Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema - Full Text View

Sponsor:	Odense University Hospital
Information provided by:	Odense University Hospital
ClinicalTrials.gov Identifier:	NCT00442091

Purpose

Dandelion juice has been used in herbal medicine for at least 1000 years. Vesicular hand eczema is a rare, but difficult to treat, type of hand eczema. One case report has shown that ingestion of dandelion juice could induce a beneficial effect on this type of eczema. The purpose of this study is to test whether this effect can be retrieved in other patients.

Condition	Intervention
Vesicular Palmoplantar Eczema Pompholyx	Drug: dandelion juice

Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment
Official Title:	Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

Resource links provided by NLM:

MedlinePlus related topics: Eczema

U.S. FDA Resources

Further study details as provided by Odense University Hospital:

Primary Outcome Measures:

Improvement in dyshidrotic hand eczema in the study period assessed by HECSI score. [ Time Frame: 3-4 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Improvement in dyshidrotic eczema in the study period assessed by the patient (Visual Analog Scale). [ Time Frame: 3-4 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment:	4
Study Start Date:	December 2010
Estimated Study Completion Date:	December 2011
Estimated Primary Completion Date:	December 2011 (Final data collection date for primary outcome measure)

Intervention Details:

10 ml bid for 20-30 days

Detailed Description:

Dandelion juice has been used in herbal medicine for at least 1000 years. One case report has shown a beneficial effect of this herbal remedy on dyshidrotic hand eczema, and the purpose of this pilot study is to test whether this effect can be retrieved in other patients.

The patients are recruited from our out-patient clinic. Only patients with negative patch tests to Compositae are offered treatment with dandelion juice for 20-30 days.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Adult patients with dyshidrotic eczema for at least 1 year and negative patch test reactions to Compositae (tested within the last 3 years) and normal renal and hepatic blood tests.

Exclusion Criteria:

Treatment with systemic steroids or other immunosuppressive/-modulating drugs, including UV therapy, within the last 3 months.
Pregnancy, lactation.
Compositae contact allergy.
Liver or gall bladder disease.
Abnormal renal or hepatic blood tests.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00442091

Contacts

Contact: Evy Paulsen, Dr.

+6541 2705

evy.paulsen@regionsyddanmark.dk

Locations

Denmark
Department of Dermatology, Odense University Hospital	Recruiting
Odense, Denmark, DK-5000
Contact: Evy Paulsen, Dr. +45 6541 2705 evy.paulsen@regionsyddanmark.dk
Contact: Klaus E Andersen, Professor +45 6541 2700 klaus.ejner.andersen@regionsyddanmark.dk
Principal Investigator: Evy Paulsen, Dr.

Sponsors and Collaborators

Odense University Hospital

Investigators

Principal Investigator:

Evy Paulsen, Dr.

Department of Dermatology, Odense University Hospital, DK-5000 Odense C

More Information

No publications provided

Responsible Party:	Evy Paulsen, Dept. of Dermatology, Odense University Hospital, Odense, Denmark
ClinicalTrials.gov Identifier:	NCT00442091 History of Changes
Other Study ID Numbers:	20070010
Study First Received:	February 28, 2007
Last Updated:	July 21, 2011
Health Authority:	Denmark: Ethics Committee

Keywords provided by Odense University Hospital:

Dandelion
herbal remedy
hand eczema
Compositae

Additional relevant MeSH terms:

Eczema
Eczema, Dyshidrotic
Dermatitis

Skin Diseases
Skin Diseases, Eczematous
Skin Diseases, Vesiculobullous

ClinicalTrials.gov processed this record on February 12, 2012