Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

This study has been completed.

First Received on January 19, 2007. Last Updated on February 4, 2009 History of Changes

Sponsor:	University of Aarhus
Information provided by:	University of Aarhus
ClinicalTrials.gov Identifier:	NCT00424957

Purpose

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Condition
Cirrhosis Hepatic Encephalopathy

Study Type:	Observational
Study Design:	Observational Model: Case Control Time Perspective: Cross-Sectional
Official Title:	Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Resource links provided by NLM:

Genetics Home Reference related topics: North American Indian childhood cirrhosis

MedlinePlus related topics: Cirrhosis Liver Diseases

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Estimated Enrollment:	18
Study Start Date:	November 2006
Study Completion Date:	October 2008
Primary Completion Date:	April 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	45 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects age and sex matched

Criteria

Inclusion Criteria:

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
6 healthy subjects age and sex matched

Exclusion Criteria:

Neurological and/or psychiatric condition,
Non-treated diabetes,
Pregnancy/breast-feeding

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00424957

Locations

Denmark
PET Centre, Aarhus University Hospital
Aarhus, Denmark, 8000

Sponsors and Collaborators

University of Aarhus

Investigators

Study Chair:

Susanne Keiding, MD

PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital

More Information

Additional Information:

Liver research group at PET Centre, Aarhus University Hospital This link exits the ClinicalTrials.gov site

Publications:

Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. Review.

Responsible Party:	Peter Iversen, PET Center, Aarhus University Hospital
ClinicalTrials.gov Identifier:	NCT00424957 History of Changes
Other Study ID Numbers:	20060120
Study First Received:	January 19, 2007
Last Updated:	February 4, 2009
Health Authority:	Denmark: Ethics Committee; Denmark: The Danish National Committee on Biomedical Research Ethics; Denmark: Danish Dataprotection Agency

Keywords provided by University of Aarhus:

Ammonia
Astrocytes
Citric acid cycle
Alpha ketoglutarate dehydrogenase

Additional relevant MeSH terms:

Hepatic Encephalopathy
Liver Cirrhosis
Fibrosis
Brain Damage, Chronic
Delirium
Encephalitis
Neurotoxicity Syndromes
Liver Failure
Hepatic Insufficiency
Liver Diseases
Digestive System Diseases
Brain Diseases, Metabolic
Brain Diseases
Central Nervous System Diseases

Nervous System Diseases
Metabolic Diseases
Pathologic Processes
Confusion
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Central Nervous System Viral Diseases
Virus Diseases
Central Nervous System Infections
Poisoning
Substance-Related Disorders

ClinicalTrials.gov processed this record on February 09, 2012