
| Wolverhampton, United Kingdom, WV10 0QP | |
Sponsors and Collaborators
Hoffmann-La Roche
Investigators
| Study Director: | Clinical Trials | Hoffmann-La Roche |
More Information
No publications provided
| Responsible Party: | Hoffmann-La Roche |
| ClinicalTrials.gov Identifier: | NCT00528567 History of Changes |
| Other Study ID Numbers: | BO20289 |
| Study First Received: | September 11, 2007 |
| Last Updated: | February 4, 2013 |
| Health Authority: | France: AFSSAPS |
Additional relevant MeSH terms:
|
Breast Neoplasms Neoplasms by Site Neoplasms Breast Diseases Skin Diseases Adjuvants, Immunologic Bevacizumab Immunologic Factors |
Physiological Effects of Drugs Pharmacologic Actions Angiogenesis Inhibitors Angiogenesis Modulating Agents Growth Substances Growth Inhibitors Antineoplastic Agents Therapeutic Uses |
ClinicalTrials.gov processed this record on May 19, 2013