Growth and Metabolic Response to GH and GnRHa Treatment Versus GH Alone in Boys Born SGA.

This study has been completed.
Sponsor:
Collaborator:
Pfizer
Information provided by:
Rabin Medical Center
ClinicalTrials.gov Identifier:
NCT00522743
First received: August 29, 2007
Last updated: July 13, 2010
Last verified: July 2010
  Purpose

A 2-arms randomized open prospective intervention study to determine the Growth and metabolic response to growth hormone and gonadotropin-releasing hormone agonist treatment versus growth hormone alone in boys born SGA.

All subjects will be treated with NorditropinSimplex at a dosage of 100mcg/kg/d.

At onset of puberty, subjects will be randomized into either combined treatment with GH and GnRHa or GH alone.


Condition Intervention
SGA and Growth
Drug: growth hormone and gonadotropin-releasing hormone agonist
Drug: growth hormone

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Two Arms, Open, Controlled, Prospective, Intervention Study to Evaluate the Growth and Metabolic Response to Growth Hormone and Gonadotropin-releasing Hormone Agonist Treatment Versus Growth Hormone Alone in Boys Born SGA

Resource links provided by NLM:


Further study details as provided by Rabin Medical Center:

Primary Outcome Measures:
  • Height measurements [ Time Frame: every 3 monthes, during all study period ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • IGF-1 concentration [ Time Frame: every 6 monthes, during all study period ] [ Designated as safety issue: Yes ]
  • Hormone profile, Lipid and lipoprotein concentrations [ Time Frame: once a year during all study period ] [ Designated as safety issue: No ]
  • Prepubertal changes [ Time Frame: every 3 monthes during all study peiod ] [ Designated as safety issue: No ]
  • Bone age [ Time Frame: once a year, during all study period ] [ Designated as safety issue: No ]
  • quality of life questionnaire [ Time Frame: once a year, during all study period ] [ Designated as safety issue: No ]
  • Psychological questionnaire [ Time Frame: once a year, during all study peiod ] [ Designated as safety issue: No ]

Enrollment: 17
Study Start Date: May 2005
Study Completion Date: July 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
GH & GNRHa treatment
Drug: growth hormone and gonadotropin-releasing hormone agonist
GH & GNRHa treatment
Active Comparator: 2
GH treatment
Drug: growth hormone
GH treatment

  Hide Detailed Description

Detailed Description:

A 2-arms randomized open prospective intervention study including 20 boys, in order to determine the effect of growth hormone (GH) and gonadotropin-releasing hormone agonist treatment versus growth hormone (GnRHa) alone on growth and metabolic response.

Objectives:

The primary objective is to investigate the effect of delaying the pubertal process by pubertal suppression on growth and final height of boys who were born SGA and treated with GH.

The secondary objectives are to determine the metabolic effect of the combined therapy of GH plus gonadotropin agonists to that of GH alone on the dietary intake, serum leptin, ghrelin, IGF-1, lipid and lipoprotein concentrations prior to and during treatment, and to assess the quality of life between the two groups.

Study population:

20 prepubertal boys.

Inclusion Criteria:

  1. Ages 10-13
  2. IUGR
  3. Height of at least 2 standard deviations below the mean height for chronological age and sex according to the 2000 standards from the Centers for Disease Control and Prevention (CDC).
  4. prepubertal(Tanner stage 1) at commencement of trail.
  5. Peak GH above 10ng/ml in at least one provocative test for GH secretion.
  6. Signed informed consent form.

Exclusion criteria:

  1. Growth retardation associated with malignancy, severe chronic disease, genetic syndromes and endocrine disorders.
  2. Diabetes.
  3. Treatment with any medical product which may interfere with GH effects.

Trail design:

A prospective, randomized controlled study assessing the impact of two years of combined treatment with GH and GnRHa on height of boys with severe growth failure due to SGA with height >2.25 SDS , compared with GH alone.

All subjects will be treated with NorditropinSimplex at a dosage of 100mcg/kg/d. At onset of puberty (testicular volume greater than 4 ml in consecutive examinations) subjects will be randomized into either combined treatment with GH and GnRHa or GH alone.

Methods:

  1. Urine test will be held every three months.
  2. X-ray photograph for bone age determination will be taken at baseline and every year after.
  3. Blood will be taken at baseline and every year after in order to evaluate the following parameters: Lipid and lipoprotein concentrations, ghrelin, leptin, glucose, insulin and HbA1c.
  4. Blood will be taken on randomization visit and three months after in order to evaluated the following parameters: LH, FSH and Testosterone
  5. Blood will be taken at baseline and every half a year after to evaluate levels of IGF-1.
  6. For evaluation of the growth hormone response, additional blood tests will be preformed one month and three months after treatment with growth hormone.
  7. On every blood and urine that will be taken, proteomic analysis will be held.
  8. Before treatment with growth hormone, one year after treatment and in the end of the study quality of life questionnaire, appetite questionnaire and Psychological questionnaires will be filled.

The safety of growth hormone treatment will be assessed from:

  1. Monitoring of adverse events.
  2. Measurement of HbA1c.
  3. Measurement of hematology, serum biochemistry and urinalysis laboratory variables.
  4. Measurement of fasting glucose and insulin concentrations.
  5. IGF-1
  6. Physical examinations and measurements of vital signs height and body weight.
  7. Measurement of bone age.
  Eligibility

Ages Eligible for Study:   9 Years to 13 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Boys
  2. IUGR
  3. Ages 10-13
  4. height of at list 2.0 standard deviations below the mean height for chronological age and sex according to the 2000 standards from the Centers for Disease Control and Prevention (CDC)
  5. Prepubertal (tanner stage 1) at commencement of trail
  6. Peak GH above 10ng/ml in at least one provocative test for GH secretion 7.Signed informed consent

Exclusion Criteria:

  1. Growth retardation associated with malignancy, severe chronic disease, genetic syndromes and endocrine disorders
  2. Diabetes
  3. Treatment with any medical product which may interfere with GH effects
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00522743

Locations
Israel
Schnider children medical center
Petach-Tikva, Israel
Sponsors and Collaborators
Rabin Medical Center
Pfizer
Investigators
Principal Investigator: Moshe Phillip, Professor Rabin Medical Center
  More Information

No publications provided

Responsible Party: Prof. Moshe Phillip, Rabin Medical Center
ClinicalTrials.gov Identifier: NCT00522743     History of Changes
Other Study ID Numbers: rmc073243ctil, SGA boys 3243
Study First Received: August 29, 2007
Last Updated: July 13, 2010
Health Authority: Israel: Ministry of Health

Keywords provided by Rabin Medical Center:
SGA
GH
GnRHa
IGF-1

Additional relevant MeSH terms:
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on April 23, 2014