Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
Trial record 1 of 1 for:    CALGB 140503
Previous Study | Return to List | Next Study

Comparison of Different Types of Surgery in Treating Patients With Stage IA Non-Small Cell Lung Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2013 by National Cancer Institute (NCI)
Sponsor:
Collaborators:
Radiation Therapy Oncology Group
American College of Surgeons
Southwest Oncology Group
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00499330
First received: July 10, 2007
Last updated: February 15, 2013
Last verified: February 2013
  Purpose

RATIONALE: Wedge resection or segmentectomy may be less invasive types of surgery than lobectomy for non-small cell lung cancer and may have fewer side effects and improve recovery. It is not yet known whether wedge resection or segmentectomy are more effective than lobectomy in treating stage IA non-small cell lung cancer.

PURPOSE: This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer.


Condition Intervention Phase
Lung Cancer
Procedure: therapeutic thoracoscopy
Procedure: videothoracoscopy
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment
Official Title: A Phase III Randomized Trial of Lobectomy Versus Sublobar Resection for Small (≤ 2 CM) Peripheral Non-Small Cell Lung Cancer

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Disease-free survival [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Overall survival [ Designated as safety issue: No ]
  • Rate of loco-regional and systemic recurrence [ Designated as safety issue: No ]
  • Pulmonary function as measured by expiratory flow rate 6 months postoperatively [ Designated as safety issue: No ]

Estimated Enrollment: 1258
Study Start Date: June 2007
Estimated Primary Completion Date: March 2021 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Arm I
Patients undergo lobectomy by open thoracotomy or video-assisted thoracoscopic surgery (VATS).
Procedure: therapeutic thoracoscopy
Patients undergo lobectomy, wedge resection, or anatomical segmentectomy by thoracoscopic surgery
Procedure: videothoracoscopy
Patients undergo lobectomy, wedge resection, or anatomical segmentectomy by video-assisted thoracoscopic surgery
Experimental: Arm II
Patients undergo a wedge resection or anatomical segmentectomy by open thoracotomy or VATS.
Procedure: therapeutic thoracoscopy
Patients undergo lobectomy, wedge resection, or anatomical segmentectomy by thoracoscopic surgery
Procedure: videothoracoscopy
Patients undergo lobectomy, wedge resection, or anatomical segmentectomy by video-assisted thoracoscopic surgery

Detailed Description:

OBJECTIVES:

Primary

  • Compare the disease-free survival of patients with small (≤ 2 cm) peripheral stage IA non-small cell lung cancer undergoing lobectomy vs sublobar resection (wedge resection or segmentectomy).

Secondary

  • Compare the overall survival of patients undergoing lobectomy vs sublobar resection.
  • Compare the rates of loco-regional and systemic recurrence in patients undergoing lobectomy vs sublobar resection.
  • Compare the pulmonary function of these patients, as measured by expiratory flow rates at 6 months postoperatively.
  • Explore the relationship between characteristics of the primary lung cancer, as revealed by pre-operative CT scan and positron emission tomography (PET) imaging, and outcomes.
  • Determine the false-negative rate of preoperative PET scan for identification of involved hilar and mediastinal lymph nodes.
  • Assess the utility of annual follow-up CT scan after surgical resection in these patients.

OUTLINE: This is a multicenter, randomized study. Patients are stratified according to tumor size (< 1 cm vs 1-1.5 cm vs > 1.5-2.0 cm) (based on the maximum dimension determined from the preoperative scan), histology (squamous cell carcinoma vs adenocarcinoma vs other), and smoking status (never smoked [smoked < 100 cigarettes over lifetime] vs former smoker [smoked > 100 cigarettes AND quit ≥ 1 year ago] vs current smoker [quit < 1 year ago or currently smokes]). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo lobectomy by open thoracotomy or video-assisted thoracoscopic surgery (VATS).
  • Arm II: Patients undergo a wedge resection or anatomical segmentectomy by open thoracotomy or VATS.

After completion of study treatment, patients are followed up every 6 months for 2 years and then annually for 5 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Suspected or proven non-small cell lung cancer (NSCLC), meeting both preoperative and intraoperative criteria:

    • Preoperative criteria

      • Peripheral lung nodule ≤ 2 cm by CT scan

        • Center of the tumor must be located in the outer third of the lung in either the transverse, coronal, or sagittal plan
        • Tumor location must be suitable for either lobar or sublobar resection (wedge resection or segmentectomy)
      • No pure ground opacities or pathologically confirmed N1 or N2 disease
    • Intraoperative criteria

      • Histologically confirmed NSCLC
      • Confirmation of N0 status by frozen section examination of nodal levels 4, 7, and 10 on the right side and 5, 6, 7, and 10 on the left side*

        • Levels 4 and 7 nodes may be sampled by mediastinoscopy, endobronchial ultrasound (EBUS), and/or endoscopic ultrasound (EUS), or at the time of thoracotomy or video-assisted thoracoscopic surgery (VATS) exploration* NOTE: *Nodes previously sampled by mediastinoscopy (or EBUS and/or EUS) either immediately before or within 6 weeks of the definitive surgical procedure (thoracotomy or VATS) do not need to be resampled
  • No evidence of locally advanced or metastatic disease

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-2
  • No other malignancy within the past 3 years except for nonmelanoma skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

  • No prior chemotherapy or radiotherapy for this malignancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00499330

  Hide Study Locations
Locations
United States, Alabama
UAB Comprehensive Cancer Center Recruiting
Birmingham, Alabama, United States, 35294
Contact: Clinical Trials Office - UAB Comprehensive Cancer Center    205-934-0309      
United States, Arkansas
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Clinical Trial Office - Arkansas Cancer Research Center at Uni    501-686-8274      
United States, California
Mercy Cancer Center at Mercy San Juan Medical Center Recruiting
Carmichael, California, United States, 95608
Contact: Costanzo A. DiPerna    916-904-3440      
Rebecca and John Moores UCSD Cancer Center Recruiting
La Jolla, California, United States, 92093-0658
Contact: Clinical Trials Office - Rebecca and John Moores UCSD Cancer    858-822-5354    cancercto@ucsd.edu   
Veterans Affairs Medical Center - Loma Linda (Pettis) Recruiting
Loma Linda, California, United States, 92357
Contact: Mark E. Reeves, MD, PhD    909-825-7084ext.6064      
University of California Davis Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Clinical Trials Office - University of California Davis Cancer    916-734-3089      
United States, Colorado
University of Colorado Cancer Center at UC Health Sciences Center Recruiting
Aurora, Colorado, United States, 80045
Contact: Clinical Trials Office - University of Colorado Cancer Center    720-848-0650      
United States, Connecticut
St. Vincent's Medical Center Recruiting
Bridgeport, Connecticut, United States, 06606
Contact: Albert C. DiMeo    203-576-6000      
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center Recruiting
Hartford, Connecticut, United States, 06105
Contact: Philip J. Stella, MD    734-712-1000      
United States, Delaware
Tunnell Cancer Center at Beebe Medical Center Recruiting
Lewes, Delaware, United States, 19958
Contact: Clinical Trials Office - Tunnell Cancer Center    302-645-3171      
CCOP - Christiana Care Health Services Recruiting
Newark, Delaware, United States, 19713
Contact: Clinical Trial Office - CCOP - Christiana Care Health Services    302-623-4450      
United States, Florida
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Recruiting
Fort Lauderdale, Florida, United States, 33308
Contact: Clinical Trials Office - Michael and Dianne Bienes Comprehensi    954-776-3239      
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Recruiting
Jupiter, Florida, United States, 33458
Contact: Clinical Trials Office - Ella Milbank Foshay Cancer Center    561-745-5768      
CCOP - Mount Sinai Medical Center Recruiting
Miami Beach, Florida, United States, 33140
Contact: Roy F. Williams    305-674-2625      
United States, Georgia
Winship Cancer Institute of Emory University Recruiting
Atlanta, Georgia, United States, 30322
Contact: Clinical Trials Office - Winship Cancer Institute    404-778-1900      
United States, Idaho
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Recruiting
Boise, Idaho, United States, 83706
Contact: Clinical Trials Office - Saint Alphonsus Cancer Care Center    208-367-7954      
United States, Illinois
University of Chicago Cancer Research Center Recruiting
Chicago, Illinois, United States, 60637-1470
Contact: Clinical Trials Office - University of Chicago Cancer Research    773-834-7424      
Evanston Hospital Recruiting
Evanston, Illinois, United States, 60201-1781
Contact: Clinical Trials Office - Evanston Hospital    847-570-1381      
United States, Indiana
Indiana University Melvin and Bren Simon Cancer Center Recruiting
Indianapolis, Indiana, United States, 46202-5289
Contact: Clinical Trials Office - Indiana University Cancer Center    317-274-2552      
Veterans Affairs Medical Center - Indianapolis Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Thomas J. Birdas    317-554-0000      
William N. Wishard Memorial Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Thomas J. Birdas    317-639-6671      
United States, Kansas
Menorah Medical Center Recruiting
Overland Park, Kansas, United States, 66209
Contact: Rakesh Gaur, MD    913-948-5588      
Saint Luke's Hospital - South Recruiting
Overland Park, Kansas, United States, 66213
Contact: Rakesh Gaur, MD    913-948-5588      
CCOP - Kansas City Recruiting
Prairie Village, Kansas, United States, 66208
Contact: Rakesh Gaur, MD    913-948-5588      
United States, Kentucky
Lucille P. Markey Cancer Center at University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536-0093
Contact: Clinical Trials Office - Markey Cancer Center at University of    859-257-3379      
United States, Louisiana
Ochsner Cancer Institute at Ochsner Clinic Foundation Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Abbas E. Abbas, MD    614-293-8000      
United States, Maryland
Greenebaum Cancer Center at University of Maryland Medical Center Recruiting
Baltimore, Maryland, United States, 21201
Contact: Clinical Trials Office - Greenebaum Cancer Center at Universit    800-888-8823      
Veterans Affairs Medical Center - Baltimore Recruiting
Baltimore, Maryland, United States, 21201
Contact: Richard J. Battafarano, MD, PhD    410-328-6366      
Upper Chesapeake Medical Center Recruiting
Bel Air, Maryland, United States, 21014
Contact: Richard J. Battafarano, MD, PhD    410-328-6366      
Union Hospital of Cecil County Recruiting
Elkton MD, Maryland, United States, 21921
Contact: Thomas L. Bauer, MD    302-623-4530      
Holy Cross Hospital Recruiting
Silver Spring, Maryland, United States, 20910
Contact: Clinical Trials Office - Holy Cross Hospital    310-754-7552      
United States, Massachusetts
UMASS Memorial Cancer Center - University Campus Recruiting
Worcester, Massachusetts, United States, 01605
Contact: Karl F.L. Uy    508-856-0011      
United States, Michigan
CCOP - Michigan Cancer Research Consortium Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Philip J. Stella, MD    734-712-1000      
Saint Joseph Mercy Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48106-0995
Contact: Philip J. Stella, MD    734-712-1000      
Oakwood Cancer Center at Oakwood Hospital and Medical Center Recruiting
Dearborn, Michigan, United States, 48123-2500
Contact: Clinical Trials Office - Oakwood Cancer Center at Oakwood Hosp    313-593-8090      
Genesys Hurley Cancer Institute Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Genesys Hurley Cancer Institute    810-762-8057      
Hurley Medical Center Recruiting
Flint, Michigan, United States, 48503
Contact: Clinical Trials Office - Hurley Medical Center    810-762-8057      
Genesys Regional Medical Center Recruiting
Grand Blanc, Michigan, United States, 48439
Contact: Philip J. Stella, MD    734-712-1000      
Van Elslander Cancer Center at St. John Hospital and Medical Center Recruiting
Grosse Pointe Woods, Michigan, United States, 48236
Contact: Clincial Trials Office - Van Elslander Cancer Center at St. Jo    313-343-3166      
Foote Memorial Hospital Recruiting
Jackson, Michigan, United States, 49201
Contact: Philip J. Stella, MD    734-712-1000      
Sparrow Regional Cancer Center Recruiting
Lansing, Michigan, United States, 48912-1811
Contact: Clinical Trials Office - Sparrow Regional Cancer Center    517-364-2890      
St. Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Philip J. Stella, MD    734-712-1000      
St. Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341-2985
Contact: Philip J. Stella, MD    734-712-1000      
Mercy Regional Cancer Center at Mercy Hospital Recruiting
Port Huron, Michigan, United States, 48060
Contact: Philip J. Stella, MD    734-712-1000      
Seton Cancer Institute at Saint Mary's - Saginaw Recruiting
Saginaw, Michigan, United States, 48601
Contact: Clinical Trials Office - Seton Cancer Institute - Saginaw    989-776-8411      
St. John Macomb Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Philip J. Stella, MD    734-712-1000      
United States, Minnesota
Mayo Clinic Cancer Center Recruiting
Rochester, Minnesota, United States, 55905
Contact: Clinical Trials Office - All Mayo Clinic Locations    507-538-7623      
United States, Missouri
Saint Luke's Cancer Institute at Saint Luke's Hospital Recruiting
Kansas City, Missouri, United States, 64111
Contact: Rakesh Gaur, MD    913-948-5588      
Heartland Hematology Oncology Associates, Incorporated Recruiting
Kansas City, Missouri, United States, 64118
Contact: Rakesh Gaur, MD    913-948-5588      
Research Medical Center Recruiting
Kansas City, Missouri, United States, 64132
Contact: Rakesh Gaur, MD    913-948-5588      
North Kansas City Hospital Recruiting
Kansas City, Missouri, United States, 64116
Contact: Rakesh Gaur, MD    913-948-5588      
Saint Luke's East - Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64086
Contact: Rakesh Gaur, MD    913-948-5588      
Parvin Radiation Oncology Recruiting
Liberty, Missouri, United States, 64068
Contact: Rakesh Gaur, MD    913-948-5588      
Heartland Regional Medical Center Recruiting
Saint Joseph, Missouri, United States, 64506
Contact: Rakesh Gaur, MD    913-948-5588      
Saint Joseph Oncology, Incorporated Recruiting
Saint Joseph, Missouri, United States, 64507
Contact: Rakesh Gaur, MD    913-948-5588      
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Traves D. Crabtree    314-747-7222      
United States, New Jersey
Valley Hospital - Ridgewood Recruiting
Ridgewood, New Jersey, United States, 07450
Contact: Benjamin E. Lee    201-634-5339      
Cancer Institute of New Jersey at Cooper - Voorhees Recruiting
Voorhees, New Jersey, United States, 08043
Contact: Clinical Trials Office - Cancer Institute of New Jersey at Coo    856-325-6757      
United States, New York
Roswell Park Cancer Institute Recruiting
Buffalo, New York, United States, 14263-0001
Contact: Clinical Trials Office - Roswell Park Cancer Institute    877-275-7724      
New York Weill Cornell Cancer Center at Cornell University Recruiting
New York, New York, United States, 10021
Contact: Clinical Trials Office - New York Weill Cornell Cancer Center    212-746-1848      
James P. Wilmot Cancer Center at University of Rochester Medical Center Recruiting
Rochester, New York, United States, 14642
Contact: Jonathan W. Friedberg    585-275-5345      
SUNY Upstate Medical University Hospital Recruiting
Syracuse, New York, United States, 13210
Contact: Clinical Trials Office - SUNY Upstate Medical University Hospi    315-464-5476      
United States, North Carolina
Veterans Affairs Medical Center - Asheville Recruiting
Asheville, North Carolina, United States, 28805
Contact: John C. Lucke, MD    828-299-2540      
Duke Cancer Institute Recruiting
Durham, North Carolina, United States, 27710
Contact: Clinical Trials Office - Duke Cancer Institute    888-275-3853      
Wayne Memorial Hospital, Incorporated Recruiting
Goldsboro, North Carolina, United States, 27534
Contact: James N. Atkins, MD    919-580-0000      
United States, Ohio
Mercy Cancer Center at Mercy Medical Center Recruiting
Canton, Ohio, United States, 44708
Contact: Mitchell Haut, MD    330-453-9993      
Adena Regional Medical Center Recruiting
Chillicothe, Ohio, United States, 45601
Contact: Clinical Trials Office - Adena Regional Medical Center    877-779-7585      
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210-1240
Contact: Ohio State University Cancer Clinical Trial Matching Service    866-627-7616    Jamesline@osumc.edu   
CCOP - Columbus Recruiting
Columbus, Ohio, United States, 43215
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Doctors Hospital at Ohio Health Recruiting
Columbus, Ohio, United States, 43228
Contact: Clinical Trials Office - Doctors Hospital at Ohio Health    614-566-3275      
Grant Medical Center Cancer Care Recruiting
Columbus, Ohio, United States, 43215
Contact: Clinical Trials Office - Grant Medical Center Cancer Care    614-566-4475      
Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Riverside Methodist Hospital Cancer Care Recruiting
Columbus, Ohio, United States, 43214-3998
Contact: Clinical Trials Office - Riverside Methodist Hospital Cancer C    614-566-4475      
Mount Carmel Health - West Hospital Recruiting
Columbus, Ohio, United States, 43222
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Grady Memorial Hospital Recruiting
Delaware, Ohio, United States, 43015
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Fairfield Medical Center Recruiting
Lancaster, Ohio, United States, 43130
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Strecker Cancer Center at Marietta Memorial Hospital Recruiting
Marietta, Ohio, United States, 45750
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Knox Community Hospital Recruiting
Mount Vernon, Ohio, United States, 43050
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Licking Memorial Cancer Care Program at Licking Memorial Hospital Recruiting
Newark, Ohio, United States, 43055
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Southern Ohio Medical Center Cancer Center Recruiting
Portsmouth, Ohio, United States, 45662
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Community Hospital of Springfield and Clark County Recruiting
Springfield, Ohio, United States, 45505
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Mount Carmel St. Ann's Cancer Center Recruiting
Westerville, Ohio, United States, 43081
Contact: J. Philip Kuebler, MD, PhD    614-442-3130      
Genesis - Good Samaritan Hospital Recruiting
Zanesville, Ohio, United States, 43701
Contact: Clinical Trials Office - Genesis - Good Samaritan Hospital    740-454-5232      
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Alison K. Conlin    503-513-3300      
Providence Milwaukie Hospital Recruiting
Milwaukie, Oregon, United States, 97222
Contact: Alison K. Conlin    503-513-8300      
Providence Newberg Medical Center Recruiting
Newberg, Oregon, United States, 97132
Contact: Alison K. Conlin    503-537-1555      
Willamette Falls Hospital Recruiting
Oregon City, Oregon, United States, 97045
Contact: Alison K. Conlin    503-650-6758      
Providence St. Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Clinical Trials Office - Providence St. Vincent Medical Center    503-215-6412      
Providence Cancer Center at Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213-2967
Contact: Clinical Trials Office - Providence Cancer Center at Providenc    503-215-6412      
CCOP - Columbia River Oncology Program Recruiting
Portland, Oregon, United States, 97225
Contact: Alison K. Conlin    503-216-6260      
United States, Pennsylvania
Geisinger Cancer Institute at Geisinger Health Recruiting
Danville, Pennsylvania, United States, 17822-0001
Contact: Clinical Trials Office - Geisinger Cancer Institute    570-271-5251      
Forbes Regional Hospital Recruiting
Monroeville, Pennsylvania, United States, 15146
Contact: Robert J. Keenan, MD    412-359-6202      
Alle-Kiski Medical Center Recruiting
Natrona Heights, Pennsylvania, United States, 15065
Contact: Robert J. Keenan, MD    412-359-6202      
Jameson Memorial Hospital - North Campus Recruiting
New Castle, Pennsylvania, United States, 16105
Contact: Rodney J. Landreneau, MD    412-623-2025      
Fox Chase Cancer Center - Philadelphia Recruiting
Philadelphia, Pennsylvania, United States, 19111-2497
Contact: Clinical Trials Office - Fox Chase Cancer Center - Philadelphi    215-728-4790      
UPMC Cancer Centers Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Clinical Trials Office - UPMC Cancer Centers    412-647-8073      
Allegheny Cancer Center at Allegheny General Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15212
Contact: Robert J. Keenan, MD    412-359-6202      
United States, South Carolina
Cancer Centers of the Carolinas - Easley Recruiting
Easley, South Carolina, United States, 29640
Contact: Clinical Trials Office - Cancer Centers of the Carolinas    864-241-6251      
Cancer Centers of the Carolinas - Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: Clinical Trials Office - Cancer Centers of the Carolinas    864-241-6251      
Cancer Centers of the Carolinas - Faris Road Recruiting
Greenville, South Carolina, United States, 29605
Contact: David L. Grisell    864-679-3900      
Cancer Centers of the Carolinas - Grove Commons Recruiting
Greenville, South Carolina, United States, 29605
Contact: Clinical Trials Office - Cancer Centers of the Carolinas    864-241-6251      
CCOP - Greenville Recruiting
Greenville, South Carolina, United States, 29615
Contact: David L. Grisell    864-241-6251      
Greenville Hospital Cancer Center Recruiting
Greenville, South Carolina, United States, 29605
Contact: Clinical Trials Office - Greenville Hospital Cancer Center    864-241-6251      
Cancer Centers of the Carolinas - Greer Radiation Oncology Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-334-4900      
Cancer Centers of the Carolinas - Greer Medical Oncology Recruiting
Greer, South Carolina, United States, 29650
Contact: David L. Grisell    864-662-4000      
Cancer Centers of the Carolinas - Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: David L. Grisell    864-888-3717      
Cancer Centers of the Carolinas - Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: David L. Grisell    864-699-5700      
United States, Tennessee
U.T. Medical Center Cancer Institute Recruiting
Knoxville, Tennessee, United States, 37920-6999
Contact: Clinical Trials Office - U.T. Medical Center Cancer Institute    865-544-9773      
United States, Vermont
Fletcher Allen Health Care - University Health Center Campus Recruiting
Burlington, Vermont, United States, 05401
Contact: Clinical Trials Office - Fletcher Allen Health Care    802-656-8990      
United States, Virginia
University of Virginia Cancer Center Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Benjamin D. Kozower    434-924-9333      
United States, Washington
Island Hospital Cancer Care Center at Island Hospital Recruiting
Anacortes, Washington, United States, 98221
Contact: Saul E. Rivkin, MD    206-386-2441      
Auburn Regional Center for Cancer Care Recruiting
Auburn, Washington, United States, 98002
Contact: Yoshio Inoue    253-333-2737      
St. Joseph Cancer Center Recruiting
Bellingham, Washington, United States, 98225
Contact: Saul E. Rivkin, MD    206-386-2441      
Olympic Hematology and Oncology Recruiting
Bremerton, Washington, United States, 98310
Contact: Saul E. Rivkin, MD    206-386-2441      
Highline Medical Center Cancer Center Recruiting
Burien, Washington, United States, 98166
Contact: Saul E. Rivkin, MD    206-386-2441      
Providence Centralia Hospital Recruiting
Centralia, Washington, United States, 98531-9027
Contact: Clinical Trials Office - Providence Centralia H    360-493-4300      
St. Francis Hospital Recruiting
Federal Way, Washington, United States, 98003
Contact: Yoshio Inoue    253-944-7997      
Swedish Medical Center - Issaquah Campus Recruiting
Issaquah, Washington, United States, 98029
Contact: Saul E. Rivkin, MD    206-386-2441      
Columbia Basin Hematology Recruiting
Kennewick, Washington, United States, 99336
Contact: Saul E. Rivkin, MD    206-386-2441      
Skagit Valley Hospital Cancer Care Center Recruiting
Mount Vernon, Washington, United States, 98274
Contact: Saul E. Rivkin, MD    206-386-2441      
Providence St. Peter Hospital Regional Cancer Center Recruiting
Olympia, Washington, United States, 98506-5166
Contact: Yoshio Inoue    360-493-7514      
Harrison Poulsbo Hematology and Onocology Recruiting
Poulsbo, Washington, United States, 98370
Contact: Saul E. Rivkin, MD    206-386-2441      
Good Samaritan Cancer Center Recruiting
Puyallup, Washington, United States, 98372
Contact: Yoshio Inoue    253-697-4000      
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Recruiting
Seattle, Washington, United States, 98122-4307
Contact: Saul E. Rivkin, MD    206-386-2441      
Group Health Central Hospital Recruiting
Seattle, Washington, United States, 98112
Contact: Clinical Trials Office - Group Health Central Hospital    206-287-2900      
Harborview Medical Center Recruiting
Seattle, Washington, United States, 98104
Contact: Saul E. Rivkin, MD    206-386-2441      
Minor and James Medical, PLLC Recruiting
Seattle, Washington, United States, 98104
Contact: Saul E. Rivkin, MD    206-386-2441      
Fred Hutchinson Cancer Research Center Recruiting
Seattle, Washington, United States, 98109
Contact: Saul E. Rivkin, MD    206-386-2441      
University Cancer Center at University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: Saul E. Rivkin, MD    206-386-2441      
North Puget Oncology at United General Hospital Recruiting
Sedro-Woolley, Washington, United States, 98284
Contact: Saul E. Rivkin, MD    206-386-2441      
Cancer Care Northwest - Spokane South Recruiting
Spokane, Washington, United States, 99202
Contact: Clinical Trials Office - Cancer Care Northwest - Spokane South    509-228-1083      
Evergreen Hematology and Oncology, PS Recruiting
Spokane, Washington, United States, 99218
Contact: Saul E. Rivkin, MD    206-386-2441      
Allenmore Hospital Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-459-6446      
CCOP - Northwest Recruiting
Tacoma, Washington, United States, 98405
Contact: Yoshio Inoue    253-403-1461      
Franciscan Cancer Center at St. Joseph Medical Center Recruiting
Tacoma, Washington, United States, 98405-3004
Contact: Clinical Trials Office - Franciscan Cancer Center    253-426-6914      
St. Clare Hospital Recruiting
Tacoma, Washington, United States, 98499
Contact: Yoshio Inoue    253-588-1711      
MultiCare Regional Cancer Center at Tacoma General Hospital Recruiting
Tacoma, Washington, United States, 98405
Contact: Clinical Trials Office - MultiCare Regional Cancer Center    253-403-3229      
Northwest Cancer Specialists at Vancouver Cancer Center Recruiting
Vancouver, Washington, United States, 98684
Contact: Alison K. Conlin    360-944-9889      
Southwest Washington Medical Center Cancer Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Alison K. Conlin    360-514-2174      
Wenatchee Valley Medical Center Recruiting
Wenatchee, Washington, United States, 98801-2028
Contact: Clinical Trials Office - Wenatchee Valley Medical Center    509-665-5800      
Canada, British Columbia
Surrey Memorial Hospital Recruiting
Surrey, British Columbia, Canada, V3V 1Z2
Contact: Ahmad S. Ashrafi    604-581-2211      
Canada, Nova Scotia
Nova Scotia Cancer Centre Recruiting
Halifax, Nova Scotia, Canada, B3H 1V8
Contact: Gordon Buduhan    902-473-6000      
Canada, Ontario
St. Joseph's Hospital - Charlton Campus Recruiting
Hamilton, Ontario, Canada, L8N 4A6
Contact: Yaron Shargall    905-522-4941      
London Regional Cancer Program at London Health Sciences Centre Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Richard A. Malthaner    519-685-8615      
Ottawa Hospital Regional Cancer Centre - General Campus Recruiting
Ottawa, Ontario, Canada, K1H 1C4
Contact: Andrew J.E. Seely    613-737-7700 ext. 70209      
Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Marc de Perrot    416-946-2811      
Canada, Quebec
Hopital Notre-Dame du CHUM Recruiting
Montreal, Quebec, Canada, H2L 4M1
Contact: Moishe Liberman    514-281-6000      
CHUS-Hopital Fleurimont Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Marco Sirois    819-346-1110      
Canada
L'Hopital Laval Recruiting
Quebec, Canada, G1V 4G5
Contact: Jean Deslauriers    418-656-4810      
Sponsors and Collaborators
Cancer and Leukemia Group B
Radiation Therapy Oncology Group
American College of Surgeons
Southwest Oncology Group
Investigators
Study Chair: Nasser K. Altorki, MD Weill Medical College of Cornell University
Study Chair: Harvey I. Pass, MD New York University School of Medicine
Study Chair: Daniel L. Miller, MD Emory University
Study Chair: Kemp H. Kernstine, MD, PhD Holden Comprehensive Cancer Center
  More Information

Additional Information:
No publications provided

Responsible Party: Monica M. Bertagnolli, Cancer and Leukemia Group B
ClinicalTrials.gov Identifier: NCT00499330     History of Changes
Other Study ID Numbers: CDR0000555324, CALGB-140503, ECOG-40503
Study First Received: July 10, 2007
Last Updated: February 15, 2013
Health Authority: Unspecified

Keywords provided by National Cancer Institute (NCI):
stage IA non-small cell lung cancer
adenocarcinoma of the lung
squamous cell lung cancer
large cell lung cancer
adenosquamous cell lung cancer
bronchoalveolar cell lung cancer

Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Bronchial Neoplasms
Carcinoma, Bronchogenic
Lung Diseases
Neoplasms
Neoplasms by Site
Respiratory Tract Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms

ClinicalTrials.gov processed this record on November 23, 2014