Trial record 6 of 15 for:
Alzheimer rosiglitazone
Open-Label Extension Study Of Rosiglitazone XR As Adjunctive Therapy In Subjects With Mild-to-Moderate Alzheimers
This study has been terminated.
(Based on preliminary parent study results)
Sponsor:
GlaxoSmithKline
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT00490568
First received: June 21, 2007
Last updated: May 31, 2012
Last verified: April 2012
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Purpose
This is a Phase III, multicenter, open-label extension, single-group study in male and female outpatients with mild-to-moderate Alzheimer's disease (AD) who have completed either AVA102670 or AVA102672. All subjects will receive rosiglitazone extended-release (RSG XR) 4mg once daily for the first 4 weeks of the study followed by 8mg RSG XR as adjunctive therapy to their existing dose of acetylcholinesterase inhibitor. Subject participation will last until one of 5 conditions applies. After a 52-week open-label treatment phase, subjects will attend a final Follow-Up Visit 6 weeks after the end of treatment. The primary objective of this study is to evaluate the long-term safety and tolerability of RSG XR in subjects with mild-to-moderate AD who have completed either AVA102670 or AVA102672. The secondary objective of this study is to explore further the long-term efficacy of RSG XR in terms of cognitive function and overall clinical response as a function of apolipoprotein E (APOE) e4 allele status.
| Condition | Intervention | Phase |
|---|---|---|
|
Alzheimer's Disease Mild-to-moderate Alzheimers Disease |
Drug: Rosiglitazone XR |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | An Open-label Extension Study of the Long-term Safety and Efficacy of Rosiglitazone Extended-release (RSG XR) as Adjunctive Therapy to Acetylcholinesterase Inhibitors in Subjects With Mild-to-moderate Alzheimers Disease (REFLECT-4). |
Resource links provided by NLM:
Genetics Home Reference related topics:
Alzheimer disease
MedlinePlus related topics:
Alzheimer's Disease
U.S. FDA Resources
Further study details as provided by GlaxoSmithKline:
Primary Outcome Measures:
- Incidence and severity of Adverse Events. [ Time Frame: 52 weeks ]
Secondary Outcome Measures:
- ADAS-cog, CDR-SB, MMSE, DAD and NPI total scores as a function of APOE e4 status. Incidence and severity of SAEs, percentage of subjects with edema, change from baseline in vital signs, weight, non-fasting measures of lipid metabolism. [ Time Frame: 52 weeks ]
| Enrollment: | 1480 |
| Study Start Date: | August 2007 |
| Study Completion Date: | April 2009 |
| Primary Completion Date: | April 2009 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: Arm 1 |
Drug: Rosiglitazone XR
Experimental drug
Other Name: Rosiglitazone XR
|
Eligibility| Ages Eligible for Study: | 51 Years to 91 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion criteria:
- Successful completion of AVA102670 or AVA102672 without safety or tolerability issues. Regular caregiver.
Exclusion criteria:
- Congestive Heart Failure (NYHA 1-4), clinically significant peripheral edema, other neurological conditions that might disqualify participation. SAE, clinically significant laboratory abnormality or significant cardiovascular event during prior study.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00490568
Hide Study Locations
Hide Study LocationsLocations
| United States, Arizona | |
| GSK Investigational Site | |
| Litchfield Park, Arizona, United States, 85340 | |
| GSK Investigational Site | |
| Tucson, Arizona, United States, 85741 | |
| United States, Arkansas | |
| GSK Investigational Site | |
| Little Rock, Arkansas, United States, 72205 | |
| United States, California | |
| GSK Investigational Site | |
| Fresno, California, United States, 93720 | |
| GSK Investigational Site | |
| Rancho Mirage, California, United States, 92270 | |
| GSK Investigational Site | |
| Sacramento, California, United States, 95816 | |
| GSK Investigational Site | |
| San Diego, California, United States, 92103 | |
| GSK Investigational Site | |
| San Francisco, California, United States, 94109 | |
| GSK Investigational Site | |
| Sherman Oaks, California, United States, 91403 | |
| United States, Connecticut | |
| GSK Investigational Site | |
| New Haven, Connecticut, United States, 06510 | |
| GSK Investigational Site | |
| Norwalk, Connecticut, United States, 06851 | |
| United States, Florida | |
| GSK Investigational Site | |
| Deerfield Beach, Florida, United States, 33064 | |
| GSK Investigational Site | |
| Delray Beach, Florida, United States, 33445 | |
| GSK Investigational Site | |
| Hialeah, Florida, United States, 33016 | |
| GSK Investigational Site | |
| Ocala, Florida, United States, 34471 | |
| GSK Investigational Site | |
| St. Petersburg, Florida, United States, 33702 | |
| GSK Investigational Site | |
| West Palm Beach, Florida, United States, 33407 | |
| United States, Indiana | |
| GSK Investigational Site | |
| Fort Wayne, Indiana, United States, 46805 | |
| United States, Maryland | |
| GSK Investigational Site | |
| Rockville, Maryland, United States, 20852 | |
| United States, Massachusetts | |
| GSK Investigational Site | |
| Springfield, Massachusetts, United States, 01104 | |
| GSK Investigational Site | |
| West Yarmouth, Massachusetts, United States, 02673 | |
| United States, Minnesota | |
| GSK Investigational Site | |
| St. Paul, Minnesota, United States, 55101 | |
| United States, New Jersey | |
| GSK Investigational Site | |
| Morristown, New Jersey, United States, 07960 | |
| GSK Investigational Site | |
| Stratford, New Jersey, United States, 08084 | |
| GSK Investigational Site | |
| Toms River, New Jersey, United States, 08755 | |
| United States, New York | |
| GSK Investigational Site | |
| Albany, New York, United States, 12205 | |
| GSK Investigational Site | |
| Brooklyn, New York, United States, 11235 | |
| GSK Investigational Site | |
| New York, New York, United States, 10016 | |
| GSK Investigational Site | |
| Syracuse, New York, United States, 13210 | |
| United States, North Carolina | |
| GSK Investigational Site | |
| Raleigh, North Carolina, United States, 27607 | |
| GSK Investigational Site | |
| Winston-Salem, North Carolina, United States, 27103 | |
| United States, Ohio | |
| GSK Investigational Site | |
| Columbus, Ohio, United States, 43210 | |
| GSK Investigational Site | |
| Toledo, Ohio, United States, 43623 | |
| United States, Oklahoma | |
| GSK Investigational Site | |
| Tulsa, Oklahoma, United States, 74104 | |
| United States, Pennsylvania | |
| GSK Investigational Site | |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| United States, Rhode Island | |
| GSK Investigational Site | |
| Providence, Rhode Island, United States, 02906 | |
| United States, Texas | |
| GSK Investigational Site | |
| Austin, Texas, United States, 78757 | |
| United States, Utah | |
| GSK Investigational Site | |
| South Ogden, Utah, United States, 84403 | |
| United States, Vermont | |
| GSK Investigational Site | |
| Bennington, Vermont, United States, 05201 | |
| United States, Wisconsin | |
| GSK Investigational Site | |
| Milwaukee, Wisconsin, United States, 53226 | |
| Argentina | |
| GSK Investigational Site | |
| Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1192AAW | |
| GSK Investigational Site | |
| Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1419HDN | |
| GSK Investigational Site | |
| Ciudad de Buenos Aires, Buenos Aires, Argentina, C1431FWO | |
| GSK Investigational Site | |
| Cordoba, Córdova, Argentina, 5000 | |
| GSK Investigational Site | |
| Córdoba, Córdova, Argentina, X5004AOA | |
| GSK Investigational Site | |
| Córdoba, Córdova, Argentina, x5009bin | |
| GSK Investigational Site | |
| Godoy Cruz, Mendoza, Argentina, M5504FMI | |
| GSK Investigational Site | |
| Ciudad Autonoma de Buenos Aires, Argentina, C1425CDC | |
| GSK Investigational Site | |
| Mendoza, Argentina, CPM5500HIF | |
| Australia, New South Wales | |
| GSK Investigational Site | |
| Hornsby, New South Wales, Australia, 2077 | |
| GSK Investigational Site | |
| Randwick, New South Wales, Australia, 2031 | |
| Australia, Queensland | |
| GSK Investigational Site | |
| Auchenflower, Queensland, Australia, 4066 | |
| GSK Investigational Site | |
| Chermside, Queensland, Australia, 4032 | |
| GSK Investigational Site | |
| Kippa Ring, Queensland, Australia, 4021 | |
| Australia, South Australia | |
| GSK Investigational Site | |
| Woodville, South Australia, Australia, 5011 | |
| Australia, Victoria | |
| GSK Investigational Site | |
| Cheltenham, Victoria, Australia, 3192 | |
| GSK Investigational Site | |
| Heidelberg Heights, Victoria, Australia, 3084 | |
| GSK Investigational Site | |
| Kew, Victoria, Australia, 3101 | |
| Australia, Western Australia | |
| GSK Investigational Site | |
| Nedlands, Western Australia, Australia, 6009 | |
| Austria | |
| GSK Investigational Site | |
| Hall in Tirol, Austria, A-6060 | |
| GSK Investigational Site | |
| Vienna, Austria, A-1220 | |
| GSK Investigational Site | |
| Vienna, Austria, A-1130 | |
| GSK Investigational Site | |
| Vienna, Austria, 1030 | |
| Belgium | |
| GSK Investigational Site | |
| Kortrijk, Belgium, 8500 | |
| GSK Investigational Site | |
| Leuven, Belgium, 3000 | |
| GSK Investigational Site | |
| Woluwe-Saint-Lambert, Belgium, 1200 | |
| Bulgaria | |
| GSK Investigational Site | |
| Sofia, Bulgaria, 1527 | |
| GSK Investigational Site | |
| Sofia, Bulgaria, 1113 | |
| GSK Investigational Site | |
| Sofia, Bulgaria, 1431 | |
| GSK Investigational Site | |
| Varna, Bulgaria, 9010 | |
| Canada, New Brunswick | |
| GSK Investigational Site | |
| Saint John, New Brunswick, Canada, E2L 3L6 | |
| Canada, Nova Scotia | |
| GSK Investigational Site | |
| Kentville, Nova Scotia, Canada, B4N 4K9 | |
| Canada, Ontario | |
| GSK Investigational Site | |
| Kingston, Ontario, Canada, K7L 4X3 | |
| GSK Investigational Site | |
| Kingston, Ontario, Canada, K7L 5G2 | |
| GSK Investigational Site | |
| Ottawa, Ontario, Canada, K1G 4G3 | |
| GSK Investigational Site | |
| Ottawa, Ontario, Canada, K1N 5C8 | |
| GSK Investigational Site | |
| Peterborough, Ontario, Canada, K9H 2P4 | |
| GSK Investigational Site | |
| Toronto, Ontario, Canada, M3B 2S7 | |
| GSK Investigational Site | |
| Toronto, Ontario, Canada, M5T 2S8 | |
| GSK Investigational Site | |
| Toronto, Ontario, Canada, M6M 3Z5 | |
| GSK Investigational Site | |
| Whitby, Ontario, Canada, L1N 5S9 | |
| Canada, Prince Edward Island | |
| GSK Investigational Site | |
| Charlottetown, Prince Edward Island, Canada, C1A 5Y8 | |
| Canada, Quebec | |
| GSK Investigational Site | |
| Greenfield Park, Quebec, Canada, J4V 2J2 | |
| GSK Investigational Site | |
| Montreal, Quebec, Canada, H1T 2M4 | |
| GSK Investigational Site | |
| Montreal, Quebec, Canada, H4H 1R3 | |
| GSK Investigational Site | |
| Québec, Quebec, Canada, G1R 3X5 | |
| GSK Investigational Site | |
| Sherbrooke, Quebec, Canada, J1H 1Z1 | |
| GSK Investigational Site | |
| Sherbrooke, Quebec, Canada, J1J 3H5 | |
| Canada, Saskatchewan | |
| GSK Investigational Site | |
| Regina, Saskatchewan, Canada, S4T 1A5 | |
| Chile | |
| GSK Investigational Site | |
| Providencia / Santiago, Región Metro De Santiago, Chile, 7500710 | |
| GSK Investigational Site | |
| Santiago, Región Metro De Santiago, Chile, 7560356 | |
| GSK Investigational Site | |
| Viña del Mar, Valparaíso, Chile, 252-0997 | |
| Czech Republic | |
| GSK Investigational Site | |
| Olomouc, Czech Republic, 775 20 | |
| GSK Investigational Site | |
| Ostrava, Czech Republic, 702 00 | |
| GSK Investigational Site | |
| Praha 10, Czech Republic, 10000 | |
| GSK Investigational Site | |
| Praha 2, Czech Republic, 120 00 | |
| GSK Investigational Site | |
| Praha 2, Czech Republic, 120 00 | |
| GSK Investigational Site | |
| Praha 5, Czech Republic, 150 18 | |
| GSK Investigational Site | |
| Praha 7, Czech Republic, 170 00 | |
| GSK Investigational Site | |
| Praha 8, Czech Republic, 180 00 | |
| GSK Investigational Site | |
| Trutnov, Czech Republic, 541 01 | |
| Finland | |
| GSK Investigational Site | |
| Helsinki, Finland, 00120 | |
| GSK Investigational Site | |
| Kuopio, Finland, 70211 | |
| France | |
| GSK Investigational Site | |
| Bourg en Bresse, France, 01012 | |
| GSK Investigational Site | |
| Caen, France, 14033 | |
| GSK Investigational Site | |
| Dijon, France, 21000 | |
| GSK Investigational Site | |
| Ivry, France, 94206 | |
| GSK Investigational Site | |
| La Seyne sur Mer, France, 83500 | |
| GSK Investigational Site | |
| Lille, France, 59000 | |
| GSK Investigational Site | |
| Limoges, France, 87042 | |
| GSK Investigational Site | |
| Luynes, France, 37230 | |
| GSK Investigational Site | |
| Lyon, France, 69006 | |
| GSK Investigational Site | |
| Marseille, France, 13008 | |
| GSK Investigational Site | |
| Marseille, France, 13009 | |
| GSK Investigational Site | |
| Metz, France, 57038 | |
| GSK Investigational Site | |
| Nantes, France, 44300 | |
| GSK Investigational Site | |
| Nantes, France, 44000 | |
| GSK Investigational Site | |
| Nantes, France, 44200 | |
| GSK Investigational Site | |
| Nantes, France, 44093 | |
| GSK Investigational Site | |
| Nice, France, 06002 | |
| GSK Investigational Site | |
| Paris, France, 75013 | |
| GSK Investigational Site | |
| Pau, France, 64000 | |
| GSK Investigational Site | |
| Rodez, France, 12000 | |
| GSK Investigational Site | |
| Saint Ouen la Rouerie, France, 35460 | |
| GSK Investigational Site | |
| Saint-Etienne, France, 42100 | |
| GSK Investigational Site | |
| Sautron, France, 44880 | |
| GSK Investigational Site | |
| Tinteniac, France, 35190 | |
| GSK Investigational Site | |
| Toulon, France, 83000 | |
| GSK Investigational Site | |
| Toulouse, France, 31300 | |
| GSK Investigational Site | |
| Tours, France, 37100 | |
| GSK Investigational Site | |
| Vichy, France, 03200 | |
| Germany | |
| GSK Investigational Site | |
| Aalen, Baden-Wuerttemberg, Germany, 73430 | |
| GSK Investigational Site | |
| Ellwangen, Baden-Wuerttemberg, Germany, 73479 | |
| GSK Investigational Site | |
| Ludwigsburg, Baden-Wuerttemberg, Germany, 71634 | |
| GSK Investigational Site | |
| Ostfildern, Baden-Wuerttemberg, Germany, 73760 | |
| GSK Investigational Site | |
| Stuttgart, Baden-Wuerttemberg, Germany, 70176 | |
| GSK Investigational Site | |
| Tuebingen, Baden-Wuerttemberg, Germany, 72076 | |
| GSK Investigational Site | |
| Ulm, Baden-Wuerttemberg, Germany, 89075 | |
| GSK Investigational Site | |
| Alzenau, Bayern, Germany, 63755 | |
| GSK Investigational Site | |
| Muenchen, Bayern, Germany, 80331 | |
| GSK Investigational Site | |
| Muenchen, Bayern, Germany, 80333 | |
| GSK Investigational Site | |
| Muenchen, Bayern, Germany, 81667 | |
| GSK Investigational Site | |
| Muenchen, Bayern, Germany, 81675 | |
| GSK Investigational Site | |
| Nuernberg, Bayern, Germany, 90402 | |
| GSK Investigational Site | |
| Regensburg, Bayern, Germany, 93053 | |
| GSK Investigational Site | |
| Unterhaching, Bayern, Germany, 82008 | |
| GSK Investigational Site | |
| Bad Saarow, Brandenburg, Germany, 15526 | |
| GSK Investigational Site | |
| Bad Homburg, Hessen, Germany, 61348 | |
| GSK Investigational Site | |
| Erbach, Hessen, Germany, 64711 | |
| GSK Investigational Site | |
| Schwerin, Mecklenburg-Vorpommern, Germany, 19053 | |
| GSK Investigational Site | |
| Achim, Niedersachsen, Germany, 28832 | |
| GSK Investigational Site | |
| Bockhorn, Niedersachsen, Germany, 26345 | |
| GSK Investigational Site | |
| Ganderkesee, Niedersachsen, Germany, 27777 | |
| GSK Investigational Site | |
| Goettingen, Niedersachsen, Germany, 37075 | |
| GSK Investigational Site | |
| Hannover, Niedersachsen, Germany, 30559 | |
| GSK Investigational Site | |
| Lueneburg, Niedersachsen, Germany, 21335 | |
| GSK Investigational Site | |
| Westerstede, Niedersachsen, Germany, 26655 | |
| GSK Investigational Site | |
| Bad Honnef, Nordrhein-Westfalen, Germany, 53604 | |
| GSK Investigational Site | |
| Baesweiler, Nordrhein-Westfalen, Germany, 52499 | |
| GSK Investigational Site | |
| Bergisch Gladbach, Nordrhein-Westfalen, Germany, 51465 | |
| GSK Investigational Site | |
| Bochum, Nordrhein-Westfalen, Germany, 44805 | |
| GSK Investigational Site | |
| Bochum, Nordrhein-Westfalen, Germany, 44791 | |
| GSK Investigational Site | |
| Bochum, Nordrhein-Westfalen, Germany, 44869 | |
| GSK Investigational Site | |
| Dueren, Nordrhein-Westfalen, Germany, 52349 | |
| GSK Investigational Site | |
| Duisburg, Nordrhein-Westfalen, Germany, 47051 | |
| GSK Investigational Site | |
| Essen, Nordrhein-Westfalen, Germany, 45138 | |
| GSK Investigational Site | |
| Hattingen, Nordrhein-Westfalen, Germany, 45525 | |
| GSK Investigational Site | |
| Juelich, Nordrhein-Westfalen, Germany, 52428 | |
| GSK Investigational Site | |
| Koeln, Nordrhein-Westfalen, Germany, 50767 | |
| GSK Investigational Site | |
| Krefeld, Nordrhein-Westfalen, Germany, 47800 | |
| GSK Investigational Site | |
| Siegen, Nordrhein-Westfalen, Germany, 57072 | |
| GSK Investigational Site | |
| Chemnitz, Sachsen, Germany, 09111 | |
| GSK Investigational Site | |
| Dresden, Sachsen, Germany, 01307 | |
| GSK Investigational Site | |
| Dresden, Sachsen, Germany, 01097 | |
| GSK Investigational Site | |
| Leipzig, Sachsen, Germany, 04107 | |
| GSK Investigational Site | |
| Leipzig, Sachsen, Germany, 04157 | |
| GSK Investigational Site | |
| Gera, Thueringen, Germany, 07551 | |
| GSK Investigational Site | |
| Jena, Thueringen, Germany, 07743 | |
| GSK Investigational Site | |
| Berlin, Germany, 12163 | |
| GSK Investigational Site | |
| Berlin, Germany, 13156 | |
| GSK Investigational Site | |
| Berlin, Germany, 13439 | |
| GSK Investigational Site | |
| Berlin, Germany, 12167 | |
| GSK Investigational Site | |
| Berlin, Germany, 13357 | |
| GSK Investigational Site | |
| Berlin, Germany, 12555 | |
| GSK Investigational Site | |
| Hamburg, Germany, 22083 | |
| GSK Investigational Site | |
| Hamburg, Germany, 21149 | |
| Greece | |
| GSK Investigational Site | |
| Athens, Greece, 115 21 | |
| GSK Investigational Site | |
| Melissia, Greece, 151 27 | |
| GSK Investigational Site | |
| Thessaloniki, Greece, 57010 | |
| Hong Kong | |
| GSK Investigational Site | |
| Hong Kong, Hong Kong | |
| GSK Investigational Site | |
| Shatin, Hong Kong | |
| Hungary | |
| GSK Investigational Site | |
| Győr, Hungary, 9024 | |
| GSK Investigational Site | |
| Szeged, Hungary, 6725 | |
| Italy | |
| GSK Investigational Site | |
| Chieti Scalo, Abruzzo, Italy, 66013 | |
| GSK Investigational Site | |
| San Felice a Cancello Caserta, Campania, Italy, 81027 | |
| GSK Investigational Site | |
| Roma, Lazio, Italy, 00163 | |
| GSK Investigational Site | |
| Roma, Lazio, Italy, 00186 | |
| GSK Investigational Site | |
| Roma, Lazio, Italy, 00148 | |
| GSK Investigational Site | |
| Brescia, Lombardia, Italy, 25125 | |
| GSK Investigational Site | |
| Milano, Lombardia, Italy, 20127 | |
| GSK Investigational Site | |
| Milano, Lombardia, Italy, 20122 | |
| GSK Investigational Site | |
| Pavia, Lombardia, Italy, 27100 | |
| GSK Investigational Site | |
| Rho, Lombardia, Italy, 20017 | |
| GSK Investigational Site | |
| Torrette (AN), Marche, Italy, 60020 | |
| GSK Investigational Site | |
| Arezzo, Toscana, Italy, 52100 | |
| GSK Investigational Site | |
| Firenze, Toscana, Italy, 50134 | |
| GSK Investigational Site | |
| Pisa, Toscana, Italy, 56126 | |
| Korea, Republic of | |
| GSK Investigational Site | |
| Seongnam-si,, Korea, Republic of, 463-707 | |
| GSK Investigational Site | |
| Seoul, Korea, Republic of, 138-736 | |
| GSK Investigational Site | |
| Seoul, Korea, Republic of, 150-713 | |
| Mexico | |
| GSK Investigational Site | |
| Monterrey, Nuevo León, Mexico, 64710 | |
| Netherlands | |
| GSK Investigational Site | |
| Alkmaar, Netherlands, 1815 JD | |
| GSK Investigational Site | |
| Blaricum, Netherlands, 1261 AN | |
| GSK Investigational Site | |
| Den Bosch, Netherlands, 5232 JL | |
| GSK Investigational Site | |
| Den Haag, Netherlands, 2545 CH | |
| GSK Investigational Site | |
| Hengelo, Netherlands, 7555 DL | |
| GSK Investigational Site | |
| Hilversum, Netherlands, 1213 XZ | |
| Philippines | |
| GSK Investigational Site | |
| Pasig City, Philippines, 1600 | |
| Poland | |
| GSK Investigational Site | |
| Bydgoszcz, Poland, 85-096 | |
| GSK Investigational Site | |
| Bydgoszcz, Poland, 85-796 | |
| GSK Investigational Site | |
| Katowice, Poland, 40-752 | |
| GSK Investigational Site | |
| Mosina, Poland, 62-050 | |
| GSK Investigational Site | |
| Poznan, Poland, 61-298 | |
| GSK Investigational Site | |
| Sopot, Poland, 81-824 | |
| GSK Investigational Site | |
| Warsaw, Poland, 02-097 | |
| Portugal | |
| GSK Investigational Site | |
| Coimbra, Portugal, 3000-548 | |
| GSK Investigational Site | |
| Lisboa, Portugal, 1649-035 | |
| Slovakia | |
| GSK Investigational Site | |
| Bratislava, Slovakia, 811 01 | |
| GSK Investigational Site | |
| Bratislava, Slovakia, 811 07 | |
| GSK Investigational Site | |
| Bratislava, Slovakia, 825 56 | |
| GSK Investigational Site | |
| Kosice, Slovakia, 041 66 | |
| Slovenia | |
| GSK Investigational Site | |
| Ljubljana, Slovenia, 1000 | |
| GSK Investigational Site | |
| Šempeter, Slovenia, 5290 | |
| South Africa | |
| GSK Investigational Site | |
| Loeventstein, South Africa, 7530 | |
| GSK Investigational Site | |
| Oakdale, South Africa, 7530 | |
| GSK Investigational Site | |
| Richards Bay, South Africa, 3900 | |
| GSK Investigational Site | |
| Rosebank, South Africa, 2196 | |
| GSK Investigational Site | |
| Somerset West, South Africa, 7130 | |
| GSK Investigational Site | |
| Waverley, Bloemfontein, South Africa, 9301 | |
| GSK Investigational Site | |
| Willows, X14, Pretoria, South Africa, 0040 | |
| Spain | |
| GSK Investigational Site | |
| Barcelona, Spain, 08014 | |
| GSK Investigational Site | |
| Barcelona, Spain, 08003 | |
| GSK Investigational Site | |
| Barcelona, Spain, 08907 | |
| GSK Investigational Site | |
| Burgos, Spain, 09006 | |
| GSK Investigational Site | |
| Castellón, Spain, 12004 | |
| GSK Investigational Site | |
| Elche (Alicante), Spain, 03202 | |
| GSK Investigational Site | |
| Gerona, Spain, 17190 | |
| GSK Investigational Site | |
| Madrid, Spain, 28006 | |
| GSK Investigational Site | |
| Murcia, Spain, 30120 | |
| GSK Investigational Site | |
| Palma de Mallorca, Spain, 07014 | |
| GSK Investigational Site | |
| Tarrasa, Barcelona, Spain, 08221 | |
| GSK Investigational Site | |
| Valencia, Spain, 46010 | |
| Sweden | |
| GSK Investigational Site | |
| Jönköping, Sweden, SE-551 85 | |
| GSK Investigational Site | |
| Kalix, Sweden, SE-952 82 | |
| GSK Investigational Site | |
| Mölndal, Sweden, SE-431 41 | |
| GSK Investigational Site | |
| Sundsvall, Sweden, SE-851 86 | |
| GSK Investigational Site | |
| Umeå, Sweden, SE-901 85 | |
| United Kingdom | |
| GSK Investigational Site | |
| Blackpool, Lancashire, United Kingdom, FY2 0JH | |
| GSK Investigational Site | |
| Bradford, United Kingdom, BD3 0DQ | |
| GSK Investigational Site | |
| Liverpool, United Kingdom, L9 7LJ | |
| GSK Investigational Site | |
| West of Scotland Science Park, Glasgow, United Kingdom, G20 0XA | |
Sponsors and Collaborators
GlaxoSmithKline
Investigators
| Study Director: | GSK Clinical Trials | GlaxoSmithKline |
More Information
No publications provided
| Responsible Party: | GlaxoSmithKline |
| ClinicalTrials.gov Identifier: | NCT00490568 History of Changes |
| Other Study ID Numbers: | AVA102675 |
| Study First Received: | June 21, 2007 |
| Last Updated: | May 31, 2012 |
| Health Authority: | United States: Food and Drug Administration |
Keywords provided by GlaxoSmithKline:
|
cognition Alzheimer's disease Rosiglitazone extended-release (XR) safety |
adjunctive therapy BRL-049653 tolerability open-label extension |
Additional relevant MeSH terms:
|
Alzheimer Disease Rosiglitazone Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases Tauopathies Neurodegenerative Diseases Delirium, Dementia, Amnestic, Cognitive Disorders |
Mental Disorders Cholinesterase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Cholinergic Agents Neurotransmitter Agents Physiological Effects of Drugs Hypoglycemic Agents |
ClinicalTrials.gov processed this record on May 19, 2013